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Aleukemic leukemia cutis

MedGen UID:: 168394
•Concept ID:: C0887846
•: Neoplastic Process

Synonym:	Leukemia subleukemic

Monarch Initiative:	MONDO:0003729

Definition

Infiltration of the skin and subcutaneous tissue by leukemic cells without evidence of leukemia in the bone marrow and peripheral blood. It results in clinically identifiable skin lesions. It may be the first manifestation of acute leukemia, preceding the involvement of the bone marrow and peripheral blood by the leukemic process. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAleukemic leukemia cutis

Disorder by Site
- Hematopoietic and Lymphoid System Disorder
  - Hematologic disorder
    - Hematologic neoplasm
      - Leukemia
        Aleukemic leukemia
        Aleukemic leukemia cutis
        Aleukemic Acute Lymphoblastic Leukemia Cutis
        Aleukemic monocytic leukemia cutis

Professional guidelines

PubMed

Characteristics and treatment of acute myeloid neoplasms with cutaneous involvement in infants up to 6 months of age: A retrospective study.

Renaud J, Goemans BF, Locatelli F, Pigazzi M, Redmond S, Kuehni CE, Destaillats A, Alonzo TA, Gerbing RB, Gamis A, Aplenc R, Renella R, Cooper T, Ceppi F
Pediatr Blood Cancer 2024 Jul;71(7):e31006. Epub 2024 Apr 14 doi: 10.1002/pbc.31006. PMID: 38616361

See all (1)

Recent clinical studies

Etiology

Characteristics and treatment of acute myeloid neoplasms with cutaneous involvement in infants up to 6 months of age: A retrospective study.

Pediatric leukemia cutis: A case series.

Andriescu EC, Coughlin CC, Cheng CE, Prajapati VH, Huang JT, Schmidt BA, Degar BA, Aplenc R, Pillai V, Yan AC, Liang MG
Pediatr Dermatol 2019 Sep;36(5):658-663. Epub 2019 Jul 5 doi: 10.1111/pde.13864. PMID: 31273836

Recurrent aleukemic leukemia cutis in a patient with pre-B-cell acute lymphoblastic leukemia.

Ansell LH, Mehta J, Cotliar J
J Clin Oncol 2013 Jul 10;31(20):e353-5. Epub 2013 Jun 3 doi: 10.1200/JCO.2012.46.1939. PMID: 23733764

Aleukemic leukemia cutis presenting as benign-appearing exanthema.

Benez A, Metzger S, Metzler G, Fierlbeck G
Acta Derm Venereol 2001 Jan-Feb;81(1):45-7. doi: 10.1080/00015550117638. PMID: 11411915

See all (4)

Diagnosis

Aleukemic leukemia cutis.

Abraham TN, Morawiecki P, Flischel A, Agrawal B
Cleve Clin J Med 2019 Feb;86(2):85-86. doi: 10.3949/ccjm.86a.18057. PMID: 30742583

Pediatric aleukemic leukemia cutis: report of 3 cases and review of the literature.

Gru AA, Coughlin CC, Schapiro ML, Lombardi M, Martin A, Bayliss SJ, Frater J, Dehner LP
Am J Dermatopathol 2015 Jun;37(6):477-84. doi: 10.1097/DAD.0000000000000190. PMID: 25148106

Aleukemic leukemia cutis.

Vishalakshi V, Torsekar RG, Shinde S
Indian J Dermatol Venereol Leprol 2007 Mar-Apr;73(2):109-11. doi: 10.4103/0378-6323.31897. PMID: 17456918

Lymphocytic aleukemic leukemia cutis.

Taniguchi S, Hamada T, Kutsuna H, Ishii M
J Am Acad Dermatol 1996 Nov;35(5 Pt 2):849-50. doi: 10.1016/s0190-9622(96)90101-2. PMID: 8912603

Aleukemic leukemia cutis.

Yoder FW, Schuen RL
Arch Dermatol 1976 Mar;112(3):367-9. PMID: 1062968

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Therapy

Primary aleukemic myeloid leukemia cutis treated successfully with combination chemotherapy: report of a case and review of the literature.

Chang H, Shih LY, Kuo TT
Ann Hematol 2003 Jul;82(7):435-9. Epub 2003 May 24 doi: 10.1007/s00277-003-0673-6. PMID: 12768324

Aleukemic monocytic leukemia cutis.

Barzilai A, Lyakhovitsky A, Goldberg I, Meytes D, Trau H
Cutis 2002 Apr;69(4):301-4. PMID: 12080951

Monocytic aleukemic leukemia cutis.

Török L, Lueff S, Garay G, Tápai M
J Eur Acad Dermatol Venereol 1999 Jul;13(1):54-8. PMID: 10565632

Aleukemic leukemia cutis.

Ohno S, Yokoo T, Ohta M, Yamamoto M, Danno K, Hamato N, Tomii K, Ohno Y, Kobashi Y
J Am Acad Dermatol 1990 Feb;22(2 Pt 2):374-7. doi: 10.1016/0190-9622(90)70052-j. PMID: 2406302

Aleukemic leukemia cutis.

Hansen RM, Barnett J, Hanson G, Klehm D, Schneider T, Ash R
Arch Dermatol 1986 Jul;122(7):812-4. PMID: 3729513

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Prognosis

Pediatric leukemia cutis: A case series.

Aleukemic leukemia cutis preceding acute monocytic leukemia: a case report.

Martínez-Poventud G, Fradera J, Pérez S, Fernández A, Pacheco E, Acabá L, López-Enriquez A, Román-Díaz A, Castro-Montalvo J, Vélez-García E
P R Health Sci J 2008 Sep;27(3):256-8. PMID: 18782972

Aleukemic leukemia cutis.

Vishalakshi V, Torsekar RG, Shinde S
Indian J Dermatol Venereol Leprol 2007 Mar-Apr;73(2):109-11. doi: 10.4103/0378-6323.31897. PMID: 17456918

Aleukemic monocytic leukemia cutis.

Barzilai A, Lyakhovitsky A, Goldberg I, Meytes D, Trau H
Cutis 2002 Apr;69(4):301-4. PMID: 12080951

Monocytic aleukemic leukemia cutis.

Török L, Lueff S, Garay G, Tápai M
J Eur Acad Dermatol Venereol 1999 Jul;13(1):54-8. PMID: 10565632

See all (16)