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Unresectable Angiosarcoma

MedGen UID:
1720178
•Concept ID:
C5239071
•
Neoplastic Process

Definition

An angiosarcoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Angiosarcoma

Professional guidelines

PubMed

A 14-year retrospective review of angiosarcoma: clinical characteristics, prognostic factors, and treatment outcomes with surgery and chemotherapy.
Fury MG, Antonescu CR, Van Zee KJ, Brennan MF, Maki RG
Cancer J 2005 May-Jun;11(3):241-7. doi: 10.1097/00130404-200505000-00011. PMID: 16053668

Recent clinical studies

Etiology

Definitive Radiotherapy Using Electron Beam and Intensity-modulated Radiotherapy for Unresectable Angiosarcoma of the Scalp.
Okano N, Yumisaki H, Saito S, Kubo N, Okada K, Kawamura H, Yasuda M, Ohno T
Anticancer Res 2022 Dec;42(12):5991-5997. doi: 10.21873/anticanres.16110. PMID: 36456135
Multicenter phase II trial (SWOG S1609, cohort 51) of ipilimumab and nivolumab in metastatic or unresectable angiosarcoma: a substudy of dual anti-CTLA-4 and anti-PD-1 blockade in rare tumors (DART).
Wagner MJ, Othus M, Patel SP, Ryan C, Sangal A, Powers B, Budd GT, Victor AI, Hsueh CT, Chugh R, Nair S, Leu KM, Agulnik M, Sharon E, Mayerson E, Plets M, Blanke C, Streicher H, Chae YK, Kurzrock R
J Immunother Cancer 2021 Aug;9(8) doi: 10.1136/jitc-2021-002990. PMID: 34380663Free PMC Article
An open-label single-arm phase II study of regorafenib for the treatment of angiosarcoma.
Agulnik M, Schulte B, Robinson S, Hirbe AC, Kozak K, Chawla SP, Attia S, Rademaker A, Zhang H, Abbinanti S, Cehic R, Monga V, Milhem M, Okuno S, Van Tine BA
Eur J Cancer 2021 Sep;154:201-208. Epub 2021 Jul 17 doi: 10.1016/j.ejca.2021.06.027. PMID: 34284255
A 14-year retrospective review of angiosarcoma: clinical characteristics, prognostic factors, and treatment outcomes with surgery and chemotherapy.
Fury MG, Antonescu CR, Van Zee KJ, Brennan MF, Maki RG
Cancer J 2005 May-Jun;11(3):241-7. doi: 10.1097/00130404-200505000-00011. PMID: 16053668

Diagnosis

Congenital angiosarcoma with transient response to paclitaxel.
Good AB, Nascimento A, Welker KM, Arndt CA
J Pediatr Hematol Oncol 2008 Jun;30(6):451-3. doi: 10.1097/MPH.0b013e31816916d1. PMID: 18525462
A 14-year retrospective review of angiosarcoma: clinical characteristics, prognostic factors, and treatment outcomes with surgery and chemotherapy.
Fury MG, Antonescu CR, Van Zee KJ, Brennan MF, Maki RG
Cancer J 2005 May-Jun;11(3):241-7. doi: 10.1097/00130404-200505000-00011. PMID: 16053668

Therapy

Definitive Radiotherapy Using Electron Beam and Intensity-modulated Radiotherapy for Unresectable Angiosarcoma of the Scalp.
Okano N, Yumisaki H, Saito S, Kubo N, Okada K, Kawamura H, Yasuda M, Ohno T
Anticancer Res 2022 Dec;42(12):5991-5997. doi: 10.21873/anticanres.16110. PMID: 36456135
Multicenter phase II trial (SWOG S1609, cohort 51) of ipilimumab and nivolumab in metastatic or unresectable angiosarcoma: a substudy of dual anti-CTLA-4 and anti-PD-1 blockade in rare tumors (DART).
Wagner MJ, Othus M, Patel SP, Ryan C, Sangal A, Powers B, Budd GT, Victor AI, Hsueh CT, Chugh R, Nair S, Leu KM, Agulnik M, Sharon E, Mayerson E, Plets M, Blanke C, Streicher H, Chae YK, Kurzrock R
J Immunother Cancer 2021 Aug;9(8) doi: 10.1136/jitc-2021-002990. PMID: 34380663Free PMC Article
An open-label single-arm phase II study of regorafenib for the treatment of angiosarcoma.
Agulnik M, Schulte B, Robinson S, Hirbe AC, Kozak K, Chawla SP, Attia S, Rademaker A, Zhang H, Abbinanti S, Cehic R, Monga V, Milhem M, Okuno S, Van Tine BA
Eur J Cancer 2021 Sep;154:201-208. Epub 2021 Jul 17 doi: 10.1016/j.ejca.2021.06.027. PMID: 34284255
Phase II trial of weekly paclitaxel for unresectable angiosarcoma: the ANGIOTAX Study.
Penel N, Bui BN, Bay JO, Cupissol D, Ray-Coquard I, Piperno-Neumann S, Kerbrat P, Fournier C, Taieb S, Jimenez M, Isambert N, Peyrade F, Chevreau C, Bompas E, Brain EG, Blay JY
J Clin Oncol 2008 Nov 10;26(32):5269-74. Epub 2008 Sep 22 doi: 10.1200/JCO.2008.17.3146. PMID: 18809609
A 14-year retrospective review of angiosarcoma: clinical characteristics, prognostic factors, and treatment outcomes with surgery and chemotherapy.
Fury MG, Antonescu CR, Van Zee KJ, Brennan MF, Maki RG
Cancer J 2005 May-Jun;11(3):241-7. doi: 10.1097/00130404-200505000-00011. PMID: 16053668

Prognosis

Congenital angiosarcoma with transient response to paclitaxel.
Good AB, Nascimento A, Welker KM, Arndt CA
J Pediatr Hematol Oncol 2008 Jun;30(6):451-3. doi: 10.1097/MPH.0b013e31816916d1. PMID: 18525462
A 14-year retrospective review of angiosarcoma: clinical characteristics, prognostic factors, and treatment outcomes with surgery and chemotherapy.
Fury MG, Antonescu CR, Van Zee KJ, Brennan MF, Maki RG
Cancer J 2005 May-Jun;11(3):241-7. doi: 10.1097/00130404-200505000-00011. PMID: 16053668
Cancer chemotherapy after solid organ transplantation.
Horn M, Phebus C, Blatt J
Cancer 1990 Oct 1;66(7):1468-71. doi: 10.1002/1097-0142(19901001)66:7<1468::aid-cncr2820660705>3.0.co;2-b. PMID: 2207997

Clinical prediction guides

Definitive Radiotherapy Using Electron Beam and Intensity-modulated Radiotherapy for Unresectable Angiosarcoma of the Scalp.
Okano N, Yumisaki H, Saito S, Kubo N, Okada K, Kawamura H, Yasuda M, Ohno T
Anticancer Res 2022 Dec;42(12):5991-5997. doi: 10.21873/anticanres.16110. PMID: 36456135
An open-label single-arm phase II study of regorafenib for the treatment of angiosarcoma.
Agulnik M, Schulte B, Robinson S, Hirbe AC, Kozak K, Chawla SP, Attia S, Rademaker A, Zhang H, Abbinanti S, Cehic R, Monga V, Milhem M, Okuno S, Van Tine BA
Eur J Cancer 2021 Sep;154:201-208. Epub 2021 Jul 17 doi: 10.1016/j.ejca.2021.06.027. PMID: 34284255

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