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Neutrophil nuclear clefts

MedGen UID:
1705120
•Concept ID:
C5209289
•
Finding
HPO: HP:0041043

Definition

An abnormality of the nucleus of neutrophils, which presents as either a type I nuclear cleft, where the nuclear cleft may show a transition into a round/oval shape. The second type nuclear cleft, which runs perpendicular to the nuclear surface, and this type of cleft might be related to nuclear lobe formation. [from HPO]

Conditions with this feature

Specific granule deficiency 1
MedGen UID:
1644049
•Concept ID:
C4551556
•
Disease or Syndrome
Any specific granule deficiency in which the cause of the disease is a mutation in the CEBPE gene.
See: Condition Record
Specific granule deficiency 1

Recent clinical studies

Etiology

Invasive micropapillary carcinomas of the ampullo-pancreatobiliary region and their association with tumor-infiltrating neutrophils.
Khayyata S, Basturk O, Adsay NV
Mod Pathol 2005 Nov;18(11):1504-11. doi: 10.1038/modpathol.3800460. PMID: 16007065
Mollaret's meningitis: cytopathologic analysis of fourteen cases.
Chan TY, Parwani AV, Levi AW, Ali SZ
Diagn Cytopathol 2003 May;28(5):227-31. doi: 10.1002/dc.10261. PMID: 12722116

Diagnosis

Mollaret's meningitis: cytopathologic analysis of fourteen cases.
Chan TY, Parwani AV, Levi AW, Ali SZ
Diagn Cytopathol 2003 May;28(5):227-31. doi: 10.1002/dc.10261. PMID: 12722116

Therapy

Multiple congenital abnormalities in a newborn boy associated with maternal use of fluphenazine enanthate and other drugs during pregnancy.
Donaldson GL, Bury RG
Acta Paediatr Scand 1982 Mar;71(2):335-8. doi: 10.1111/j.1651-2227.1982.tb09428.x. PMID: 7136644

Prognosis

Invasive micropapillary carcinomas of the ampullo-pancreatobiliary region and their association with tumor-infiltrating neutrophils.
Khayyata S, Basturk O, Adsay NV
Mod Pathol 2005 Nov;18(11):1504-11. doi: 10.1038/modpathol.3800460. PMID: 16007065

Clinical prediction guides

Invasive micropapillary carcinomas of the ampullo-pancreatobiliary region and their association with tumor-infiltrating neutrophils.
Khayyata S, Basturk O, Adsay NV
Mod Pathol 2005 Nov;18(11):1504-11. doi: 10.1038/modpathol.3800460. PMID: 16007065

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