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Soft Tissue Sarcoma, Excluding Liposarcoma

MedGen UID:
1652256
•Concept ID:
C4727197
•
Neoplastic Process

Definition

A finding indicating the presence of a sarcoma arising from the soft tissue, other than liposarcoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSoft Tissue Sarcoma, Excluding Liposarcoma

Professional guidelines

PubMed

Overview of primary adult retroperitoneal tumours.
Improta L, Tzanis D, Bouhadiba T, Abdelhafidh K, Bonvalot S
Eur J Surg Oncol 2020 Sep;46(9):1573-1579. Epub 2020 May 21 doi: 10.1016/j.ejso.2020.04.054. PMID: 32600897
Trabectedin and Eribulin: Where Do They Fit in the Management of Soft Tissue Sarcoma?
Ratan R, Patel SR
Curr Treat Options Oncol 2017 Jun;18(6):34. doi: 10.1007/s11864-017-0477-x. PMID: 28534249
Current concepts and future perspectives in retroperitoneal soft-tissue sarcoma management.
Thomas DM, O'Sullivan B, Gronchi A
Expert Rev Anticancer Ther 2009 Aug;9(8):1145-57. doi: 10.1586/era.09.77. PMID: 19671034

Recent clinical studies

Etiology

Pazopanib in patients with advanced intermediate-grade or high-grade liposarcoma.
Chamberlain FE, Wilding C, Jones RL, Huang P
Expert Opin Investig Drugs 2019 Jun;28(6):505-511. Epub 2019 Apr 22 doi: 10.1080/13543784.2019.1607291. PMID: 31010343
Soft-Tissue Sarcomas: Assessment of MRI Features Correlating with Histologic Grade and Patient Outcome.
Crombé A, Marcellin PJ, Buy X, Stoeckle E, Brouste V, Italiano A, Le Loarer F, Kind M
Radiology 2019 Jun;291(3):710-721. Epub 2019 Apr 9 doi: 10.1148/radiol.2019181659. PMID: 30964422
Subclassification of pleomorphic sarcomas: How and why should we care?
Hornick JL
Ann Diagn Pathol 2018 Dec;37:118-124. Epub 2018 Oct 11 doi: 10.1016/j.anndiagpath.2018.10.006. PMID: 30340082
Molecular analyses in the diagnosis and prediction of prognosis in non-GIST soft tissue sarcomas: A systematic review and meta-analysis.
Kandel RA, Yao X, Dickson BC, Ghert M, Popovic S, Purgina BM, Verma S, Werier J
Cancer Treat Rev 2018 May;66:74-81. Epub 2018 Apr 22 doi: 10.1016/j.ctrv.2018.04.005. PMID: 29709714
Prevalence of bone and soft tissue tumors.
Yücetürk G, Sabah D, Keçeci B, Kara AD, Yalçinkaya S
Acta Orthop Traumatol Turc 2011;45(3):135-43. doi: 10.3944/AOTT.2011.2504. PMID: 21765225

Diagnosis

Esophageal Lipoma and Liposarcoma: A Systematic Review.
Ferrari D, Bernardi D, Siboni S, Lazzari V, Asti E, Bonavina L
World J Surg 2021 Jan;45(1):225-234. Epub 2020 Oct 7 doi: 10.1007/s00268-020-05789-4. PMID: 33026474Free PMC Article
Overview of primary adult retroperitoneal tumours.
Improta L, Tzanis D, Bouhadiba T, Abdelhafidh K, Bonvalot S
Eur J Surg Oncol 2020 Sep;46(9):1573-1579. Epub 2020 May 21 doi: 10.1016/j.ejso.2020.04.054. PMID: 32600897
Soft-Tissue Sarcomas: Assessment of MRI Features Correlating with Histologic Grade and Patient Outcome.
Crombé A, Marcellin PJ, Buy X, Stoeckle E, Brouste V, Italiano A, Le Loarer F, Kind M
Radiology 2019 Jun;291(3):710-721. Epub 2019 Apr 9 doi: 10.1148/radiol.2019181659. PMID: 30964422
Subclassification of pleomorphic sarcomas: How and why should we care?
Hornick JL
Ann Diagn Pathol 2018 Dec;37:118-124. Epub 2018 Oct 11 doi: 10.1016/j.anndiagpath.2018.10.006. PMID: 30340082
Trabectedin and Eribulin: Where Do They Fit in the Management of Soft Tissue Sarcoma?
Ratan R, Patel SR
Curr Treat Options Oncol 2017 Jun;18(6):34. doi: 10.1007/s11864-017-0477-x. PMID: 28534249

Therapy

Preoperative Radiotherapy in Patients With Primary Retroperitoneal Sarcoma: EORTC-62092 Trial (STRASS) Versus Off-trial (STREXIT) Results.
Callegaro D, Raut CP, Ajayi T, Strauss D, Bonvalot S, Ng D, Stoeckle E, Fairweather M, Rutkowski P, van Houdt WJ, Gelderblom H, Sangalli C, Hayes A, Honoré C, Gladdy RA, Fau M, Haas R, Tzanis D, Miah AB, Chung P, Baldini EH, Marreaud S, Litiere S, Swallow CJ, Gronchi A
Ann Surg 2023 Jul 1;278(1):127-134. Epub 2022 Jul 14 doi: 10.1097/SLA.0000000000005492. PMID: 35833413
Pazopanib in patients with advanced intermediate-grade or high-grade liposarcoma.
Chamberlain FE, Wilding C, Jones RL, Huang P
Expert Opin Investig Drugs 2019 Jun;28(6):505-511. Epub 2019 Apr 22 doi: 10.1080/13543784.2019.1607291. PMID: 31010343
Trabectedin and Eribulin: Where Do They Fit in the Management of Soft Tissue Sarcoma?
Ratan R, Patel SR
Curr Treat Options Oncol 2017 Jun;18(6):34. doi: 10.1007/s11864-017-0477-x. PMID: 28534249
Histology- and non-histology-driven therapy for treatment of soft tissue sarcomas.
Casali PG
Ann Oncol 2012 Sep;23 Suppl 10:x167-9. doi: 10.1093/annonc/mds349. PMID: 22987955
Current concepts and future perspectives in retroperitoneal soft-tissue sarcoma management.
Thomas DM, O'Sullivan B, Gronchi A
Expert Rev Anticancer Ther 2009 Aug;9(8):1145-57. doi: 10.1586/era.09.77. PMID: 19671034

Prognosis

Natural history and treatment efficacy in an ambispective case series of NTRK-rearranged mesenchymal tumors.
Dufresne A, Pissaloux D, Ngo C, Penel N, Le Cesne A, Macagno N, Vanacker H, Hénon C, Jean-Denis M, Rughoo K, Tirode F, Blay JY, Brahmi M
ESMO Open 2023 Apr;8(2):101202. Epub 2023 Apr 11 doi: 10.1016/j.esmoop.2023.101202. PMID: 37054503Free PMC Article
Does Advanced Imaging Have a Role in Detecting Local Recurrence of Soft-tissue Sarcoma?
England P, Hong Z, Rhea L, Hirbe A, McDonald D, Cipriano C
Clin Orthop Relat Res 2020 Dec;478(12):2812-2820. doi: 10.1097/CORR.0000000000001351. PMID: 32667755Free PMC Article
Soft-Tissue Sarcomas: Assessment of MRI Features Correlating with Histologic Grade and Patient Outcome.
Crombé A, Marcellin PJ, Buy X, Stoeckle E, Brouste V, Italiano A, Le Loarer F, Kind M
Radiology 2019 Jun;291(3):710-721. Epub 2019 Apr 9 doi: 10.1148/radiol.2019181659. PMID: 30964422
Molecular analyses in the diagnosis and prediction of prognosis in non-GIST soft tissue sarcomas: A systematic review and meta-analysis.
Kandel RA, Yao X, Dickson BC, Ghert M, Popovic S, Purgina BM, Verma S, Werier J
Cancer Treat Rev 2018 May;66:74-81. Epub 2018 Apr 22 doi: 10.1016/j.ctrv.2018.04.005. PMID: 29709714
Prevalence of bone and soft tissue tumors.
Yücetürk G, Sabah D, Keçeci B, Kara AD, Yalçinkaya S
Acta Orthop Traumatol Turc 2011;45(3):135-43. doi: 10.3944/AOTT.2011.2504. PMID: 21765225

Clinical prediction guides

Preoperative Radiotherapy in Patients With Primary Retroperitoneal Sarcoma: EORTC-62092 Trial (STRASS) Versus Off-trial (STREXIT) Results.
Callegaro D, Raut CP, Ajayi T, Strauss D, Bonvalot S, Ng D, Stoeckle E, Fairweather M, Rutkowski P, van Houdt WJ, Gelderblom H, Sangalli C, Hayes A, Honoré C, Gladdy RA, Fau M, Haas R, Tzanis D, Miah AB, Chung P, Baldini EH, Marreaud S, Litiere S, Swallow CJ, Gronchi A
Ann Surg 2023 Jul 1;278(1):127-134. Epub 2022 Jul 14 doi: 10.1097/SLA.0000000000005492. PMID: 35833413
Soft-Tissue Sarcomas: Assessment of MRI Features Correlating with Histologic Grade and Patient Outcome.
Crombé A, Marcellin PJ, Buy X, Stoeckle E, Brouste V, Italiano A, Le Loarer F, Kind M
Radiology 2019 Jun;291(3):710-721. Epub 2019 Apr 9 doi: 10.1148/radiol.2019181659. PMID: 30964422
Molecular analyses in the diagnosis and prediction of prognosis in non-GIST soft tissue sarcomas: A systematic review and meta-analysis.
Kandel RA, Yao X, Dickson BC, Ghert M, Popovic S, Purgina BM, Verma S, Werier J
Cancer Treat Rev 2018 May;66:74-81. Epub 2018 Apr 22 doi: 10.1016/j.ctrv.2018.04.005. PMID: 29709714
Expression of MDM2 and p16 in angiomyolipoma.
Lin X, Laskin WB, Lu X, Zhang Y
Hum Pathol 2018 May;75:34-40. Epub 2018 Feb 10 doi: 10.1016/j.humpath.2018.01.022. PMID: 29432785
Current concepts and future perspectives in retroperitoneal soft-tissue sarcoma management.
Thomas DM, O'Sullivan B, Gronchi A
Expert Rev Anticancer Ther 2009 Aug;9(8):1145-57. doi: 10.1586/era.09.77. PMID: 19671034

Recent systematic reviews

Esophageal Lipoma and Liposarcoma: A Systematic Review.
Ferrari D, Bernardi D, Siboni S, Lazzari V, Asti E, Bonavina L
World J Surg 2021 Jan;45(1):225-234. Epub 2020 Oct 7 doi: 10.1007/s00268-020-05789-4. PMID: 33026474Free PMC Article
Liver resection for sarcoma metastases: A systematic review and experience from two European centres.
Tirotta F, Hodson J, Parente A, Pasquali S, Sutcliffe R, Desai A, Muiesan P, Ford SJ, Fiore M, Gronchi A, Almond LM
Eur J Surg Oncol 2020 Oct;46(10 Pt A):1807-1813. Epub 2020 Jun 4 doi: 10.1016/j.ejso.2020.05.024. PMID: 32798014
An evidence-based guideline on the application of molecular testing in the diagnosis, prediction of prognosis, and selection of therapy in non-GIST soft tissue sarcomas.
Yao X, Ghert M, Dickson BC, Popovic S, Purgina BM, Verma S, Werier J, Kandel RA
Cancer Treat Rev 2020 Apr;85:101987. Epub 2020 Feb 14 doi: 10.1016/j.ctrv.2020.101987. PMID: 32092619
Molecular analyses in the diagnosis and prediction of prognosis in non-GIST soft tissue sarcomas: A systematic review and meta-analysis.
Kandel RA, Yao X, Dickson BC, Ghert M, Popovic S, Purgina BM, Verma S, Werier J
Cancer Treat Rev 2018 May;66:74-81. Epub 2018 Apr 22 doi: 10.1016/j.ctrv.2018.04.005. PMID: 29709714

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