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Well Differentiated Neuroendocrine Lesion

MedGen UID:
1663813
•Concept ID:
C4744423
•
Finding

Definition

A neoplastic lesion with neuroendocrine differentiation and well differentiated histological features. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWell Differentiated Neuroendocrine Lesion

Professional guidelines

PubMed

Challenging differential diagnoses in small biopsies from the sinonasal tract.
Israel AK, Cracolici V, Griffith CC
Semin Diagn Pathol 2023 Sep;40(5):321-332. Epub 2023 Apr 14 doi: 10.1053/j.semdp.2023.04.011. PMID: 37085435
Diagnosis and management of neuroendocrine tumours.
Cuthbertson DJ, Shankland R, Srirajaskanthan R
Clin Med (Lond) 2023 Mar;23(2):119-124. doi: 10.7861/clinmed.2023-0044. PMID: 36958842Free PMC Article
Diagnosis and Treatment of Parasellar Lesions.
Gatto F, Perez-Rivas LG, Olarescu NC, Khandeva P, Chachlaki K, Trivellin G, Gahete MD, Cuny T; on behalf of the ENEA Young Researchers Committee (EYRC)
Neuroendocrinology 2020;110(9-10):728-739. Epub 2020 Mar 4 doi: 10.1159/000506905. PMID: 32126547

Recent clinical studies

Etiology

The 2022 WHO classification of thyroid tumors: novel concepts in nomenclature and grading.
Christofer Juhlin C, Mete O, Baloch ZW
Endocr Relat Cancer 2023 Feb 1;30(2) Epub 2022 Dec 22 doi: 10.1530/ERC-22-0293. PMID: 36445235
New PET Radiotracers for the Imaging of Neuroendocrine Neoplasms.
Fortunati E, Argalia G, Zanoni L, Fanti S, Ambrosini V
Curr Treat Options Oncol 2022 May;23(5):703-720. Epub 2022 Mar 24 doi: 10.1007/s11864-022-00967-z. PMID: 35325412Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Nothing But NET: A Review of Neuroendocrine Tumors and Carcinomas.
Oronsky B, Ma PC, Morgensztern D, Carter CA
Neoplasia 2017 Dec;19(12):991-1002. Epub 2017 Nov 5 doi: 10.1016/j.neo.2017.09.002. PMID: 29091800Free PMC Article
Composite intestinal adenoma-microcarcinoid.
Lin J, Goldblum JR, Bennett AE, Bronner MP, Liu X
Am J Surg Pathol 2012 Feb;36(2):292-5. doi: 10.1097/PAS.0b013e318236e4d2. PMID: 22082602

Diagnosis

The 2022 WHO classification of thyroid tumors: novel concepts in nomenclature and grading.
Christofer Juhlin C, Mete O, Baloch ZW
Endocr Relat Cancer 2023 Feb 1;30(2) Epub 2022 Dec 22 doi: 10.1530/ERC-22-0293. PMID: 36445235
Overview of the 2022 WHO Classification of Neuroendocrine Neoplasms.
Rindi G, Mete O, Uccella S, Basturk O, La Rosa S, Brosens LAA, Ezzat S, de Herder WW, Klimstra DS, Papotti M, Asa SL
Endocr Pathol 2022 Mar;33(1):115-154. Epub 2022 Mar 16 doi: 10.1007/s12022-022-09708-2. PMID: 35294740
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Immunohistochemistry in the diagnosis and classification of neuroendocrine neoplasms: what can brown do for you?
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article
Nothing But NET: A Review of Neuroendocrine Tumors and Carcinomas.
Oronsky B, Ma PC, Morgensztern D, Carter CA
Neoplasia 2017 Dec;19(12):991-1002. Epub 2017 Nov 5 doi: 10.1016/j.neo.2017.09.002. PMID: 29091800Free PMC Article

Therapy

Diagnosis and management of neuroendocrine tumours.
Cuthbertson DJ, Shankland R, Srirajaskanthan R
Clin Med (Lond) 2023 Mar;23(2):119-124. doi: 10.7861/clinmed.2023-0044. PMID: 36958842Free PMC Article
EUS-guided intra-tumoral therapies.
Marc B, Monino L, Rimbas M
Best Pract Res Clin Gastroenterol 2022 Sep-Dec;60-61:101817. Epub 2022 Dec 14 doi: 10.1016/j.bpg.2022.101817. PMID: 36577536
New PET Radiotracers for the Imaging of Neuroendocrine Neoplasms.
Fortunati E, Argalia G, Zanoni L, Fanti S, Ambrosini V
Curr Treat Options Oncol 2022 May;23(5):703-720. Epub 2022 Mar 24 doi: 10.1007/s11864-022-00967-z. PMID: 35325412Free PMC Article
Consensus on molecular imaging and theranostics in neuroendocrine neoplasms.
Ambrosini V, Kunikowska J, Baudin E, Bodei L, Bouvier C, Capdevila J, Cremonesi M, de Herder WW, Dromain C, Falconi M, Fani M, Fanti S, Hicks RJ, Kabasakal L, Kaltsas G, Lewington V, Minozzi S, Cinquini M, Öberg K, Oyen WJG, O'Toole D, Pavel M, Ruszniewski P, Scarpa A, Strosberg J, Sundin A, Taïeb D, Virgolini I, Wild D, Herrmann K, Yao J
Eur J Cancer 2021 Mar;146:56-73. Epub 2021 Feb 12 doi: 10.1016/j.ejca.2021.01.008. PMID: 33588146Free PMC Article
Pancreatic α-cell hyperplasia: facts and myths.
Yu R
J Clin Endocrinol Metab 2014 Mar;99(3):748-56. Epub 2013 Nov 27 doi: 10.1210/jc.2013-2952. PMID: 24285676

Prognosis

The 2022 WHO classification of thyroid tumors: novel concepts in nomenclature and grading.
Christofer Juhlin C, Mete O, Baloch ZW
Endocr Relat Cancer 2023 Feb 1;30(2) Epub 2022 Dec 22 doi: 10.1530/ERC-22-0293. PMID: 36445235
An introduction to the WHO 5th edition 2022 classification of testicular tumours.
Berney DM, Cree I, Rao V, Moch H, Srigley JR, Tsuzuki T, Amin MB, Comperat EM, Hartmann A, Menon S, Netto GJ, Rubin MA, Turajlic S, Raspollini MR, Tickoo SK
Histopathology 2022 Oct;81(4):459-466. Epub 2022 Jul 1 doi: 10.1111/his.14675. PMID: 35502823Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Immunohistochemistry in the diagnosis and classification of neuroendocrine neoplasms: what can brown do for you?
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article
Nothing But NET: A Review of Neuroendocrine Tumors and Carcinomas.
Oronsky B, Ma PC, Morgensztern D, Carter CA
Neoplasia 2017 Dec;19(12):991-1002. Epub 2017 Nov 5 doi: 10.1016/j.neo.2017.09.002. PMID: 29091800Free PMC Article

Clinical prediction guides

Therapeutic Challenges for Gastric Neuroendocrine Neoplasms: Take It or Leave It?
Cavalcoli F, Gallo C, Coltro LA, Rausa E, Cantù P, Invernizzi P, Massironi S
Medicina (Kaunas) 2023 Oct 1;59(10) doi: 10.3390/medicina59101757. PMID: 37893475Free PMC Article
EUS-guided intra-tumoral therapies.
Marc B, Monino L, Rimbas M
Best Pract Res Clin Gastroenterol 2022 Sep-Dec;60-61:101817. Epub 2022 Dec 14 doi: 10.1016/j.bpg.2022.101817. PMID: 36577536
Immunohistochemistry in the diagnosis and classification of neuroendocrine neoplasms: what can brown do for you?
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article
Primary well differentiated neuroendocrine tumor of the filum terminale. Case report and literature review.
Revuelta Barbero JM, Saab Mazzei A, Cotúa Quinteros C, de Reina L
Neurocirugia (Astur : Engl Ed) 2018 Sep-Oct;29(5):244-249. Epub 2017 Dec 30 doi: 10.1016/j.neucir.2017.11.002. PMID: 29295804
Immunohistochemical approach for the diagnosis of a liver mass on small biopsy specimens.
Choi WT, Ramachandran R, Kakar S
Hum Pathol 2017 May;63:1-13. Epub 2017 Jan 11 doi: 10.1016/j.humpath.2016.12.025. PMID: 28087475

Recent systematic reviews

Differentiated high grade thyroid carcinomas: Diagnostic consideration and clinical features.
Tondi Resta I, Gubbiotti MA, Montone KT, Livolsi VA, Baloch ZW
Hum Pathol 2024 Feb;144:53-60. Epub 2024 Jan 19 doi: 10.1016/j.humpath.2024.01.002. PMID: 38244615
Primary Gamma Knife Radiosurgery for pineal region tumors: A systematic review and pooled analysis of available literature with histological stratification.
Gagliardi F, De Domenico P, Garbin E, Snider S, Mortini P
J Pineal Res 2023 Dec;75(4):e12910. Epub 2023 Sep 13 doi: 10.1111/jpi.12910. PMID: 37705383
Persisting Embryonal Infundibular Recess (PEIR): Two Case Reports and Systematic Literature Review.
Belotti F, Lupi I, Cosottini M, Ambrosi C, Gasparotti R, Bogazzi F, Fontanella MM, Doglietto F
J Clin Endocrinol Metab 2018 Jul 1;103(7):2424-2429. doi: 10.1210/jc.2018-00437. PMID: 29788483
Use of fine-needle aspirate calcitonin to detect medullary thyroid carcinoma: A systematic review.
Trimboli P, Guidobaldi L, Bongiovanni M, Crescenzi A, Alevizaki M, Giovanella L
Diagn Cytopathol 2016 Jan;44(1):45-51. Epub 2015 Oct 19 doi: 10.1002/dc.23375. PMID: 26481456
Liver transplantation for hepatic tumors: a systematic review.
Ravaioli M, Ercolani G, Neri F, Cescon M, Stacchini G, Del Gaudio M, Cucchetti A, Pinna AD
World J Gastroenterol 2014 May 14;20(18):5345-52. doi: 10.3748/wjg.v20.i18.5345. PMID: 24833864Free PMC Article

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