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Metastatic Squamous Cell Carcinoma in the Cervical Lymph Nodes

MedGen UID:
1676273
•Concept ID:
C4763628
•
Neoplastic Process
Synonym: Metastatic Squamous Cell Carcinoma in Cervical Lymph Node

Definition

A squamous cell carcinoma that has spread from its original site of growth to the cervical lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Squamous Cell Carcinoma in the Cervical Lymph Nodes

Professional guidelines

PubMed

The management of metastatic squamous cell carcinoma in cervical lymph nodes from an unknown primary.
Medini E, Medini AM, Lee CK, Gapany M, Levitt SH
Am J Clin Oncol 1998 Apr;21(2):121-5. doi: 10.1097/00000421-199804000-00004. PMID: 9537194

Recent clinical studies

Etiology

Epidemiology of advanced cutaneous squamous cell carcinoma.
Dessinioti C, Pitoulias M, Stratigos AJ
J Eur Acad Dermatol Venereol 2022 Jan;36(1):39-50. Epub 2021 Oct 11 doi: 10.1111/jdv.17709. PMID: 34592000
The Utility of Ultrasonography in the Diagnosis of Cervical Lymph Nodes after Chemoradiotherapy for Head and Neck Squamous Cell Carcinoma.
Terada H, Shimode Y, Furukawa M, Sato Y, Hanai N
Medicina (Kaunas) 2021 Apr 23;57(5) doi: 10.3390/medicina57050407. PMID: 33922457Free PMC Article
Lymph node characteristics and their prognostic significance in oral squamous cell carcinoma.
Arun I, Maity N, Hameed S, Jain PV, Manikantan K, Sharan R, Arun P
Head Neck 2021 Feb;43(2):520-533. Epub 2020 Oct 6 doi: 10.1002/hed.26499. PMID: 33021340
The role of cytology in the era of HPV-related head and neck carcinoma.
Roy-Chowdhuri S, Krishnamurthy S
Semin Diagn Pathol 2015 Jul;32(4):250-7. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.006. PMID: 25638437
Metastatic cutaneous squamous cell carcinoma to the parotid and cervical lymph nodes: treatment and outcomes.
Bumpous J
Curr Opin Otolaryngol Head Neck Surg 2009 Apr;17(2):122-5. doi: 10.1097/MOO.0b013e32832924e0. PMID: 19346945

Diagnosis

Epidemiology of advanced cutaneous squamous cell carcinoma.
Dessinioti C, Pitoulias M, Stratigos AJ
J Eur Acad Dermatol Venereol 2022 Jan;36(1):39-50. Epub 2021 Oct 11 doi: 10.1111/jdv.17709. PMID: 34592000
Squamous cell carcinoma of uterine cervix metastatic to the axillary lymph node.
Chundriger Q, Chishti U, Idrees R
BMJ Case Rep 2021 Jul 12;14(7) doi: 10.1136/bcr-2021-243989. PMID: 34253531Free PMC Article
The Utility of Ultrasonography in the Diagnosis of Cervical Lymph Nodes after Chemoradiotherapy for Head and Neck Squamous Cell Carcinoma.
Terada H, Shimode Y, Furukawa M, Sato Y, Hanai N
Medicina (Kaunas) 2021 Apr 23;57(5) doi: 10.3390/medicina57050407. PMID: 33922457Free PMC Article
Chapter 6 Non-Squamous Cell Causes of Cervical Lymphadenopathy.
Agarwal M, Nabavizadeh SA, Mohan S
Semin Ultrasound CT MR 2017 Oct;38(5):516-530. Epub 2017 May 20 doi: 10.1053/j.sult.2017.05.006. PMID: 29031368
The role of cytology in the era of HPV-related head and neck carcinoma.
Roy-Chowdhuri S, Krishnamurthy S
Semin Diagn Pathol 2015 Jul;32(4):250-7. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.006. PMID: 25638437

Therapy

Real world data of cemiplimab in locally advanced and metastatic cutaneous squamous cell carcinoma.
Baggi A, Quaglino P, Rubatto M, Depenni R, Guida M, Ascierto PA, Trojaniello C, Queirolo P, Saponara M, Peris K, Spagnolo F, Bianchi L, De Galitiis F, Potenza MC, Proietti I, Marconcini R, Botticelli A, Barbieri V, Licitra L, Alfieri S, Ficorella C, Cortellini A, Fargnoli MC, Troiani T, Tondulli L, Bossi P
Eur J Cancer 2021 Nov;157:250-258. Epub 2021 Sep 15 doi: 10.1016/j.ejca.2021.08.018. PMID: 34536948
Pembrolizumab with or without radiotherapy for metastatic non-small-cell lung cancer: a pooled analysis of two randomised trials.
Theelen WSME, Chen D, Verma V, Hobbs BP, Peulen HMU, Aerts JGJV, Bahce I, Niemeijer ALN, Chang JY, de Groot PM, Nguyen QN, Comeaux NI, Simon GR, Skoulidis F, Lin SH, He K, Patel R, Heymach J, Baas P, Welsh JW
Lancet Respir Med 2021 May;9(5):467-475. Epub 2020 Oct 20 doi: 10.1016/S2213-2600(20)30391-X. PMID: 33096027
Surgical versus clinical staging prior to primary chemoradiation in patients with cervical cancer FIGO stages IIB-IVA: oncologic results of a prospective randomized international multicenter (Uterus-11) intergroup study.
Marnitz S, Tsunoda AT, Martus P, Vieira M, Affonso Junior RJ, Nunes J, Budach V, Hertel H, Mustea A, Sehouli J, Scharf JP, Ulrich U, Ebert A, Piwonski I, Kohler C
Int J Gynecol Cancer 2020 Dec;30(12):1855-1861. doi: 10.1136/ijgc-2020-001973. PMID: 33293284Free PMC Article
Machine Learning-Guided Adjuvant Treatment of Head and Neck Cancer.
Howard FM, Kochanny S, Koshy M, Spiotto M, Pearson AT
JAMA Netw Open 2020 Nov 2;3(11):e2025881. doi: 10.1001/jamanetworkopen.2020.25881. PMID: 33211108Free PMC Article
Integrin β4-Targeted Cancer Immunotherapies Inhibit Tumor Growth and Decrease Metastasis.
Ruan S, Lin M, Zhu Y, Lum L, Thakur A, Jin R, Shao W, Zhang Y, Hu Y, Huang S, Hurt EM, Chang AE, Wicha MS, Li Q
Cancer Res 2020 Feb 15;80(4):771-783. Epub 2019 Dec 16 doi: 10.1158/0008-5472.CAN-19-1145. PMID: 31843981Free PMC Article

Prognosis

Epidemiology of advanced cutaneous squamous cell carcinoma.
Dessinioti C, Pitoulias M, Stratigos AJ
J Eur Acad Dermatol Venereol 2022 Jan;36(1):39-50. Epub 2021 Oct 11 doi: 10.1111/jdv.17709. PMID: 34592000
The Utility of Ultrasonography in the Diagnosis of Cervical Lymph Nodes after Chemoradiotherapy for Head and Neck Squamous Cell Carcinoma.
Terada H, Shimode Y, Furukawa M, Sato Y, Hanai N
Medicina (Kaunas) 2021 Apr 23;57(5) doi: 10.3390/medicina57050407. PMID: 33922457Free PMC Article
Lymph node characteristics and their prognostic significance in oral squamous cell carcinoma.
Arun I, Maity N, Hameed S, Jain PV, Manikantan K, Sharan R, Arun P
Head Neck 2021 Feb;43(2):520-533. Epub 2020 Oct 6 doi: 10.1002/hed.26499. PMID: 33021340
The role of cytology in the era of HPV-related head and neck carcinoma.
Roy-Chowdhuri S, Krishnamurthy S
Semin Diagn Pathol 2015 Jul;32(4):250-7. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.006. PMID: 25638437
Metastatic cutaneous squamous cell carcinoma to the parotid and cervical lymph nodes: treatment and outcomes.
Bumpous J
Curr Opin Otolaryngol Head Neck Surg 2009 Apr;17(2):122-5. doi: 10.1097/MOO.0b013e32832924e0. PMID: 19346945

Clinical prediction guides

Prognostic value of lymph node involvement in oral squamous cell carcinoma.
Voss JO, Freund L, Neumann F, Mrosk F, Rubarth K, Kreutzer K, Doll C, Heiland M, Koerdt S
Clin Oral Investig 2022 Nov;26(11):6711-6720. Epub 2022 Jul 27 doi: 10.1007/s00784-022-04630-7. PMID: 35895143Free PMC Article
Intra-arterial chemotherapy targeting metastatic cervical lymph nodes in head and neck cancer.
Murono S, Komori T, Endo K, Kondo S, Wakisaka N, Yoshizaki T
Acta Otolaryngol 2021 Dec;141(12):1063-1069. Epub 2021 Nov 26 doi: 10.1080/00016489.2021.2003858. PMID: 34825623
Cervicothoracoscopic Approach in Esophagectomy.
Okamura A, Watanabe M, Imamura Y, Hayami M, Yuda M, Yamashita K, Shoji Y, Mine S
Ann Surg Oncol 2018 Jan;25(1):333. Epub 2017 Oct 30 doi: 10.1245/s10434-017-6119-5. PMID: 29086127
Parotidectomy for Parotid Cancer.
Cracchiolo JR, Shaha AR
Otolaryngol Clin North Am 2016 Apr;49(2):415-24. Epub 2016 Feb 17 doi: 10.1016/j.otc.2015.10.007. PMID: 26895698Free PMC Article
The role of cytology in the era of HPV-related head and neck carcinoma.
Roy-Chowdhuri S, Krishnamurthy S
Semin Diagn Pathol 2015 Jul;32(4):250-7. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.006. PMID: 25638437

Recent systematic reviews

Prognostic factors of head and neck cutaneous squamous cell carcinoma: a systematic review.
Lubov J, Labbé M, Sioufi K, Morand GB, Hier MP, Khanna M, Sultanem K, Mlynarek AM
J Otolaryngol Head Neck Surg 2021 Sep 7;50(1):54. doi: 10.1186/s40463-021-00529-7. PMID: 34493343Free PMC Article
The prevalence of human papillomavirus in squamous cell carcinoma of unknown primary site metastatic to neck lymph nodes: a systematic review.
Boscolo-Rizzo P, Schroeder L, Romeo S, Pawlita M
Clin Exp Metastasis 2015 Dec;32(8):835-45. Epub 2015 Sep 10 doi: 10.1007/s10585-015-9744-z. PMID: 26358913
Diffusion-weighted imaging in head and neck squamous cell carcinomas: a systematic review.
Driessen JP, van Kempen PM, van der Heijden GJ, Philippens ME, Pameijer FA, Stegeman I, Terhaard CH, Janssen LM, Grolman W
Head Neck 2015 Mar;37(3):440-8. Epub 2014 Feb 12 doi: 10.1002/hed.23575. PMID: 24347513
Utility of head and neck cutaneous squamous cell carcinoma sentinel node biopsy: a systematic review.
Ahmed MM, Moore BA, Schmalbach CE
Otolaryngol Head Neck Surg 2014 Feb;150(2):180-7. Epub 2013 Nov 7 doi: 10.1177/0194599813511949. PMID: 24201060
Lymph node metastases from auricular squamous cell carcinoma. A systematic review and meta-analysis.
Clark RR, Soutar DS
J Plast Reconstr Aesthet Surg 2008 Oct;61(10):1140-7. doi: 10.1016/j.bjps.2008.04.036. PMID: 18675609

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