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Unresectable NUT Carcinoma

MedGen UID:
1692883
•Concept ID:
C5205123
•
Neoplastic Process

Definition

NUT carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable NUT Carcinoma

Recent clinical studies

Etiology

NUT Carcinoma in Children and Adolescents: The Expert European Standard Clinical Practice Harmonized Recommendations.
Lemelle L, Flaadt T, Fresneau B, Moya-Plana A, Timmermann B, Roganovic J, Ferrari A, Fichera G, Lauer UM, Ben-Ami T, Schneider DT, Vokuhl C, Bolle S, Fox E, DuBois SG, Rodriguez-Galindo C, Bisogno G, Surun A, Brecht IB, Orbach D
J Pediatr Hematol Oncol 2023 May 1;45(4):165-173. Epub 2022 Oct 10 doi: 10.1097/MPH.0000000000002568. PMID: 36219702
Poroid adnexal skin tumors with YAP1 fusions exhibit similar histopathologic features: A series of six YAP1-rearranged adnexal skin tumors.
Prieto-Granada C, Morlote D, Pavlidakey P, Rodriguez-Waitkus P, Ramirez C, Florento E, Swensen J, Gatalica Z, Stevens TM
J Cutan Pathol 2021 Sep;48(9):1139-1149. Epub 2021 Mar 21 doi: 10.1111/cup.14008. PMID: 33704800
NUT Carcinoma Without Upfront Surgical Resection: A Case Report.
Leeman R, Pinkney K, Bradley JA, Ruiz R, DuBois SG, French C, Trucco M
J Pediatr Hematol Oncol 2021 Jul 1;43(5):e707-e710. doi: 10.1097/MPH.0000000000001865. PMID: 32555033Free PMC Article
High ERCC1 expression predicts cisplatin-based chemotherapy resistance and poor outcome in unresectable squamous cell carcinoma of head and neck in a betel-chewing area.
Chiu TJ, Chen CH, Chien CY, Li SH, Tsai HT, Chen YJ
J Transl Med 2011 Mar 23;9:31. doi: 10.1186/1479-5876-9-31. PMID: 21426588Free PMC Article

Diagnosis

NUT Carcinoma in Children and Adolescents: The Expert European Standard Clinical Practice Harmonized Recommendations.
Lemelle L, Flaadt T, Fresneau B, Moya-Plana A, Timmermann B, Roganovic J, Ferrari A, Fichera G, Lauer UM, Ben-Ami T, Schneider DT, Vokuhl C, Bolle S, Fox E, DuBois SG, Rodriguez-Galindo C, Bisogno G, Surun A, Brecht IB, Orbach D
J Pediatr Hematol Oncol 2023 May 1;45(4):165-173. Epub 2022 Oct 10 doi: 10.1097/MPH.0000000000002568. PMID: 36219702
Complete Response Induced by Concurrent Chemoradiotherapy in a Patient with NUT Carcinoma.
Muramatsu J, Takada K, Sugita S, Tsuchiya T, Yamamoto K, Takagi M, Murase K, Ameda S, Arihara Y, Miyanishi K, Sakata KI, Kato J
Intern Med 2022 Apr 15;61(8):1299-1304. Epub 2021 Oct 5 doi: 10.2169/internalmedicine.7741-21. PMID: 34615820Free PMC Article
Poroid adnexal skin tumors with YAP1 fusions exhibit similar histopathologic features: A series of six YAP1-rearranged adnexal skin tumors.
Prieto-Granada C, Morlote D, Pavlidakey P, Rodriguez-Waitkus P, Ramirez C, Florento E, Swensen J, Gatalica Z, Stevens TM
J Cutan Pathol 2021 Sep;48(9):1139-1149. Epub 2021 Mar 21 doi: 10.1111/cup.14008. PMID: 33704800
NUT Carcinoma Without Upfront Surgical Resection: A Case Report.
Leeman R, Pinkney K, Bradley JA, Ruiz R, DuBois SG, French C, Trucco M
J Pediatr Hematol Oncol 2021 Jul 1;43(5):e707-e710. doi: 10.1097/MPH.0000000000001865. PMID: 32555033Free PMC Article
A case of endobronchial NUT midline carcinoma with intraluminal growth.
Watanabe S, Hirano S, Mine S, Yoshida A, Motoi T, Ishii S, Naka G, Takeda Y, Igari T, Sugiyama H, Kobayashi N
Anticancer Res 2015 Mar;35(3):1607-12. PMID: 25750317

Therapy

NUT Carcinoma in Children and Adolescents: The Expert European Standard Clinical Practice Harmonized Recommendations.
Lemelle L, Flaadt T, Fresneau B, Moya-Plana A, Timmermann B, Roganovic J, Ferrari A, Fichera G, Lauer UM, Ben-Ami T, Schneider DT, Vokuhl C, Bolle S, Fox E, DuBois SG, Rodriguez-Galindo C, Bisogno G, Surun A, Brecht IB, Orbach D
J Pediatr Hematol Oncol 2023 May 1;45(4):165-173. Epub 2022 Oct 10 doi: 10.1097/MPH.0000000000002568. PMID: 36219702
Complete Response Induced by Concurrent Chemoradiotherapy in a Patient with NUT Carcinoma.
Muramatsu J, Takada K, Sugita S, Tsuchiya T, Yamamoto K, Takagi M, Murase K, Ameda S, Arihara Y, Miyanishi K, Sakata KI, Kato J
Intern Med 2022 Apr 15;61(8):1299-1304. Epub 2021 Oct 5 doi: 10.2169/internalmedicine.7741-21. PMID: 34615820Free PMC Article
NUT Carcinoma Without Upfront Surgical Resection: A Case Report.
Leeman R, Pinkney K, Bradley JA, Ruiz R, DuBois SG, French C, Trucco M
J Pediatr Hematol Oncol 2021 Jul 1;43(5):e707-e710. doi: 10.1097/MPH.0000000000001865. PMID: 32555033Free PMC Article
High ERCC1 expression predicts cisplatin-based chemotherapy resistance and poor outcome in unresectable squamous cell carcinoma of head and neck in a betel-chewing area.
Chiu TJ, Chen CH, Chien CY, Li SH, Tsai HT, Chen YJ
J Transl Med 2011 Mar 23;9:31. doi: 10.1186/1479-5876-9-31. PMID: 21426588Free PMC Article

Prognosis

NUT Carcinoma in Children and Adolescents: The Expert European Standard Clinical Practice Harmonized Recommendations.
Lemelle L, Flaadt T, Fresneau B, Moya-Plana A, Timmermann B, Roganovic J, Ferrari A, Fichera G, Lauer UM, Ben-Ami T, Schneider DT, Vokuhl C, Bolle S, Fox E, DuBois SG, Rodriguez-Galindo C, Bisogno G, Surun A, Brecht IB, Orbach D
J Pediatr Hematol Oncol 2023 May 1;45(4):165-173. Epub 2022 Oct 10 doi: 10.1097/MPH.0000000000002568. PMID: 36219702
High ERCC1 expression predicts cisplatin-based chemotherapy resistance and poor outcome in unresectable squamous cell carcinoma of head and neck in a betel-chewing area.
Chiu TJ, Chen CH, Chien CY, Li SH, Tsai HT, Chen YJ
J Transl Med 2011 Mar 23;9:31. doi: 10.1186/1479-5876-9-31. PMID: 21426588Free PMC Article

Clinical prediction guides

High ERCC1 expression predicts cisplatin-based chemotherapy resistance and poor outcome in unresectable squamous cell carcinoma of head and neck in a betel-chewing area.
Chiu TJ, Chen CH, Chien CY, Li SH, Tsai HT, Chen YJ
J Transl Med 2011 Mar 23;9:31. doi: 10.1186/1479-5876-9-31. PMID: 21426588Free PMC Article

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