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Refractory Acute Biphenotypic Leukemia

MedGen UID:
1731320
•Concept ID:
C5420334
•
Neoplastic Process

Definition

Acute biphenotypic leukemia that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Acute Biphenotypic Leukemia

Professional guidelines

PubMed

Selective treatment of mixed-lineage leukemia leukemic stem cells through targeting glycogen synthase kinase 3 and the canonical Wnt/β-catenin pathway.
Fung TK, Gandillet A, So CW
Curr Opin Hematol 2012 Jul;19(4):280-6. doi: 10.1097/MOH.0b013e3283545615. PMID: 22525581
4-demethoxydaunorubicin (idarubicin) in combination with 1-beta-D-arabinofuranosylcytosine in the treatment of relapsed or refractory acute leukemia.
Berman E, Raymond V, Daghestani A, Arlin ZA, Gee TS, Kempin S, Hancock C, Williams L, Stevens YW, Clarkson BD
Cancer Res 1989 Jan 15;49(2):477-81. PMID: 2910465

Recent clinical studies

Etiology

Phase 1 study of the histone deacetylase inhibitor entinostat plus clofarabine for poor-risk Philadelphia chromosome-negative (newly diagnosed older adults or adults with relapsed refractory disease) acute lymphoblastic leukemia or biphenotypic leukemia.
Carraway HE, Sawalha Y, Gojo I, Lee MJ, Lee S, Tomita Y, Yuno A, Greer J, Smith BD, Pratz KW, Levis MJ, Gore SD, Ghosh N, Dezern A, Blackford AL, Baer MR, Gore L, Piekarz R, Trepel JB, Karp JE
Leuk Res 2021 Nov;110:106707. Epub 2021 Sep 10 doi: 10.1016/j.leukres.2021.106707. PMID: 34563945Free PMC Article
Phase II trial of clofarabine with topotecan, vinorelbine, and thiotepa in pediatric patients with relapsed or refractory acute leukemia.
Shukla N, Kobos R, Renaud T, Steinherz LJ, Steinherz PG
Pediatr Blood Cancer 2014 Mar;61(3):431-5. Epub 2013 Sep 24 doi: 10.1002/pbc.24789. PMID: 24115731
A Phase 1 and pharmacokinetic clinical trial of paclitaxel for the treatment of refractory leukemia in children: a Children's Oncology Group study.
Horton TM, Ames MM, Reid JM, Krailo MD, Pendergrass T, Mosher R, Reaman GH, Seibel NL; Children's Oncology Group
Pediatr Blood Cancer 2008 Apr;50(4):788-92. doi: 10.1002/pbc.21310. PMID: 17668866Free PMC Article
Early stem cell transplantation for refractory acute leukemia after salvage therapy with high-dose etoposide and cyclophosphamide.
Johny A, Song KW, Nantel SH, Lavoie JC, Toze CL, Hogge DE, Forrest DL, Sutherland HJ, Le A, Nitta JY, Barnett MJ, Smith CA, Shepherd JD, Nevill TJ
Biol Blood Marrow Transplant 2006 Apr;12(4):480-9. doi: 10.1016/j.bbmt.2005.12.031. PMID: 16545732
FLAG (fludarabine, high-dose cytarabine, and G-CSF) for refractory and high-risk relapsed acute leukemia in children.
McCarthy AJ, Pitcher LA, Hann IM, Oakhill A
Med Pediatr Oncol 1999 Jun;32(6):411-5. doi: 10.1002/(sici)1096-911x(199906)32:6<411::aid-mpo3>3.0.co;2-k. PMID: 10358698

Diagnosis

Phase 1 study of the histone deacetylase inhibitor entinostat plus clofarabine for poor-risk Philadelphia chromosome-negative (newly diagnosed older adults or adults with relapsed refractory disease) acute lymphoblastic leukemia or biphenotypic leukemia.
Carraway HE, Sawalha Y, Gojo I, Lee MJ, Lee S, Tomita Y, Yuno A, Greer J, Smith BD, Pratz KW, Levis MJ, Gore SD, Ghosh N, Dezern A, Blackford AL, Baer MR, Gore L, Piekarz R, Trepel JB, Karp JE
Leuk Res 2021 Nov;110:106707. Epub 2021 Sep 10 doi: 10.1016/j.leukres.2021.106707. PMID: 34563945Free PMC Article
High-dose etoposide and cyclophosphamide in adults and children with primary refractory and multiply relapsed acute leukaemias: The Royal Marsden experience.
Carceller F, Hirsch SG, Khabra K, Petterson T, Malik R, Guerra-García P, Moreno L, Marshall LV, Taj M, Atra A, Ethell M, Potter M, Lancaster D
Leuk Res 2019 Oct;85:106217. Epub 2019 Aug 13 doi: 10.1016/j.leukres.2019.106217. PMID: 31493701
Active acute leukaemia: should transplant be offered to all patients?
Avni B, Shapira MY, Resnick IB, Stepensky P, Or R, Grisariu S
Hematol Oncol 2017 Dec;35(4):797-803. Epub 2016 Jun 24 doi: 10.1002/hon.2308. PMID: 27338621
Temozolomide and cisplatin in relapsed/refractory acute leukemia.
Seiter K, Katragadda S, Ponce D, Rasul M, Ahmed N
J Hematol Oncol 2009 May 22;2:21. doi: 10.1186/1756-8722-2-21. PMID: 19463179Free PMC Article
Pathologic diagnosis of acute lymphocytic leukemia.
Lai R, Hirsch-Ginsberg CF, Bueso-Ramos C
Hematol Oncol Clin North Am 2000 Dec;14(6):1209-35. doi: 10.1016/s0889-8588(05)70183-0. PMID: 11147220

Therapy

Phase 1 study of the histone deacetylase inhibitor entinostat plus clofarabine for poor-risk Philadelphia chromosome-negative (newly diagnosed older adults or adults with relapsed refractory disease) acute lymphoblastic leukemia or biphenotypic leukemia.
Carraway HE, Sawalha Y, Gojo I, Lee MJ, Lee S, Tomita Y, Yuno A, Greer J, Smith BD, Pratz KW, Levis MJ, Gore SD, Ghosh N, Dezern A, Blackford AL, Baer MR, Gore L, Piekarz R, Trepel JB, Karp JE
Leuk Res 2021 Nov;110:106707. Epub 2021 Sep 10 doi: 10.1016/j.leukres.2021.106707. PMID: 34563945Free PMC Article
Phase 1 study of belinostat (PXD-101) and bortezomib (Velcade, PS-341) in patients with relapsed or refractory acute leukemia and myelodysplastic syndrome.
Holkova B, Shafer D, Yazbeck V, Dave S, Bose P, Tombes MB, Shrader E, Wan W, Bandyopadhyay D, Weir C, Collins EB, Garnett A, Kmieciak M, Roberts JD, Garcia-Manero G, Grant S
Leuk Lymphoma 2021 May;62(5):1187-1194. Epub 2020 Dec 28 doi: 10.1080/10428194.2020.1861270. PMID: 33356689Free PMC Article
Outcomes of CAG regimen for refractory biphenotypic acute leukemia patients.
He GS, Zhang X, Wu DP, Sun AN, Jin ZM, Qiu HY, Miao M, Tang XW, Fu ZZ, Han Y
Chin Med Sci J 2009 Sep;24(3):178-81. doi: 10.1016/s1001-9294(09)60085-7. PMID: 19848320
Temozolomide and cisplatin in relapsed/refractory acute leukemia.
Seiter K, Katragadda S, Ponce D, Rasul M, Ahmed N
J Hematol Oncol 2009 May 22;2:21. doi: 10.1186/1756-8722-2-21. PMID: 19463179Free PMC Article
Monoclonal antibodies in the study and therapy of hematopoietic cancers.
Matthews DC, Smith FO, Bernstein ID
Curr Opin Immunol 1992 Oct;4(5):641-6. doi: 10.1016/0952-7915(92)90040-l. PMID: 1418732

Prognosis

Phase 1 study of the histone deacetylase inhibitor entinostat plus clofarabine for poor-risk Philadelphia chromosome-negative (newly diagnosed older adults or adults with relapsed refractory disease) acute lymphoblastic leukemia or biphenotypic leukemia.
Carraway HE, Sawalha Y, Gojo I, Lee MJ, Lee S, Tomita Y, Yuno A, Greer J, Smith BD, Pratz KW, Levis MJ, Gore SD, Ghosh N, Dezern A, Blackford AL, Baer MR, Gore L, Piekarz R, Trepel JB, Karp JE
Leuk Res 2021 Nov;110:106707. Epub 2021 Sep 10 doi: 10.1016/j.leukres.2021.106707. PMID: 34563945Free PMC Article
Phase 1 study of belinostat (PXD-101) and bortezomib (Velcade, PS-341) in patients with relapsed or refractory acute leukemia and myelodysplastic syndrome.
Holkova B, Shafer D, Yazbeck V, Dave S, Bose P, Tombes MB, Shrader E, Wan W, Bandyopadhyay D, Weir C, Collins EB, Garnett A, Kmieciak M, Roberts JD, Garcia-Manero G, Grant S
Leuk Lymphoma 2021 May;62(5):1187-1194. Epub 2020 Dec 28 doi: 10.1080/10428194.2020.1861270. PMID: 33356689Free PMC Article
Blinatumomab-induced donor T-cell activation for post-stem cell transplant-relapsed acute CD19-positive biphenotypic leukemia.
Alcharakh M, Yun S, Dong Y, Vincelette ND, Daud M, Manzoor S, Riaz IB, Anwer F
Immunotherapy 2016 Jul;8(8):847-52. doi: 10.2217/imt-2015-0023. PMID: 27381683
Pathologic diagnosis of acute lymphocytic leukemia.
Lai R, Hirsch-Ginsberg CF, Bueso-Ramos C
Hematol Oncol Clin North Am 2000 Dec;14(6):1209-35. doi: 10.1016/s0889-8588(05)70183-0. PMID: 11147220
Monoclonal antibodies in the study and therapy of hematopoietic cancers.
Matthews DC, Smith FO, Bernstein ID
Curr Opin Immunol 1992 Oct;4(5):641-6. doi: 10.1016/0952-7915(92)90040-l. PMID: 1418732

Clinical prediction guides

Phase 1 study of belinostat (PXD-101) and bortezomib (Velcade, PS-341) in patients with relapsed or refractory acute leukemia and myelodysplastic syndrome.
Holkova B, Shafer D, Yazbeck V, Dave S, Bose P, Tombes MB, Shrader E, Wan W, Bandyopadhyay D, Weir C, Collins EB, Garnett A, Kmieciak M, Roberts JD, Garcia-Manero G, Grant S
Leuk Lymphoma 2021 May;62(5):1187-1194. Epub 2020 Dec 28 doi: 10.1080/10428194.2020.1861270. PMID: 33356689Free PMC Article
Active acute leukaemia: should transplant be offered to all patients?
Avni B, Shapira MY, Resnick IB, Stepensky P, Or R, Grisariu S
Hematol Oncol 2017 Dec;35(4):797-803. Epub 2016 Jun 24 doi: 10.1002/hon.2308. PMID: 27338621
Second reduced intensity conditioning allogeneic transplant as a rescue strategy for acute leukaemia patients who relapse after an initial RIC allogeneic transplantation: analysis of risk factors and treatment outcomes.
Vrhovac R, Labopin M, Ciceri F, Finke J, Holler E, Tischer J, Lioure B, Gribben J, Kanz L, Blaise D, Dreger P, Held G, Arnold R, Nagler A, Mohty M; Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT)
Bone Marrow Transplant 2016 Feb;51(2):186-93. Epub 2015 Oct 5 doi: 10.1038/bmt.2015.221. PMID: 26437057
Early stem cell transplantation for refractory acute leukemia after salvage therapy with high-dose etoposide and cyclophosphamide.
Johny A, Song KW, Nantel SH, Lavoie JC, Toze CL, Hogge DE, Forrest DL, Sutherland HJ, Le A, Nitta JY, Barnett MJ, Smith CA, Shepherd JD, Nevill TJ
Biol Blood Marrow Transplant 2006 Apr;12(4):480-9. doi: 10.1016/j.bbmt.2005.12.031. PMID: 16545732
Homoharringtonine is safe and effective for patients with acute myelogenous leukemia.
Feldman E, Arlin Z, Ahmed T, Mittelman A, Puccio C, Chun H, Cook P, Baskind P
Leukemia 1992 Nov;6(11):1185-8. PMID: 1434802

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