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Low neutrophil alkaline phosphatase

MedGen UID:
1685638
•Concept ID:
C5209290
•
Finding
HPO: HP:0041044

Definition

An abnormally reduced level of alkaline phosphatase in neutrophils, which could be due to absence of enzyme or the production of defective enzyme. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLow neutrophil alkaline phosphatase

Conditions with this feature

Specific granule deficiency 1
MedGen UID:
1644049
•Concept ID:
C4551556
•
Disease or Syndrome
Any specific granule deficiency in which the cause of the disease is a mutation in the CEBPE gene.
See: Condition Record
Specific granule deficiency 1

Professional guidelines

PubMed

Optimization of Radium-223 Treatment of Castration-resistant Prostate Cancer Based on the Burden of Skeletal Metastasis and Clinical Parameters.
Shariftabrizi A, Kothari S, George S, Attwood K, Levine E, Lamonica D
Oncologist 2023 Mar 17;28(3):246-251. doi: 10.1093/oncolo/oyac245. PMID: 36651837Free PMC Article
Efficacy of apatinib combined with FOLFIRI in the first-line treatment of patients with metastatic colorectal cancer.
Rong X, Liu H, Yu H, Zhao J, Wang J, Wang Y
Invest New Drugs 2022 Apr;40(2):340-348. Epub 2022 Jan 8 doi: 10.1007/s10637-021-01205-3. PMID: 34997351Free PMC Article
Evaluation of diagnostic criteria in polycythemia vera.
Pearson TC
Semin Hematol 2001 Jan;38(1 Suppl 2):21-4. doi: 10.1016/s0037-1963(01)90136-2. PMID: 11242598

Recent clinical studies

Etiology

BCR-ABL positive essential thrombocythaemia: a variant of chronic myelogerous leukaemia or a distinct clinical entity: a special case report.
Fadilah SA, Cheong SK
Singapore Med J 2000 Dec;41(12):595-8. PMID: 11296785

Diagnosis

BCR-ABL positive essential thrombocythaemia: a variant of chronic myelogerous leukaemia or a distinct clinical entity: a special case report.
Fadilah SA, Cheong SK
Singapore Med J 2000 Dec;41(12):595-8. PMID: 11296785
Two additional cases of acute myeloid leukemia with t(7;11)(p15;p15) having low neutrophil alkaline phosphatase scores.
Fujimura T, Ohyashiki K, Ohyashiki JH, Kawakubo K, Iwabuchi A, Kodama A, Toyama K
Cancer Genet Cytogenet 1993 Jul 15;68(2):143-6. doi: 10.1016/0165-4608(93)90012-b. PMID: 8353806
16;21 translocation in acute nonlymphocytic leukemia with abnormal eosinophils: a unique subtype.
Sadamori N, Yao E, Tagawa M, Nakamura H, Sasagawa I, Itoyama T, Tokunaga S, Ichimaru M, Nakamura I, Kamei T
Acta Haematol 1990;84(4):212-6. doi: 10.1159/000205069. PMID: 2125791

Therapy

BCR-ABL positive essential thrombocythaemia: a variant of chronic myelogerous leukaemia or a distinct clinical entity: a special case report.
Fadilah SA, Cheong SK
Singapore Med J 2000 Dec;41(12):595-8. PMID: 11296785
Two additional cases of acute myeloid leukemia with t(7;11)(p15;p15) having low neutrophil alkaline phosphatase scores.
Fujimura T, Ohyashiki K, Ohyashiki JH, Kawakubo K, Iwabuchi A, Kodama A, Toyama K
Cancer Genet Cytogenet 1993 Jul 15;68(2):143-6. doi: 10.1016/0165-4608(93)90012-b. PMID: 8353806

Prognosis

BCR-ABL positive essential thrombocythaemia: a variant of chronic myelogerous leukaemia or a distinct clinical entity: a special case report.
Fadilah SA, Cheong SK
Singapore Med J 2000 Dec;41(12):595-8. PMID: 11296785
Chronic myeloid leukemia with minor-bcr breakpoint developed hybrid type of blast crisis.
Ohno T, Hada S, Sugiyama T, Mizumoto T, Furukawa H, Nagai K
Am J Hematol 1998 Apr;57(4):320-5. doi: 10.1002/(sici)1096-8652(199804)57:4<320::aid-ajh9>3.0.co;2-w. PMID: 9544977
16;21 translocation in acute nonlymphocytic leukemia with abnormal eosinophils: a unique subtype.
Sadamori N, Yao E, Tagawa M, Nakamura H, Sasagawa I, Itoyama T, Tokunaga S, Ichimaru M, Nakamura I, Kamei T
Acta Haematol 1990;84(4):212-6. doi: 10.1159/000205069. PMID: 2125791
C-G translocation in acute myelocytic leukemia with low neutrophil alkaline phosphatase activity.
Kamada N, Okada K, Oguma N, Tanaka R, Mikami M
Cancer 1976 May;37(5):2380-7. doi: 10.1002/1097-0142(197605)37:5<2380::aid-cncr2820370530>3.0.co;2-#. PMID: 1063058

Clinical prediction guides

Absent or extremely low neutrophil alkaline phosphatase activity levels in patients with myelodysplastic syndromes.
Yoshida Y, Katsurada T, Oguma S, Nakabo Y, Yoshinaga N, Kawahara M, Kawabata H
Intern Med 2013;52(4):479-82. Epub 2013 Feb 15 doi: 10.2169/internalmedicine.52.9114. PMID: 23411705
Chronic myeloid leukemia with minor-bcr breakpoint developed hybrid type of blast crisis.
Ohno T, Hada S, Sugiyama T, Mizumoto T, Furukawa H, Nagai K
Am J Hematol 1998 Apr;57(4):320-5. doi: 10.1002/(sici)1096-8652(199804)57:4<320::aid-ajh9>3.0.co;2-w. PMID: 9544977
P190BCR-ABL chronic myeloid leukaemia: the missing link with chronic myelomonocytic leukaemia?
Melo JV, Myint H, Galton DA, Goldman JM
Leukemia 1994 Jan;8(1):208-11. PMID: 8289491
Two additional cases of acute myeloid leukemia with t(7;11)(p15;p15) having low neutrophil alkaline phosphatase scores.
Fujimura T, Ohyashiki K, Ohyashiki JH, Kawakubo K, Iwabuchi A, Kodama A, Toyama K
Cancer Genet Cytogenet 1993 Jul 15;68(2):143-6. doi: 10.1016/0165-4608(93)90012-b. PMID: 8353806
Reciprocal translocation involving the short arms of chromosomes 7 and 11, t(7p-;11p+), associated with myeloid leukemia with maturation.
Sato Y, Abe S, Mise K, Sasaki M, Kamada N, Kouda K, Musashi M, Saburi Y, Horikoshi A, Minami Y
Blood 1987 Nov;70(5):1654-8. PMID: 3478104

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