U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal tubular basement membrane morphology

MedGen UID:
1697885
•Concept ID:
C5209229
•
Anatomical Abnormality
HPO: HP:0020131

Definition

Abnormal structure of the basement membrane of the renal tubulus. [from HPO]

Recent clinical studies

Etiology

Association of Histologic Parameters with Outcome in C3 Glomerulopathy and Idiopathic Immunoglobulin-Associated Membranoproliferative Glomerulonephritis.
Lomax-Browne HJ, Medjeral-Thomas NR, Barbour SJ, Gisby J, Han H, Bomback AS, Fervenza FC, Cairns TH, Szydlo R, Tan SJ, Marks SD, Waters AM, Appel GB, D'Agati VD, Sethi S, Nast CC, Bajema I, Alpers CE, Fogo AB, Licht C, Fakhouri F, Cattran DC, Peters JE, Cook HT, Pickering MC
Clin J Am Soc Nephrol 2022 Jul;17(7):994-1007. doi: 10.2215/CJN.16801221. PMID: 35777834Free PMC Article
Development of an exon skipping therapy for X-linked Alport syndrome with truncating variants in COL4A5.
Yamamura T, Horinouchi T, Adachi T, Terakawa M, Takaoka Y, Omachi K, Takasato M, Takaishi K, Shoji T, Onishi Y, Kanazawa Y, Koizumi M, Tomono Y, Sugano A, Shono A, Minamikawa S, Nagano C, Sakakibara N, Ishiko S, Aoto Y, Kamura M, Harita Y, Miura K, Kanda S, Morisada N, Rossanti R, Ye MJ, Nozu Y, Matsuo M, Kai H, Iijima K, Nozu K
Nat Commun 2020 Jun 2;11(1):2777. doi: 10.1038/s41467-020-16605-x. PMID: 32488001Free PMC Article
Nephronophthisis: should we target cysts or fibrosis?
Slaats GG, Lilien MR, Giles RH
Pediatr Nephrol 2016 Apr;31(4):545-54. Epub 2015 Jul 29 doi: 10.1007/s00467-015-3162-y. PMID: 26219413
Anti-glomerular basement membrane antibodies.
Silvariño R, Noboa O, Cervera R
Isr Med Assoc J 2014 Nov;16(11):727-32. PMID: 25558706
Inherited renal diseases.
Leung JC
Curr Pediatr Rev 2014;10(2):95-100. doi: 10.2174/157339631002140513101755. PMID: 25088262

Diagnosis

Association of Histologic Parameters with Outcome in C3 Glomerulopathy and Idiopathic Immunoglobulin-Associated Membranoproliferative Glomerulonephritis.
Lomax-Browne HJ, Medjeral-Thomas NR, Barbour SJ, Gisby J, Han H, Bomback AS, Fervenza FC, Cairns TH, Szydlo R, Tan SJ, Marks SD, Waters AM, Appel GB, D'Agati VD, Sethi S, Nast CC, Bajema I, Alpers CE, Fogo AB, Licht C, Fakhouri F, Cattran DC, Peters JE, Cook HT, Pickering MC
Clin J Am Soc Nephrol 2022 Jul;17(7):994-1007. doi: 10.2215/CJN.16801221. PMID: 35777834Free PMC Article
Nephronophthisis: should we target cysts or fibrosis?
Slaats GG, Lilien MR, Giles RH
Pediatr Nephrol 2016 Apr;31(4):545-54. Epub 2015 Jul 29 doi: 10.1007/s00467-015-3162-y. PMID: 26219413
Anti-glomerular basement membrane antibodies.
Silvariño R, Noboa O, Cervera R
Isr Med Assoc J 2014 Nov;16(11):727-32. PMID: 25558706
IgG4-related renal disease: clinical and pathological characteristics.
Kuroda N, Nao T, Fukuhara H, Karashima T, Inoue K, Taniguchi Y, Takeuchi M, Zen Y, Sato Y, Notohara K, Yoshino T
Int J Clin Exp Pathol 2014;7(9):6379-85. Epub 2014 Aug 15 PMID: 25337295Free PMC Article
Kidney disease.
Mihatsch MJ, Zollinger HU
Pathol Res Pract 1980 May;167(1):88-117. doi: 10.1016/S0344-0338(80)80183-X. PMID: 7454603

Therapy

Vascular, valvular and kidney calcification manifested in mouse models of adenine-induced chronic kidney disease.
Yang X, Liu Y, Zhu X, Chen P, Xie X, Xu T, Zhang X, Zhao Y
Ren Fail 2023 Dec;45(1):2228920. doi: 10.1080/0886022X.2023.2228920. PMID: 37369635Free PMC Article
Nephronophthisis: should we target cysts or fibrosis?
Slaats GG, Lilien MR, Giles RH
Pediatr Nephrol 2016 Apr;31(4):545-54. Epub 2015 Jul 29 doi: 10.1007/s00467-015-3162-y. PMID: 26219413
Anti-glomerular basement membrane antibodies.
Silvariño R, Noboa O, Cervera R
Isr Med Assoc J 2014 Nov;16(11):727-32. PMID: 25558706
IgG4-related renal disease: clinical and pathological characteristics.
Kuroda N, Nao T, Fukuhara H, Karashima T, Inoue K, Taniguchi Y, Takeuchi M, Zen Y, Sato Y, Notohara K, Yoshino T
Int J Clin Exp Pathol 2014;7(9):6379-85. Epub 2014 Aug 15 PMID: 25337295Free PMC Article
Ultrastructure and organization of the cutaneous microvasculature in normal and pathologic states.
Braverman IM
J Invest Dermatol 1989 Aug;93(2 Suppl):2S-9S. doi: 10.1111/1523-1747.ep12580893. PMID: 2666519

Prognosis

Association of Histologic Parameters with Outcome in C3 Glomerulopathy and Idiopathic Immunoglobulin-Associated Membranoproliferative Glomerulonephritis.
Lomax-Browne HJ, Medjeral-Thomas NR, Barbour SJ, Gisby J, Han H, Bomback AS, Fervenza FC, Cairns TH, Szydlo R, Tan SJ, Marks SD, Waters AM, Appel GB, D'Agati VD, Sethi S, Nast CC, Bajema I, Alpers CE, Fogo AB, Licht C, Fakhouri F, Cattran DC, Peters JE, Cook HT, Pickering MC
Clin J Am Soc Nephrol 2022 Jul;17(7):994-1007. doi: 10.2215/CJN.16801221. PMID: 35777834Free PMC Article
Anti-glomerular basement membrane antibodies.
Silvariño R, Noboa O, Cervera R
Isr Med Assoc J 2014 Nov;16(11):727-32. PMID: 25558706
IgG4-related renal disease: clinical and pathological characteristics.
Kuroda N, Nao T, Fukuhara H, Karashima T, Inoue K, Taniguchi Y, Takeuchi M, Zen Y, Sato Y, Notohara K, Yoshino T
Int J Clin Exp Pathol 2014;7(9):6379-85. Epub 2014 Aug 15 PMID: 25337295Free PMC Article
Cellular and molecular mechanisms of proteinuria in diabetic nephropathy.
Wolf G, Ziyadeh FN
Nephron Physiol 2007;106(2):p26-31. Epub 2007 Jun 6 doi: 10.1159/000101797. PMID: 17570945
Dysproteinemia and the kidney.
Markowitz GS
Adv Anat Pathol 2004 Jan;11(1):49-63. doi: 10.1097/00125480-200401000-00005. PMID: 14676640

Clinical prediction guides

Vascular, valvular and kidney calcification manifested in mouse models of adenine-induced chronic kidney disease.
Yang X, Liu Y, Zhu X, Chen P, Xie X, Xu T, Zhang X, Zhao Y
Ren Fail 2023 Dec;45(1):2228920. doi: 10.1080/0886022X.2023.2228920. PMID: 37369635Free PMC Article
Association of Histologic Parameters with Outcome in C3 Glomerulopathy and Idiopathic Immunoglobulin-Associated Membranoproliferative Glomerulonephritis.
Lomax-Browne HJ, Medjeral-Thomas NR, Barbour SJ, Gisby J, Han H, Bomback AS, Fervenza FC, Cairns TH, Szydlo R, Tan SJ, Marks SD, Waters AM, Appel GB, D'Agati VD, Sethi S, Nast CC, Bajema I, Alpers CE, Fogo AB, Licht C, Fakhouri F, Cattran DC, Peters JE, Cook HT, Pickering MC
Clin J Am Soc Nephrol 2022 Jul;17(7):994-1007. doi: 10.2215/CJN.16801221. PMID: 35777834Free PMC Article
IgG4-related renal disease: clinical and pathological characteristics.
Kuroda N, Nao T, Fukuhara H, Karashima T, Inoue K, Taniguchi Y, Takeuchi M, Zen Y, Sato Y, Notohara K, Yoshino T
Int J Clin Exp Pathol 2014;7(9):6379-85. Epub 2014 Aug 15 PMID: 25337295Free PMC Article
Nephronophthisis.
Salomon R, Saunier S, Niaudet P
Pediatr Nephrol 2009 Dec;24(12):2333-44. Epub 2008 Jul 8 doi: 10.1007/s00467-008-0840-z. PMID: 18607645Free PMC Article
Acute rejection-associated tubular basement membrane defects and chronic allograft nephropathy.
Bonsib SM, Abul-Ezz SR, Ahmad I, Young SM, Ellis EN, Schneider DL, Walker PD
Kidney Int 2000 Nov;58(5):2206-14. doi: 10.1111/j.1523-1755.2000.00395.x. PMID: 11044243

Supplemental Content

Table of contents

    Clinical resources

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...