U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Refractory Acute Undifferentiated Leukemia

MedGen UID:
1741970
•Concept ID:
C5420238
•
Neoplastic Process

Definition

Acute undifferentiated leukemia that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Acute Undifferentiated Leukemia

Professional guidelines

PubMed

Galinpepimut-S (GPS): an investigational agent for the treatment of acute myeloid leukemia.
Jain AG, Talati C, Pinilla-Ibarz J
Expert Opin Investig Drugs 2021 Jun;30(6):595-601. Epub 2021 May 31 doi: 10.1080/13543784.2021.1928635. PMID: 34053383
FLAG-IDA in the treatment of refractory/relapsed acute leukaemias: single centre study.
Hashmi KU, Khan B, Ahmed P, Raza S, Hussain I, Mahmood A, Iqbal H, Malik HS, Anwar M
J Pak Med Assoc 2005 Jun;55(6):234-8. PMID: 16045091
Treatment of relapsed or refractory acute leukemia in childhood with bisantrene combined with high dose aracytine.
Leblanc T, Deméocq F, Leverger G, Baruchel A, Lemerle S, Vannier JP, Nelken B, Guillot T, Schaison G
Med Pediatr Oncol 1994;22(2):119-24. doi: 10.1002/mpo.2950220211. PMID: 8259097

Recent clinical studies

Etiology

Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia.
Isobe T, Takagi M, Sato-Otsubo A, Nishimura A, Nagae G, Yamagishi C, Tamura M, Tanaka Y, Asada S, Takeda R, Tsuchiya A, Wang X, Yoshida K, Nannya Y, Ueno H, Akazawa R, Kato I, Mikami T, Watanabe K, Sekiguchi M, Seki M, Kimura S, Hiwatari M, Kato M, Fukuda S, Tatsuno K, Tsutsumi S, Kanai A, Inaba T, Shiozawa Y, Shiraishi Y, Chiba K, Tanaka H, Kotecha RS, Cruickshank MN, Ishikawa F, Morio T, Eguchi M, Deguchi T, Kiyokawa N, Arakawa Y, Koh K, Aoki Y, Ishihara T, Tomizawa D, Miyamura T, Ishii E, Mizutani S, Wilson NK, Göttgens B, Miyano S, Kitamura T, Goyama S, Yokoyama A, Aburatani H, Ogawa S, Takita J
Nat Commun 2022 Aug 30;13(1):4501. doi: 10.1038/s41467-022-32266-4. PMID: 36042201Free PMC Article
Chronic neutrophilic leukemia (CNL): a clinical, pathologic and cytogenetic study.
Elliott MA, Dewald GW, Tefferi A, Hanson CA
Leukemia 2001 Jan;15(1):35-40. doi: 10.1038/sj.leu.2401993. PMID: 11243396
Treatment of relapsed or refractory acute leukemia in childhood with bisantrene combined with high dose aracytine.
Leblanc T, Deméocq F, Leverger G, Baruchel A, Lemerle S, Vannier JP, Nelken B, Guillot T, Schaison G
Med Pediatr Oncol 1994;22(2):119-24. doi: 10.1002/mpo.2950220211. PMID: 8259097
AMSA--a promising new agent in refractory acute leukemia.
Lawrence HJ, Ries CA, Reynolds RD, Lewis JP, Koretz MM, Torti FM
Cancer Treat Rep 1982 Jul;66(7):1475-8. PMID: 7046928
Phase II study of VM-26 in acute leukemia, neuroblastoma, and other refractory childhood malignancies: a report from the Children's Cancer Study Group.
Bleyer WA, Krivit W, Chard RL Jr, Hammond D
Cancer Treat Rep 1979 Jun;63(6):977-81. PMID: 380803

Diagnosis

Cardiac glycoside ouabain efficiently targets leukemic stem cell apoptotic machinery independent of cell differentiation status.
Poohadsuan J, O'Doherty GA, Owattanapanich W, Kungwankiattichai S, Rojanasakul Y, Issaragrisil S, Luanpitpong S
Cell Commun Signal 2023 Oct 12;21(1):283. doi: 10.1186/s12964-023-01317-8. PMID: 37828578Free PMC Article
Chronic neutrophilic leukemia (CNL): a clinical, pathologic and cytogenetic study.
Elliott MA, Dewald GW, Tefferi A, Hanson CA
Leukemia 2001 Jan;15(1):35-40. doi: 10.1038/sj.leu.2401993. PMID: 11243396
Cytogenetic and clinicobiological features of acute leukemia with stem cell phenotype: study of nine cases.
Cuneo A, Ferrant A, Michaux JL, Bosly A, Chatelain B, Stul M, Dal Cin P, Dierlamm J, Cassiman JJ, Hossfeld DK, Castoldi G, Van den Berghe H
Cancer Genet Cytogenet 1996 Nov;92(1):31-6. doi: 10.1016/s0165-4608(96)00127-6. PMID: 8956868
Treatment of relapsed or refractory acute leukemia in childhood with bisantrene combined with high dose aracytine.
Leblanc T, Deméocq F, Leverger G, Baruchel A, Lemerle S, Vannier JP, Nelken B, Guillot T, Schaison G
Med Pediatr Oncol 1994;22(2):119-24. doi: 10.1002/mpo.2950220211. PMID: 8259097
Acute undifferentiated leukemia with CD7+ and CD13+ immunophenotype. Lack of molecular lineage commitment and association with poor prognostic features.
Bassan R, Biondi A, Benvestito S, Tini ML, Abbate M, Viero P, Barbui T, Rambaldi A
Cancer 1992 Jan 15;69(2):396-404. doi: 10.1002/1097-0142(19920115)69:2<396::aid-cncr2820690220>3.0.co;2-e. PMID: 1370211

Therapy

Cardiac glycoside ouabain efficiently targets leukemic stem cell apoptotic machinery independent of cell differentiation status.
Poohadsuan J, O'Doherty GA, Owattanapanich W, Kungwankiattichai S, Rojanasakul Y, Issaragrisil S, Luanpitpong S
Cell Commun Signal 2023 Oct 12;21(1):283. doi: 10.1186/s12964-023-01317-8. PMID: 37828578Free PMC Article
Inhibitors of Chemoresistance Pathways in Combination with Ara-C to Overcome Multidrug Resistance in AML. A Mini Review.
Fajardo-Orduña GR, Ledesma-Martínez E, Aguiñiga-Sánchez I, Mora-García ML, Weiss-Steider B, Santiago-Osorio E
Int J Mol Sci 2021 May 7;22(9) doi: 10.3390/ijms22094955. PMID: 34066940Free PMC Article
Galinpepimut-S (GPS): an investigational agent for the treatment of acute myeloid leukemia.
Jain AG, Talati C, Pinilla-Ibarz J
Expert Opin Investig Drugs 2021 Jun;30(6):595-601. Epub 2021 May 31 doi: 10.1080/13543784.2021.1928635. PMID: 34053383
Treatment of refractory adult acute lymphocytic leukaemia and acute undifferentiated leukaemia with an anthracycline antibiotic and cytosine arabinoside.
Early AP, Preisler HD, Gottlieb AJ, Lanchant NA
Br J Haematol 1981 Jul;48(3):369-75. doi: 10.1111/j.1365-2141.1981.tb02728.x. PMID: 7259987
Combination 6-mercaptopurine-adriamycin in refractory adult acute leukemia.
Rodriguez V, Bodey GP, McCredie KB, Freireich EJ, Minow RA, Casey JH, Luna M
Clin Pharmacol Ther 1975 Oct;18(4):462-6. doi: 10.1002/cpt1975184462. PMID: 1100309

Prognosis

Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia.
Isobe T, Takagi M, Sato-Otsubo A, Nishimura A, Nagae G, Yamagishi C, Tamura M, Tanaka Y, Asada S, Takeda R, Tsuchiya A, Wang X, Yoshida K, Nannya Y, Ueno H, Akazawa R, Kato I, Mikami T, Watanabe K, Sekiguchi M, Seki M, Kimura S, Hiwatari M, Kato M, Fukuda S, Tatsuno K, Tsutsumi S, Kanai A, Inaba T, Shiozawa Y, Shiraishi Y, Chiba K, Tanaka H, Kotecha RS, Cruickshank MN, Ishikawa F, Morio T, Eguchi M, Deguchi T, Kiyokawa N, Arakawa Y, Koh K, Aoki Y, Ishihara T, Tomizawa D, Miyamura T, Ishii E, Mizutani S, Wilson NK, Göttgens B, Miyano S, Kitamura T, Goyama S, Yokoyama A, Aburatani H, Ogawa S, Takita J
Nat Commun 2022 Aug 30;13(1):4501. doi: 10.1038/s41467-022-32266-4. PMID: 36042201Free PMC Article
Chronic neutrophilic leukemia (CNL): a clinical, pathologic and cytogenetic study.
Elliott MA, Dewald GW, Tefferi A, Hanson CA
Leukemia 2001 Jan;15(1):35-40. doi: 10.1038/sj.leu.2401993. PMID: 11243396
Acute undifferentiated leukemia with CD7+ and CD13+ immunophenotype. Lack of molecular lineage commitment and association with poor prognostic features.
Bassan R, Biondi A, Benvestito S, Tini ML, Abbate M, Viero P, Barbui T, Rambaldi A
Cancer 1992 Jan 15;69(2):396-404. doi: 10.1002/1097-0142(19920115)69:2<396::aid-cncr2820690220>3.0.co;2-e. PMID: 1370211
Treatment of refractory adult acute lymphocytic leukaemia and acute undifferentiated leukaemia with an anthracycline antibiotic and cytosine arabinoside.
Early AP, Preisler HD, Gottlieb AJ, Lanchant NA
Br J Haematol 1981 Jul;48(3):369-75. doi: 10.1111/j.1365-2141.1981.tb02728.x. PMID: 7259987
Refractory acute leukaemia in adults treated with sequential colaspase and high-dose methotrexate.
Yap BS, McCredie KB, Benjamin RS, Bodey GP, Freireich EJ
Br Med J 1978 Sep 16;2(6140):791-3. doi: 10.1136/bmj.2.6140.791. PMID: 279387Free PMC Article

Clinical prediction guides

Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia.
Isobe T, Takagi M, Sato-Otsubo A, Nishimura A, Nagae G, Yamagishi C, Tamura M, Tanaka Y, Asada S, Takeda R, Tsuchiya A, Wang X, Yoshida K, Nannya Y, Ueno H, Akazawa R, Kato I, Mikami T, Watanabe K, Sekiguchi M, Seki M, Kimura S, Hiwatari M, Kato M, Fukuda S, Tatsuno K, Tsutsumi S, Kanai A, Inaba T, Shiozawa Y, Shiraishi Y, Chiba K, Tanaka H, Kotecha RS, Cruickshank MN, Ishikawa F, Morio T, Eguchi M, Deguchi T, Kiyokawa N, Arakawa Y, Koh K, Aoki Y, Ishihara T, Tomizawa D, Miyamura T, Ishii E, Mizutani S, Wilson NK, Göttgens B, Miyano S, Kitamura T, Goyama S, Yokoyama A, Aburatani H, Ogawa S, Takita J
Nat Commun 2022 Aug 30;13(1):4501. doi: 10.1038/s41467-022-32266-4. PMID: 36042201Free PMC Article
A phase I-II trial of escalating doses of mitoxantrone with fixed doses of cytarabine plus fludarabine as salvage therapy for patients with acute leukemia and the blastic phase of chronic myelogenous leukemia.
Koller CA, Kantarjian HM, Feldman EJ, O'Brien S, Rios MB, Estey E, Keating M
Cancer 1999 Dec 1;86(11):2246-51. doi: 10.1002/(sici)1097-0142(19991201)86:11<2246::aid-cncr11>3.0.co;2-i. PMID: 10590364
Cytogenetic and clinicobiological features of acute leukemia with stem cell phenotype: study of nine cases.
Cuneo A, Ferrant A, Michaux JL, Bosly A, Chatelain B, Stul M, Dal Cin P, Dierlamm J, Cassiman JJ, Hossfeld DK, Castoldi G, Van den Berghe H
Cancer Genet Cytogenet 1996 Nov;92(1):31-6. doi: 10.1016/s0165-4608(96)00127-6. PMID: 8956868
CD33+ B-cell precursor acute lymphoblastic leukemia in children: a distinct subgroup of B-cell precursor acute lymphoblastic leukemia.
Hara J, Hosoi G, Okamura T, Osugi Y, Ishihara S, Yumura-Yagi K, Kawa-Ha K, Tawa A
Int J Hematol 1995 Feb;61(2):77-84. doi: 10.1016/0925-5710(94)00348-i. PMID: 7734715
Phase II evaluation of diglycoaldehyde (Inox) in children with acute leukemia: a children's cancer study group report.
Higgins GR, Finklestein J, Krivit W, Hammond D
Cancer Treat Rep 1980 Apr-May;64(4-5):625-8. PMID: 7427952

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...