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Atypical Vascular Lesion of Breast

MedGen UID:
1744840
•Concept ID:
C5419511
•
Disease or Syndrome
Synonym: Atypical Vascular Proliferation of Breast

Definition

Benign vascular proliferations following external radiation for breast carcinoma. The lesions arise from the radiated skin and are papules, small vesicles, or erythematous ecchymotic plaques with prominent telangiectasias. There is an increased risk for subsequent development of angiosarcoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAtypical Vascular Lesion of Breast

Professional guidelines

PubMed

Low to Intermediate (Borderline) Grade Breast Spindle Cell Lesions on Needle Biopsy: Diagnostic Approach and Clinical Management.
Russell DH, Montgomery EA, Susnik B
Adv Anat Pathol 2022 Sep 1;29(5):309-323. Epub 2022 Jul 12 doi: 10.1097/PAP.0000000000000353. PMID: 35838633
Follow-up outcomes of benign vascular lesions of breast diagnosed on core needle biopsy: A study of 117 cases.
Zhang H, Han M, Varma K, Dabbs DJ
Breast J 2019 May;25(3):401-407. Epub 2019 Apr 18 doi: 10.1111/tbj.13233. PMID: 31001867
Diagnosis and management of benign, atypical, and indeterminate breast lesions detected on core needle biopsy.
Neal L, Sandhu NP, Hieken TJ, Glazebrook KN, Mac Bride MB, Dilaveri CA, Wahner-Roedler DL, Ghosh K, Visscher DW
Mayo Clin Proc 2014 Apr;89(4):536-47. doi: 10.1016/j.mayocp.2014.02.004. PMID: 24684875

Recent clinical studies

Etiology

Radiation Induced Atypical Vascular Lesion in the Breast.
Gotland N, Loya A, Lanng C, Rønning H, Tvedskov TF
Clin Breast Cancer 2022 Dec;22(8):e874-e876. Epub 2022 Aug 27 doi: 10.1016/j.clbc.2022.08.010. PMID: 36137938
Spectrum of imaging findings of papillary breast disease: A radiopathological review in a tertiary center.
Fadzli F, Rahmat K, Ramli MT, Rozalli FI, Hooi TK, Fadzli AN, Hoong SM, Ramli NM, Taib NAM
Medicine (Baltimore) 2021 Apr 23;100(16):e25297. doi: 10.1097/MD.0000000000025297. PMID: 33879660Free PMC Article
Vascular lesions of the breast.
Baker GM, Schnitt SJ
Semin Diagn Pathol 2017 Sep;34(5):410-419. Epub 2017 May 30 doi: 10.1053/j.semdp.2017.05.013. PMID: 28676174
Diagnosis and management of benign, atypical, and indeterminate breast lesions detected on core needle biopsy.
Neal L, Sandhu NP, Hieken TJ, Glazebrook KN, Mac Bride MB, Dilaveri CA, Wahner-Roedler DL, Ghosh K, Visscher DW
Mayo Clin Proc 2014 Apr;89(4):536-47. doi: 10.1016/j.mayocp.2014.02.004. PMID: 24684875
Precursors and preinvasive lesions of the breast: the role of molecular prognostic markers in the diagnostic and therapeutic dilemma.
Zagouri F, Sergentanis TN, Zografos GC
World J Surg Oncol 2007 May 31;5:57. doi: 10.1186/1477-7819-5-57. PMID: 17540032Free PMC Article

Diagnosis

Radiation Induced Atypical Vascular Lesion in the Breast.
Gotland N, Loya A, Lanng C, Rønning H, Tvedskov TF
Clin Breast Cancer 2022 Dec;22(8):e874-e876. Epub 2022 Aug 27 doi: 10.1016/j.clbc.2022.08.010. PMID: 36137938
Atypical vascular proliferations of the neck.
Wollina U, Schönlebe J, Koch A, Tirant M, Cardoso JC, Karadag AS
Wien Med Wochenschr 2021 Mar;171(3-4):57-60. Epub 2020 Aug 5 doi: 10.1007/s10354-020-00774-x. PMID: 32757107
Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.
Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889
Post-radiation vascular lesions of the breast.
Ronen S, Ivan D, Torres-Cabala CA, Curry JL, Tetzlaff MT, Aung PP, Nagarajan P, Suster S, Prieto VG
J Cutan Pathol 2019 Jan;46(1):52-58. Epub 2018 Nov 4 doi: 10.1111/cup.13363. PMID: 30251277
Vascular lesions of the breast.
Baker GM, Schnitt SJ
Semin Diagn Pathol 2017 Sep;34(5):410-419. Epub 2017 May 30 doi: 10.1053/j.semdp.2017.05.013. PMID: 28676174

Therapy

Post-radiotherapy vascular lesions of the breast: immunohistochemical and molecular features of 74 cases with long-term follow-up and literature review.
Corradini AG, Asioli S, Morandi L, Brotto M, Righi A, Iommi M, Agostinelli C, Rucci P, Asioli S, Sapino A, Viale G, Foschini MP
Histopathology 2020 Aug;77(2):293-302. Epub 2020 Jul 23 doi: 10.1111/his.14090. PMID: 32043616
Post-radiation vascular lesions of the breast.
Ronen S, Ivan D, Torres-Cabala CA, Curry JL, Tetzlaff MT, Aung PP, Nagarajan P, Suster S, Prieto VG
J Cutan Pathol 2019 Jan;46(1):52-58. Epub 2018 Nov 4 doi: 10.1111/cup.13363. PMID: 30251277
Angiosarcoma and atypical vascular lesions of the breast: diagnostic and prognostic role of MYC gene amplification and protein expression.
Fraga-Guedes C, André S, Mastropasqua MG, Botteri E, Toesca A, Rocha RM, Peradze N, Rotmensz N, Viale G, Veronesi P, Gobbi H
Breast Cancer Res Treat 2015 May;151(1):131-40. Epub 2015 Apr 19 doi: 10.1007/s10549-015-3379-2. PMID: 25893585
Post radiation skin tumors: basal cell carcinomas, squamous cell carcinomas and angiosarcomas. A review of this late effect of radiotherapy.
Cuperus E, Leguit R, Albregts M, Toonstra J
Eur J Dermatol 2013 Nov-Dec;23(6):749-57. doi: 10.1684/ejd.2013.2106. PMID: 24153098
Radiotherapy-associated atypical vascular lesions of the breast.
Uchin JM, Billings SD
J Cutan Pathol 2009 Jan;36(1):87-8. doi: 10.1111/j.1600-0560.2008.01211.x. PMID: 19125741

Prognosis

Benign Vascular Lesions of the Breast: A Clinical, Radiographic, and Pathologic Review.
Braun A, Solari M, Gattuso P, Agarwal I
Int J Surg Pathol 2023 Dec;31(8):1437-1448. Epub 2023 Apr 9 doi: 10.1177/10668969231160254. PMID: 37032453
Radiation Induced Atypical Vascular Lesion in the Breast.
Gotland N, Loya A, Lanng C, Rønning H, Tvedskov TF
Clin Breast Cancer 2022 Dec;22(8):e874-e876. Epub 2022 Aug 27 doi: 10.1016/j.clbc.2022.08.010. PMID: 36137938
Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.
Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889
Post-radiation vascular lesions of the breast.
Ronen S, Ivan D, Torres-Cabala CA, Curry JL, Tetzlaff MT, Aung PP, Nagarajan P, Suster S, Prieto VG
J Cutan Pathol 2019 Jan;46(1):52-58. Epub 2018 Nov 4 doi: 10.1111/cup.13363. PMID: 30251277
Vascular lesions of the breast.
Baker GM, Schnitt SJ
Semin Diagn Pathol 2017 Sep;34(5):410-419. Epub 2017 May 30 doi: 10.1053/j.semdp.2017.05.013. PMID: 28676174

Clinical prediction guides

Clinicopathologic and immunohistochemical study of breast angiosarcoma.
Yan M, Gilmore H, Bomeisl P, Harbhajanka A
Ann Diagn Pathol 2021 Oct;54:151795. Epub 2021 Jul 19 doi: 10.1016/j.anndiagpath.2021.151795. PMID: 34392127
Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.
Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889
Effectiveness of Superb Microvascular Imaging for the differentiation of intraductal breast lesions.
Bakdik S, Arslan S, Oncu F, Durmaz MS, Altunkeser A, Eryilmaz MA, Unlu Y
Med Ultrason 2018 Aug 30;20(3):306-312. doi: 10.11152/mu-1433. PMID: 30167583
Vascular lesions of the breast.
Baker GM, Schnitt SJ
Semin Diagn Pathol 2017 Sep;34(5):410-419. Epub 2017 May 30 doi: 10.1053/j.semdp.2017.05.013. PMID: 28676174
Atypical vascular lesion of the breast.
Mandrell J, Mehta S, McClure S
J Am Acad Dermatol 2010 Aug;63(2):337-40. doi: 10.1016/j.jaad.2009.08.017. PMID: 20138394

Recent systematic reviews

MYC gene amplification by fluorescence in situ hybridization and MYC protein expression by immunohistochemistry in the diagnosis of cutaneous angiosarcoma: Systematic review and appropriate use criteria.
Motaparthi K, Lauer SR, Patel RM, Vidal CI, Linos K
J Cutan Pathol 2021 Apr;48(4):578-586. Epub 2020 Nov 16 doi: 10.1111/cup.13912. PMID: 33128474
Granular cell tumor a study of 42 cases and systemic review of the literature.
Mobarki M, Dumollard JM, Dal Col P, Camy F, Peoc'h M, Karpathiou G
Pathol Res Pract 2020 Apr;216(4):152865. Epub 2020 Feb 12 doi: 10.1016/j.prp.2020.152865. PMID: 32089415

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