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Metastatic Bladder Nested Urothelial Carcinoma

MedGen UID:
1674334
•Concept ID:
C4763842
•
Neoplastic Process
Synonyms: Metastatic Infiltrating Bladder Urothelial Carcinoma, Nested Variant; Metastatic Invasive Bladder Urothelial Carcinoma, Nested Variant; Metastatic Nested Bladder Urothelial Carcinoma; Metastatic Nested Urothelial Carcinoma of the Bladder

Definition

Bladder nested urothelial carcinoma that has spread to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Bladder Nested Urothelial Carcinoma

Recent clinical studies

Etiology

Radical cystectomy for bladder urothelial carcinoma with aggressive variant histology.
Mehrnoush V, Brennan L, Ismail A, Zakaria A, Elmansy H, Shahrour W, Prowse O, Kotb A
Arch Ital Urol Androl 2022 Sep 26;94(3):291-294. doi: 10.4081/aiua.2022.3.291. PMID: 36165473
PAX8 expression and TERT promoter mutations in the nested variant of urothelial carcinoma: a clinicopathologic study with immunohistochemical and molecular correlates.
Taylor AS, McKenney JK, Osunkoya AO, Chan MP, Al-Ahmadie HA, Spratt DE, Fullen DR, Chinnaiyan AM, Brown NA, Mehra R
Mod Pathol 2020 Jun;33(6):1165-1171. Epub 2020 Jan 13 doi: 10.1038/s41379-020-0453-z. PMID: 31932679
Clinical significance of prominent retraction clefts in invasive urothelial carcinoma.
Shah TS, Kaag M, Raman JD, Chan W, Tran T, Kunchala S, Shuman L, DeGraff DJ, Chen G, Warrick JI
Hum Pathol 2017 Mar;61:90-96. Epub 2016 Nov 4 doi: 10.1016/j.humpath.2016.10.021. PMID: 27818288
Value of uroplakin III in distinguishing variants of primary bladder urothelial carcinoma from malignancy metastatic to the urinary bladder.
Klopfer K, Delahunt B, Adamson M, Samaratunga H
Anticancer Res 2014 Nov;34(11):6779-84. PMID: 25368291
Large nested variant of urothelial carcinoma: 23 cases mimicking von Brunn nests and inverted growth pattern of noninvasive papillary urothelial carcinoma.
Cox R, Epstein JI
Am J Surg Pathol 2011 Sep;35(9):1337-42. doi: 10.1097/PAS.0b013e318222a653. PMID: 21836490

Diagnosis

Metastatic upper tract urothelial carcinoma with nest-like features presenting as malignant pleural effusion.
Arienzo F, Valenti A, Ricci P, Ascoli V
Diagn Cytopathol 2024 Jun;52(6):E124-E128. Epub 2024 Feb 23 doi: 10.1002/dc.25293. PMID: 38396316
PAX8 expression and TERT promoter mutations in the nested variant of urothelial carcinoma: a clinicopathologic study with immunohistochemical and molecular correlates.
Taylor AS, McKenney JK, Osunkoya AO, Chan MP, Al-Ahmadie HA, Spratt DE, Fullen DR, Chinnaiyan AM, Brown NA, Mehra R
Mod Pathol 2020 Jun;33(6):1165-1171. Epub 2020 Jan 13 doi: 10.1038/s41379-020-0453-z. PMID: 31932679
Divergent differentiation in urothelial carcinoma and other bladder cancer subtypes with selected mimics.
Shanks JH, Iczkowski KA
Histopathology 2009 Jun;54(7):885-900. Epub 2008 Oct 30 doi: 10.1111/j.1365-2559.2008.03167.x. PMID: 19178589
Carcinoid tumors of the urinary tract and prostate.
Murali R, Kneale K, Lalak N, Delprado W
Arch Pathol Lab Med 2006 Nov;130(11):1693-706. doi: 10.5858/2006-130-1693-CTOTUT. PMID: 17076534
The role of immunohistochemistry in the diagnosis of urinary bladder neoplasms.
McKenney JK, Amin MB
Semin Diagn Pathol 2005 Feb;22(1):69-87. doi: 10.1053/j.semdp.2005.11.005. PMID: 16512600

Therapy

Nested variant of urothelial carcinoma: a clinicopathologic and immunohistochemical study of 30 pure and mixed cases.
Wasco MJ, Daignault S, Bradley D, Shah RB
Hum Pathol 2010 Feb;41(2):163-71. Epub 2009 Oct 1 doi: 10.1016/j.humpath.2009.07.015. PMID: 19800100

Prognosis

Large nested variant of urothelial carcinoma: a clinicopathological study of 36 cases.
Compérat E, McKenney JK, Hartmann A, Hes O, Bertz S, Varinot J, Brimo F
Histopathology 2017 Nov;71(5):703-710. Epub 2017 Aug 14 doi: 10.1111/his.13280. PMID: 28805264
Clinical significance of prominent retraction clefts in invasive urothelial carcinoma.
Shah TS, Kaag M, Raman JD, Chan W, Tran T, Kunchala S, Shuman L, DeGraff DJ, Chen G, Warrick JI
Hum Pathol 2017 Mar;61:90-96. Epub 2016 Nov 4 doi: 10.1016/j.humpath.2016.10.021. PMID: 27818288
Value of uroplakin III in distinguishing variants of primary bladder urothelial carcinoma from malignancy metastatic to the urinary bladder.
Klopfer K, Delahunt B, Adamson M, Samaratunga H
Anticancer Res 2014 Nov;34(11):6779-84. PMID: 25368291
Divergent differentiation in urothelial carcinoma and other bladder cancer subtypes with selected mimics.
Shanks JH, Iczkowski KA
Histopathology 2009 Jun;54(7):885-900. Epub 2008 Oct 30 doi: 10.1111/j.1365-2559.2008.03167.x. PMID: 19178589
The role of immunohistochemistry in the diagnosis of urinary bladder neoplasms.
McKenney JK, Amin MB
Semin Diagn Pathol 2005 Feb;22(1):69-87. doi: 10.1053/j.semdp.2005.11.005. PMID: 16512600

Clinical prediction guides

PAX8 expression and TERT promoter mutations in the nested variant of urothelial carcinoma: a clinicopathologic study with immunohistochemical and molecular correlates.
Taylor AS, McKenney JK, Osunkoya AO, Chan MP, Al-Ahmadie HA, Spratt DE, Fullen DR, Chinnaiyan AM, Brown NA, Mehra R
Mod Pathol 2020 Jun;33(6):1165-1171. Epub 2020 Jan 13 doi: 10.1038/s41379-020-0453-z. PMID: 31932679
Clinical significance of prominent retraction clefts in invasive urothelial carcinoma.
Shah TS, Kaag M, Raman JD, Chan W, Tran T, Kunchala S, Shuman L, DeGraff DJ, Chen G, Warrick JI
Hum Pathol 2017 Mar;61:90-96. Epub 2016 Nov 4 doi: 10.1016/j.humpath.2016.10.021. PMID: 27818288
Endometrial stromal sarcoma involving the urinary bladder: a study of 6 cases.
Tian W, Latour M, Epstein JI
Am J Surg Pathol 2014 Jul;38(7):982-9. doi: 10.1097/PAS.0000000000000214. PMID: 24705317
Nested variant of urothelial carcinoma: a clinicopathologic and immunohistochemical study of 30 pure and mixed cases.
Wasco MJ, Daignault S, Bradley D, Shah RB
Hum Pathol 2010 Feb;41(2):163-71. Epub 2009 Oct 1 doi: 10.1016/j.humpath.2009.07.015. PMID: 19800100
Expression of transitional cell-specific genes, uroplakin Ia and II, in bladder cancer: detection of circulating cancer cells in the peripheral blood of metastatic patients.
Yuasa T, Yoshiki T, Isono T, Tanaka T, Hayashida H, Okada Y
Int J Urol 1999 Jun;6(6):286-92. doi: 10.1046/j.1442-2042.1999.00064.x. PMID: 10404304

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