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Sinonasal Seromucinous Hamartoma

MedGen UID:
1736218
•Concept ID:
C5420041
•
Disease or Syndrome

Definition

A benign overgrowth of indigenous seromucinous glands of the nasal cavity and paranasal sinuses. (WHO 2017) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSinonasal Seromucinous Hamartoma

Recent clinical studies

Etiology

Transformation from Sinonasal Seromucinous Hamartoma to Adenocarcinoma: A Case Report.
Rengifo DA, Varadarajan VV, Lai J, Justice JM
ORL J Otorhinolaryngol Relat Spec 2021;83(6):478-480. Epub 2021 Jul 8 doi: 10.1159/000514641. PMID: 34237726
Sinonasal seromucinous hamartoma.
Huang YW, Kuo YJ, Ho CY, Lan MY
Eur Arch Otorhinolaryngol 2018 Mar;275(3):743-749. Epub 2018 Jan 30 doi: 10.1007/s00405-018-4885-8. PMID: 29380040
Olfactory Epithelial Hamartoma: A New Subtype of Sinonasal Hamartoma.
Kossai M, El Zein S, Wassef M, Guichard JP, Pouliquen C, Herman P, Vérillaud B, Classe M
Am J Surg Pathol 2018 Jan;42(1):9-17. doi: 10.1097/PAS.0000000000000967. PMID: 29076871
Low-Grade Epithelial Proliferations of the Sinonasal Tract.
Bullock MJ
Head Neck Pathol 2016 Mar;10(1):47-59. Epub 2016 Feb 1 doi: 10.1007/s12105-016-0691-z. PMID: 26830403Free PMC Article
Hamartomas, papillomas and adenocarcinomas of the sinonasal tract and nasopharynx.
Perez-Ordoñez B
J Clin Pathol 2009 Dec;62(12):1085-95. doi: 10.1136/jcp.2007.053702. PMID: 19946095

Diagnosis

Sinonasal seromucinous hamartoma.
Huang YW, Kuo YJ, Ho CY, Lan MY
Eur Arch Otorhinolaryngol 2018 Mar;275(3):743-749. Epub 2018 Jan 30 doi: 10.1007/s00405-018-4885-8. PMID: 29380040
Glandular Neoplasia of the Sinonasal Tract.
Stelow EB
Surg Pathol Clin 2017 Mar;10(1):89-102. doi: 10.1016/j.path.2016.10.004. PMID: 28153137
Low-Grade Epithelial Proliferations of the Sinonasal Tract.
Bullock MJ
Head Neck Pathol 2016 Mar;10(1):47-59. Epub 2016 Feb 1 doi: 10.1007/s12105-016-0691-z. PMID: 26830403Free PMC Article
Sinonasal seromucinous hamartoma: a review of the literature and a case report with focal myoepithelial cells.
Fleming KE, Perez-Ordoñez B, Nasser JG, Psooy B, Bullock MJ
Head Neck Pathol 2012 Sep;6(3):395-9. Epub 2012 Mar 6 doi: 10.1007/s12105-012-0339-6. PMID: 22392408Free PMC Article
Seromucinous hamartoma of the nasal cavity: a report of two cases and review of the literature.
Khan RA, Chernock RD, Lewis JS Jr
Head Neck Pathol 2011 Sep;5(3):241-7. Epub 2011 May 27 doi: 10.1007/s12105-011-0269-8. PMID: 21618016Free PMC Article

Prognosis

Immunohistochemical and genetic analysis of respiratory epithelial adenomatoid hamartomas and seromucinous hamartomas: are they precursor lesions to sinonasal low-grade tubulopapillary adenocarcinomas?
Baněčková M, Michal M, Laco J, Leivo I, Ptáková N, Horáková M, Michal M, Skálová A
Hum Pathol 2020 Mar;97:94-102. Epub 2019 Nov 5 doi: 10.1016/j.humpath.2019.09.018. PMID: 31698004
Seromucinous hamartoma of inferior turbinate: A case report.
Lee DH, Yoon TM, Lee JK, Lim SC
Medicine (Baltimore) 2018 Nov;97(45):e13022. doi: 10.1097/MD.0000000000013022. PMID: 30407294Free PMC Article
Sinonasal seromucinous hamartoma.
Huang YW, Kuo YJ, Ho CY, Lan MY
Eur Arch Otorhinolaryngol 2018 Mar;275(3):743-749. Epub 2018 Jan 30 doi: 10.1007/s00405-018-4885-8. PMID: 29380040
Olfactory Epithelial Hamartoma: A New Subtype of Sinonasal Hamartoma.
Kossai M, El Zein S, Wassef M, Guichard JP, Pouliquen C, Herman P, Vérillaud B, Classe M
Am J Surg Pathol 2018 Jan;42(1):9-17. doi: 10.1097/PAS.0000000000000967. PMID: 29076871
Hamartomas, papillomas and adenocarcinomas of the sinonasal tract and nasopharynx.
Perez-Ordoñez B
J Clin Pathol 2009 Dec;62(12):1085-95. doi: 10.1136/jcp.2007.053702. PMID: 19946095

Clinical prediction guides

Analysis of KRAS, BRAF, and EGFR mutational status in respiratory epithelial adenomatoid hamartoma (REAH).
Guimarães LM, Vieira TDS, De Marco LA, Thompson LDR, Gomes CC
J Oral Pathol Med 2023 Jul;52(6):548-553. Epub 2022 Dec 21 doi: 10.1111/jop.13394. PMID: 36504219
Immunohistochemical and genetic analysis of respiratory epithelial adenomatoid hamartomas and seromucinous hamartomas: are they precursor lesions to sinonasal low-grade tubulopapillary adenocarcinomas?
Baněčková M, Michal M, Laco J, Leivo I, Ptáková N, Horáková M, Michal M, Skálová A
Hum Pathol 2020 Mar;97:94-102. Epub 2019 Nov 5 doi: 10.1016/j.humpath.2019.09.018. PMID: 31698004
Olfactory Epithelial Hamartoma: A New Subtype of Sinonasal Hamartoma.
Kossai M, El Zein S, Wassef M, Guichard JP, Pouliquen C, Herman P, Vérillaud B, Classe M
Am J Surg Pathol 2018 Jan;42(1):9-17. doi: 10.1097/PAS.0000000000000967. PMID: 29076871

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