U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Recurrent Ampulla of Vater Adenocarcinoma

MedGen UID:
1652316
•Concept ID:
C4727362
•
Neoplastic Process

Definition

The reemergence of ampulla of Vater adenocarcinoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Ampulla of Vater Adenocarcinoma

Professional guidelines

PubMed

Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Chiorean EG, Chiaro MD, Tempero MA, Malafa MP, Benson AB, Cardin DB, Christensen JA, Chung V, Czito B, Dillhoff M, Donahue TR, Dotan E, Fountzilas C, Glazer ES, Hardacre J, Hawkins WG, Klute K, Ko AH, Kunstman JW, LoConte N, Lowy AM, Masood A, Moravek C, Nakakura EK, Narang AK, Nardo L, Obando J, Polanco PM, Reddy S, Reyngold M, Scaife C, Shen J, Truty MJ, Vollmer C, Wolff RA, Wolpin BM, Rn BM, Lubin S, Darlow SD
J Natl Compr Canc Netw 2023 Jul;21(7):753-782. doi: 10.6004/jnccn.2023.0034. PMID: 37433437
Treatment Approach to Adenocarcinoma of the Ampulla of Vater.
Patel M, Uboha NV
Curr Treat Options Oncol 2021 Sep 29;22(11):103. doi: 10.1007/s11864-021-00894-5. PMID: 34586537
Endoscopic diagnosis and management of ampullary lesions.
El Hajj II, Coté GA
Gastrointest Endosc Clin N Am 2013 Jan;23(1):95-109. Epub 2012 Oct 26 doi: 10.1016/j.giec.2012.10.004. PMID: 23168121

Recent clinical studies

Etiology

Neoadjuvant therapy for cholangiocarcinoma: A comprehensive literature review.
Rizzo A, Brandi G
Cancer Treat Res Commun 2021;27:100354. Epub 2021 Mar 16 doi: 10.1016/j.ctarc.2021.100354. PMID: 33756174
Prognostic factors of non-ampullary duodenal adenocarcinoma.
Hirashita T, Ohta M, Tada K, Saga K, Takayama H, Endo Y, Uchida H, Iwashita Y, Inomata M
Jpn J Clin Oncol 2018 Aug 1;48(8):743-747. doi: 10.1093/jjco/hyy086. PMID: 29931295
Transduodenal ampullectomy for ampullary tumors.
Mansukhani VM, Desai GS, Mouli S, Shirodkar K, Shah RC, Palepu J
Indian J Gastroenterol 2017 Jan;36(1):62-65. Epub 2017 Jan 5 doi: 10.1007/s12664-016-0726-0. PMID: 28054258
Ampullary cancer: an overview.
Ahn DH, Bekaii-Saab T
Am Soc Clin Oncol Educ Book 2014:112-5. doi: 10.14694/EdBook_AM.2014.34.112. PMID: 24857067Free PMC Article
Endoscopic diagnosis and management of ampullary lesions.
El Hajj II, Coté GA
Gastrointest Endosc Clin N Am 2013 Jan;23(1):95-109. Epub 2012 Oct 26 doi: 10.1016/j.giec.2012.10.004. PMID: 23168121

Diagnosis

Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Chiorean EG, Chiaro MD, Tempero MA, Malafa MP, Benson AB, Cardin DB, Christensen JA, Chung V, Czito B, Dillhoff M, Donahue TR, Dotan E, Fountzilas C, Glazer ES, Hardacre J, Hawkins WG, Klute K, Ko AH, Kunstman JW, LoConte N, Lowy AM, Masood A, Moravek C, Nakakura EK, Narang AK, Nardo L, Obando J, Polanco PM, Reddy S, Reyngold M, Scaife C, Shen J, Truty MJ, Vollmer C, Wolff RA, Wolpin BM, Rn BM, Lubin S, Darlow SD
J Natl Compr Canc Netw 2023 Jul;21(7):753-782. doi: 10.6004/jnccn.2023.0034. PMID: 37433437
Treatment Approach to Adenocarcinoma of the Ampulla of Vater.
Patel M, Uboha NV
Curr Treat Options Oncol 2021 Sep 29;22(11):103. doi: 10.1007/s11864-021-00894-5. PMID: 34586537
Neoadjuvant therapy for cholangiocarcinoma: A comprehensive literature review.
Rizzo A, Brandi G
Cancer Treat Res Commun 2021;27:100354. Epub 2021 Mar 16 doi: 10.1016/j.ctarc.2021.100354. PMID: 33756174
Prognostic factors of non-ampullary duodenal adenocarcinoma.
Hirashita T, Ohta M, Tada K, Saga K, Takayama H, Endo Y, Uchida H, Iwashita Y, Inomata M
Jpn J Clin Oncol 2018 Aug 1;48(8):743-747. doi: 10.1093/jjco/hyy086. PMID: 29931295
Endoscopic diagnosis and management of ampullary lesions.
El Hajj II, Coté GA
Gastrointest Endosc Clin N Am 2013 Jan;23(1):95-109. Epub 2012 Oct 26 doi: 10.1016/j.giec.2012.10.004. PMID: 23168121

Therapy

Treatment Approach to Adenocarcinoma of the Ampulla of Vater.
Patel M, Uboha NV
Curr Treat Options Oncol 2021 Sep 29;22(11):103. doi: 10.1007/s11864-021-00894-5. PMID: 34586537
Neoadjuvant therapy for cholangiocarcinoma: A comprehensive literature review.
Rizzo A, Brandi G
Cancer Treat Res Commun 2021;27:100354. Epub 2021 Mar 16 doi: 10.1016/j.ctarc.2021.100354. PMID: 33756174
Adenocarcinoma of the ampulla of Vater metastasising into the right ventricle.
Moser M, Wiedemann D, Kitzwögerer M, Frank H
BMJ Case Rep 2016 Apr 8;2016 doi: 10.1136/bcr-2015-212650. PMID: 27060070Free PMC Article
Ampullary cancer: an overview.
Ahn DH, Bekaii-Saab T
Am Soc Clin Oncol Educ Book 2014:112-5. doi: 10.14694/EdBook_AM.2014.34.112. PMID: 24857067Free PMC Article
Ampullary and periampullary adenocarcinoma: new challenges in management of recurrence.
Ramfidis VS, Syrigos KN, Saif MW
JOP 2013 Mar 10;14(2):158-60. doi: 10.6092/1590-8577/1471. PMID: 23474562

Prognosis

Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Chiorean EG, Chiaro MD, Tempero MA, Malafa MP, Benson AB, Cardin DB, Christensen JA, Chung V, Czito B, Dillhoff M, Donahue TR, Dotan E, Fountzilas C, Glazer ES, Hardacre J, Hawkins WG, Klute K, Ko AH, Kunstman JW, LoConte N, Lowy AM, Masood A, Moravek C, Nakakura EK, Narang AK, Nardo L, Obando J, Polanco PM, Reddy S, Reyngold M, Scaife C, Shen J, Truty MJ, Vollmer C, Wolff RA, Wolpin BM, Rn BM, Lubin S, Darlow SD
J Natl Compr Canc Netw 2023 Jul;21(7):753-782. doi: 10.6004/jnccn.2023.0034. PMID: 37433437
Treatment Approach to Adenocarcinoma of the Ampulla of Vater.
Patel M, Uboha NV
Curr Treat Options Oncol 2021 Sep 29;22(11):103. doi: 10.1007/s11864-021-00894-5. PMID: 34586537
Neoadjuvant therapy for cholangiocarcinoma: A comprehensive literature review.
Rizzo A, Brandi G
Cancer Treat Res Commun 2021;27:100354. Epub 2021 Mar 16 doi: 10.1016/j.ctarc.2021.100354. PMID: 33756174
Ampullary cancer: an overview.
Ahn DH, Bekaii-Saab T
Am Soc Clin Oncol Educ Book 2014:112-5. doi: 10.14694/EdBook_AM.2014.34.112. PMID: 24857067Free PMC Article
Ampullary and periampullary adenocarcinoma: new challenges in management of recurrence.
Ramfidis VS, Syrigos KN, Saif MW
JOP 2013 Mar 10;14(2):158-60. doi: 10.6092/1590-8577/1471. PMID: 23474562

Clinical prediction guides

Clinical impact of ampulla of Vater cancer subtype classification based on immunohistochemical staining.
Kwon CH, Ahn JH, Seo HI, Kim DU, Han SY, Kim S, Lee NK, Hong SB, Park YM, Noh BG
World J Surg Oncol 2024 Jan 3;22(1):5. doi: 10.1186/s12957-023-03289-y. PMID: 38167037Free PMC Article
Neoadjuvant therapy for cholangiocarcinoma: A comprehensive literature review.
Rizzo A, Brandi G
Cancer Treat Res Commun 2021;27:100354. Epub 2021 Mar 16 doi: 10.1016/j.ctarc.2021.100354. PMID: 33756174
Prediction of tumor recurrence and poor survival of ampullary adenocarcinoma using preoperative clinical and CT findings.
Yoen H, Kim JH, Hur BY, Ahn SJ, Jeon SK, Choi SY, Lee KB, Han JK
Eur Radiol 2021 Apr;31(4):2433-2443. Epub 2020 Sep 30 doi: 10.1007/s00330-020-07316-4. PMID: 33000305
Histopathologic Predictors of Survival and Recurrence in Resected Ampullary Adenocarcinoma: International Multicenter Cohort Study.
Moekotte AL, Lof S, Van Roessel S, Fontana M, Dreyer S, Shablak A, Casciani F, Mavroeidis VK, Robinson S, Khalil K, Gradinariu G, Mowbray N, Al-Sarireh B, Fusai GK, Roberts K, White S, Soonawalla Z, Jamieson NB, Salvia R, Besselink MG, Abu Hilal M
Ann Surg 2020 Dec;272(6):1086-1093. doi: 10.1097/SLA.0000000000003177. PMID: 30628913
Extranodal extension in N1-adenocarcinoma of the pancreas and papilla of Vater: a systematic review and meta-analysis of its prognostic significance.
Luchini C, Veronese N, Pea A, Sergi G, Manzato E, Nottegar A, Solmi M, Capelli P, Scarpa A
Eur J Gastroenterol Hepatol 2016 Feb;28(2):205-9. doi: 10.1097/MEG.0000000000000520. PMID: 26566063

Recent systematic reviews

Management and outcomes of mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A systematic review and pooled analysis of 56 patients.
Ziogas IA, Rallis KS, Tasoudis PT, Moris D, Schulick RD, Del Chiaro M
Eur J Surg Oncol 2023 Apr;49(4):682-687. Epub 2023 Jan 9 doi: 10.1016/j.ejso.2023.01.005. PMID: 36646615
Surgical resection of liver metastasis in pancreatic and periampullary carcinoma.
Lopez-Lopez V, Robles-Campos R, López-Conesa A, Brusadin R, Carbonel G, Gomez-Ruiz A, Ruiz JJ, Parrilla P
Minerva Chir 2019 Jun;74(3):253-262. Epub 2019 Jan 2 doi: 10.23736/S0026-4733.18.07972-5. PMID: 30600968
Perineural Invasion is a Strong Prognostic Moderator in Ampulla of Vater Carcinoma: A Meta-analysis.
Luchini C, Veronese N, Nottegar A, Riva G, Pilati C, Mafficini A, Stubbs B, Simbolo M, Mombello A, Corbo V, Cheng L, Yachida S, Wood LD, Lawlor RT, Salvia R, Scarpa A
Pancreas 2019 Jan;48(1):70-76. doi: 10.1097/MPA.0000000000001194. PMID: 30451797
Metastasectomy of pancreatic and periampullary adenocarcinoma to solid organ: The current evidence.
Saedon M, Maroulis I, Brooks A, Alexiou E, Bouliaris K, Amanatidis T, Germanos S
J BUON 2018 Nov-Dec;23(6):1648-1654. PMID: 30610789
Extranodal extension in N1-adenocarcinoma of the pancreas and papilla of Vater: a systematic review and meta-analysis of its prognostic significance.
Luchini C, Veronese N, Pea A, Sergi G, Manzato E, Nottegar A, Solmi M, Capelli P, Scarpa A
Eur J Gastroenterol Hepatol 2016 Feb;28(2):205-9. doi: 10.1097/MEG.0000000000000520. PMID: 26566063

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...