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Increased Osteoid

MedGen UID:
1620612
•Concept ID:
C4528296
•
Finding

Definition

An increase in the amount of unmineralized bone matrix as compared to a standard or norm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased Osteoid

Professional guidelines

PubMed

Treatment of Human Immunodeficiency Virus Infection With Tenofovir Disoproxil Fumarate-Containing Antiretrovirals Maintains Low Bone Formation Rate, But Increases Osteoid Volume on Bone Histomorphometry.
Ramalho J, Martins CSW, Galvão J, Furukawa LN, Domingues WV, Oliveira IB, Dos Reis LM, Pereira RM, Nickolas TL, Yin MT, Eira M, Jorgetti V, Moyses RM
J Bone Miner Res 2019 Sep;34(9):1574-1584. Epub 2019 Jul 3 doi: 10.1002/jbmr.3751. PMID: 31269294Free PMC Article
Decreased serum ionized calcium and normal vitamin D metabolite levels with anticonvulsant drug treatment.
Weinstein RS, Bryce GF, Sappington LJ, King DW, Gallagher BB
J Clin Endocrinol Metab 1984 Jun;58(6):1003-9. doi: 10.1210/jcem-58-6-1003. PMID: 6725504

Recent clinical studies

Etiology

Role of periosteum during healing of alveolar critical size bone defects in the mandible: a pilot study.
Duong LT, Petit S, Kerner S, Clerc MM, Arnoult C, Nowwarote N, Osathanon T, Fournier BPJ, Isaac J, Ferré FC
Clin Oral Investig 2023 Aug;27(8):4541-4552. Epub 2023 Jun 1 doi: 10.1007/s00784-023-05079-y. PMID: 37261496
Bone histomorphometry in celiac disease.
Arnala I, Kemppainen T, Kröger H, Janatuinen E, Alhava EM
Ann Chir Gynaecol 2001;90(2):100-4. PMID: 11459257
Histopathological characterization of melorheostosis.
Hoshi K, Amizuka N, Kurokawa T, Nakamura K, Shiro R, Ozawa H
Orthopedics 2001 Mar;24(3):273-7. doi: 10.3928/0147-7447-20010301-20. PMID: 11300293
Osteomalacia associated with adult Fanconi's syndrome: clinical and diagnostic features.
Clarke BL, Wynne AG, Wilson DM, Fitzpatrick LA
Clin Endocrinol (Oxf) 1995 Oct;43(4):479-90. doi: 10.1111/j.1365-2265.1995.tb02621.x. PMID: 7586624
Pathologic assessment of bone.
Aufdemorte TB
Hosp Pract (Off Ed) 1991;26 Suppl 1:18-22. doi: 10.1080/21548331.1991.11704265. PMID: 1898509

Diagnosis

Osteoid osteoma and osteoblastoma.
Atesok KI, Alman BA, Schemitsch EH, Peyser A, Mankin H
J Am Acad Orthop Surg 2011 Nov;19(11):678-89. doi: 10.5435/00124635-201111000-00004. PMID: 22052644
Bone histomorphometry in celiac disease.
Arnala I, Kemppainen T, Kröger H, Janatuinen E, Alhava EM
Ann Chir Gynaecol 2001;90(2):100-4. PMID: 11459257
Bone mineral density and histology in distal renal tubular acidosis.
Domrongkitchaiporn S, Pongsakul C, Stitchantrakul W, Sirikulchayanonta V, Ongphiphadhanakul B, Radinahamed P, Karnsombut P, Kunkitti N, Ruang-raksa C, Rajatanavin R
Kidney Int 2001 Mar;59(3):1086-93. doi: 10.1046/j.1523-1755.2001.0590031086.x. PMID: 11231364
Osteomalacia associated with adult Fanconi's syndrome: clinical and diagnostic features.
Clarke BL, Wynne AG, Wilson DM, Fitzpatrick LA
Clin Endocrinol (Oxf) 1995 Oct;43(4):479-90. doi: 10.1111/j.1365-2265.1995.tb02621.x. PMID: 7586624
Pathologic assessment of bone.
Aufdemorte TB
Hosp Pract (Off Ed) 1991;26 Suppl 1:18-22. doi: 10.1080/21548331.1991.11704265. PMID: 1898509

Therapy

Low-intensity pulsed ultrasound increases blood vessel size during fracture healing in patients with a delayed-union of the osteotomized fibula.
Korstjens CM, Rutten S, Nolte PA, van Duin MA, Klein-Nulend J
Histol Histopathol 2018 Jul;33(7):737-746. Epub 2018 Feb 13 doi: 10.14670/HH-11-972. PMID: 29436706
Osteoid osteoma and osteoblastoma.
Atesok KI, Alman BA, Schemitsch EH, Peyser A, Mankin H
J Am Acad Orthop Surg 2011 Nov;19(11):678-89. doi: 10.5435/00124635-201111000-00004. PMID: 22052644
Fluoride and strontium accumulation in bone does not correlate with osteoid tissue in dialysis patients.
Cohen-Solal ME, Augry F, Mauras Y, Morieux C, Allain P, de Vernejoul MC
Nephrol Dial Transplant 2002 Mar;17(3):449-54. doi: 10.1093/ndt/17.3.449. PMID: 11865091
Osteomalacia associated with adult Fanconi's syndrome: clinical and diagnostic features.
Clarke BL, Wynne AG, Wilson DM, Fitzpatrick LA
Clin Endocrinol (Oxf) 1995 Oct;43(4):479-90. doi: 10.1111/j.1365-2265.1995.tb02621.x. PMID: 7586624
Quantitative bone histology in children with chronic renal failure.
Hodson EM, Evans RA, Dunstan CR, Hills EE, Shaw PF
Kidney Int 1982 Jun;21(6):833-9. doi: 10.1038/ki.1982.107. PMID: 7132053

Prognosis

Non-Lethal Type VIII Osteogenesis Imperfecta Has Elevated Bone Matrix Mineralization.
Fratzl-Zelman N, Barnes AM, Weis M, Carter E, Hefferan TE, Perino G, Chang W, Smith PA, Roschger P, Klaushofer K, Glorieux FH, Eyre DR, Raggio C, Rauch F, Marini JC
J Clin Endocrinol Metab 2016 Sep;101(9):3516-25. Epub 2016 Jul 6 doi: 10.1210/jc.2016-1334. PMID: 27383115Free PMC Article
Osteoid osteoma and osteoblastoma.
Atesok KI, Alman BA, Schemitsch EH, Peyser A, Mankin H
J Am Acad Orthop Surg 2011 Nov;19(11):678-89. doi: 10.5435/00124635-201111000-00004. PMID: 22052644
Histopathological characterization of melorheostosis.
Hoshi K, Amizuka N, Kurokawa T, Nakamura K, Shiro R, Ozawa H
Orthopedics 2001 Mar;24(3):273-7. doi: 10.3928/0147-7447-20010301-20. PMID: 11300293
Osteomalacia associated with adult Fanconi's syndrome: clinical and diagnostic features.
Clarke BL, Wynne AG, Wilson DM, Fitzpatrick LA
Clin Endocrinol (Oxf) 1995 Oct;43(4):479-90. doi: 10.1111/j.1365-2265.1995.tb02621.x. PMID: 7586624
Quantitative bone histology in children with chronic renal failure.
Hodson EM, Evans RA, Dunstan CR, Hills EE, Shaw PF
Kidney Int 1982 Jun;21(6):833-9. doi: 10.1038/ki.1982.107. PMID: 7132053

Clinical prediction guides

Treatment of Human Immunodeficiency Virus Infection With Tenofovir Disoproxil Fumarate-Containing Antiretrovirals Maintains Low Bone Formation Rate, But Increases Osteoid Volume on Bone Histomorphometry.
Ramalho J, Martins CSW, Galvão J, Furukawa LN, Domingues WV, Oliveira IB, Dos Reis LM, Pereira RM, Nickolas TL, Yin MT, Eira M, Jorgetti V, Moyses RM
J Bone Miner Res 2019 Sep;34(9):1574-1584. Epub 2019 Jul 3 doi: 10.1002/jbmr.3751. PMID: 31269294Free PMC Article
Non-Lethal Type VIII Osteogenesis Imperfecta Has Elevated Bone Matrix Mineralization.
Fratzl-Zelman N, Barnes AM, Weis M, Carter E, Hefferan TE, Perino G, Chang W, Smith PA, Roschger P, Klaushofer K, Glorieux FH, Eyre DR, Raggio C, Rauch F, Marini JC
J Clin Endocrinol Metab 2016 Sep;101(9):3516-25. Epub 2016 Jul 6 doi: 10.1210/jc.2016-1334. PMID: 27383115Free PMC Article
Fluoride and strontium accumulation in bone does not correlate with osteoid tissue in dialysis patients.
Cohen-Solal ME, Augry F, Mauras Y, Morieux C, Allain P, de Vernejoul MC
Nephrol Dial Transplant 2002 Mar;17(3):449-54. doi: 10.1093/ndt/17.3.449. PMID: 11865091
Histopathological characterization of melorheostosis.
Hoshi K, Amizuka N, Kurokawa T, Nakamura K, Shiro R, Ozawa H
Orthopedics 2001 Mar;24(3):273-7. doi: 10.3928/0147-7447-20010301-20. PMID: 11300293
Quantitative bone histology in children with chronic renal failure.
Hodson EM, Evans RA, Dunstan CR, Hills EE, Shaw PF
Kidney Int 1982 Jun;21(6):833-9. doi: 10.1038/ki.1982.107. PMID: 7132053

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