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Aortic valve prolapse

MedGen UID:: 1619
•Concept ID:: C0003505
•: Disease or Syndrome

Synonyms:	Aortic Valve Prolapse; Aortic Valve Prolapses; Prolapse, Aortic Valve; Prolapses, Aortic Valve; Valve Prolapse, Aortic; Valve Prolapses, Aortic

HPO:	HP:0025578
Monarch Initiative:	MONDO:0006655

Definition

Aortic valve prolapse can be diagnosed when either or both of the right or non-coronary aortic valve cusps (seen in the cross sectional echocardiographic long axis view) show backward bowing towards the left ventricle beyond a line joining the points of attachment of the aortic valve leaflets to the annulus. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAortic valve disorder
- Aortic valve atresia
- CROGVAortic valve calcification
- CROGVAortic valve disease 1
- CROGVAortic valve disease 2
- CROGVAortic valve disease 3
- CROGVAortic valve prolapse
- CROGVAortic valve stenosis
- CROGVFamilial bicuspid aortic valve

Disorder of cardiovascular system
- Abnormality of the cardiovascular system
  - Abnormal cardiovascular system morphology
    - Abnormal heart morphology
      - Abnormal heart valve morphology
        Abnormal aortic valve morphology
        Aortic valve prolapse

Conditions with this feature

Braddock-carey syndrome 1

MedGen UID:: 1823961
•Concept ID:: C5774188
•: Disease or Syndrome

Braddock-Carey syndrome (BRDCS) is characterized by Pierre-Robin sequence, persistent congenital thrombocytopenia, agenesis of the corpus callosum, severe developmental delay, microcephaly, high forehead, sparse curly hair, downslanting palpebral fissures, telecanthus, inverted U-shaped upper vermilion, enamel hypoplasia, large posteriorly rotated ears, clinodactyly, and camptodactyly (Braddock et al., 2016). Genetic Heterogeneity of Braddock-Carey Syndrome BRDCS2 (619981) is caused by mutation in the KIF15 gene (617569) on chromosome 3p21.

See: Condition Record

Braddock-carey syndrome 1

Professional guidelines

PubMed

Re-evaluation of the criteria for asymmetric amplatzer occluders in the closure of perimembranous ventricular septal defects: A case series report.

Li G, Liao H, Wu J, Zhou K, Hua Y, Wang C, Duan H, Shi X, Wu G, Li Y
Medicine (Baltimore) 2020 Aug 21;99(34):e21356. doi: 10.1097/MD.0000000000021356. PMID: 32846756 Free PMC Article

Surgical management of ventricular septal defect with aortic valve prolapse: clinical considerations and results.

Brauner R, Birk E, Sahar G, Blieden L, Vidne BA
Eur J Cardiothorac Surg 1995;9(6):315-9. doi: 10.1016/s1010-7940(05)80189-7. PMID: 7546804

See all (2)

Recent clinical studies

Etiology

Mitral and aortic valve regurgitation following surgical and transcatheter perimembranous ventricular septal defect closure in children and adolescents: midterm outcomes.

Edraki M, Nobakhti M, Naghshzan A, Amoozgar H, Amirghofran A, Ghasemzadeh B, Nirooie E, Mehdizadegan N, Mohammadi H, Keshavarz K
BMC Cardiovasc Disord 2022 Jul 15;22(1):315. doi: 10.1186/s12872-022-02757-9. PMID: 35840901 Free PMC Article

Inter-operative determination of the aortic root and cusp geometry associated with the aortic regurgitation grade.

Fujiyoshi T, Matsumoto R, Kamiya K, Ogino H
Surg Today 2021 Mar;51(3):384-390. Epub 2020 Aug 10 doi: 10.1007/s00595-020-02100-9. PMID: 32776293

Aortic valve stenosis and regurgitation: an overview of management.

Svensson LG
J Cardiovasc Surg (Torino) 2008 Apr;49(2):297-303. PMID: 18431353

Ventricular septal defect and aortic valve regurgitation: pathophysiology and indications for surgery.

Tweddell JS, Pelech AN, Frommelt PC
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2006:147-52. doi: 10.1053/j.pcsu.2006.02.020. PMID: 16638560

Aortic valve repair for aortic insufficiency in adults: a contemporary review and comparison with replacement techniques.

Carr JA, Savage EB
Eur J Cardiothorac Surg 2004 Jan;25(1):6-15. doi: 10.1016/j.ejcts.2003.09.018. PMID: 14690726

See all (93)

Diagnosis

Transcatheter closure of ventricular septal defect in aortic valve prolapse and aortic regurgitation.

Ghosh S, Sridhar A, Solomon N, Sivaprakasham M
Indian Heart J 2018 Jul-Aug;70(4):528-532. Epub 2017 Nov 27 doi: 10.1016/j.ihj.2017.11.023. PMID: 30170648 Free PMC Article

Aortic Valve Prolapse and Aortic Regurgitation During Long-Term Follow Up in Children with Ventricular Septal Defect.

Ugan Atik S, Guler Eroglu A
J Heart Valve Dis 2017 Nov;26(6):616-623. PMID: 30207110

Aortic valve prolapse misdiagnosed as aortic sinus aneurysm in patients with ventricular septal defect. Analysis of the echocardiographic findings.

Hu G, Zhu X, Song F
Saudi Med J 2017 Apr;38(4):431-434. doi: 10.15537/smj.2017.4.18761. PMID: 28397952 Free PMC Article

Assessment and repair of aortic valve cusp prolapse: implications for valve-sparing procedures.

Boodhwani M, de Kerchove L, Watremez C, Glineur D, Vanoverschelde JL, Noirhomme P, El Khoury G
J Thorac Cardiovasc Surg 2011 Apr;141(4):917-25. Epub 2011 Feb 3 doi: 10.1016/j.jtcvs.2010.12.006. PMID: 21292284

Transesophageal echocardiographic evaluation during aortic valve repair surgery.

Van Dyck MJ, Watremez C, Boodhwani M, Vanoverschelde JL, El Khoury G
Anesth Analg 2010 Jul;111(1):59-70. Epub 2010 Jun 3 doi: 10.1213/ANE.0b013e3181dd2579. PMID: 20522704

See all (71)

Therapy

Mitral and aortic valve regurgitation following surgical and transcatheter perimembranous ventricular septal defect closure in children and adolescents: midterm outcomes.

Long-Term Results after Aortic Valve-Sparing-Reimplantation Operation (David) in Bicuspid Aortic Valve.

Richardt D, Stierle U, Sievers HH
J Heart Valve Dis 2015 Jan;24(1):4-9. PMID: 26182614

Assessment and repair of aortic valve cusp prolapse: implications for valve-sparing procedures.

Stentless aortic valve replacement: current status and future trends.

Luciani GB
Expert Rev Cardiovasc Ther 2004 Jan;2(1):127-40. doi: 10.1586/14779072.2.1.127. PMID: 15038420

Two dimensional echocardiography in mitral, aortic and tricuspid valve prolapse. The clinical problem, cardiac nuclear imaging considerations and a proposed standard for diagnosis.

Morganroth J, Jones RH, Chen CC, Naito M
Am J Cardiol 1980 Dec 18;46(7):1164-77. doi: 10.1016/0002-9149(80)90287-8. PMID: 7006361

See all (22)

Prognosis

Prognostic factors associated with postoperative adverse outcomes in patients with aortic valve prolapse.

Ruan Y, Liu X, Meng X, Zhang H, He Y
Medicine (Baltimore) 2020 Apr;99(17):e19827. doi: 10.1097/MD.0000000000019827. PMID: 32332629 Free PMC Article

Transcatheter closure of ventricular septal defect in aortic valve prolapse and aortic regurgitation.

Ghosh S, Sridhar A, Solomon N, Sivaprakasham M
Indian Heart J 2018 Jul-Aug;70(4):528-532. Epub 2017 Nov 27 doi: 10.1016/j.ihj.2017.11.023. PMID: 30170648 Free PMC Article

Aortic Valve Prolapse and Aortic Regurgitation During Long-Term Follow Up in Children with Ventricular Septal Defect.

Ugan Atik S, Guler Eroglu A
J Heart Valve Dis 2017 Nov;26(6):616-623. PMID: 30207110

Aortic valve repair: the functional approach to leaflet prolapse and valve-sparing surgery.

Jeanmart H, de Kerchove L, Glineur D, Goffinet JM, Rougui I, Van Dyck M, Noirhomme P, El Khoury G
Ann Thorac Surg 2007 Feb;83(2):S746-51; discussion S785-90. doi: 10.1016/j.athoracsur.2006.10.089. PMID: 17257920

Aortic valve prolapse and aortic regurgitation in patients with ventricular septal defect.

Eroğlu AG, Oztunç F, Saltik L, Dedeoğlu S, Bakari S, Ahunbay G
Pediatr Cardiol 2003 Jan-Feb;24(1):36-9. Epub 2002 Sep 25 doi: 10.1007/s00246-002-1423-6. PMID: 12360382

See all (57)