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Pituitary Hyperplasia

MedGen UID:
1666905
•Concept ID:
C3670571
•
Disease or Syndrome
Synonym: Pituitary Gland Hyperplasia

Definition

A rare condition characterized by hyperplasia and hypertrophy of the pituitary gland. It is caused by hypersecretion of hypothalamic stimulating hormones. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPituitary Hyperplasia

Professional guidelines

PubMed

The diagnosis and management of Cushing's syndrome in pregnancy.
Hamblin R, Coulden A, Fountas A, Karavitaki N
J Neuroendocrinol 2022 Aug;34(8):e13118. Epub 2022 May 1 doi: 10.1111/jne.13118. PMID: 35491087Free PMC Article
Management of pituitary incidentaloma.
Boguszewski CL, de Castro Musolino NR, Kasuki L
Best Pract Res Clin Endocrinol Metab 2019 Apr;33(2):101268. Epub 2019 Apr 13 doi: 10.1016/j.beem.2019.04.002. PMID: 31027975
Diagnosis, treatment, and outcome of pituitary tumors and other abnormal intrasellar masses. Retrospective analysis of 353 patients.
Gsponer J, De Tribolet N, Déruaz JP, Janzer R, Uské A, Mirimanoff RO, Reymond MJ, Rey F, Temler E, Gaillard RC, Gomez F
Medicine (Baltimore) 1999 Jul;78(4):236-69. doi: 10.1097/00005792-199907000-00004. PMID: 10424206

Recent clinical studies

Etiology

Imaging of pituitary tumors: an update with the 5th WHO Classifications-part 2. Neoplasms other than PitNET and tumor-mimicking lesions.
Tsukamoto T, Miki Y
Jpn J Radiol 2023 Aug;41(8):808-829. Epub 2023 Mar 13 doi: 10.1007/s11604-023-01407-0. PMID: 36913010Free PMC Article
The diagnosis and management of Cushing's syndrome in pregnancy.
Hamblin R, Coulden A, Fountas A, Karavitaki N
J Neuroendocrinol 2022 Aug;34(8):e13118. Epub 2022 May 1 doi: 10.1111/jne.13118. PMID: 35491087Free PMC Article
Pituitary hyperplasia in childhood primary hypothyroidism: a review.
Sapkota S, Karn M, Sapkota S
Childs Nerv Syst 2021 Mar;37(3):749-762. Epub 2021 Jan 6 doi: 10.1007/s00381-020-05014-6. PMID: 33404718
Comprehensive Evaluation of Rare Pituitary Lesions: A Single Tertiary Care Pituitary Center Experience and Review of the Literature.
Cossu G, Brouland JP, La Rosa S, Camponovo C, Viaroli E, Daniel RT, Messerer M
Endocr Pathol 2019 Sep;30(3):219-236. doi: 10.1007/s12022-019-09581-6. PMID: 31209729
Management of pituitary incidentaloma.
Boguszewski CL, de Castro Musolino NR, Kasuki L
Best Pract Res Clin Endocrinol Metab 2019 Apr;33(2):101268. Epub 2019 Apr 13 doi: 10.1016/j.beem.2019.04.002. PMID: 31027975

Diagnosis

Management of pituitary incidentaloma.
Boguszewski CL, de Castro Musolino NR, Kasuki L
Best Pract Res Clin Endocrinol Metab 2019 Apr;33(2):101268. Epub 2019 Apr 13 doi: 10.1016/j.beem.2019.04.002. PMID: 31027975
Acromegaly.
Chanson P, Salenave S
Orphanet J Rare Dis 2008 Jun 25;3:17. doi: 10.1186/1750-1172-3-17. PMID: 18578866Free PMC Article
Pituitary hyperplasia.
Horvath E, Kovacs K, Scheithauer BW
Pituitary 1999 May;1(3-4):169-79. doi: 10.1023/a:1009952930425. PMID: 11081195
Pituitary gland.
Horvath E, Kovacs K
Pathol Res Pract 1988 Apr;183(2):129-42. doi: 10.1016/S0344-0338(88)80041-4. PMID: 3290865
Pituitary hyperplasia.
Horvath E
Pathol Res Pract 1988 Sep;183(5):623-5. doi: 10.1016/S0344-0338(88)80026-8. PMID: 2853334

Therapy

Growth impairment in children with atrophic autoimmune thyroiditis and pituitary hyperplasia.
Corica D, Abbate T, Kucharska AM, Wojcik M, Vierucci F, Valenzise M, Li Pomi A, Pepe G, Tuli G, Pyrzak B, Aversa T, Wasniewska M
Ital J Pediatr 2024 Apr 23;50(1):83. doi: 10.1186/s13052-024-01641-w. PMID: 38650008Free PMC Article
Neurological manifestation in severe hypothyroidism in pregnancy.
Sharma A, Noor N, Dadhwal V
BMJ Case Rep 2020 Dec 28;13(12) doi: 10.1136/bcr-2020-238069. PMID: 33372016Free PMC Article
Pituitary Hyperplasia, Hormonal Changes and Prolactinoma Development in Males Exposed to Estrogens-An Insight From Translational Studies.
Šošić-Jurjević B, Ajdžanović V, Miljić D, Trifunović S, Filipović B, Stanković S, Bolevich S, Jakovljević V, Milošević V
Int J Mol Sci 2020 Mar 16;21(6) doi: 10.3390/ijms21062024. PMID: 32188093Free PMC Article
Primary hypothyroidism in a child leads to pituitary hyperplasia: A case report and literature review.
Cao J, Lei T, Chen F, Zhang C, Ma C, Huang H
Medicine (Baltimore) 2018 Oct;97(42):e12703. doi: 10.1097/MD.0000000000012703. PMID: 30334955Free PMC Article
Etiological diagnosis of hyperprolactinemia.
Cortet-Rudelli C, Sapin R, Bonneville JF, Brue T
Ann Endocrinol (Paris) 2007 Jun;68(2-3):98-105. Epub 2007 May 23 doi: 10.1016/j.ando.2007.03.013. PMID: 17524347

Prognosis

Growth impairment in children with atrophic autoimmune thyroiditis and pituitary hyperplasia.
Corica D, Abbate T, Kucharska AM, Wojcik M, Vierucci F, Valenzise M, Li Pomi A, Pepe G, Tuli G, Pyrzak B, Aversa T, Wasniewska M
Ital J Pediatr 2024 Apr 23;50(1):83. doi: 10.1186/s13052-024-01641-w. PMID: 38650008Free PMC Article
Acromegaly Caused by Ectopic Growth Hormone Releasing Hormone Secretion: A Review.
Zendran I, Gut G, Kałużny M, Zawadzka K, Bolanowski M
Front Endocrinol (Lausanne) 2022;13:867965. Epub 2022 Jun 9 doi: 10.3389/fendo.2022.867965. PMID: 35757397Free PMC Article
Primary hypothyroidism with pituitary hyperplasia characterized by hypogonadotropic hypogonadism: a case report and review of the literature.
Yu W, Wu N
Ann Palliat Med 2020 Nov;9(6):4359-4370. Epub 2020 Nov 10 doi: 10.21037/apm-20-1828. PMID: 33183016
Management of pituitary incidentaloma.
Boguszewski CL, de Castro Musolino NR, Kasuki L
Best Pract Res Clin Endocrinol Metab 2019 Apr;33(2):101268. Epub 2019 Apr 13 doi: 10.1016/j.beem.2019.04.002. PMID: 31027975
Acromegaly.
Chanson P, Salenave S
Orphanet J Rare Dis 2008 Jun 25;3:17. doi: 10.1186/1750-1172-3-17. PMID: 18578866Free PMC Article

Clinical prediction guides

Growth impairment in children with atrophic autoimmune thyroiditis and pituitary hyperplasia.
Corica D, Abbate T, Kucharska AM, Wojcik M, Vierucci F, Valenzise M, Li Pomi A, Pepe G, Tuli G, Pyrzak B, Aversa T, Wasniewska M
Ital J Pediatr 2024 Apr 23;50(1):83. doi: 10.1186/s13052-024-01641-w. PMID: 38650008Free PMC Article
Gigantism: X-linked acrogigantism and GPR101 mutations.
Iacovazzo D, Korbonits M
Growth Horm IGF Res 2016 Oct-Dec;30-31:64-69. Epub 2016 Sep 29 doi: 10.1016/j.ghir.2016.09.007. PMID: 27743704
Neurology of the pituitary.
Samarasinghe S, Emanuele MA, Mazhari A
Handb Clin Neurol 2014;120:685-701. doi: 10.1016/B978-0-7020-4087-0.00047-4. PMID: 24365347
Pituitary hyperplasia secondary to primary hypothyroidism: a case report and review of the literature.
Joshi AS, Woolf PD
Pituitary 2005;8(2):99-103. doi: 10.1007/s11102-005-3281-8. PMID: 16195776
Angiotensin and calcium signaling in the pituitary and hypothalamus.
Suárez C, Tornadú IG, Cristina C, Vela J, Iglesias AG, Libertun C, Díaz-Torga G, Becu-Villalobos D
Cell Mol Neurobiol 2002 Jun;22(3):315-33. doi: 10.1023/a:1020772018703. PMID: 12469873

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