U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Kidney Paraganglioma

MedGen UID:
1686753
•Concept ID:
C5204273
•
Neoplastic Process
Synonym: Renal Paraganglioma

Definition

An extremely rare paraganglioma that arises from the renal hilum. Paragangliomas that arise from the perihilar sympathetic ganglia are not included in this category. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVKidney Paraganglioma

Professional guidelines

PubMed

Clarifying the Cause and Treatment of Paroxysmal Hypertension (Pseudopheochromocytoma).
Mann SJ, Solanki KV
Curr Hypertens Rep 2022 Sep;24(9):353-359. Epub 2022 Jun 6 doi: 10.1007/s11906-022-01198-1. PMID: 35666406
Management recommendations for pancreatic manifestations of von Hippel-Lindau disease.
Laks S, van Leeuwaarde R, Patel D, Keutgen XM, Hammel P, Nilubol N, Links TP, Halfdanarson TR, Daniels AB, Tirosh A; Pancreatic Manifestations Recommendations Development Subcommittee of the VHL Alliance
Cancer 2022 Feb 1;128(3):435-446. Epub 2021 Nov 4 doi: 10.1002/cncr.33978. PMID: 34735022
Resistant Hypertension: Diagnosis and Management.
Nagarajan N, Jalal D
Adv Chronic Kidney Dis 2019 Mar;26(2):99-109. doi: 10.1053/j.ackd.2019.03.002. PMID: 31023454

Recent clinical studies

Etiology

Von Hippel-Lindau disease: insights into oxygen sensing, protein degradation, and cancer.
Kaelin WG Jr
J Clin Invest 2022 Sep 15;132(18) doi: 10.1172/JCI162480. PMID: 36106637Free PMC Article
SDHC phaeochromocytoma and paraganglioma: A UK-wide case series.
Williams ST, Chatzikyriakou P, Carroll PV, McGowan BM, Velusamy A, White G, Obholzer R, Akker S, Tufton N, Casey RT, Maher ER, Park SM, Porteous M, Dyer R, Tan T, Wernig F, Brady AF, Kosicka-Slawinska M, Whitelaw BC, Dorkins H, Lalloo F, Brennan P, Carlow J, Martin R, Mitchell AL, Harrison R, Hawkes L, Newell-Price J, Kelsall A, Igbokwe R, Adlard J, Schirwani S, Davidson R, Morrison PJ, Chung TT, Bowles C, Izatt L
Clin Endocrinol (Oxf) 2022 Apr;96(4):499-512. Epub 2021 Sep 24 doi: 10.1111/cen.14594. PMID: 34558728
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
Intrarenal hemodynamics and kidney function in pheochromocytoma and paraganglioma before and after surgical treatment.
Januszewicz M, Dobrowolski P, Januszewicz A, Warchoł-Celińska E, Jóźwik-Plebanek K, Motyl D, Kabat M, Pęczkowska M, Michałowska I, Ambroziak U, Toutounchi S, Gałązka Z, Courcelles L, Pappaccogli M, Eisenhofer G, Persu A, Lenders JWM, Kądziela J, Prejbisz A
Blood Press 2021 Jun;30(3):172-179. Epub 2021 Feb 15 doi: 10.1080/08037051.2020.1851590. PMID: 33586556
Von Hippel-Lindau disease.
Kaelin WG
Annu Rev Pathol 2007;2:145-73. doi: 10.1146/annurev.pathol.2.010506.092049. PMID: 18039096

Diagnosis

Extracellular Vesicles and Hypertension.
Tang H, Hu Y, Deng J
Adv Exp Med Biol 2023;1418:69-80. doi: 10.1007/978-981-99-1443-2_5. PMID: 37603273
Hypoxia-Inducible Factor 2 Alpha (HIF2α) Inhibitors: Targeting Genetically Driven Tumor Hypoxia.
Toledo RA, Jimenez C, Armaiz-Pena G, Arenillas C, Capdevila J, Dahia PLM
Endocr Rev 2023 Mar 4;44(2):312-322. doi: 10.1210/endrev/bnac025. PMID: 36301191Free PMC Article
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
Resistant Hypertension: Diagnosis and Management.
Nagarajan N, Jalal D
Adv Chronic Kidney Dis 2019 Mar;26(2):99-109. doi: 10.1053/j.ackd.2019.03.002. PMID: 31023454
von Hippel-Lindau syndrome.
Chou A, Toon C, Pickett J, Gill AJ
Front Horm Res 2013;41:30-49. Epub 2013 Mar 19 doi: 10.1159/000345668. PMID: 23652669

Therapy

Belzutifan: First Approval.
Deeks ED
Drugs 2021 Nov;81(16):1921-1927. doi: 10.1007/s40265-021-01606-x. PMID: 34613603
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
Resistant Hypertension: Diagnosis and Management.
Nagarajan N, Jalal D
Adv Chronic Kidney Dis 2019 Mar;26(2):99-109. doi: 10.1053/j.ackd.2019.03.002. PMID: 31023454
Catecholamine excess: pseudopheochromocytoma and beyond.
Garcha AS, Cohen DL
Adv Chronic Kidney Dis 2015 May;22(3):218-23. doi: 10.1053/j.ackd.2014.11.002. PMID: 25908471
Clonidine and the kidney.
Itskovitz HD
J Cardiovasc Pharmacol 1980;2 Suppl 1:S47-60. doi: 10.1097/00005344-198000021-00006. PMID: 6154836

Prognosis

Extracellular Vesicles and Hypertension.
Tang H, Hu Y, Deng J
Adv Exp Med Biol 2023;1418:69-80. doi: 10.1007/978-981-99-1443-2_5. PMID: 37603273
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
Succinate Dehydrogenase-Deficient Renal Cell Carcinoma.
Tsai TH, Lee WY
Arch Pathol Lab Med 2019 May;143(5):643-647. Epub 2018 Dec 21 doi: 10.5858/arpa.2018-0024-RS. PMID: 31026220
Endocrine manifestations of von Hippel-Lindau disease.
Cassol C, Mete O
Arch Pathol Lab Med 2015 Feb;139(2):263-8. doi: 10.5858/arpa.2013-0520-RS. PMID: 25611110
Pheochromocytoma-induced aggression?
Altiner S, Dodell G, Abed J, Blackford L, Colt E
Endocr Pract 2011 Sep-Oct;17(5):e126-9. doi: 10.4158/EP10336.CR. PMID: 21803721

Clinical prediction guides

Hemangioblastomas and Other Vascular Origating Tumors of Brain or Spinal Cord.
Vetrano IG, Gioppo A, Faragò G, Pinzi V, Pollo B, Broggi M, Schiariti M, Ferroli P, Acerbi F
Adv Exp Med Biol 2023;1405:377-403. doi: 10.1007/978-3-031-23705-8_14. PMID: 37452946
Hypoxia-Inducible Factor 2 Alpha (HIF2α) Inhibitors: Targeting Genetically Driven Tumor Hypoxia.
Toledo RA, Jimenez C, Armaiz-Pena G, Arenillas C, Capdevila J, Dahia PLM
Endocr Rev 2023 Mar 4;44(2):312-322. doi: 10.1210/endrev/bnac025. PMID: 36301191Free PMC Article
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
Intrarenal hemodynamics and kidney function in pheochromocytoma and paraganglioma before and after surgical treatment.
Januszewicz M, Dobrowolski P, Januszewicz A, Warchoł-Celińska E, Jóźwik-Plebanek K, Motyl D, Kabat M, Pęczkowska M, Michałowska I, Ambroziak U, Toutounchi S, Gałązka Z, Courcelles L, Pappaccogli M, Eisenhofer G, Persu A, Lenders JWM, Kądziela J, Prejbisz A
Blood Press 2021 Jun;30(3):172-179. Epub 2021 Feb 15 doi: 10.1080/08037051.2020.1851590. PMID: 33586556
MYO5B mutations in pheochromocytoma/paraganglioma promote cancer progression.
Tomić TT, Olausson J, Rehammar A, Deland L, Muth A, Ejeskär K, Nilsson S, Kristiansson E, Wassén ON, Abel F
PLoS Genet 2020 Jun;16(6):e1008803. Epub 2020 Jun 8 doi: 10.1371/journal.pgen.1008803. PMID: 32511227Free PMC Article

Recent systematic reviews

Pheochromocytoma Turned Malignant During Pregnancy in a Patient With Neurofibromatosis Type I - A Case Report and Systematic Review of the Current Literature.
Zeitler C, Fuderer L, Schmitz K, Arora R, Dammerer D
Anticancer Res 2022 Sep;42(9):4647-4656. doi: 10.21873/anticanres.15969. PMID: 36039448
Pheochromocytoma as a frequent false-positive in adrenal washout CT: A systematic review and meta-analysis.
Woo S, Suh CH, Kim SY, Cho JY, Kim SH
Eur Radiol 2018 Mar;28(3):1027-1036. Epub 2017 Oct 12 doi: 10.1007/s00330-017-5076-5. PMID: 29026974
Systematic review of ablation techniques for the treatment of malignant or aggressive benign lesions in children.
Gómez FM, Patel PA, Stuart S, Roebuck DJ
Pediatr Radiol 2014 Oct;44(10):1281-9. Epub 2014 May 13 doi: 10.1007/s00247-014-3001-5. PMID: 24821394

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...