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Abnormal metabolism

MedGen UID:
1703500
•Concept ID:
C5139220
•
Finding
HPO: HP:0032245

Definition

An abnormality in the function of the chemical reactions related to processes including conversion of food to enter, synthesis of proteins, lipids, nucleic acids, and carbohydrates, or the elimination of waste products. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal metabolism

Professional guidelines

PubMed

Gout and Diet: A Comprehensive Review of Mechanisms and Management.
Zhang Y, Chen S, Yuan M, Xu Y, Xu H
Nutrients 2022 Aug 26;14(17) doi: 10.3390/nu14173525. PMID: 36079783Free PMC Article
Pancreatic Cancer: A Review of Risk Factors, Diagnosis, and Treatment.
Zhao Z, Liu W
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820962117. doi: 10.1177/1533033820962117. PMID: 33357065Free PMC Article
Diagnosis and treatment of heart failure in hereditary transthyretin amyloidosis.
Puig-Carrion GD, Reyentovich A, Katz SD
Clin Auton Res 2019 Sep;29(Suppl 1):45-53. Epub 2019 Aug 26 doi: 10.1007/s10286-019-00629-5. PMID: 31452023Free PMC Article

Recent clinical studies

Etiology

Gout and Diet: A Comprehensive Review of Mechanisms and Management.
Zhang Y, Chen S, Yuan M, Xu Y, Xu H
Nutrients 2022 Aug 26;14(17) doi: 10.3390/nu14173525. PMID: 36079783Free PMC Article
Pancreatic Cancer: A Review of Risk Factors, Diagnosis, and Treatment.
Zhao Z, Liu W
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820962117. doi: 10.1177/1533033820962117. PMID: 33357065Free PMC Article
Altered gut microbial profile is associated with abnormal metabolism activity of Autism Spectrum Disorder.
Dan Z, Mao X, Liu Q, Guo M, Zhuang Y, Liu Z, Chen K, Chen J, Xu R, Tang J, Qin L, Gu B, Liu K, Su C, Zhang F, Xia Y, Hu Z, Liu X
Gut Microbes 2020 Sep 2;11(5):1246-1267. Epub 2020 Apr 21 doi: 10.1080/19490976.2020.1747329. PMID: 32312186Free PMC Article
Definition and classification of cancer cachexia: an international consensus.
Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, Jatoi A, Loprinzi C, MacDonald N, Mantovani G, Davis M, Muscaritoli M, Ottery F, Radbruch L, Ravasco P, Walsh D, Wilcock A, Kaasa S, Baracos VE
Lancet Oncol 2011 May;12(5):489-95. Epub 2011 Feb 4 doi: 10.1016/S1470-2045(10)70218-7. PMID: 21296615
Alpha-thalassaemia.
Harteveld CL, Higgs DR
Orphanet J Rare Dis 2010 May 28;5:13. doi: 10.1186/1750-1172-5-13. PMID: 20507641Free PMC Article

Diagnosis

Pancreatic Cancer: A Review of Risk Factors, Diagnosis, and Treatment.
Zhao Z, Liu W
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820962117. doi: 10.1177/1533033820962117. PMID: 33357065Free PMC Article
Hypoxic Pulmonary Vasoconstriction: From Molecular Mechanisms to Medicine.
Dunham-Snary KJ, Wu D, Sykes EA, Thakrar A, Parlow LRG, Mewburn JD, Parlow JL, Archer SL
Chest 2017 Jan;151(1):181-192. Epub 2016 Sep 16 doi: 10.1016/j.chest.2016.09.001. PMID: 27645688Free PMC Article
Fibrinolysis and the control of blood coagulation.
Chapin JC, Hajjar KA
Blood Rev 2015 Jan;29(1):17-24. Epub 2014 Sep 16 doi: 10.1016/j.blre.2014.09.003. PMID: 25294122Free PMC Article
Definition and classification of cancer cachexia: an international consensus.
Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, Jatoi A, Loprinzi C, MacDonald N, Mantovani G, Davis M, Muscaritoli M, Ottery F, Radbruch L, Ravasco P, Walsh D, Wilcock A, Kaasa S, Baracos VE
Lancet Oncol 2011 May;12(5):489-95. Epub 2011 Feb 4 doi: 10.1016/S1470-2045(10)70218-7. PMID: 21296615
Alpha-thalassaemia.
Harteveld CL, Higgs DR
Orphanet J Rare Dis 2010 May 28;5:13. doi: 10.1186/1750-1172-5-13. PMID: 20507641Free PMC Article

Therapy

Protein tyrosine kinase inhibitor resistance in malignant tumors: molecular mechanisms and future perspective.
Yang Y, Li S, Wang Y, Zhao Y, Li Q
Signal Transduct Target Ther 2022 Sep 17;7(1):329. doi: 10.1038/s41392-022-01168-8. PMID: 36115852Free PMC Article
Hypoxia-responsive nanoparticles for tumor-targeted drug delivery.
Li Y, Jeon J, Park JH
Cancer Lett 2020 Oct 10;490:31-43. Epub 2020 Jun 23 doi: 10.1016/j.canlet.2020.05.032. PMID: 32585414
Insight into the complex pathophysiology of sickle cell anaemia and possible treatment.
Piccin A, Murphy C, Eakins E, Rondinelli MB, Daves M, Vecchiato C, Wolf D, Mc Mahon C, Smith OP
Eur J Haematol 2019 Apr;102(4):319-330. Epub 2019 Feb 21 doi: 10.1111/ejh.13212. PMID: 30664257
Cryofibrinogenemia.
Michaud M, Pourrat J
J Clin Rheumatol 2013 Apr;19(3):142-8. doi: 10.1097/RHU.0b013e318289e06e. PMID: 23519183
Definition and classification of cancer cachexia: an international consensus.
Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, Jatoi A, Loprinzi C, MacDonald N, Mantovani G, Davis M, Muscaritoli M, Ottery F, Radbruch L, Ravasco P, Walsh D, Wilcock A, Kaasa S, Baracos VE
Lancet Oncol 2011 May;12(5):489-95. Epub 2011 Feb 4 doi: 10.1016/S1470-2045(10)70218-7. PMID: 21296615

Prognosis

PHGDH Inhibits Ferroptosis and Promotes Malignant Progression by Upregulating SLC7A11 in Bladder Cancer.
Shen L, Zhang J, Zheng Z, Yang F, Liu S, Wu Y, Chen Y, Xu T, Mao S, Yan Y, Li W, Zhang W, Yao X
Int J Biol Sci 2022;18(14):5459-5474. Epub 2022 Aug 29 doi: 10.7150/ijbs.74546. PMID: 36147463Free PMC Article
Gout and Diet: A Comprehensive Review of Mechanisms and Management.
Zhang Y, Chen S, Yuan M, Xu Y, Xu H
Nutrients 2022 Aug 26;14(17) doi: 10.3390/nu14173525. PMID: 36079783Free PMC Article
Pancreatic Cancer: A Review of Risk Factors, Diagnosis, and Treatment.
Zhao Z, Liu W
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820962117. doi: 10.1177/1533033820962117. PMID: 33357065Free PMC Article
Cardiovascular risk factors in China: a nationwide population-based cohort study.
Li X, Wu C, Lu J, Chen B, Li Y, Yang Y, Hu S, Li J
Lancet Public Health 2020 Dec;5(12):e672-e681. doi: 10.1016/S2468-2667(20)30191-2. PMID: 33271080
Fibrinolysis and the control of blood coagulation.
Chapin JC, Hajjar KA
Blood Rev 2015 Jan;29(1):17-24. Epub 2014 Sep 16 doi: 10.1016/j.blre.2014.09.003. PMID: 25294122Free PMC Article

Clinical prediction guides

PHGDH Inhibits Ferroptosis and Promotes Malignant Progression by Upregulating SLC7A11 in Bladder Cancer.
Shen L, Zhang J, Zheng Z, Yang F, Liu S, Wu Y, Chen Y, Xu T, Mao S, Yan Y, Li W, Zhang W, Yao X
Int J Biol Sci 2022;18(14):5459-5474. Epub 2022 Aug 29 doi: 10.7150/ijbs.74546. PMID: 36147463Free PMC Article
Pancreatic Cancer: A Review of Risk Factors, Diagnosis, and Treatment.
Zhao Z, Liu W
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820962117. doi: 10.1177/1533033820962117. PMID: 33357065Free PMC Article
Altered gut microbial profile is associated with abnormal metabolism activity of Autism Spectrum Disorder.
Dan Z, Mao X, Liu Q, Guo M, Zhuang Y, Liu Z, Chen K, Chen J, Xu R, Tang J, Qin L, Gu B, Liu K, Su C, Zhang F, Xia Y, Hu Z, Liu X
Gut Microbes 2020 Sep 2;11(5):1246-1267. Epub 2020 Apr 21 doi: 10.1080/19490976.2020.1747329. PMID: 32312186Free PMC Article
Fibrinolysis and the control of blood coagulation.
Chapin JC, Hajjar KA
Blood Rev 2015 Jan;29(1):17-24. Epub 2014 Sep 16 doi: 10.1016/j.blre.2014.09.003. PMID: 25294122Free PMC Article
Alpha-thalassaemia.
Harteveld CL, Higgs DR
Orphanet J Rare Dis 2010 May 28;5:13. doi: 10.1186/1750-1172-5-13. PMID: 20507641Free PMC Article

Recent systematic reviews

Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
[18F]FDG brain PET and clinical symptoms in different autoantibodies of autoimmune encephalitis: a systematic review.
Nabizadeh F, Ramezannezhad E, Sardaripour A, Seyedi SA, Salehi N, Rezaeimanesh N, Naser Moghadasi A
Neurol Sci 2022 Aug;43(8):4701-4718. Epub 2022 Apr 29 doi: 10.1007/s10072-022-06094-9. PMID: 35486333
The prognostic role of cardiac positron emission tomography imaging in patients with sarcoidosis: A systematic review.
Ahmed AI, Abebe AT, Han Y, Alnabelsi T, Agrawal T, Kassi M, Aljizeeri A, Taylor A, Tleyjeh IM, Al-Mallah MH
J Nucl Cardiol 2021 Aug;28(4):1545-1552. Epub 2021 Jul 6 doi: 10.1007/s12350-021-02681-z. PMID: 34228337
Mineral bone disorders in chronic kidney disease.
Hou YC, Lu CL, Lu KC
Nephrology (Carlton) 2018 Oct;23 Suppl 4:88-94. doi: 10.1111/nep.13457. PMID: 30298663
Proton magnetic resonance spectroscopy in oncology: the fingerprints of cancer?
García-Figueiras R, Baleato-González S, Padhani AR, Oleaga L, Vilanova JC, Luna A, Cobas Gómez JC
Diagn Interv Radiol 2016 Jan-Feb;22(1):75-89. doi: 10.5152/dir.2015.15009. PMID: 26712681Free PMC Article

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