U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Metastatic Oropharyngeal Carcinoma

MedGen UID:
1654364
•Concept ID:
C4745364
•
Neoplastic Process

Definition

A carcinoma that arises from the oropharynx and has metastasized to another anatomic site. [from NCI]

Professional guidelines

PubMed

Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
SEOM clinical guidelines for the treatment of head and neck cancer (2020).
Mesia R, Iglesias L, Lambea J, Martínez-Trufero J, Soria A, Taberna M, Trigo J, Chaves M, García-Castaño A, Cruz J
Clin Transl Oncol 2021 May;23(5):913-921. Epub 2021 Feb 26 doi: 10.1007/s12094-020-02533-1. PMID: 33635468Free PMC Article
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Recent clinical studies

Etiology

Assessment of Toxic Effects and Survival in Treatment Deescalation With Radiotherapy vs Transoral Surgery for HPV-Associated Oropharyngeal Squamous Cell Carcinoma: The ORATOR2 Phase 2 Randomized Clinical Trial.
Palma DA, Prisman E, Berthelet E, Tran E, Hamilton S, Wu J, Eskander A, Higgins K, Karam I, Poon I, Husain Z, Enepekides D, Hier M, Sultanem K, Richardson K, Mlynarek A, Johnson-Obaseki S, Odell M, Bayley A, Dowthwaite S, Jackson JE, Dzienis M, O'Neil J, Chandarana S, Banerjee R, Hart R, Chung J, Tenenholtz T, Krishnan S, Le H, Yoo J, Mendez A, Winquist E, Kuruvilla S, Stewart P, Warner A, Mitchell S, Chen J, Parker C, Wehrli B, Kwan K, Theurer J, Sathya J, Hammond JA, Read N, Venkatesan V, MacNeil SD, Fung K, Nichols AC
JAMA Oncol 2022 Jun 1;8(6):1-7. doi: 10.1001/jamaoncol.2022.0615. PMID: 35482348Free PMC Article
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
Nodal staging convergence for HPV- and HPV+ oropharyngeal carcinoma.
Ho AS, Luu M, Kim S, Tighiouart M, Mita AC, Scher KS, Mallen-St Clair J, Walgama ES, Lin DC, Nguyen AT, Zumsteg ZS
Cancer 2021 May 15;127(10):1590-1597. Epub 2021 Feb 17 doi: 10.1002/cncr.33414. PMID: 33595897
Radiotherapy in Metastatic Oropharyngeal Cancer.
Nguy S, Oh C, Karp JM, Wu SP, Li Z, Persky MJ, Hu KS, Givi B, Tam MM
Laryngoscope 2021 Jun;131(6):E1847-E1853. Epub 2020 Nov 3 doi: 10.1002/lary.29245. PMID: 33141455
Machine Learning-Guided Adjuvant Treatment of Head and Neck Cancer.
Howard FM, Kochanny S, Koshy M, Spiotto M, Pearson AT
JAMA Netw Open 2020 Nov 2;3(11):e2025881. doi: 10.1001/jamanetworkopen.2020.25881. PMID: 33211108Free PMC Article

Diagnosis

Prognostic implications of p16 and HPV discordance in oropharyngeal cancer (HNCIG-EPIC-OPC): a multicentre, multinational, individual patient data analysis.
Mehanna H, Taberna M, von Buchwald C, Tous S, Brooks J, Mena M, Morey F, Grønhøj C, Rasmussen JH, Garset-Zamani M, Bruni L, Batis N, Brakenhoff RH, Leemans CR, Baatenburg de Jong RJ, Klussmann JP, Wuerdemann N, Wagner S, Dalianis T, Marklund L, Mirghani H, Schache A, James JA, Huang SH, O'Sullivan B, Nankivell P, Broglie MA, Hoffmann M, Quabius ES, Alemany L; HNCIG-EPIC group
Lancet Oncol 2023 Mar;24(3):239-251. Epub 2023 Feb 13 doi: 10.1016/S1470-2045(23)00013-X. PMID: 36796393
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
SEOM clinical guidelines for the treatment of head and neck cancer (2020).
Mesia R, Iglesias L, Lambea J, Martínez-Trufero J, Soria A, Taberna M, Trigo J, Chaves M, García-Castaño A, Cruz J
Clin Transl Oncol 2021 May;23(5):913-921. Epub 2021 Feb 26 doi: 10.1007/s12094-020-02533-1. PMID: 33635468Free PMC Article
Machine Learning-Guided Adjuvant Treatment of Head and Neck Cancer.
Howard FM, Kochanny S, Koshy M, Spiotto M, Pearson AT
JAMA Netw Open 2020 Nov 2;3(11):e2025881. doi: 10.1001/jamanetworkopen.2020.25881. PMID: 33211108Free PMC Article
Human papillomavirus-related oropharyngeal cancer.
Taberna M, Mena M, Pavón MA, Alemany L, Gillison ML, Mesía R
Ann Oncol 2017 Oct 1;28(10):2386-2398. doi: 10.1093/annonc/mdx304. PMID: 28633362

Therapy

Assessment of Toxic Effects and Survival in Treatment Deescalation With Radiotherapy vs Transoral Surgery for HPV-Associated Oropharyngeal Squamous Cell Carcinoma: The ORATOR2 Phase 2 Randomized Clinical Trial.
Palma DA, Prisman E, Berthelet E, Tran E, Hamilton S, Wu J, Eskander A, Higgins K, Karam I, Poon I, Husain Z, Enepekides D, Hier M, Sultanem K, Richardson K, Mlynarek A, Johnson-Obaseki S, Odell M, Bayley A, Dowthwaite S, Jackson JE, Dzienis M, O'Neil J, Chandarana S, Banerjee R, Hart R, Chung J, Tenenholtz T, Krishnan S, Le H, Yoo J, Mendez A, Winquist E, Kuruvilla S, Stewart P, Warner A, Mitchell S, Chen J, Parker C, Wehrli B, Kwan K, Theurer J, Sathya J, Hammond JA, Read N, Venkatesan V, MacNeil SD, Fung K, Nichols AC
JAMA Oncol 2022 Jun 1;8(6):1-7. doi: 10.1001/jamaoncol.2022.0615. PMID: 35482348Free PMC Article
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
SEOM clinical guidelines for the treatment of head and neck cancer (2020).
Mesia R, Iglesias L, Lambea J, Martínez-Trufero J, Soria A, Taberna M, Trigo J, Chaves M, García-Castaño A, Cruz J
Clin Transl Oncol 2021 May;23(5):913-921. Epub 2021 Feb 26 doi: 10.1007/s12094-020-02533-1. PMID: 33635468Free PMC Article
Palliative Radiation Therapy for Head and Neck Cancers.
Grewal AS, Jones J, Lin A
Int J Radiat Oncol Biol Phys 2019 Oct 1;105(2):254-266. Epub 2019 May 22 doi: 10.1016/j.ijrobp.2019.05.024. PMID: 31128145
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Prognosis

Prognostic implications of p16 and HPV discordance in oropharyngeal cancer (HNCIG-EPIC-OPC): a multicentre, multinational, individual patient data analysis.
Mehanna H, Taberna M, von Buchwald C, Tous S, Brooks J, Mena M, Morey F, Grønhøj C, Rasmussen JH, Garset-Zamani M, Bruni L, Batis N, Brakenhoff RH, Leemans CR, Baatenburg de Jong RJ, Klussmann JP, Wuerdemann N, Wagner S, Dalianis T, Marklund L, Mirghani H, Schache A, James JA, Huang SH, O'Sullivan B, Nankivell P, Broglie MA, Hoffmann M, Quabius ES, Alemany L; HNCIG-EPIC group
Lancet Oncol 2023 Mar;24(3):239-251. Epub 2023 Feb 13 doi: 10.1016/S1470-2045(23)00013-X. PMID: 36796393
Human papillomavirus-related oropharyngeal carcinoma.
Saito Y, Homma A, Kiyota N, Tahara M, Hanai N, Asakage T, Matsuura K, Ota I, Yokota T, Sano D, Kodaira T, Motegi A, Yasuda K, Takahashi S, Tanaka K, Onoe T, Okano S, Imamura Y, Ariizumi Y, Hayashi R
Jpn J Clin Oncol 2022 Jul 8;52(7):700-706. doi: 10.1093/jjco/hyac049. PMID: 35383359
Molecular prognostic indicators in HPV-positive oropharyngeal cancer: an updated review.
Morand GB, Diaconescu A, Ibrahim I, Lamarche G, Ruas JS, Dalfen J, Hier MP, Alaoui-Jamali MA, Maschietto M, da Silva SD
Clin Exp Metastasis 2022 Jun;39(3):407-416. Epub 2022 Jan 27 doi: 10.1007/s10585-022-10148-9. PMID: 35084607
Radiotherapy in Metastatic Oropharyngeal Cancer.
Nguy S, Oh C, Karp JM, Wu SP, Li Z, Persky MJ, Hu KS, Givi B, Tam MM
Laryngoscope 2021 Jun;131(6):E1847-E1853. Epub 2020 Nov 3 doi: 10.1002/lary.29245. PMID: 33141455
Machine Learning-Guided Adjuvant Treatment of Head and Neck Cancer.
Howard FM, Kochanny S, Koshy M, Spiotto M, Pearson AT
JAMA Netw Open 2020 Nov 2;3(11):e2025881. doi: 10.1001/jamanetworkopen.2020.25881. PMID: 33211108Free PMC Article

Clinical prediction guides

Assessment of Toxic Effects and Survival in Treatment Deescalation With Radiotherapy vs Transoral Surgery for HPV-Associated Oropharyngeal Squamous Cell Carcinoma: The ORATOR2 Phase 2 Randomized Clinical Trial.
Palma DA, Prisman E, Berthelet E, Tran E, Hamilton S, Wu J, Eskander A, Higgins K, Karam I, Poon I, Husain Z, Enepekides D, Hier M, Sultanem K, Richardson K, Mlynarek A, Johnson-Obaseki S, Odell M, Bayley A, Dowthwaite S, Jackson JE, Dzienis M, O'Neil J, Chandarana S, Banerjee R, Hart R, Chung J, Tenenholtz T, Krishnan S, Le H, Yoo J, Mendez A, Winquist E, Kuruvilla S, Stewart P, Warner A, Mitchell S, Chen J, Parker C, Wehrli B, Kwan K, Theurer J, Sathya J, Hammond JA, Read N, Venkatesan V, MacNeil SD, Fung K, Nichols AC
JAMA Oncol 2022 Jun 1;8(6):1-7. doi: 10.1001/jamaoncol.2022.0615. PMID: 35482348Free PMC Article
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
Radiotherapy in Metastatic Oropharyngeal Cancer.
Nguy S, Oh C, Karp JM, Wu SP, Li Z, Persky MJ, Hu KS, Givi B, Tam MM
Laryngoscope 2021 Jun;131(6):E1847-E1853. Epub 2020 Nov 3 doi: 10.1002/lary.29245. PMID: 33141455
Machine Learning-Guided Adjuvant Treatment of Head and Neck Cancer.
Howard FM, Kochanny S, Koshy M, Spiotto M, Pearson AT
JAMA Netw Open 2020 Nov 2;3(11):e2025881. doi: 10.1001/jamanetworkopen.2020.25881. PMID: 33211108Free PMC Article
Human papillomavirus-related oropharyngeal cancer.
Taberna M, Mena M, Pavón MA, Alemany L, Gillison ML, Mesía R
Ann Oncol 2017 Oct 1;28(10):2386-2398. doi: 10.1093/annonc/mdx304. PMID: 28633362

Recent systematic reviews

Systematic review of neuroendocrine carcinomas of the oropharynx.
Froehlich MH, Shih MC, Shehee L, Kompelli AR, Aylward A, Nguyen SA, Kaczmar JM, Nathan CA, Day T, Neskey DM
Head Neck 2022 Jul;44(7):1725-1736. Epub 2022 Apr 18 doi: 10.1002/hed.27055. PMID: 35437851
Treatment de-escalation for HPV+ oropharyngeal cancer: A systematic review and meta-analysis.
Petrelli F, Luciani A, Ghidini A, Cherri S, Gamba P, Maddalo M, Bossi P, Zaniboni A
Head Neck 2022 May;44(5):1255-1266. Epub 2022 Mar 3 doi: 10.1002/hed.27019. PMID: 35238114
Molecular prognostic indicators in HPV-positive oropharyngeal cancer: an updated review.
Morand GB, Diaconescu A, Ibrahim I, Lamarche G, Ruas JS, Dalfen J, Hier MP, Alaoui-Jamali MA, Maschietto M, da Silva SD
Clin Exp Metastasis 2022 Jun;39(3):407-416. Epub 2022 Jan 27 doi: 10.1007/s10585-022-10148-9. PMID: 35084607
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
Survival outcomes following salvage surgery for oropharyngeal squamous cell carcinoma: systematic review.
Kao SS, Ooi EH
J Laryngol Otol 2018 Apr;132(4):299-313. Epub 2017 May 15 doi: 10.1017/S0022215117000998. PMID: 28502256

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...