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Localized Head and Neck Carcinoma

MedGen UID:
1708242
•Concept ID:
C5206653
•
Neoplastic Process
Synonym: Non-Metastatic Head and Neck Carcinoma

Definition

Head and neck carcinoma that is confined to the site in which it initially manifested without evidence of spread to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocalized Head and Neck Carcinoma

Professional guidelines

PubMed

Current opinions on diagnosis and treatment of adenoid cystic carcinoma.
Fang Y, Peng Z, Wang Y, Gao K, Liu Y, Fan R, Zhang H, Xie Z, Jiang W
Oral Oncol 2022 Jul;130:105945. Epub 2022 Jun 2 doi: 10.1016/j.oraloncology.2022.105945. PMID: 35662026
Management of locally recurrent nasopharyngeal carcinoma.
Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A
Cancer Treat Rev 2019 Sep;79:101890. Epub 2019 Aug 21 doi: 10.1016/j.ctrv.2019.101890. PMID: 31470314
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Recent clinical studies

Etiology

Survival and prognosis of metastatic head and neck adenoid cystic carcinoma.
Zhang D, Chai Y, Wei Y, Qi F, Dong M
Head Neck 2022 Nov;44(11):2407-2416. Epub 2022 Jul 13 doi: 10.1002/hed.27143. PMID: 35822446
Elective neck treatment in sinonasal undifferentiated carcinoma: Systematic review and meta-analysis.
Faisal M, Seemann R, Lill C, Hamzavi S, Wutzl A, Erovic BM, Janik S
Head Neck 2020 May;42(5):1057-1066. Epub 2020 Jan 10 doi: 10.1002/hed.26077. PMID: 31922316Free PMC Article
Stereotactic body radiotherapy for recurrent head and neck cancer: A critical review.
Baliga S, Kabarriti R, Ohri N, Haynes-Lewis H, Yaparpalvi R, Kalnicki S, Garg MK
Head Neck 2017 Mar;39(3):595-601. Epub 2016 Dec 20 doi: 10.1002/hed.24633. PMID: 27997054
Salvage surgery after head and neck squamous cell carcinoma treated with bioradiotherapy.
Rovira A, Tornero J, Oliva M, Taberna M, Montal R, Nogues J, Farre A, Lares H, Navarro V, Mari A, Vinals JM, Lozano A, Mesia R, Manos M
Head Neck 2017 Jan;39(1):116-121. Epub 2016 Jul 26 doi: 10.1002/hed.24549. PMID: 27459296
Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications.
Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
Head Neck 2015 May;37(5):763-70. Epub 2015 Jan 27 doi: 10.1002/hed.23837. PMID: 24995469

Diagnosis

S1-Guideline Sebaceous Carcinoma.
Utikal J, Nagel P, Müller V, Becker JC, Dippel E, Frisman A, Gschnell M, Griewank K, Hadaschik E, Helbig D, Hillen U, Leiter U, Pföhler C, Krönig L, Ziemer M, Ugurel S
J Dtsch Dermatol Ges 2024 May;22(5):730-747. Epub 2024 Apr 28 doi: 10.1111/ddg.15405. PMID: 38679790
Oligometastatic head and neck cancer: Comprehensive review.
Vengaloor Thomas T, Packianathan S, Bhanat E, Albert A, Abraham A, Gordy X, Kanakamedala M, Mehta D, Vijayakumar S
Head Neck 2020 Aug;42(8):2194-2201. Epub 2020 Mar 27 doi: 10.1002/hed.26144. PMID: 32220043
Cancer Stem Cells in Head and Neck Carcinomas: Identification and Possible Therapeutic Implications.
Wolmarans E, Boy SC, Nel S, Mercier AE, Pepper MS
Adv Exp Med Biol 2018;1083:89-102. doi: 10.1007/5584_2017_116. PMID: 29139089
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243
Head and neck cancer.
Argiris A, Karamouzis MV, Raben D, Ferris RL
Lancet 2008 May 17;371(9625):1695-709. doi: 10.1016/S0140-6736(08)60728-X. PMID: 18486742Free PMC Article

Therapy

Xevinapant or placebo plus chemoradiotherapy in locally advanced squamous cell carcinoma of the head and neck: TrilynX phase III study design.
Bourhis J, Burtness B, Licitra LF, Nutting C, Schoenfeld JD, Omar M, Bouisset F, Nauwelaerts H, Urfer Y, Zanna C, Cohen EE
Future Oncol 2022 May;18(14):1669-1678. Epub 2022 Feb 17 doi: 10.2217/fon-2021-1634. PMID: 35172587
Phase 1/2a, open-label, multicenter study of RM-1929 photoimmunotherapy in patients with locoregional, recurrent head and neck squamous cell carcinoma.
Cognetti DM, Johnson JM, Curry JM, Kochuparambil ST, McDonald D, Mott F, Fidler MJ, Stenson K, Vasan NR, Razaq MA, Campana J, Ha P, Mann G, Ishida K, Garcia-Guzman M, Biel M, Gillenwater AM
Head Neck 2021 Dec;43(12):3875-3887. Epub 2021 Oct 9 doi: 10.1002/hed.26885. PMID: 34626024Free PMC Article
Head and neck cancer and non-steroidal anti-inflammatory drugs: Systematic review and meta-analysis.
Saka-Herrán C, Jané-Salas E, Estrugo-Devesa A, López-López J
Head Neck 2021 May;43(5):1664-1682. Epub 2021 Mar 8 doi: 10.1002/hed.26663. PMID: 33682986
Pembrolizumab given concomitantly with chemoradiation and as maintenance therapy for locally advanced head and neck squamous cell carcinoma: KEYNOTE-412.
Machiels JP, Tao Y, Burtness B, Tahara M, Licitra L, Rischin D, Waldron J, Simon C, Gregoire V, Harrington K, Alves GV, Figueiredo Lima IP, Pointreau Y, M Hughes BG, Aksoy S, Hetnal M, Ge JY, Brown H, Cheng J, Bidadi B, Siu LL
Future Oncol 2020 Jun;16(18):1235-1243. Epub 2020 Jun 3 doi: 10.2217/fon-2020-0184. PMID: 32490686
Head and neck cancer.
Argiris A, Karamouzis MV, Raben D, Ferris RL
Lancet 2008 May 17;371(9625):1695-709. doi: 10.1016/S0140-6736(08)60728-X. PMID: 18486742Free PMC Article

Prognosis

Survival and prognosis of metastatic head and neck adenoid cystic carcinoma.
Zhang D, Chai Y, Wei Y, Qi F, Dong M
Head Neck 2022 Nov;44(11):2407-2416. Epub 2022 Jul 13 doi: 10.1002/hed.27143. PMID: 35822446
Radioresistance and genomic alterations in head and neck squamous cell cancer: Sub-analysis of the ProfiLER protocol.
Rowinski E, Magné N, Fayette J, Daguenet E, Racadot S, Pommier P, Méry B, Vallard A, Tinquaut F, Neidhardt-Berard EM, Cassier P, Attignon V, Pissaloux D, Wang Q, Sohier E, Pérol D, Blay JY, Trédan O
Head Neck 2021 Dec;43(12):3899-3910. Epub 2021 Oct 13 doi: 10.1002/hed.26891. PMID: 34643313
Stereotactic body radiotherapy for recurrent head and neck cancer: A critical review.
Baliga S, Kabarriti R, Ohri N, Haynes-Lewis H, Yaparpalvi R, Kalnicki S, Garg MK
Head Neck 2017 Mar;39(3):595-601. Epub 2016 Dec 20 doi: 10.1002/hed.24633. PMID: 27997054
Salvage surgery after head and neck squamous cell carcinoma treated with bioradiotherapy.
Rovira A, Tornero J, Oliva M, Taberna M, Montal R, Nogues J, Farre A, Lares H, Navarro V, Mari A, Vinals JM, Lozano A, Mesia R, Manos M
Head Neck 2017 Jan;39(1):116-121. Epub 2016 Jul 26 doi: 10.1002/hed.24549. PMID: 27459296
Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications.
Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
Head Neck 2015 May;37(5):763-70. Epub 2015 Jan 27 doi: 10.1002/hed.23837. PMID: 24995469

Clinical prediction guides

Radioresistance and genomic alterations in head and neck squamous cell cancer: Sub-analysis of the ProfiLER protocol.
Rowinski E, Magné N, Fayette J, Daguenet E, Racadot S, Pommier P, Méry B, Vallard A, Tinquaut F, Neidhardt-Berard EM, Cassier P, Attignon V, Pissaloux D, Wang Q, Sohier E, Pérol D, Blay JY, Trédan O
Head Neck 2021 Dec;43(12):3899-3910. Epub 2021 Oct 13 doi: 10.1002/hed.26891. PMID: 34643313
Head and neck cancer and non-steroidal anti-inflammatory drugs: Systematic review and meta-analysis.
Saka-Herrán C, Jané-Salas E, Estrugo-Devesa A, López-López J
Head Neck 2021 May;43(5):1664-1682. Epub 2021 Mar 8 doi: 10.1002/hed.26663. PMID: 33682986
Elective neck treatment in sinonasal undifferentiated carcinoma: Systematic review and meta-analysis.
Faisal M, Seemann R, Lill C, Hamzavi S, Wutzl A, Erovic BM, Janik S
Head Neck 2020 May;42(5):1057-1066. Epub 2020 Jan 10 doi: 10.1002/hed.26077. PMID: 31922316Free PMC Article
Molecular profiling of head and neck squamous cell carcinoma.
Feldman R, Gatalica Z, Knezetic J, Reddy S, Nathan CA, Javadi N, Teknos T
Head Neck 2016 Apr;38 Suppl 1(Suppl 1):E1625-38. Epub 2015 Nov 28 doi: 10.1002/hed.24290. PMID: 26614708Free PMC Article
Clinical applications of genomics in head and neck cancer.
Chung CH, Levy S, Yarbrough WG
Head Neck 2006 Apr;28(4):360-8. doi: 10.1002/hed.20323. PMID: 16284976

Recent systematic reviews

Head and neck cancer associated with myiasis.
Gonçalves KKN, de Araújo ESM, Barbirato DS, do Lago CAP, do Egito Vasconcelos BC
Int J Oral Maxillofac Surg 2022 Jul;51(7):847-853. Epub 2021 Oct 1 doi: 10.1016/j.ijom.2021.08.011. PMID: 34602319
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
Head and neck cancer and non-steroidal anti-inflammatory drugs: Systematic review and meta-analysis.
Saka-Herrán C, Jané-Salas E, Estrugo-Devesa A, López-López J
Head Neck 2021 May;43(5):1664-1682. Epub 2021 Mar 8 doi: 10.1002/hed.26663. PMID: 33682986
Interventions for basal cell carcinoma of the skin.
Thomson J, Hogan S, Leonardi-Bee J, Williams HC, Bath-Hextall FJ
Cochrane Database Syst Rev 2020 Nov 17;11(11):CD003412. doi: 10.1002/14651858.CD003412.pub3. PMID: 33202063Free PMC Article
Elective neck treatment in sinonasal undifferentiated carcinoma: Systematic review and meta-analysis.
Faisal M, Seemann R, Lill C, Hamzavi S, Wutzl A, Erovic BM, Janik S
Head Neck 2020 May;42(5):1057-1066. Epub 2020 Jan 10 doi: 10.1002/hed.26077. PMID: 31922316Free PMC Article

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