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Unresectable Epithelioid Hemangioendothelioma

MedGen UID:
1710197
•Concept ID:
C5239076
•
Neoplastic Process

Definition

An epithelioid hemangioendothelioma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Epithelioid Hemangioendothelioma

Professional guidelines

PubMed

Hepatic epithelioid haemangioendothelioma: is transplantation the only treatment option?
Grotz TE, Nagorney D, Donohue J, Que F, Kendrick M, Farnell M, Harmsen S, Mulligan D, Nguyen J, Rosen C, Reid-Lombardo KM
HPB (Oxford) 2010 Oct;12(8):546-53. Epub 2010 Sep 2 doi: 10.1111/j.1477-2574.2010.00213.x. PMID: 20887322Free PMC Article
Vascular endothelial growth factor expression in hepatic epithelioid hemangioendothelioma: Implications for treatment and surgical management.
Emamaullee JA, Edgar R, Toso C, Thiesen A, Bain V, Bigam D, Kneteman N, Shapiro AM
Liver Transpl 2010 Feb;16(2):191-7. doi: 10.1002/lt.21964. PMID: 20104492

Recent clinical studies

Etiology

Clinical characteristics of epithelioid hemangioendothelioma: a single-center retrospective study.
Wu X, Li B, Zheng C, Hong T, He X
Eur J Med Res 2019 Feb 28;24(1):16. doi: 10.1186/s40001-019-0375-8. PMID: 30819247Free PMC Article
Liver Transplant for Nonhepatocellular Carcinoma Malignancy.
Haberal Reyhan N
Exp Clin Transplant 2017 Mar;15(Suppl 2):69-73. doi: 10.6002/ect.TOND16.L18. PMID: 28302003
Epithelioid hemangioendothelioma of the liver as a rare indication for liver transplantation.
Remiszewski P, Szczerba E, Kalinowski P, Gierej B, Dudek K, Grodzicki M, Kotulski M, Paluszkiewicz R, Patkowski W, Zieniewicz K, Krawczyk M
World J Gastroenterol 2014 Aug 28;20(32):11333-9. doi: 10.3748/wjg.v20.i32.11333. PMID: 25170219Free PMC Article
Liver transplantation for malignancies.
Eghtesad B, Aucejo F
J Gastrointest Cancer 2014 Sep;45(3):353-62. doi: 10.1007/s12029-014-9590-2. PMID: 24604263
Hepatic malignant epithelioid hemangioendothelioma: a case report and review of the literature.
Woodall CE, Scoggins CR, Lewis AM, McMasters KM, Martin RC
Am Surg 2008 Jan;74(1):64-8. PMID: 18274433

Diagnosis

Clinical characteristics of epithelioid hemangioendothelioma: a single-center retrospective study.
Wu X, Li B, Zheng C, Hong T, He X
Eur J Med Res 2019 Feb 28;24(1):16. doi: 10.1186/s40001-019-0375-8. PMID: 30819247Free PMC Article
Epithelioid hemangioendothelioma of the liver as a rare indication for liver transplantation.
Remiszewski P, Szczerba E, Kalinowski P, Gierej B, Dudek K, Grodzicki M, Kotulski M, Paluszkiewicz R, Patkowski W, Zieniewicz K, Krawczyk M
World J Gastroenterol 2014 Aug 28;20(32):11333-9. doi: 10.3748/wjg.v20.i32.11333. PMID: 25170219Free PMC Article
Hepatic malignant epithelioid hemangioendothelioma: a case report and review of the literature.
Woodall CE, Scoggins CR, Lewis AM, McMasters KM, Martin RC
Am Surg 2008 Jan;74(1):64-8. PMID: 18274433
Transplantation for liver and biliary cancer.
Strong RW
Semin Surg Oncol 2000 Sep-Oct;19(2):189-99. doi: 10.1002/1098-2388(200009)19:2<189::aid-ssu10>3.0.co;2-u. PMID: 11126382
Tumor diagnosis in the adult liver transplant candidate.
Mahfouz A, Vogl T, Hamm B
Eur Radiol 1999;9(5):841-52. doi: 10.1007/s003300050754. PMID: 10369978

Therapy

The TAZ-CAMTA1 Fusion Protein Promotes Tumorigenesis via Connective Tissue Growth Factor and Ras-MAPK Signaling in Epithelioid Hemangioendothelioma.
Ma S, Kanai R, Pobbati AV, Li S, Che K, Seavey CN, Hallett A, Burtscher A, Lamar JM, Rubin BP
Clin Cancer Res 2022 Jul 15;28(14):3116-3126. doi: 10.1158/1078-0432.CCR-22-0421. PMID: 35443056Free PMC Article
Liver Transplant for Nonhepatocellular Carcinoma Malignancy.
Haberal Reyhan N
Exp Clin Transplant 2017 Mar;15(Suppl 2):69-73. doi: 10.6002/ect.TOND16.L18. PMID: 28302003
Liver transplantation for hepatobiliary malignancies: a new era of "Transplant Oncology" has begun.
Hibi T, Itano O, Shinoda M, Kitagawa Y
Surg Today 2017 Apr;47(4):403-415. Epub 2016 Apr 29 doi: 10.1007/s00595-016-1337-1. PMID: 27130463
Liver transplantation for malignancies.
Eghtesad B, Aucejo F
J Gastrointest Cancer 2014 Sep;45(3):353-62. doi: 10.1007/s12029-014-9590-2. PMID: 24604263
Transplantation for liver and biliary cancer.
Strong RW
Semin Surg Oncol 2000 Sep-Oct;19(2):189-99. doi: 10.1002/1098-2388(200009)19:2<189::aid-ssu10>3.0.co;2-u. PMID: 11126382

Prognosis

VEGF-VEGFR pathway seems to be the best target in hepatic epithelioid hemangioendothelioma: A case series with review of the literature.
Telli TA, Okten IN, Tuylu TB, Demircan NC, Arikan R, Alan O, Ercelep O, Ones T, Yildirim AT, Dane F, Yumuk PF
Curr Probl Cancer 2020 Oct;44(5):100568. Epub 2020 Mar 14 doi: 10.1016/j.currproblcancer.2020.100568. PMID: 32201052
Clinical characteristics of epithelioid hemangioendothelioma: a single-center retrospective study.
Wu X, Li B, Zheng C, Hong T, He X
Eur J Med Res 2019 Feb 28;24(1):16. doi: 10.1186/s40001-019-0375-8. PMID: 30819247Free PMC Article
Epithelioid hemangioendothelioma of the liver as a rare indication for liver transplantation.
Remiszewski P, Szczerba E, Kalinowski P, Gierej B, Dudek K, Grodzicki M, Kotulski M, Paluszkiewicz R, Patkowski W, Zieniewicz K, Krawczyk M
World J Gastroenterol 2014 Aug 28;20(32):11333-9. doi: 10.3748/wjg.v20.i32.11333. PMID: 25170219Free PMC Article
Liver transplantation for malignancy.
Hertl M, Cosimi AB
Oncologist 2005 Apr;10(4):269-81. doi: 10.1634/theoncologist.10-4-269. PMID: 15821247
Tumor diagnosis in the adult liver transplant candidate.
Mahfouz A, Vogl T, Hamm B
Eur Radiol 1999;9(5):841-52. doi: 10.1007/s003300050754. PMID: 10369978

Clinical prediction guides

Epithelioid hemangioendothelioma of the liver as a rare indication for liver transplantation.
Remiszewski P, Szczerba E, Kalinowski P, Gierej B, Dudek K, Grodzicki M, Kotulski M, Paluszkiewicz R, Patkowski W, Zieniewicz K, Krawczyk M
World J Gastroenterol 2014 Aug 28;20(32):11333-9. doi: 10.3748/wjg.v20.i32.11333. PMID: 25170219Free PMC Article
Hepatic epithelioid haemangioendothelioma: is transplantation the only treatment option?
Grotz TE, Nagorney D, Donohue J, Que F, Kendrick M, Farnell M, Harmsen S, Mulligan D, Nguyen J, Rosen C, Reid-Lombardo KM
HPB (Oxford) 2010 Oct;12(8):546-53. Epub 2010 Sep 2 doi: 10.1111/j.1477-2574.2010.00213.x. PMID: 20887322Free PMC Article
Liver transplantation for non-hepatocellular carcinoma malignancy: Indications, limitations, and analysis of the current literature.
Grossman EJ, Millis JM
Liver Transpl 2010 Aug;16(8):930-42. doi: 10.1002/lt.22106. PMID: 20677284
Vascular endothelial growth factor expression in hepatic epithelioid hemangioendothelioma: Implications for treatment and surgical management.
Emamaullee JA, Edgar R, Toso C, Thiesen A, Bain V, Bigam D, Kneteman N, Shapiro AM
Liver Transpl 2010 Feb;16(2):191-7. doi: 10.1002/lt.21964. PMID: 20104492
Tumor diagnosis in the adult liver transplant candidate.
Mahfouz A, Vogl T, Hamm B
Eur Radiol 1999;9(5):841-52. doi: 10.1007/s003300050754. PMID: 10369978

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