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Genital blistering

MedGen UID:
1616961
Concept ID:
C3854369
Finding
HPO: HP:0031464

Definition

The presence of one or more bullae on the skin of the genital region, defined as fluid-filled blisters more than 5 mm in diameter with thin walls. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGenital blistering

Professional guidelines

PubMed

Schmidt E, Rashid H, Marzano AV, Lamberts A, Di Zenzo G, Diercks GFH, Alberti-Violetti S, Barry RJ, Borradori L, Caproni M, Carey B, Carrozzo M, Cianchini G, Corrà A, Dikkers FG, Feliciani C, Geerling G, Genovese G, Hertl M, Joly P, Meijer JM, Mercadante V, Murrell DF, Ormond M, Pas HH, Patsatsi A, Rauz S, van Rhijn BD, Roth M, Setterfield J, Zillikens D, C Prost, Zambruno G, Horváth B, Caux F
J Eur Acad Dermatol Venereol 2021 Oct;35(10):1926-1948. Epub 2021 Jul 26 doi: 10.1111/jdv.17395. PMID: 34309078Free PMC Article
Kłysik K, Pietraszek A, Karewicz A, Nowakowska M
Curr Med Chem 2020;27(24):4118-4137. doi: 10.2174/0929867325666180309105519. PMID: 29521211
Ismail SB, Kumar SK, Zain RB
J Oral Sci 2007 Jun;49(2):89-106. doi: 10.2334/josnusd.49.89. PMID: 17634721

Recent clinical studies

Etiology

Polansky H, Javaherian A, Itzkovitz E
J Evid Based Integr Med 2018 Jan-Dec;23:2515690X18806269. doi: 10.1177/2515690X18806269. PMID: 30362389Free PMC Article
Lerch M, Mainetti C, Terziroli Beretta-Piccoli B, Harr T
Clin Rev Allergy Immunol 2018 Feb;54(1):147-176. doi: 10.1007/s12016-017-8654-z. PMID: 29188475
Dodiuk-Gad RP, Chung WH, Valeyrie-Allanore L, Shear NH
Am J Clin Dermatol 2015 Dec;16(6):475-93. doi: 10.1007/s40257-015-0158-0. PMID: 26481651
Mustafa MB, Porter SR, Smoller BR, Sitaru C
Autoimmun Rev 2015 Oct;14(10):930-51. Epub 2015 Jun 24 doi: 10.1016/j.autrev.2015.06.005. PMID: 26117595
Kwok CS, Gibbs S, Bennett C, Holland R, Abbott R
Cochrane Database Syst Rev 2012 Sep 12;2012(9):CD001781. doi: 10.1002/14651858.CD001781.pub3. PMID: 22972052Free PMC Article

Diagnosis

Schmidt E, Rashid H, Marzano AV, Lamberts A, Di Zenzo G, Diercks GFH, Alberti-Violetti S, Barry RJ, Borradori L, Caproni M, Carey B, Carrozzo M, Cianchini G, Corrà A, Dikkers FG, Feliciani C, Geerling G, Genovese G, Hertl M, Joly P, Meijer JM, Mercadante V, Murrell DF, Ormond M, Pas HH, Patsatsi A, Rauz S, van Rhijn BD, Roth M, Setterfield J, Zillikens D, C Prost, Zambruno G, Horváth B, Caux F
J Eur Acad Dermatol Venereol 2021 Oct;35(10):1926-1948. Epub 2021 Jul 26 doi: 10.1111/jdv.17395. PMID: 34309078Free PMC Article
Sung WH, Tsao YT, Shen CJ, Tsai CY, Cheng CM
J Nanobiotechnology 2021 Apr 21;19(1):114. doi: 10.1186/s12951-021-00852-1. PMID: 33882955Free PMC Article
Gonçalves R, Gata L, Brett A
BMJ Case Rep 2021 Apr 15;14(4) doi: 10.1136/bcr-2020-239086. PMID: 33858884Free PMC Article
Lerch M, Mainetti C, Terziroli Beretta-Piccoli B, Harr T
Clin Rev Allergy Immunol 2018 Feb;54(1):147-176. doi: 10.1007/s12016-017-8654-z. PMID: 29188475
Ismail SB, Kumar SK, Zain RB
J Oral Sci 2007 Jun;49(2):89-106. doi: 10.2334/josnusd.49.89. PMID: 17634721

Therapy

Polansky H, Javaherian A, Itzkovitz E
J Evid Based Integr Med 2018 Jan-Dec;23:2515690X18806269. doi: 10.1177/2515690X18806269. PMID: 30362389Free PMC Article
Lerch M, Mainetti C, Terziroli Beretta-Piccoli B, Harr T
Clin Rev Allergy Immunol 2018 Feb;54(1):147-176. doi: 10.1007/s12016-017-8654-z. PMID: 29188475
Kwok CS, Gibbs S, Bennett C, Holland R, Abbott R
Cochrane Database Syst Rev 2012 Sep 12;2012(9):CD001781. doi: 10.1002/14651858.CD001781.pub3. PMID: 22972052Free PMC Article
Ismail SB, Kumar SK, Zain RB
J Oral Sci 2007 Jun;49(2):89-106. doi: 10.2334/josnusd.49.89. PMID: 17634721
Bowers M
BETA 1998 Jul:41-2. PMID: 11365563

Prognosis

Imafuku S
J Dermatol 2023 Mar;50(3):299-304. Epub 2023 Feb 13 doi: 10.1111/1346-8138.16734. PMID: 36779390
Sung WH, Tsao YT, Shen CJ, Tsai CY, Cheng CM
J Nanobiotechnology 2021 Apr 21;19(1):114. doi: 10.1186/s12951-021-00852-1. PMID: 33882955Free PMC Article
Dodiuk-Gad RP, Chung WH, Valeyrie-Allanore L, Shear NH
Am J Clin Dermatol 2015 Dec;16(6):475-93. doi: 10.1007/s40257-015-0158-0. PMID: 26481651
Gerull R, Nelle M, Schaible T
Crit Care Med 2011 Jun;39(6):1521-32. doi: 10.1097/CCM.0b013e31821201ed. PMID: 21358399
Lo Russo L, Fedele S, Guiglia R, Ciavarella D, Lo Muzio L, Gallo P, Di Liberto C, Campisi G
J Periodontol 2008 Jan;79(1):4-24. doi: 10.1902/jop.2008.070231. PMID: 18166088

Clinical prediction guides

Mollel JT, Said JS, Masalu RJ, Hannoun C, Mbunde MVN, Nondo RSO, Bergström T, Trybala E
J Ethnopharmacol 2022 Jun 28;292:115204. Epub 2022 Mar 16 doi: 10.1016/j.jep.2022.115204. PMID: 35304278
Burkett LS, Siddique M, Zeymo A, Brunn EA, Gutman RE, Park AJ, Iglesia CB
Obstet Gynecol 2021 Jun 1;137(6):968-978. doi: 10.1097/AOG.0000000000004332. PMID: 33957642
Zaouak A, Chabchoub I, Essid D, Ben Jennet S, Hammami H, Fenniche S
Skinmed 2019;17(5):306-309. Epub 2019 Sep 1 PMID: 31782703
Lerch M, Mainetti C, Terziroli Beretta-Piccoli B, Harr T
Clin Rev Allergy Immunol 2018 Feb;54(1):147-176. doi: 10.1007/s12016-017-8654-z. PMID: 29188475
Akhyani M, Chams-Davatchi C, Naraghi Z, Daneshpazhooh M, Toosi S, Asgari M, Malekhami F
Br J Dermatol 2008 Mar;158(3):478-82. Epub 2007 Dec 6 doi: 10.1111/j.1365-2133.2007.08356.x. PMID: 18070212

Recent systematic reviews

Wilson A, Murrell DF
Clin Exp Dermatol 2022 May;47(5):873-881. Epub 2022 Jan 2 doi: 10.1111/ced.15059. PMID: 34919291
Münstedt K
Complement Ther Med 2019 Apr;43:81-84. Epub 2019 Jan 22 doi: 10.1016/j.ctim.2019.01.014. PMID: 30935560
Kwok CS, Gibbs S, Bennett C, Holland R, Abbott R
Cochrane Database Syst Rev 2012 Sep 12;2012(9):CD001781. doi: 10.1002/14651858.CD001781.pub3. PMID: 22972052Free PMC Article

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