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Mueller-weiss syndrome

MedGen UID:
1708314
Concept ID:
C4761149
Disease or Syndrome
Synonyms: Brailsford disease; Mueller Weiss osteonecrosis of tarsal bone; Mueller Weiss syndrome; Mueller-Weiss osteonecrosis of the tarsal bone; Mueller-Weiss syndrome; mueller-weiss syndrome
SNOMED CT: Mueller Weiss osteonecrosis of tarsal bone (1222676004); Mueller Weiss syndrome (1222676004); Brailsford disease (1222676004)
 
Monarch Initiative: MONDO:0035452
Orphanet: ORPHA566943

Definition

A rare bone disease with characteristics of spontaneous adult-onset tarsal navicular osteonecrosis. Patients present with chronic mid and hindfoot pain, swelling and tenderness over the dorsomedial aspect of the midfoot, flattening of the medial longitudinal arch, and pes planovarus. Radiographic findings include comma-shaped deformity due to collapse of the lateral part of the navicular bone and medial or dorsal protrusion of a portion or the entire bone. The condition may be bilateral or asymmetric and associated with pathological fractures. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMueller-weiss syndrome

Recent clinical studies

Etiology

Uzer G, Demirel M, Kara D, Toker B, Yildiz F, Ucan V
Acta Orthop Belg 2024 Mar;90(1):154-159. doi: 10.52628/90.1.10628. PMID: 38669667
Janositz G, Sisák K, Tóth K
Knee Surg Sports Traumatol Arthrosc 2011 Apr;19(4):688-90. Epub 2010 Nov 10 doi: 10.1007/s00167-010-1305-z. PMID: 21063683

Diagnosis

Mairal E, Imbert L, Marie PY, Bahloul A
Eur J Nucl Med Mol Imaging 2022 Jul;49(9):3295-3296. Epub 2022 Feb 22 doi: 10.1007/s00259-022-05733-9. PMID: 35192019
Samim M, Moukaddam HA, Smitaman E
AJR Am J Roentgenol 2016 Aug;207(2):W8-W18. Epub 2016 May 4 doi: 10.2214/AJR.15.15843. PMID: 27145453
Bartolotta RJ, McCullion JC, Belfi LM, Hentel KD
Clin Imaging 2014 Nov-Dec;38(6):895-8. Epub 2014 Jun 27 doi: 10.1016/j.clinimag.2014.06.012. PMID: 25064253
Marchi SE, Monteiro SS, Fernandes Ede A
Rev Assoc Med Bras (1992) 2014 Mar-Apr;60(2):103-4. doi: 10.1590/1806-9282.60.02.005. PMID: 24918995
Nguyen AS, Tagoylo GH, Mote GA
J Am Podiatr Med Assoc 2014 Jan-Feb;104(1):110-4. doi: 10.7547/0003-0538-104.1.110. PMID: 24504587

Prognosis

Janositz G, Sisák K, Tóth K
Knee Surg Sports Traumatol Arthrosc 2011 Apr;19(4):688-90. Epub 2010 Nov 10 doi: 10.1007/s00167-010-1305-z. PMID: 21063683

Clinical prediction guides

Uzer G, Demirel M, Kara D, Toker B, Yildiz F, Ucan V
Acta Orthop Belg 2024 Mar;90(1):154-159. doi: 10.52628/90.1.10628. PMID: 38669667

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