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Clinically Significant Depressive Symptoms

MedGen UID:
1652464
•Concept ID:
C4725635
•
Finding

Definition

An indication that an individual''s depressive symptoms are or were clinically significant. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClinically Significant Depressive Symptoms

Professional guidelines

PubMed

Depression and cardiovascular risk in primary care patients.
Hooker SA, O'Connor PJ, Sperl-Hillen JM, Crain AL, Ohnsorg K, Kane S, Rossom R
J Psychosom Res 2022 Jul;158:110920. Epub 2022 Apr 19 doi: 10.1016/j.jpsychores.2022.110920. PMID: 35461074Free PMC Article
A Review of Asenapine in the Treatment of Bipolar Disorder.
Vieta E, Montes JM
Clin Drug Investig 2018 Feb;38(2):87-99. doi: 10.1007/s40261-017-0592-2. PMID: 29067671Free PMC Article
Management of Depression in Older Adults: A Review.
Kok RM, Reynolds CF 3rd
JAMA 2017 May 23;317(20):2114-2122. doi: 10.1001/jama.2017.5706. PMID: 28535241

Recent clinical studies

Etiology

Depressive Symptoms and Burnout Among Medical Students: a Prospective Study.
Ranasinghe PD, Owusu JT, Bertram A, Michtalik H, Yeh HC, Cofrancesco J Jr, Levine D, Miller Iii ER, Marinopoulos S
J Gen Intern Med 2022 Jan;37(1):64-69. Epub 2021 May 26 doi: 10.1007/s11606-021-06765-x. PMID: 34037922Free PMC Article
Effect of a Digital Intervention on Depressive Symptoms in Patients With Comorbid Hypertension or Diabetes in Brazil and Peru: Two Randomized Clinical Trials.
Araya R, Menezes PR, Claro HG, Brandt LR, Daley KL, Quayle J, Diez-Canseco F, Peters TJ, Vera Cruz D, Toyama M, Aschar S, Hidalgo-Padilla L, Martins H, Cavero V, Rocha T, Scotton G, de Almeida Lopes IF, Begale M, Mohr DC, Miranda JJ
JAMA 2021 May 11;325(18):1852-1862. doi: 10.1001/jama.2021.4348. PMID: 33974019Free PMC Article
Association of Depression With All-Cause and Cardiovascular Disease Mortality Among Adults in China.
Meng R, Yu C, Liu N, He M, Lv J, Guo Y, Bian Z, Yang L, Chen Y, Zhang X, Chen Z, Wu T, Pan A, Li L; China Kadoorie Biobank Collaborative Group
JAMA Netw Open 2020 Feb 5;3(2):e1921043. doi: 10.1001/jamanetworkopen.2019.21043. PMID: 32049295Free PMC Article
Efficacy of Transdermal Estradiol and Micronized Progesterone in the Prevention of Depressive Symptoms in the Menopause Transition: A Randomized Clinical Trial.
Gordon JL, Rubinow DR, Eisenlohr-Moul TA, Xia K, Schmidt PJ, Girdler SS
JAMA Psychiatry 2018 Feb 1;75(2):149-157. doi: 10.1001/jamapsychiatry.2017.3998. PMID: 29322164Free PMC Article
Management of Depression in Older Adults: A Review.
Kok RM, Reynolds CF 3rd
JAMA 2017 May 23;317(20):2114-2122. doi: 10.1001/jama.2017.5706. PMID: 28535241

Diagnosis

The association between adolescent depression and dyslipidemia.
Khalfan AF, Campisi SC, Lo RF, McCrindle BW, Korczak DJ
J Affect Disord 2023 Oct 1;338:239-245. Epub 2023 Jun 9 doi: 10.1016/j.jad.2023.06.017. PMID: 37302507
Depressive Symptoms and Burnout Among Medical Students: a Prospective Study.
Ranasinghe PD, Owusu JT, Bertram A, Michtalik H, Yeh HC, Cofrancesco J Jr, Levine D, Miller Iii ER, Marinopoulos S
J Gen Intern Med 2022 Jan;37(1):64-69. Epub 2021 May 26 doi: 10.1007/s11606-021-06765-x. PMID: 34037922Free PMC Article
Clinically Significant Depressive Symptoms Are Prevalent in People With Extremely Short Prognoses-A Systematic Review.
Lee W, Pulbrook M, Sheehan C, Kochovska S, Chang S, Hosie A, Lobb E, Parker D, Draper B, Agar MR, Currow DC
J Pain Symptom Manage 2021 Jan;61(1):143-166.e2. Epub 2020 Jul 17 doi: 10.1016/j.jpainsymman.2020.07.011. PMID: 32688012
Association of Depression With All-Cause and Cardiovascular Disease Mortality Among Adults in China.
Meng R, Yu C, Liu N, He M, Lv J, Guo Y, Bian Z, Yang L, Chen Y, Zhang X, Chen Z, Wu T, Pan A, Li L; China Kadoorie Biobank Collaborative Group
JAMA Netw Open 2020 Feb 5;3(2):e1921043. doi: 10.1001/jamanetworkopen.2019.21043. PMID: 32049295Free PMC Article
Depression in long-term care.
Thakur M, Blazer DG
J Am Med Dir Assoc 2008 Feb;9(2):82-7. doi: 10.1016/j.jamda.2007.09.007. PMID: 18261699

Therapy

Association Between Depressive Symptoms and Cardiac Structure and Function in a Peruvian Population.
Santiago C, Peña MB, Brown T, Shakil S, Januzzi J, Velazquez E, Miranda JJ, Rivera D, Checkley W
Glob Heart 2022;17(1):78. Epub 2022 Oct 27 doi: 10.5334/gh.981. PMID: 36382157Free PMC Article
Effect of a Digital Intervention on Depressive Symptoms in Patients With Comorbid Hypertension or Diabetes in Brazil and Peru: Two Randomized Clinical Trials.
Araya R, Menezes PR, Claro HG, Brandt LR, Daley KL, Quayle J, Diez-Canseco F, Peters TJ, Vera Cruz D, Toyama M, Aschar S, Hidalgo-Padilla L, Martins H, Cavero V, Rocha T, Scotton G, de Almeida Lopes IF, Begale M, Mohr DC, Miranda JJ
JAMA 2021 May 11;325(18):1852-1862. doi: 10.1001/jama.2021.4348. PMID: 33974019Free PMC Article
Clinically Significant Depressive Symptoms Are Prevalent in People With Extremely Short Prognoses-A Systematic Review.
Lee W, Pulbrook M, Sheehan C, Kochovska S, Chang S, Hosie A, Lobb E, Parker D, Draper B, Agar MR, Currow DC
J Pain Symptom Manage 2021 Jan;61(1):143-166.e2. Epub 2020 Jul 17 doi: 10.1016/j.jpainsymman.2020.07.011. PMID: 32688012
Efficacy of Transdermal Estradiol and Micronized Progesterone in the Prevention of Depressive Symptoms in the Menopause Transition: A Randomized Clinical Trial.
Gordon JL, Rubinow DR, Eisenlohr-Moul TA, Xia K, Schmidt PJ, Girdler SS
JAMA Psychiatry 2018 Feb 1;75(2):149-157. doi: 10.1001/jamapsychiatry.2017.3998. PMID: 29322164Free PMC Article
Management of Depression in Older Adults: A Review.
Kok RM, Reynolds CF 3rd
JAMA 2017 May 23;317(20):2114-2122. doi: 10.1001/jama.2017.5706. PMID: 28535241

Prognosis

The association between adolescent depression and dyslipidemia.
Khalfan AF, Campisi SC, Lo RF, McCrindle BW, Korczak DJ
J Affect Disord 2023 Oct 1;338:239-245. Epub 2023 Jun 9 doi: 10.1016/j.jad.2023.06.017. PMID: 37302507
Depressive Symptoms and Burnout Among Medical Students: a Prospective Study.
Ranasinghe PD, Owusu JT, Bertram A, Michtalik H, Yeh HC, Cofrancesco J Jr, Levine D, Miller Iii ER, Marinopoulos S
J Gen Intern Med 2022 Jan;37(1):64-69. Epub 2021 May 26 doi: 10.1007/s11606-021-06765-x. PMID: 34037922Free PMC Article
Prevalence of Anxiety and Depressive Symptoms Among Pharmacy Students.
Shangraw AM, Silvers J, Warholak T, Vadiei N
Am J Pharm Educ 2021 Feb;85(2):8166. Epub 2020 Nov 24 doi: 10.5688/ajpe8166. PMID: 34283739Free PMC Article
Clinically Significant Depressive Symptoms Are Prevalent in People With Extremely Short Prognoses-A Systematic Review.
Lee W, Pulbrook M, Sheehan C, Kochovska S, Chang S, Hosie A, Lobb E, Parker D, Draper B, Agar MR, Currow DC
J Pain Symptom Manage 2021 Jan;61(1):143-166.e2. Epub 2020 Jul 17 doi: 10.1016/j.jpainsymman.2020.07.011. PMID: 32688012
Efficacy of Transdermal Estradiol and Micronized Progesterone in the Prevention of Depressive Symptoms in the Menopause Transition: A Randomized Clinical Trial.
Gordon JL, Rubinow DR, Eisenlohr-Moul TA, Xia K, Schmidt PJ, Girdler SS
JAMA Psychiatry 2018 Feb 1;75(2):149-157. doi: 10.1001/jamapsychiatry.2017.3998. PMID: 29322164Free PMC Article

Clinical prediction guides

Depressive Symptoms and Burnout Among Medical Students: a Prospective Study.
Ranasinghe PD, Owusu JT, Bertram A, Michtalik H, Yeh HC, Cofrancesco J Jr, Levine D, Miller Iii ER, Marinopoulos S
J Gen Intern Med 2022 Jan;37(1):64-69. Epub 2021 May 26 doi: 10.1007/s11606-021-06765-x. PMID: 34037922Free PMC Article
Depressive Symptoms Among Older Adults Pre- and Post-COVID-19 Pandemic.
Briggs R, McDowell CP, De Looze C, Kenny RA, Ward M
J Am Med Dir Assoc 2021 Nov;22(11):2251-2257. Epub 2021 Sep 13 doi: 10.1016/j.jamda.2021.09.003. PMID: 34597531Free PMC Article
Effect of a Digital Intervention on Depressive Symptoms in Patients With Comorbid Hypertension or Diabetes in Brazil and Peru: Two Randomized Clinical Trials.
Araya R, Menezes PR, Claro HG, Brandt LR, Daley KL, Quayle J, Diez-Canseco F, Peters TJ, Vera Cruz D, Toyama M, Aschar S, Hidalgo-Padilla L, Martins H, Cavero V, Rocha T, Scotton G, de Almeida Lopes IF, Begale M, Mohr DC, Miranda JJ
JAMA 2021 May 11;325(18):1852-1862. doi: 10.1001/jama.2021.4348. PMID: 33974019Free PMC Article
Efficacy of Transdermal Estradiol and Micronized Progesterone in the Prevention of Depressive Symptoms in the Menopause Transition: A Randomized Clinical Trial.
Gordon JL, Rubinow DR, Eisenlohr-Moul TA, Xia K, Schmidt PJ, Girdler SS
JAMA Psychiatry 2018 Feb 1;75(2):149-157. doi: 10.1001/jamapsychiatry.2017.3998. PMID: 29322164Free PMC Article
Management of Depression in Older Adults: A Review.
Kok RM, Reynolds CF 3rd
JAMA 2017 May 23;317(20):2114-2122. doi: 10.1001/jama.2017.5706. PMID: 28535241

Recent systematic reviews

Clinically Significant Depressive Symptoms Are Prevalent in People With Extremely Short Prognoses-A Systematic Review.
Lee W, Pulbrook M, Sheehan C, Kochovska S, Chang S, Hosie A, Lobb E, Parker D, Draper B, Agar MR, Currow DC
J Pain Symptom Manage 2021 Jan;61(1):143-166.e2. Epub 2020 Jul 17 doi: 10.1016/j.jpainsymman.2020.07.011. PMID: 32688012
Mindfulness-based stress reduction for family carers of people with dementia.
Liu Z, Sun YY, Zhong BL
Cochrane Database Syst Rev 2018 Aug 14;8(8):CD012791. doi: 10.1002/14651858.CD012791.pub2. PMID: 30106471Free PMC Article
Vitamin D supplementation for depressive symptoms: a systematic review and meta-analysis of randomized controlled trials.
Shaffer JA, Edmondson D, Wasson LT, Falzon L, Homma K, Ezeokoli N, Li P, Davidson KW
Psychosom Med 2014 Apr;76(3):190-6. doi: 10.1097/PSY.0000000000000044. PMID: 24632894Free PMC Article
Depressive morbidity and gender in community-dwelling Brazilian elderly: systematic review and meta-analysis.
Barcelos-Ferreira R, Izbicki R, Steffens DC, Bottino CM
Int Psychogeriatr 2010 Aug;22(5):712-26. Epub 2010 May 18 doi: 10.1017/S1041610210000463. PMID: 20478096
Depression in general intensive care unit survivors: a systematic review.
Davydow DS, Gifford JM, Desai SV, Bienvenu OJ, Needham DM
Intensive Care Med 2009 May;35(5):796-809. Epub 2009 Jan 23 doi: 10.1007/s00134-009-1396-5. PMID: 19165464Free PMC Article

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