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Atypical Spitz Nevus

MedGen UID:
1623401
•Concept ID:
C4522245
•
Neoplastic Process
Synonyms: Atypical Spitz Tumor; Atypical Spitz Tumor of Uncertain Malignant Potential; Melanocytic Tumor of Unknown Malignant Potential; Pagetoid Spitz Nevus; Spindle and Epithelioid Cell Nevus with Atypia and Metastasis; Spitz Tumor with One or More Atypical Features; Spitzoid Tumor of Uncertain Malignant Potential

Definition

A junctional or compound melanocytic neoplasm not fulfilling the histopathologic criteria of melanoma but with one of the following features: asymmetry, predominance of single melanocytes over nests in lesions 4 mm or larger, ulceration, large dermal sheets of melanocytes, lack of maturation in dermis, deep dermal mitotic figures, extensive involvement of subcutis, and nuclear pleomorphism. (Mod Pathol 2006;19: S21) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAtypical Spitz Nevus

Professional guidelines

PubMed

Reevaluation of established and new criteria in differential diagnosis of Spitz nevus and melanoma.
Ritter A, Tronnier M, Vaske B, Mitteldorf C
Arch Dermatol Res 2018 May;310(4):329-342. Epub 2018 Feb 7 doi: 10.1007/s00403-018-1818-8. PMID: 29417221

Recent clinical studies

Etiology

TERT Promoter Mutational Analysis as an Ancillary Diagnostic Tool for Diagnostically Challenging Melanocytic Neoplasms.
Boutko A, Asadbeigi S, Roth A, Lampley N, Olivares S, Dittmann D, Dittmann D, Jennings L, Gerami P
Am J Dermatopathol 2023 May 1;45(5):289-299. Epub 2023 Feb 17 doi: 10.1097/DAD.0000000000002366. PMID: 36898007
A digital mRNA expression signature to classify challenging Spitzoid melanocytic neoplasms.
Hillen LM, Geybels MS, Spassova I, Becker JC, Gambichler T, Garmyn M, Zur Hausen A, van den Oord J, Winnepenninckx V
FEBS Open Bio 2020 Jul;10(7):1326-1341. Epub 2020 Jun 5 doi: 10.1002/2211-5463.12897. PMID: 32431053Free PMC Article
Reevaluation of established and new criteria in differential diagnosis of Spitz nevus and melanoma.
Ritter A, Tronnier M, Vaske B, Mitteldorf C
Arch Dermatol Res 2018 May;310(4):329-342. Epub 2018 Feb 7 doi: 10.1007/s00403-018-1818-8. PMID: 29417221
Spitz nevi: diverse clinical, dermatoscopic and histopathological features in childhood.
Dika E, Neri I, Fanti PA, Barisani A, Ravaioli GM, Patrizi A
J Dtsch Dermatol Ges 2017 Jan;15(1):70-75. Epub 2016 Nov 10 doi: 10.1111/ddg.12904. PMID: 27860221
The surgical management of Spitz nevi.
Murphy ME, Boyer JD, Stashower ME, Zitelli JA
Dermatol Surg 2002 Nov;28(11):1065-9; discussion 1069. doi: 10.1046/j.1524-4725.2002.02067.x. PMID: 12460304

Diagnosis

TERT Promoter Mutational Analysis as an Ancillary Diagnostic Tool for Diagnostically Challenging Melanocytic Neoplasms.
Boutko A, Asadbeigi S, Roth A, Lampley N, Olivares S, Dittmann D, Dittmann D, Jennings L, Gerami P
Am J Dermatopathol 2023 May 1;45(5):289-299. Epub 2023 Feb 17 doi: 10.1097/DAD.0000000000002366. PMID: 36898007
Spitz Nevus: Review and Update.
Brown A, Sawyer JD, Neumeister MW
Clin Plast Surg 2021 Oct;48(4):677-686. Epub 2021 Aug 18 doi: 10.1016/j.cps.2021.06.002. PMID: 34503728
Detection of Genetic Aberrations in the Assessment and Prognosis of Melanoma.
High WA
Dermatol Clin 2017 Oct;35(4):525-536. Epub 2017 Jul 28 doi: 10.1016/j.det.2017.06.015. PMID: 28886809
Spitz nevus, Spitz tumor, and spitzoid melanoma: a comprehensive clinicopathologic overview.
Ferrara G, Gianotti R, Cavicchini S, Salviato T, Zalaudek I, Argenziano G
Dermatol Clin 2013 Oct;31(4):589-98, viii. doi: 10.1016/j.det.2013.06.012. PMID: 24075547
Classic and atypical Spitz nevi: review of the literature.
Sulit DJ, Guardiano RA, Krivda S
Cutis 2007 Feb;79(2):141-6. PMID: 17388217

Prognosis

Spitz Nevus: Review and Update.
Brown A, Sawyer JD, Neumeister MW
Clin Plast Surg 2021 Oct;48(4):677-686. Epub 2021 Aug 18 doi: 10.1016/j.cps.2021.06.002. PMID: 34503728
Reevaluation of established and new criteria in differential diagnosis of Spitz nevus and melanoma.
Ritter A, Tronnier M, Vaske B, Mitteldorf C
Arch Dermatol Res 2018 May;310(4):329-342. Epub 2018 Feb 7 doi: 10.1007/s00403-018-1818-8. PMID: 29417221
Detection of Genetic Aberrations in the Assessment and Prognosis of Melanoma.
High WA
Dermatol Clin 2017 Oct;35(4):525-536. Epub 2017 Jul 28 doi: 10.1016/j.det.2017.06.015. PMID: 28886809
Classic and atypical Spitz nevi: review of the literature.
Sulit DJ, Guardiano RA, Krivda S
Cutis 2007 Feb;79(2):141-6. PMID: 17388217
Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis.
Kapur P, Selim MA, Roy LC, Yegappan M, Weinberg AG, Hoang MP
Mod Pathol 2005 Feb;18(2):197-204. doi: 10.1038/modpathol.3800281. PMID: 15467715

Clinical prediction guides

Spitz Nevus: Review and Update.
Brown A, Sawyer JD, Neumeister MW
Clin Plast Surg 2021 Oct;48(4):677-686. Epub 2021 Aug 18 doi: 10.1016/j.cps.2021.06.002. PMID: 34503728
The spectrum of Spitz nevi: a clinicopathologic study of 83 cases.
Ferrara G, Argenziano G, Soyer HP, Chimenti S, Di Blasi A, Pellacani G, Peris K, Piccolo D, Rubegni P, Seidenari S, Staibano S, Zalaudek I, De Rosa G
Arch Dermatol 2005 Nov;141(11):1381-7. doi: 10.1001/archderm.141.11.1381. PMID: 16301385
Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis.
Kapur P, Selim MA, Roy LC, Yegappan M, Weinberg AG, Hoang MP
Mod Pathol 2005 Feb;18(2):197-204. doi: 10.1038/modpathol.3800281. PMID: 15467715
Atypical Spitz nevi/tumors: lack of consensus for diagnosis, discrimination from melanoma, and prediction of outcome.
Barnhill RL, Argenyi ZB, From L, Glass LF, Maize JC, Mihm MC Jr, Rabkin MS, Ronan SG, White WL, Piepkorn M
Hum Pathol 1999 May;30(5):513-20. doi: 10.1016/s0046-8177(99)90193-4. PMID: 10333219

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