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Locally Advanced Gastric Carcinoma

MedGen UID:
1698287
•Concept ID:
C5206813
•
Neoplastic Process

Definition

A gastric carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Professional guidelines

PubMed

Differential diagnosis of malignant gastric tumors. A pathological appraisal with reference to locally advanced gastric carcinoma.
Canzonieri V, Bidoli E
Suppl Tumori 2003 Sep-Oct;2(5):S5-9. PMID: 12914380

Recent clinical studies

Etiology

Apatinib plus chemotherapy versus chemotherapy alone as neoadjuvant therapy in locally advanced gastric carcinoma patients: a prospective, cohort study.
Sun Y, Fan Y, Ye Z, Dong J, Zhang L, Peng Y
Ir J Med Sci 2023 Jun;192(3):1033-1040. Epub 2022 Jul 11 doi: 10.1007/s11845-022-03075-x. PMID: 35819743
Laparoscopic vs. Open Gastrectomy for Locally Advanced Gastric Cancer: A Propensity Score-Matched Retrospective Case-Control Study.
Caruso S, Giudicissi R, Mariatti M, Cantafio S, Paroli GM, Scatizzi M
Curr Oncol 2022 Mar 9;29(3):1840-1865. doi: 10.3390/curroncol29030151. PMID: 35323351Free PMC Article
The role of neoadjuvant FLOT chemotherapy with and without omega 3 in locally advanced gastric carcinoma.
Mohamed Abd Elaziz L, Salah T, Gharib F
J BUON 2020 Nov-Dec;25(6):2672-2677. PMID: 33455112
Surgical outcomes and survival after multiorgan resection for locally advanced gastric cancer.
Ozer I, Bostanci EB, Orug T, Ozogul YB, Ulas M, Ercan M, Kece C, Atalay F, Akoglu M
Am J Surg 2009 Jul;198(1):25-30. Epub 2008 Sep 27 doi: 10.1016/j.amjsurg.2008.06.031. PMID: 18823618
Neoadjuvant radiochemotherapy in locally advanced gastric carcinoma.
Klautke G, Foitzik T, Ludwig K, Ketterer P, Klar E, Fietkau R
Strahlenther Onkol 2004 Nov;180(11):695-700. doi: 10.1007/s00066-004-9194-z. PMID: 15549187

Diagnosis

Laparoscopic vs. Open Gastrectomy for Locally Advanced Gastric Cancer: A Propensity Score-Matched Retrospective Case-Control Study.
Caruso S, Giudicissi R, Mariatti M, Cantafio S, Paroli GM, Scatizzi M
Curr Oncol 2022 Mar 9;29(3):1840-1865. doi: 10.3390/curroncol29030151. PMID: 35323351Free PMC Article
Neoadjuvant radiochemotherapy in locally advanced gastric carcinoma.
Klautke G, Foitzik T, Ludwig K, Ketterer P, Klar E, Fietkau R
Strahlenther Onkol 2004 Nov;180(11):695-700. doi: 10.1007/s00066-004-9194-z. PMID: 15549187
Differential diagnosis of malignant gastric tumors. A pathological appraisal with reference to locally advanced gastric carcinoma.
Canzonieri V, Bidoli E
Suppl Tumori 2003 Sep-Oct;2(5):S5-9. PMID: 12914380
Neoadjuvant and adjuvant chemotherapy of locally advanced stomach cancer.
Morant R
Onkologie 2001 Apr;24(2):116-21. doi: 10.1159/000050297. PMID: 11441289
Selection of locally advanced gastric carcinoma by preoperative staging laparoscopy.
D'Ugo DM, Persiani R, Caracciolo F, Ronconi P, Coco C, Picciocchi A
Surg Endosc 1997 Dec;11(12):1159-62. doi: 10.1007/s004649900560. PMID: 9373285

Therapy

Apatinib plus chemotherapy versus chemotherapy alone as neoadjuvant therapy in locally advanced gastric carcinoma patients: a prospective, cohort study.
Sun Y, Fan Y, Ye Z, Dong J, Zhang L, Peng Y
Ir J Med Sci 2023 Jun;192(3):1033-1040. Epub 2022 Jul 11 doi: 10.1007/s11845-022-03075-x. PMID: 35819743
The role of neoadjuvant FLOT chemotherapy with and without omega 3 in locally advanced gastric carcinoma.
Mohamed Abd Elaziz L, Salah T, Gharib F
J BUON 2020 Nov-Dec;25(6):2672-2677. PMID: 33455112
Histopathological factors predicting response to neoadjuvant therapy in gastric carcinoma.
Sánchez de Molina ML, Díaz Del Arco C, Vorwald P, García-Olmo D, Estrada L, Fernández-Aceñero MJ
Clin Transl Oncol 2018 Feb;20(2):253-257. Epub 2017 Jun 26 doi: 10.1007/s12094-017-1707-1. PMID: 28653276
Neoadjuvant radiochemotherapy in locally advanced gastric carcinoma.
Klautke G, Foitzik T, Ludwig K, Ketterer P, Klar E, Fietkau R
Strahlenther Onkol 2004 Nov;180(11):695-700. doi: 10.1007/s00066-004-9194-z. PMID: 15549187
Neoadjuvant and adjuvant chemotherapy of locally advanced stomach cancer.
Morant R
Onkologie 2001 Apr;24(2):116-21. doi: 10.1159/000050297. PMID: 11441289

Prognosis

A propensity score-matched case-control comparative study of laparoscopic and open gastrectomy for locally advanced gastric carcinoma.
Zhang X, Sun F, Li S, Gao W, Wang Y, Hu SY
J BUON 2016 Jan-Feb;21(1):118-24. PMID: 27061539
Surgical outcomes and survival after multiorgan resection for locally advanced gastric cancer.
Ozer I, Bostanci EB, Orug T, Ozogul YB, Ulas M, Ercan M, Kece C, Atalay F, Akoglu M
Am J Surg 2009 Jul;198(1):25-30. Epub 2008 Sep 27 doi: 10.1016/j.amjsurg.2008.06.031. PMID: 18823618
Differential diagnosis of malignant gastric tumors. A pathological appraisal with reference to locally advanced gastric carcinoma.
Canzonieri V, Bidoli E
Suppl Tumori 2003 Sep-Oct;2(5):S5-9. PMID: 12914380
Neoadjuvant and adjuvant chemotherapy of locally advanced stomach cancer.
Morant R
Onkologie 2001 Apr;24(2):116-21. doi: 10.1159/000050297. PMID: 11441289
Selection of locally advanced gastric carcinoma by preoperative staging laparoscopy.
D'Ugo DM, Persiani R, Caracciolo F, Ronconi P, Coco C, Picciocchi A
Surg Endosc 1997 Dec;11(12):1159-62. doi: 10.1007/s004649900560. PMID: 9373285

Clinical prediction guides

Laparoscopic vs. Open Gastrectomy for Locally Advanced Gastric Cancer: A Propensity Score-Matched Retrospective Case-Control Study.
Caruso S, Giudicissi R, Mariatti M, Cantafio S, Paroli GM, Scatizzi M
Curr Oncol 2022 Mar 9;29(3):1840-1865. doi: 10.3390/curroncol29030151. PMID: 35323351Free PMC Article
The role of neoadjuvant FLOT chemotherapy with and without omega 3 in locally advanced gastric carcinoma.
Mohamed Abd Elaziz L, Salah T, Gharib F
J BUON 2020 Nov-Dec;25(6):2672-2677. PMID: 33455112
A propensity score-matched case-control comparative study of laparoscopic and open gastrectomy for locally advanced gastric carcinoma.
Zhang X, Sun F, Li S, Gao W, Wang Y, Hu SY
J BUON 2016 Jan-Feb;21(1):118-24. PMID: 27061539
A phase II study of perioperative S-1 combined with weekly docetaxel in patients with locally advanced gastric carcinoma: clinical outcomes and clinicopathological and pharmacogenetic predictors for survival.
Kim YW, Kim MJ, Ryu KW, Lim HS, Lee JH, Kong SY, Lee JS, Choi IJ, Kim CG, Lee JY, Cho SJ, Kook MC, Park YI, Kim SK, Park SR
Gastric Cancer 2016 Apr;19(2):586-596. Epub 2015 Apr 8 doi: 10.1007/s10120-015-0490-3. PMID: 25851942
Selection of locally advanced gastric carcinoma by preoperative staging laparoscopy.
D'Ugo DM, Persiani R, Caracciolo F, Ronconi P, Coco C, Picciocchi A
Surg Endosc 1997 Dec;11(12):1159-62. doi: 10.1007/s004649900560. PMID: 9373285

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