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Metastatic Bladder Micropapillary Urothelial Carcinoma

MedGen UID:
1683732
•Concept ID:
C4763839
•
Neoplastic Process
Synonyms: Metastatic Infiltrating Bladder Urothelial Carcinoma, Micropapillary Variant; Metastatic Invasive Bladder Urothelial Carcinoma, Micropapillary Variant; Metastatic Micropapillary Bladder Urothelial Carcinoma; Metastatic Micropapillary Urothelial Carcinoma of the Bladder

Definition

Bladder micropapillary urothelial carcinoma that has spread to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Bladder Micropapillary Urothelial Carcinoma

Professional guidelines

PubMed

What Is the Prognostic and Clinical Importance of Urothelial and Nonurothelial Histological Variants of Bladder Cancer in Predicting Oncological Outcomes in Patients with Muscle-invasive and Metastatic Bladder Cancer? A European Association of Urology Muscle Invasive and Metastatic Bladder Cancer Guidelines Panel Systematic Review.
Veskimäe E, Espinos EL, Bruins HM, Yuan Y, Sylvester R, Kamat AM, Shariat SF, Witjes JA, Compérat EM
Eur Urol Oncol 2019 Nov;2(6):625-642. Epub 2019 Oct 8 doi: 10.1016/j.euo.2019.09.003. PMID: 31601522
The case for conservative management in the treatment of patients with non-muscle-invasive micropapillary bladder carcinoma without carcinoma in situ.
Gaya JM, Palou J, Algaba F, Arce J, Rodríguez-Faba O, Villavicencio H
Can J Urol 2010 Oct;17(5):5370-6. PMID: 20974029
The case for early cystectomy in the treatment of nonmuscle invasive micropapillary bladder carcinoma.
Kamat AM, Gee JR, Dinney CP, Grossman HB, Swanson DA, Millikan RE, Detry MA, Robinson TL, Pisters LL
J Urol 2006 Mar;175(3 Pt 1):881-5. doi: 10.1016/S0022-5347(05)00423-4. PMID: 16469571

Recent clinical studies

Etiology

Radical cystectomy for bladder urothelial carcinoma with aggressive variant histology.
Mehrnoush V, Brennan L, Ismail A, Zakaria A, Elmansy H, Shahrour W, Prowse O, Kotb A
Arch Ital Urol Androl 2022 Sep 26;94(3):291-294. doi: 10.4081/aiua.2022.3.291. PMID: 36165473
Efficacy of Pembrolizumab in Patients With Variant Urothelial Carcinoma: A Multicenter Retrospective Study.
Minato A, Furubayashi N, Harada M, Negishi T, Sakamoto N, Song Y, Hori Y, Tomoda T, Tamura S, Kuroiwa K, Seki N, Tomisaki I, Harada K, Nakamura M, Fujimoto N
Clin Genitourin Cancer 2022 Oct;20(5):499.e1-499.e8. Epub 2022 May 5 doi: 10.1016/j.clgc.2022.05.001. PMID: 35624001
Urothelial Carcinoma In Situ of the Bladder With Glandular Differentiation: Report of 92 Cases.
Yang Z, Epstein JI
Am J Surg Pathol 2018 Jul;42(7):971-976. doi: 10.1097/PAS.0000000000001073. PMID: 29683821
Micropapillary urothelial carcinoma: an aggressive variant of urothelial carcinoma.
Loghin A, Chibelean C, Orsolya M, Nechifor-Boilă A, Nechifor-Boilă A, Borda A
Rom J Morphol Embryol 2014;55(3):939-45. PMID: 25329124
Micropapillary bladder cancer.
Nishizawa K, Kobayashi T, Mitsumori K, Ide Y, Watanabe J, Ogura K
Int J Urol 2005 May;12(5):506-8. doi: 10.1111/j.1442-2042.2005.01075.x. PMID: 15948755

Diagnosis

Metastatic urothelial carcinoma to the brain, spinal cord and spine: A contemporary multi-institutional clinicopathologic analysis of 24 cases.
Ogunbona OB, Matoso A, Cheng L, Shen S, Powell SZ, Osunkoya AO
Pathol Res Pract 2021 Aug;224:153537. Epub 2021 Jul 1 doi: 10.1016/j.prp.2021.153537. PMID: 34243109
Emerging concepts in micropapillary urothelial carcinoma.
Watts KE, Hansel DE
Adv Anat Pathol 2010 May;17(3):182-6. doi: 10.1097/PAP.0b013e3181d97851. PMID: 20418672
Micropapillary urothelial carcinoma: clinico-pathologic review.
Perepletchikov AM, Parwani AV
Pathol Res Pract 2009;205(12):807-10. Epub 2009 Sep 19 doi: 10.1016/j.prp.2009.07.016. PMID: 19767154
Divergent differentiation in urothelial carcinoma and other bladder cancer subtypes with selected mimics.
Shanks JH, Iczkowski KA
Histopathology 2009 Jun;54(7):885-900. Epub 2008 Oct 30 doi: 10.1111/j.1365-2559.2008.03167.x. PMID: 19178589
Micropapillary bladder cancer.
Nishizawa K, Kobayashi T, Mitsumori K, Ide Y, Watanabe J, Ogura K
Int J Urol 2005 May;12(5):506-8. doi: 10.1111/j.1442-2042.2005.01075.x. PMID: 15948755

Therapy

What Is the Prognostic and Clinical Importance of Urothelial and Nonurothelial Histological Variants of Bladder Cancer in Predicting Oncological Outcomes in Patients with Muscle-invasive and Metastatic Bladder Cancer? A European Association of Urology Muscle Invasive and Metastatic Bladder Cancer Guidelines Panel Systematic Review.
Veskimäe E, Espinos EL, Bruins HM, Yuan Y, Sylvester R, Kamat AM, Shariat SF, Witjes JA, Compérat EM
Eur Urol Oncol 2019 Nov;2(6):625-642. Epub 2019 Oct 8 doi: 10.1016/j.euo.2019.09.003. PMID: 31601522
Impact of adjuvant chemotherapy in patients with adverse features and variant histology at radical cystectomy for muscle-invasive carcinoma of the bladder: Does histologic subtype matter?
Berg S, D'Andrea D, Vetterlein MW, Cole AP, Fletcher SA, Krimphove MJ, Marchese M, Lipsitz SR, Sonpavde G, Noldus J, Shariat SF, Kibel AS, Trinh QD, Mossanen M
Cancer 2019 May 1;125(9):1449-1458. Epub 2019 Jan 8 doi: 10.1002/cncr.31952. PMID: 30620387
Neoadjuvant systemic therapy or early cystectomy? Single-center analysis of outcomes after therapy for patients with clinically localized micropapillary urothelial carcinoma of the bladder.
Ghoneim IA, Miocinovic R, Stephenson AJ, Garcia JA, Gong MC, Campbell SC, Hansel DE, Fergany AF
Urology 2011 Apr;77(4):867-70. Epub 2011 Feb 5 doi: 10.1016/j.urology.2010.11.043. PMID: 21296399
Micropapillary urothelial carcinoma: clinico-pathologic review.
Perepletchikov AM, Parwani AV
Pathol Res Pract 2009;205(12):807-10. Epub 2009 Sep 19 doi: 10.1016/j.prp.2009.07.016. PMID: 19767154
Micropapillary bladder cancer.
Nishizawa K, Kobayashi T, Mitsumori K, Ide Y, Watanabe J, Ogura K
Int J Urol 2005 May;12(5):506-8. doi: 10.1111/j.1442-2042.2005.01075.x. PMID: 15948755

Prognosis

Micropapillary urothelial carcinoma: an aggressive variant of urothelial carcinoma.
Loghin A, Chibelean C, Orsolya M, Nechifor-Boilă A, Nechifor-Boilă A, Borda A
Rom J Morphol Embryol 2014;55(3):939-45. PMID: 25329124
Emerging concepts in micropapillary urothelial carcinoma.
Watts KE, Hansel DE
Adv Anat Pathol 2010 May;17(3):182-6. doi: 10.1097/PAP.0b013e3181d97851. PMID: 20418672
Micropapillary urothelial carcinoma: clinico-pathologic review.
Perepletchikov AM, Parwani AV
Pathol Res Pract 2009;205(12):807-10. Epub 2009 Sep 19 doi: 10.1016/j.prp.2009.07.016. PMID: 19767154
Divergent differentiation in urothelial carcinoma and other bladder cancer subtypes with selected mimics.
Shanks JH, Iczkowski KA
Histopathology 2009 Jun;54(7):885-900. Epub 2008 Oct 30 doi: 10.1111/j.1365-2559.2008.03167.x. PMID: 19178589
Micropapillary bladder cancer.
Nishizawa K, Kobayashi T, Mitsumori K, Ide Y, Watanabe J, Ogura K
Int J Urol 2005 May;12(5):506-8. doi: 10.1111/j.1442-2042.2005.01075.x. PMID: 15948755

Clinical prediction guides

Do Histology and Primary Tumor Location Influence Metastatic Patterns in Bladder Cancer?
Park HK
Curr Oncol 2023 Oct 11;30(10):9078-9089. doi: 10.3390/curroncol30100656. PMID: 37887556Free PMC Article
Detection of HPV infection in urothelial carcinoma using RNAscope: Clinicopathological characterization.
Musangile FY, Matsuzaki I, Okodo M, Shirasaki A, Mikasa Y, Iwamoto R, Takahashi Y, Kojima F, Murata SI
Cancer Med 2021 Aug;10(16):5534-5544. Epub 2021 Jun 23 doi: 10.1002/cam4.4091. PMID: 34164940Free PMC Article
Micropapillary Versus Urothelial Carcinoma of the Urinary Bladder: Stage at Presentation and Efficacy of Chemotherapy Across All Stages-A SEER-based Study.
Deuker M, Stolzenbach LF, Collà Ruvolo C, Nocera L, Mansour M, Tian Z, Roos FC, Becker A, Kluth LA, Tilki D, Shariat SF, Saad F, Chun FKH, Karakiewicz PI
Eur Urol Focus 2021 Nov;7(6):1332-1338. Epub 2020 Sep 19 doi: 10.1016/j.euf.2020.08.010. PMID: 32962961
Clinical significance of prominent retraction clefts in invasive urothelial carcinoma.
Shah TS, Kaag M, Raman JD, Chan W, Tran T, Kunchala S, Shuman L, DeGraff DJ, Chen G, Warrick JI
Hum Pathol 2017 Mar;61:90-96. Epub 2016 Nov 4 doi: 10.1016/j.humpath.2016.10.021. PMID: 27818288
Micropapillary urothelial carcinoma: clinico-pathologic review.
Perepletchikov AM, Parwani AV
Pathol Res Pract 2009;205(12):807-10. Epub 2009 Sep 19 doi: 10.1016/j.prp.2009.07.016. PMID: 19767154

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