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Architectural distortion of the lung

MedGen UID:
1711271
Concept ID:
C5397993
Anatomical Abnormality
HPO: HP:0033007

Definition

Architectural distortion is characterized by abnormal displacement of bronchi, vessels, fissures, or septa caused by diffuse or localized lung disease, particularly interstitial fibrosis. This is visible in lung biopsy and CT scans in a distorted appearance and is usually associated with pulmonary fibrosis and accompanied by volume loss. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVArchitectural distortion of the lung

Professional guidelines

PubMed

Belperio JA, Shaikh F, Abtin FG, Fishbein MC, Weigt SS, Saggar R, Lynch JP 3rd
JAMA 2022 Mar 1;327(9):856-867. doi: 10.1001/jama.2022.1570. PMID: 35230389
Meraj R, Wikenheiser-Brokamp KA, Young LR, McCormack FX
Semin Respir Crit Care Med 2012 Oct;33(5):486-97. Epub 2012 Sep 21 doi: 10.1055/s-0032-1325159. PMID: 23001803

Recent clinical studies

Etiology

Lettieri S, Bertuccio FR, Del Frate L, Perrotta F, Corsico AG, Stella GM
Int J Mol Sci 2023 Dec 31;25(1) doi: 10.3390/ijms25010547. PMID: 38203718Free PMC Article
Drakopanagiotakis F, Markart P, Steiropoulos P
Int J Mol Sci 2023 Jun 15;24(12) doi: 10.3390/ijms241210196. PMID: 37373339Free PMC Article
Wu X, Qian L, Zhao H, Lei W, Liu Y, Xu X, Li J, Yang Z, Wang D, Zhang Y, Zhang Y, Tang R, Yang Y, Tian Y
Ageing Res Rev 2023 Jan;83:101809. Epub 2022 Nov 25 doi: 10.1016/j.arr.2022.101809. PMID: 36442720
Campo I, Zorzetto M, Bonella F
Expert Rev Respir Med 2015 Aug;9(4):437-57. Epub 2015 Jul 4 doi: 10.1586/17476348.2015.1062367. PMID: 26146183
Spagnolo P, Sverzellati N, Rossi G, Cavazza A, Tzouvelekis A, Crestani B, Vancheri C
Ann Med 2015 Feb;47(1):15-27. Epub 2015 Jan 22 doi: 10.3109/07853890.2014.982165. PMID: 25613170

Diagnosis

Belperio JA, Shaikh F, Abtin FG, Fishbein MC, Weigt SS, Saggar R, Lynch JP 3rd
JAMA 2022 Mar 1;327(9):856-867. doi: 10.1001/jama.2022.1570. PMID: 35230389
Campo I, Zorzetto M, Bonella F
Expert Rev Respir Med 2015 Aug;9(4):437-57. Epub 2015 Jul 4 doi: 10.1586/17476348.2015.1062367. PMID: 26146183
Spagnolo P, Sverzellati N, Rossi G, Cavazza A, Tzouvelekis A, Crestani B, Vancheri C
Ann Med 2015 Feb;47(1):15-27. Epub 2015 Jan 22 doi: 10.3109/07853890.2014.982165. PMID: 25613170
Sieminska A, Kuziemski K
Orphanet J Rare Dis 2014 Jul 11;9:106. doi: 10.1186/s13023-014-0106-8. PMID: 25011486Free PMC Article
Myers JL
Mod Pathol 2012 Jan;25 Suppl 1:S58-67. doi: 10.1038/modpathol.2011.152. PMID: 22214971

Therapy

Ntolios P, Steiropoulos P, Karpathiou G, Anevlavis S, Karampitsakos T, Bouros E, Froudarakis ME, Bouros D, Tzouvelekis A
BioDrugs 2020 Oct;34(5):543-556. doi: 10.1007/s40259-020-00437-8. PMID: 32894503
Vigeland CL, Hughes AH, Horton MR
Respir Med 2017 Feb;123:98-104. Epub 2016 Dec 24 doi: 10.1016/j.rmed.2016.12.016. PMID: 28137504
Spagnolo P, Sverzellati N, Rossi G, Cavazza A, Tzouvelekis A, Crestani B, Vancheri C
Ann Med 2015 Feb;47(1):15-27. Epub 2015 Jan 22 doi: 10.3109/07853890.2014.982165. PMID: 25613170
Gharaee-Kermani M, Hu B, Thannickal VJ, Phan SH, Gyetko MR
Expert Opin Emerg Drugs 2007 Nov;12(4):627-46. doi: 10.1517/14728214.12.4.627. PMID: 17979604
Churg A, Muller NL, Flint J, Wright JL
Am J Surg Pathol 2006 Feb;30(2):201-8. doi: 10.1097/01.pas.0000184806.38037.3c. PMID: 16434894

Prognosis

Lettieri S, Bertuccio FR, Del Frate L, Perrotta F, Corsico AG, Stella GM
Int J Mol Sci 2023 Dec 31;25(1) doi: 10.3390/ijms25010547. PMID: 38203718Free PMC Article
Drakopanagiotakis F, Markart P, Steiropoulos P
Int J Mol Sci 2023 Jun 15;24(12) doi: 10.3390/ijms241210196. PMID: 37373339Free PMC Article
Marquis KM, Hammer MM, Steinbrecher K, Henry TS, Lin CY, Shifren A, Raptis CA
Radiographics 2023 Jul;43(7):e220176. doi: 10.1148/rg.220176. PMID: 37289644
Campo I, Zorzetto M, Bonella F
Expert Rev Respir Med 2015 Aug;9(4):437-57. Epub 2015 Jul 4 doi: 10.1586/17476348.2015.1062367. PMID: 26146183
Sieminska A, Kuziemski K
Orphanet J Rare Dis 2014 Jul 11;9:106. doi: 10.1186/s13023-014-0106-8. PMID: 25011486Free PMC Article

Clinical prediction guides

Drakopanagiotakis F, Markart P, Steiropoulos P
Int J Mol Sci 2023 Jun 15;24(12) doi: 10.3390/ijms241210196. PMID: 37373339Free PMC Article
Garza-Castillon R, Bharat A
Curr Opin Anaesthesiol 2023 Feb 1;36(1):11-19. Epub 2022 Oct 27 doi: 10.1097/ACO.0000000000001203. PMID: 36302203
Belperio JA, Shaikh F, Abtin FG, Fishbein MC, Weigt SS, Saggar R, Lynch JP 3rd
JAMA 2022 Mar 1;327(9):856-867. doi: 10.1001/jama.2022.1570. PMID: 35230389
Shaikh F, Abtin FG, Lau R, Saggar R, Belperio JA, Lynch JP 3rd
Semin Respir Crit Care Med 2020 Oct;41(5):758-784. Epub 2020 Aug 10 doi: 10.1055/s-0040-1712534. PMID: 32777856
Campo I, Zorzetto M, Bonella F
Expert Rev Respir Med 2015 Aug;9(4):437-57. Epub 2015 Jul 4 doi: 10.1586/17476348.2015.1062367. PMID: 26146183

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