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Advanced Gastric Small Cell Neuroendocrine Carcinoma

MedGen UID:
1666992
•Concept ID:
C4744986
•
Neoplastic Process
Synonym: Advanced Gastric Small Cell Carcinoma

Definition

A gastric small cell neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Gastric Small Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Curative-Intent Treatment with Durvalumab in Early-Stage Cancers.
Melillo G, Chand V, Yovine A, Gupta A, Massacesi C
Adv Ther 2021 Jun;38(6):2759-2778. Epub 2021 Apr 21 doi: 10.1007/s12325-021-01675-0. PMID: 33881745Free PMC Article
Management of esophageal adenocarcinoma.
Tougeron D, Richer JP, Silvain C
J Visc Surg 2011 Jun;148(3):e161-70. Epub 2011 Jun 28 doi: 10.1016/j.jviscsurg.2011.05.008. PMID: 21715236
Guidelines for the management of iron deficiency anaemia.
Goddard AF, James MW, McIntyre AS, Scott BB; British Society of Gastroenterology
Gut 2011 Oct;60(10):1309-16. Epub 2011 May 11 doi: 10.1136/gut.2010.228874. PMID: 21561874

Recent clinical studies

Etiology

Endoscopic submucosal dissection for superficial gastrointestinal lesions: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2022.
Pimentel-Nunes P, Libânio D, Bastiaansen BAJ, Bhandari P, Bisschops R, Bourke MJ, Esposito G, Lemmers A, Maselli R, Messmann H, Pech O, Pioche M, Vieth M, Weusten BLAM, van Hooft JE, Deprez PH, Dinis-Ribeiro M
Endoscopy 2022 Jun;54(6):591-622. Epub 2022 May 6 doi: 10.1055/a-1811-7025. PMID: 35523224
Consensus for HER2 alterations testing in non-small-cell lung cancer.
Ren S, Wang J, Ying J, Mitsudomi T, Lee DH, Wang Z, Chu Q, Mack PC, Cheng Y, Duan J, Fan Y, Han B, Hui Z, Liu A, Liu J, Lu Y, Ma Z, Shi M, Shu Y, Song Q, Song X, Song Y, Wang C, Wang X, Wang Z, Xu Y, Yao Y, Zhang L, Zhao M, Zhu B, Zhang J, Zhou C, Hirsch FR
ESMO Open 2022 Feb;7(1):100395. Epub 2022 Feb 8 doi: 10.1016/j.esmoop.2022.100395. PMID: 35149428Free PMC Article
Evorpacept alone and in combination with pembrolizumab or trastuzumab in patients with advanced solid tumours (ASPEN-01): a first-in-human, open-label, multicentre, phase 1 dose-escalation and dose-expansion study.
Lakhani NJ, Chow LQM, Gainor JF, LoRusso P, Lee KW, Chung HC, Lee J, Bang YJ, Hodi FS, Kim WS, Santana-Davila R, Fanning P, Squifflet P, Jin F, Kuo TC, Wan HI, Pons J, Randolph SS, Messersmith WA
Lancet Oncol 2021 Dec;22(12):1740-1751. Epub 2021 Nov 15 doi: 10.1016/S1470-2045(21)00584-2. PMID: 34793719
Early palliative care and quality of life of advanced cancer patients-a multicenter randomized clinical trial.
Franciosi V, Maglietta G, Degli Esposti C, Caruso G, Cavanna L, Bertè R, Bacchini G, Bocchi L, Piva E, Monfredo M, Scafuri V, Di Cesare P, Melotti B, Sequino M, Rimanti A, Binovi C, Ghisoni F, Caminiti C
Ann Palliat Med 2019 Sep;8(4):381-389. Epub 2019 Mar 14 doi: 10.21037/apm.2019.02.07. PMID: 30943735
Guidelines for the management of iron deficiency anaemia.
Goddard AF, James MW, McIntyre AS, Scott BB; British Society of Gastroenterology
Gut 2011 Oct;60(10):1309-16. Epub 2011 May 11 doi: 10.1136/gut.2010.228874. PMID: 21561874

Diagnosis

Endoscopic submucosal dissection for superficial gastrointestinal lesions: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2022.
Pimentel-Nunes P, Libânio D, Bastiaansen BAJ, Bhandari P, Bisschops R, Bourke MJ, Esposito G, Lemmers A, Maselli R, Messmann H, Pech O, Pioche M, Vieth M, Weusten BLAM, van Hooft JE, Deprez PH, Dinis-Ribeiro M
Endoscopy 2022 Jun;54(6):591-622. Epub 2022 May 6 doi: 10.1055/a-1811-7025. PMID: 35523224
Consensus for HER2 alterations testing in non-small-cell lung cancer.
Ren S, Wang J, Ying J, Mitsudomi T, Lee DH, Wang Z, Chu Q, Mack PC, Cheng Y, Duan J, Fan Y, Han B, Hui Z, Liu A, Liu J, Lu Y, Ma Z, Shi M, Shu Y, Song Q, Song X, Song Y, Wang C, Wang X, Wang Z, Xu Y, Yao Y, Zhang L, Zhao M, Zhu B, Zhang J, Zhou C, Hirsch FR
ESMO Open 2022 Feb;7(1):100395. Epub 2022 Feb 8 doi: 10.1016/j.esmoop.2022.100395. PMID: 35149428Free PMC Article
Early palliative care and quality of life of advanced cancer patients-a multicenter randomized clinical trial.
Franciosi V, Maglietta G, Degli Esposti C, Caruso G, Cavanna L, Bertè R, Bacchini G, Bocchi L, Piva E, Monfredo M, Scafuri V, Di Cesare P, Melotti B, Sequino M, Rimanti A, Binovi C, Ghisoni F, Caminiti C
Ann Palliat Med 2019 Sep;8(4):381-389. Epub 2019 Mar 14 doi: 10.21037/apm.2019.02.07. PMID: 30943735
IFN-γ-related mRNA profile predicts clinical response to PD-1 blockade.
Ayers M, Lunceford J, Nebozhyn M, Murphy E, Loboda A, Kaufman DR, Albright A, Cheng JD, Kang SP, Shankaran V, Piha-Paul SA, Yearley J, Seiwert TY, Ribas A, McClanahan TK
J Clin Invest 2017 Aug 1;127(8):2930-2940. Epub 2017 Jun 26 doi: 10.1172/JCI91190. PMID: 28650338Free PMC Article
Guidelines for the management of iron deficiency anaemia.
Goddard AF, James MW, McIntyre AS, Scott BB; British Society of Gastroenterology
Gut 2011 Oct;60(10):1309-16. Epub 2011 May 11 doi: 10.1136/gut.2010.228874. PMID: 21561874

Therapy

Efficacy and Safety of Trastuzumab Deruxtecan in Patients With HER2-Expressing Solid Tumors: Primary Results From the DESTINY-PanTumor02 Phase II Trial.
Meric-Bernstam F, Makker V, Oaknin A, Oh DY, Banerjee S, González-Martín A, Jung KH, Ługowska I, Manso L, Manzano A, Melichar B, Siena S, Stroyakovskiy D, Fielding A, Ma Y, Puvvada S, Shire N, Lee JY
J Clin Oncol 2024 Jan 1;42(1):47-58. Epub 2023 Oct 23 doi: 10.1200/JCO.23.02005. PMID: 37870536Free PMC Article
Consensus for HER2 alterations testing in non-small-cell lung cancer.
Ren S, Wang J, Ying J, Mitsudomi T, Lee DH, Wang Z, Chu Q, Mack PC, Cheng Y, Duan J, Fan Y, Han B, Hui Z, Liu A, Liu J, Lu Y, Ma Z, Shi M, Shu Y, Song Q, Song X, Song Y, Wang C, Wang X, Wang Z, Xu Y, Yao Y, Zhang L, Zhao M, Zhu B, Zhang J, Zhou C, Hirsch FR
ESMO Open 2022 Feb;7(1):100395. Epub 2022 Feb 8 doi: 10.1016/j.esmoop.2022.100395. PMID: 35149428Free PMC Article
ROS1 [corrected].
Pal P, Khan Z
J Clin Pathol 2017 Dec;70(12):1001-1009. Epub 2017 Sep 13 doi: 10.1136/jclinpath-2016-204244. PMID: 28903995
IFN-γ-related mRNA profile predicts clinical response to PD-1 blockade.
Ayers M, Lunceford J, Nebozhyn M, Murphy E, Loboda A, Kaufman DR, Albright A, Cheng JD, Kang SP, Shankaran V, Piha-Paul SA, Yearley J, Seiwert TY, Ribas A, McClanahan TK
J Clin Invest 2017 Aug 1;127(8):2930-2940. Epub 2017 Jun 26 doi: 10.1172/JCI91190. PMID: 28650338Free PMC Article
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer.
Brahmer JR, Tykodi SS, Chow LQ, Hwu WJ, Topalian SL, Hwu P, Drake CG, Camacho LH, Kauh J, Odunsi K, Pitot HC, Hamid O, Bhatia S, Martins R, Eaton K, Chen S, Salay TM, Alaparthy S, Grosso JF, Korman AJ, Parker SM, Agrawal S, Goldberg SM, Pardoll DM, Gupta A, Wigginton JM
N Engl J Med 2012 Jun 28;366(26):2455-65. Epub 2012 Jun 2 doi: 10.1056/NEJMoa1200694. PMID: 22658128Free PMC Article

Prognosis

Consensus for HER2 alterations testing in non-small-cell lung cancer.
Ren S, Wang J, Ying J, Mitsudomi T, Lee DH, Wang Z, Chu Q, Mack PC, Cheng Y, Duan J, Fan Y, Han B, Hui Z, Liu A, Liu J, Lu Y, Ma Z, Shi M, Shu Y, Song Q, Song X, Song Y, Wang C, Wang X, Wang Z, Xu Y, Yao Y, Zhang L, Zhao M, Zhu B, Zhang J, Zhou C, Hirsch FR
ESMO Open 2022 Feb;7(1):100395. Epub 2022 Feb 8 doi: 10.1016/j.esmoop.2022.100395. PMID: 35149428Free PMC Article
Evorpacept alone and in combination with pembrolizumab or trastuzumab in patients with advanced solid tumours (ASPEN-01): a first-in-human, open-label, multicentre, phase 1 dose-escalation and dose-expansion study.
Lakhani NJ, Chow LQM, Gainor JF, LoRusso P, Lee KW, Chung HC, Lee J, Bang YJ, Hodi FS, Kim WS, Santana-Davila R, Fanning P, Squifflet P, Jin F, Kuo TC, Wan HI, Pons J, Randolph SS, Messersmith WA
Lancet Oncol 2021 Dec;22(12):1740-1751. Epub 2021 Nov 15 doi: 10.1016/S1470-2045(21)00584-2. PMID: 34793719
Immunotherapeutic advances in gastric cancer.
Yoneda A, Kuroki T, Eguchi S
Surg Today 2021 Nov;51(11):1727-1735. Epub 2021 Feb 15 doi: 10.1007/s00595-021-02236-2. PMID: 33590326
Early palliative care and quality of life of advanced cancer patients-a multicenter randomized clinical trial.
Franciosi V, Maglietta G, Degli Esposti C, Caruso G, Cavanna L, Bertè R, Bacchini G, Bocchi L, Piva E, Monfredo M, Scafuri V, Di Cesare P, Melotti B, Sequino M, Rimanti A, Binovi C, Ghisoni F, Caminiti C
Ann Palliat Med 2019 Sep;8(4):381-389. Epub 2019 Mar 14 doi: 10.21037/apm.2019.02.07. PMID: 30943735
IFN-γ-related mRNA profile predicts clinical response to PD-1 blockade.
Ayers M, Lunceford J, Nebozhyn M, Murphy E, Loboda A, Kaufman DR, Albright A, Cheng JD, Kang SP, Shankaran V, Piha-Paul SA, Yearley J, Seiwert TY, Ribas A, McClanahan TK
J Clin Invest 2017 Aug 1;127(8):2930-2940. Epub 2017 Jun 26 doi: 10.1172/JCI91190. PMID: 28650338Free PMC Article

Clinical prediction guides

Efficacy and Safety of Trastuzumab Deruxtecan in Patients With HER2-Expressing Solid Tumors: Primary Results From the DESTINY-PanTumor02 Phase II Trial.
Meric-Bernstam F, Makker V, Oaknin A, Oh DY, Banerjee S, González-Martín A, Jung KH, Ługowska I, Manso L, Manzano A, Melichar B, Siena S, Stroyakovskiy D, Fielding A, Ma Y, Puvvada S, Shire N, Lee JY
J Clin Oncol 2024 Jan 1;42(1):47-58. Epub 2023 Oct 23 doi: 10.1200/JCO.23.02005. PMID: 37870536Free PMC Article
Evorpacept alone and in combination with pembrolizumab or trastuzumab in patients with advanced solid tumours (ASPEN-01): a first-in-human, open-label, multicentre, phase 1 dose-escalation and dose-expansion study.
Lakhani NJ, Chow LQM, Gainor JF, LoRusso P, Lee KW, Chung HC, Lee J, Bang YJ, Hodi FS, Kim WS, Santana-Davila R, Fanning P, Squifflet P, Jin F, Kuo TC, Wan HI, Pons J, Randolph SS, Messersmith WA
Lancet Oncol 2021 Dec;22(12):1740-1751. Epub 2021 Nov 15 doi: 10.1016/S1470-2045(21)00584-2. PMID: 34793719
Early palliative care and quality of life of advanced cancer patients-a multicenter randomized clinical trial.
Franciosi V, Maglietta G, Degli Esposti C, Caruso G, Cavanna L, Bertè R, Bacchini G, Bocchi L, Piva E, Monfredo M, Scafuri V, Di Cesare P, Melotti B, Sequino M, Rimanti A, Binovi C, Ghisoni F, Caminiti C
Ann Palliat Med 2019 Sep;8(4):381-389. Epub 2019 Mar 14 doi: 10.21037/apm.2019.02.07. PMID: 30943735
IFN-γ-related mRNA profile predicts clinical response to PD-1 blockade.
Ayers M, Lunceford J, Nebozhyn M, Murphy E, Loboda A, Kaufman DR, Albright A, Cheng JD, Kang SP, Shankaran V, Piha-Paul SA, Yearley J, Seiwert TY, Ribas A, McClanahan TK
J Clin Invest 2017 Aug 1;127(8):2930-2940. Epub 2017 Jun 26 doi: 10.1172/JCI91190. PMID: 28650338Free PMC Article
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer.
Brahmer JR, Tykodi SS, Chow LQ, Hwu WJ, Topalian SL, Hwu P, Drake CG, Camacho LH, Kauh J, Odunsi K, Pitot HC, Hamid O, Bhatia S, Martins R, Eaton K, Chen S, Salay TM, Alaparthy S, Grosso JF, Korman AJ, Parker SM, Agrawal S, Goldberg SM, Pardoll DM, Gupta A, Wigginton JM
N Engl J Med 2012 Jun 28;366(26):2455-65. Epub 2012 Jun 2 doi: 10.1056/NEJMoa1200694. PMID: 22658128Free PMC Article

Recent systematic reviews

Incidence of immunotherapy-related hyperprogressive disease (HPD) across HPD definitions and cancer types in observational studies: A systematic review and meta-analysis.
Kim MJ, Hong SPD, Park Y, Chae YK
Cancer Med 2024 Feb;13(3):e6970. doi: 10.1002/cam4.6970. PMID: 38400685Free PMC Article
Effect of liver metastasis on the efficacy of immune checkpoint inhibitors in cancer patients: a systemic review and meta-analysis.
Tian BW, Han CL, Wang HC, Yan LJ, Ding ZN, Liu H, Mao XC, Tian JC, Xue JS, Yang LS, Tan SY, Dong ZR, Yan YC, Wang DX, Li T
Clin Exp Metastasis 2023 Aug;40(4):255-287. Epub 2023 Jun 13 doi: 10.1007/s10585-023-10217-7. PMID: 37308706
Investigation on potential biomarkers of hyperprogressive disease (HPD) triggered by immune checkpoint inhibitors (ICIs).
Liu J, Wu Q, Wu S, Xie X
Clin Transl Oncol 2021 Sep;23(9):1782-1793. Epub 2021 Apr 13 doi: 10.1007/s12094-021-02579-9. PMID: 33847923
Anti-PD-1/L1-associated immune-related adverse events as harbinger of favorable clinical outcome: systematic review and meta-analysis.
Park R, Lopes L, Saeed A
Clin Transl Oncol 2021 Jan;23(1):100-109. Epub 2020 Jun 3 doi: 10.1007/s12094-020-02397-5. PMID: 32495269
LncRNA SNHG15: A new budding star in human cancers.
Shuai Y, Ma Z, Lu J, Feng J
Cell Prolif 2020 Jan;53(1):e12716. Epub 2019 Nov 27 doi: 10.1111/cpr.12716. PMID: 31774607Free PMC Article

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