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Metastatic Malignant Female Reproductive System Neoplasm

MedGen UID:: 1688604
•Concept ID:: C5206463
•: Neoplastic Process

Definition

A malignant neoplasm that arises in the female reproductive system and has spread from its original site of growth to other anatomic sites. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMetastatic Malignant Female Reproductive System Neoplasm

Disorder by Site
- Disorder of the genitourinary system
  - Reproductive system disorder
    - Female reproductive system disorder
      - Female reproductive system neoplasm
        Female reproductive organ cancer
        Metastatic Malignant Female Reproductive System Neoplasm
        Advanced Malignant Female Reproductive System Neoplasm
        Advanced Cervical Carcinoma
        Advanced Cervical Adenocarcinoma
        Advanced Cervical Adenosquamous Carcinoma
        Advanced Cervical Squamous Cell Carcinoma
        Advanced Fallopian Tube Carcinoma
        Advanced Malignant Mixed Mesodermal (Mullerian) Tumor
        Advanced Ovarian Carcinosarcoma
        Advanced Uterine Corpus Carcinosarcoma
        Advanced Ovarian Carcinoma
        Advanced Microsatellite Stable Ovarian Carcinoma
        Advanced Ovarian Clear Cell Adenocarcinoma
        Advanced Ovarian Endometrioid Adenocarcinoma
        Advanced Ovarian Serous Adenocarcinoma
        Advanced Uterine Corpus Cancer
        Advanced Endometrial Carcinoma
        Advanced Vaginal Carcinoma
        Advanced Vaginal Adenocarcinoma
        Advanced Vaginal Adenosquamous Carcinoma
        Advanced Vaginal Squamous Cell Carcinoma
        Advanced Vulvar Carcinoma
        Locally Advanced Malignant Female Reproductive System Neoplasm
        Locally Advanced Cervical Carcinoma
        Locally Advanced Cervical Adenocarcinoma
        Locally Advanced Cervical Squamous Cell Carcinoma
        Locally Advanced Unresectable Cervical Carcinoma
        Locally Advanced Endometrial Carcinoma
        Locally Advanced Endometrial Adenocarcinoma
        Locally Advanced Fallopian Tube Carcinoma
        Locally Advanced Ovarian Carcinoma
        Locally Advanced Vaginal Carcinoma
        Locally Advanced Vulvar Carcinoma
        Metastatic Cervical Carcinoma
        Metastatic Cervical Adenocarcinoma
        Metastatic Cervical Adenosquamous Carcinoma
        Metastatic Cervical Squamous Cell Carcinoma
        Metastatic Endometrial Carcinoma
        Metastatic Endometrial Adenocarcinoma
        Advanced Endometrial Adenocarcinoma
        Metastatic Endometrial Clear Cell Adenocarcinoma
        Metastatic Endometrial Endometrioid Adenocarcinoma
        Metastatic Endometrial Mixed Cell Adenocarcinoma
        Metastatic Endometrial Serous Adenocarcinoma
        Metastatic Endometrial Adenosquamous Carcinoma
        Metastatic Microsatellite Stable Endometrial Carcinoma
        Advanced Microsatellite Stable Endometrial Carcinoma
        Metastatic Fallopian Tube Carcinoma
        Metastatic Fallopian Tube High Grade Serous Adenocarcinoma
        Metastatic Ovarian Carcinoma
        Metastatic Microsatellite Stable Ovarian Carcinoma
        Metastatic Ovarian Clear Cell Adenocarcinoma
        Metastatic Ovarian Endometrioid Adenocarcinoma
        Metastatic Ovarian Serous Adenocarcinoma
        Metastatic Ovarian Small Cell Carcinoma, Hypercalcemic Type
        Metastatic Ovarian Undifferentiated Carcinoma
        Metastatic Platinum-Resistant Ovarian Carcinoma
        Metastatic Vaginal Carcinoma
        Metastatic Vaginal Adenocarcinoma
        Metastatic Vaginal Adenosquamous Carcinoma
        Metastatic Vaginal Squamous Cell Carcinoma
        Metastatic Vulvar Carcinoma
        Metastatic Vulvar Squamous Cell Carcinoma

Professional guidelines

PubMed

Advances in diagnostics and management of gestational trophoblastic disease.

Lukinovic N, Malovrh EP, Takac I, Sobocan M, Knez J
Radiol Oncol 2022 Dec 1;56(4):430-439. Epub 2022 Oct 27 doi: 10.2478/raon-2022-0038. PMID: 36286620 Free PMC Article

ESGO/ESTRO/ESP Guidelines for the management of patients with endometrial carcinoma.

Concin N, Creutzberg CL, Vergote I, Cibula D, Mirza MR, Marnitz S, Ledermann JA, Bosse T, Chargari C, Fagotti A, Fotopoulou C, González-Martín A, Lax SF, Lorusso D, Marth C, Morice P, Nout RA, O'Donnell DE, Querleu D, Raspollini MR, Sehouli J, Sturdza AE, Taylor A, Westermann AM, Wimberger P, Colombo N, Planchamp F, Matias-Guiu X
Virchows Arch 2021 Feb;478(2):153-190. doi: 10.1007/s00428-020-03007-z. PMID: 33604759

Advances in diagnosis and treatment of metastatic cervical cancer.

Li H, Wu X, Cheng X
J Gynecol Oncol 2016 Jul;27(4):e43. doi: 10.3802/jgo.2016.27.e43. PMID: 27171673 Free PMC Article

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Recent clinical studies

Etiology

Collaborative centralization of gynaecological cancer care.

Moloney K, Rao A, Obermair A
Curr Opin Oncol 2022 Sep 1;34(5):518-523. Epub 2022 Jul 27 doi: 10.1097/CCO.0000000000000865. PMID: 35900753

(68)Ga-FAPI-PET/CT in patients with various gynecological malignancies.

Dendl K, Koerber SA, Finck R, Mokoala KMG, Staudinger F, Schillings L, Heger U, Röhrich M, Kratochwil C, Sathekge M, Jäger D, Debus J, Haberkorn U, Giesel FL
Eur J Nucl Med Mol Imaging 2021 Nov;48(12):4089-4100. Epub 2021 May 29 doi: 10.1007/s00259-021-05378-0. PMID: 34050777 Free PMC Article

Lower extremity lymphedema in patients with gynecologic malignancies.

Dessources K, Aviki E, Leitao MM Jr
Int J Gynecol Cancer 2020 Feb;30(2):252-260. Epub 2020 Jan 7 doi: 10.1136/ijgc-2019-001032. PMID: 31915136 Free PMC Article

Hormone Replacement Therapy in Cancer Survivors - Review of the Literature.

Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760 Free PMC Article

Imaging of uterine malignancies.

Sohaib SA, Verma H, Attygalle AD, Ind TE
Semin Ultrasound CT MR 2010 Oct;31(5):377-87. doi: 10.1053/j.sult.2010.07.005. PMID: 20974357

See all (8156)

Diagnosis

PET Imaging of Estrogen Receptors for Gynecological Tumors.

Tsujikawa T, Makino A, Mori T, Tsuyoshi H, Kiyono Y, Yoshida Y, Okazawa H
Clin Nucl Med 2022 Jul 1;47(7):e481-e488. Epub 2022 May 12 doi: 10.1097/RLU.0000000000004258. PMID: 35675139

(68)Ga-FAPI-PET/CT in patients with various gynecological malignancies.

Gynecologic cancer in pregnancy.

Korenaga TK, Tewari KS
Gynecol Oncol 2020 Jun;157(3):799-809. Epub 2020 Apr 5 doi: 10.1016/j.ygyno.2020.03.015. PMID: 32268951 Free PMC Article

Lower extremity lymphedema in patients with gynecologic malignancies.

Dessources K, Aviki E, Leitao MM Jr
Int J Gynecol Cancer 2020 Feb;30(2):252-260. Epub 2020 Jan 7 doi: 10.1136/ijgc-2019-001032. PMID: 31915136 Free PMC Article

Imaging of uterine malignancies.

Sohaib SA, Verma H, Attygalle AD, Ind TE
Semin Ultrasound CT MR 2010 Oct;31(5):377-87. doi: 10.1053/j.sult.2010.07.005. PMID: 20974357

See all (9534)

Therapy

Tisotumab vedotin in recurrent or metastatic cervical cancer.

Bogani G, Coleman RL, Vergote I, Raspagliesi F, Lorusso D, Monk BJ
Curr Probl Cancer 2023 Jun;47(3):100952. Epub 2023 Feb 10 doi: 10.1016/j.currproblcancer.2023.100952. PMID: 36842202

Immuno-Oncology for Gynecologic Malignancies.

How JA, Patel A, Jazaeri AA
Adv Exp Med Biol 2021;1342:193-232. doi: 10.1007/978-3-030-79308-1_6. PMID: 34972966

Immunotherapy in cervix cancer.

Attademo L, Tuninetti V, Pisano C, Cecere SC, Di Napoli M, Tambaro R, Valabrega G, Musacchio L, Setola SV, Piccirillo P, Califano D, Spina A, Losito S, Greggi S, Pignata S
Cancer Treat Rev 2020 Nov;90:102088. Epub 2020 Aug 7 doi: 10.1016/j.ctrv.2020.102088. PMID: 32827839

Hormone Replacement Therapy in Cancer Survivors - Review of the Literature.

Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760 Free PMC Article

Systemic therapy in cervical cancer: 30 years in review.

Liontos M, Kyriazoglou A, Dimitriadis I, Dimopoulos MA, Bamias A
Crit Rev Oncol Hematol 2019 May;137:9-17. Epub 2019 Feb 28 doi: 10.1016/j.critrevonc.2019.02.009. PMID: 31014518

See all (6318)

Prognosis

Immunotherapy and Systemic Therapy in Metastatic/Recurrent Endometrial and Cervical Cancers.

Lima J, Ali Z, Banerjee S
Clin Oncol (R Coll Radiol) 2021 Sep;33(9):608-615. Epub 2021 Jul 24 doi: 10.1016/j.clon.2021.07.002. PMID: 34312021

Gynecologic cancer in pregnancy.

Korenaga TK, Tewari KS
Gynecol Oncol 2020 Jun;157(3):799-809. Epub 2020 Apr 5 doi: 10.1016/j.ygyno.2020.03.015. PMID: 32268951 Free PMC Article

Mucinous epithelial ovarian carcinoma.

Perren TJ
Ann Oncol 2016 Apr;27 Suppl 1:i53-i57. doi: 10.1093/annonc/mdw087. PMID: 27141073

Cervical cancer.

Moore DH
Obstet Gynecol 2006 May;107(5):1152-61. doi: 10.1097/01.AOG.0000215986.48590.79. PMID: 16648423

Mucosal melanomas.

Tomicic J, Wanebo HJ
Surg Clin North Am 2003 Apr;83(2):237-52. doi: 10.1016/S0039-6109(02)00100-7. PMID: 12744608

See all (8008)

Clinical prediction guides

Clinical development of WEE1 inhibitors in gynecological cancers: A systematic review.

Schutte T, Embaby A, Steeghs N, van der Mierden S, van Driel W, Rijlaarsdam M, Huitema A, Opdam F
Cancer Treat Rev 2023 Apr;115:102531. Epub 2023 Mar 3 doi: 10.1016/j.ctrv.2023.102531. PMID: 36893690

(68)Ga-FAPI-PET/CT in patients with various gynecological malignancies.

Outcomes of enhanced recovery after surgery (ERAS) in gynecologic oncology - A systematic review and meta-analysis.

Bisch SP, Jago CA, Kalogera E, Ganshorn H, Meyer LA, Ramirez PT, Dowdy SC, Nelson G
Gynecol Oncol 2021 Apr;161(1):46-55. Epub 2020 Dec 30 doi: 10.1016/j.ygyno.2020.12.035. PMID: 33388155

Clear cell lesions in pathology: Histomorphologic approach to diagnosis.

Kar A, Pattnaik K, Kar T, Biswal P, Mishra C, Guru L
Indian J Pathol Microbiol 2020 Apr-Jun;63(2):177-187. doi: 10.4103/IJPM.IJPM_791_19. PMID: 32317512

Immunotherapy and radiation combinatorial trials in gynecologic cancer: A potential synergy?

Lee L, Matulonis U
Gynecol Oncol 2019 Jul;154(1):236-245. Epub 2019 Apr 14 doi: 10.1016/j.ygyno.2019.03.255. PMID: 30995960

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Recent systematic reviews

The effect of ≤6 cm sized noncavity-distorting intramural fibroids on in vitro fertilization outcomes: a systematic review and meta-analysis.

Erden M, Uyanik E, Polat M, Ozbek IY, Yarali H, Mumusoglu S
Fertil Steril 2023 Jun;119(6):996-1007. Epub 2023 Feb 21 doi: 10.1016/j.fertnstert.2023.02.018. PMID: 36813123

Role of human papillomavirus (HPV) vaccination on HPV infection and recurrence of HPV related disease after local surgical treatment: systematic review and meta-analysis.

Kechagias KS, Kalliala I, Bowden SJ, Athanasiou A, Paraskevaidi M, Paraskevaidis E, Dillner J, Nieminen P, Strander B, Sasieni P, Veroniki AA, Kyrgiou M
BMJ 2022 Aug 3;378:e070135. doi: 10.1136/bmj-2022-070135. PMID: 35922074 Free PMC Article

ESGO/ESTRO/ESP Guidelines for the management of patients with endometrial carcinoma.

Outcomes of enhanced recovery after surgery (ERAS) in gynecologic oncology - A systematic review and meta-analysis.

Bisch SP, Jago CA, Kalogera E, Ganshorn H, Meyer LA, Ramirez PT, Dowdy SC, Nelson G
Gynecol Oncol 2021 Apr;161(1):46-55. Epub 2020 Dec 30 doi: 10.1016/j.ygyno.2020.12.035. PMID: 33388155

Vulvar, Perianal and Perineal Cancer After Hidradenitis Suppurativa: A Systematic Review and Pooled Analysis.

Makris GM, Poulakaki N, Papanota AM, Kotsifa E, Sergentanis TN, Psaltopoulou T
Dermatol Surg 2017 Jan;43(1):107-115. doi: 10.1097/DSS.0000000000000944. PMID: 27755170

See all (258)

MedGen

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Metastatic Malignant Female Reproductive System Neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity