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Non-Severe Aplastic Anemia

MedGen UID:
1750439
•Concept ID:
C5400677
•
Disease or Syndrome
Synonyms: Moderate Aplastic Anemia; Non Severe Aplastic Anemia

Definition

Aplastic anemia that is characterized by bone marrow cellularity less than 30% and does not meet criteria for severe aplastic anemia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Severe Aplastic Anemia

Professional guidelines

PubMed

Efficacy of hematopoietic stem cell transplantation in the treatment of children with non-severe aplastic anemia.
Zhang M, Zhu G, Cai L, Yuan M, Wu R, Jia C, Wang B, Zheng J, Ma J, Qin M, Li S
Pediatr Transplant 2022 Nov;26(7):e14340. Epub 2022 Jun 23 doi: 10.1111/petr.14340. PMID: 35735259
Effective Tacrolimus Treatment for Patients with Non-Severe Aplastic Anemia That is Refractory/Intolerant to Cyclosporine A: A Retrospective Study.
Du Y, Huang Y, Zhou W, Liu X, Chen F, Yang C, Chen M, Ruan J, Han B
Drug Des Devel Ther 2020;14:5711-5719. Epub 2020 Dec 30 doi: 10.2147/DDDT.S275975. PMID: 33408460Free PMC Article

Recent clinical studies

Etiology

Comparison of anti-thymocyte globulin-based immunosuppressive therapy and allogeneic hematopoietic stem cell transplantation in patients with transfusion-dependent non-severe aplastic anaemia: a retrospective study from a single centre.
Shen Y, Li Y, Liu Q, Liu W, Yu Q, Hu H, Liu S, Dong J, Xu M, Hong Y, Chen Y, Deng S, Zhuang H, Hu Z, Lin S, Shen Y, Shen J, Zhou Y, Ye B, Wu D
Ann Med 2023;55(2):2271475. Epub 2023 Oct 23 doi: 10.1080/07853890.2023.2271475. PMID: 37871262Free PMC Article
Transfusion-dependent non-severe aplastic anemia: characteristics and outcomes in the clinic.
Zhang Y, He Y, Wang S, Sun J, Jia J, Gong Y, He G, Li J
Front Immunol 2023;14:1197982. Epub 2023 Jul 11 doi: 10.3389/fimmu.2023.1197982. PMID: 37497227Free PMC Article
Efficacy of hematopoietic stem cell transplantation in the treatment of children with non-severe aplastic anemia.
Zhang M, Zhu G, Cai L, Yuan M, Wu R, Jia C, Wang B, Zheng J, Ma J, Qin M, Li S
Pediatr Transplant 2022 Nov;26(7):e14340. Epub 2022 Jun 23 doi: 10.1111/petr.14340. PMID: 35735259
Abnormalities of quantities and functions of CD56bright natural killer cells in non-severe aplastic Anemia.
Li Y, Ding S, Liu C, Chen T, Liu H, Li L, Shao Z, Fu R
Hematology 2019 Dec;24(1):405-412. doi: 10.1080/16078454.2019.1590963. PMID: 30907293
Clinical course of non-severe aplastic anemia in adults.
Kwon JH, Kim I, Lee YG, Koh Y, Park HC, Song EY, Kim HK, Yoon SS, Lee DS, Park SS, Shin HY, Park S, Park MH, Ahn HS, Kim BK
Int J Hematol 2010 Jun;91(5):770-5. Epub 2010 Jun 5 doi: 10.1007/s12185-010-0601-1. PMID: 20524094

Diagnosis

Deciphering treatment patterns in non-severe/moderate aplastic anemia: an international observational study.
Fattizzo B, Gurnari C, Cassanello G, Bortolotti M, Awada H, Giammarco S, Consonni D, Sica S, Gandhi S, Trikha R, Large J, Salter S, Maciejewski JP, Barcellini W, Kulasekararaj AG
Leukemia 2023 Dec;37(12):2479-2485. Epub 2023 Oct 4 doi: 10.1038/s41375-023-02047-z. PMID: 37794100Free PMC Article
Avatrombopag, a promising novel thrombopoietin receptor agonist for refractory/relapsed/intolerant non-severe aplastic anemia: a phase 2 single-arm clinical trial.
Wan Z, Chen M, Han B
Ann Med 2023 Dec;55(1):2224044. doi: 10.1080/07853890.2023.2224044. PMID: 37318085Free PMC Article
Interferon-gamma and perforin-positive T cells in acquired aplastic anemia: implication in therapeutic response.
Sharma V, Kumar P, Kumar R, Chakraborty S, Namdeo M, Sazawal S, Kanga U, Seth T, Mitra DK
Clin Exp Immunol 2022 May 12;207(3):272-278. doi: 10.1093/cei/uxab006. PMID: 35553631Free PMC Article
Abnormalities of quantities and functions of CD56bright natural killer cells in non-severe aplastic Anemia.
Li Y, Ding S, Liu C, Chen T, Liu H, Li L, Shao Z, Fu R
Hematology 2019 Dec;24(1):405-412. doi: 10.1080/16078454.2019.1590963. PMID: 30907293
Clinical course of non-severe aplastic anemia in adults.
Kwon JH, Kim I, Lee YG, Koh Y, Park HC, Song EY, Kim HK, Yoon SS, Lee DS, Park SS, Shin HY, Park S, Park MH, Ahn HS, Kim BK
Int J Hematol 2010 Jun;91(5):770-5. Epub 2010 Jun 5 doi: 10.1007/s12185-010-0601-1. PMID: 20524094

Therapy

Comparison of anti-thymocyte globulin-based immunosuppressive therapy and allogeneic hematopoietic stem cell transplantation in patients with transfusion-dependent non-severe aplastic anaemia: a retrospective study from a single centre.
Shen Y, Li Y, Liu Q, Liu W, Yu Q, Hu H, Liu S, Dong J, Xu M, Hong Y, Chen Y, Deng S, Zhuang H, Hu Z, Lin S, Shen Y, Shen J, Zhou Y, Ye B, Wu D
Ann Med 2023;55(2):2271475. Epub 2023 Oct 23 doi: 10.1080/07853890.2023.2271475. PMID: 37871262Free PMC Article
Deciphering treatment patterns in non-severe/moderate aplastic anemia: an international observational study.
Fattizzo B, Gurnari C, Cassanello G, Bortolotti M, Awada H, Giammarco S, Consonni D, Sica S, Gandhi S, Trikha R, Large J, Salter S, Maciejewski JP, Barcellini W, Kulasekararaj AG
Leukemia 2023 Dec;37(12):2479-2485. Epub 2023 Oct 4 doi: 10.1038/s41375-023-02047-z. PMID: 37794100Free PMC Article
Transfusion-dependent non-severe aplastic anemia: characteristics and outcomes in the clinic.
Zhang Y, He Y, Wang S, Sun J, Jia J, Gong Y, He G, Li J
Front Immunol 2023;14:1197982. Epub 2023 Jul 11 doi: 10.3389/fimmu.2023.1197982. PMID: 37497227Free PMC Article
Avatrombopag, a promising novel thrombopoietin receptor agonist for refractory/relapsed/intolerant non-severe aplastic anemia: a phase 2 single-arm clinical trial.
Wan Z, Chen M, Han B
Ann Med 2023 Dec;55(1):2224044. doi: 10.1080/07853890.2023.2224044. PMID: 37318085Free PMC Article
Cyclosporine Therapy in Patients with Transfusion-independent Non-severe Aplastic Anemia: A Retrospective Analysis.
Matsuda K, Koya J, Arai S, Nakazaki K, Nakamura F, Kurokawa M
Intern Med 2019 Feb 1;58(3):355-360. Epub 2018 Aug 24 doi: 10.2169/internalmedicine.1372-18. PMID: 30146592Free PMC Article

Prognosis

Comparison of anti-thymocyte globulin-based immunosuppressive therapy and allogeneic hematopoietic stem cell transplantation in patients with transfusion-dependent non-severe aplastic anaemia: a retrospective study from a single centre.
Shen Y, Li Y, Liu Q, Liu W, Yu Q, Hu H, Liu S, Dong J, Xu M, Hong Y, Chen Y, Deng S, Zhuang H, Hu Z, Lin S, Shen Y, Shen J, Zhou Y, Ye B, Wu D
Ann Med 2023;55(2):2271475. Epub 2023 Oct 23 doi: 10.1080/07853890.2023.2271475. PMID: 37871262Free PMC Article
Deciphering treatment patterns in non-severe/moderate aplastic anemia: an international observational study.
Fattizzo B, Gurnari C, Cassanello G, Bortolotti M, Awada H, Giammarco S, Consonni D, Sica S, Gandhi S, Trikha R, Large J, Salter S, Maciejewski JP, Barcellini W, Kulasekararaj AG
Leukemia 2023 Dec;37(12):2479-2485. Epub 2023 Oct 4 doi: 10.1038/s41375-023-02047-z. PMID: 37794100Free PMC Article
Transfusion-dependent non-severe aplastic anemia: characteristics and outcomes in the clinic.
Zhang Y, He Y, Wang S, Sun J, Jia J, Gong Y, He G, Li J
Front Immunol 2023;14:1197982. Epub 2023 Jul 11 doi: 10.3389/fimmu.2023.1197982. PMID: 37497227Free PMC Article
Interferon-gamma and perforin-positive T cells in acquired aplastic anemia: implication in therapeutic response.
Sharma V, Kumar P, Kumar R, Chakraborty S, Namdeo M, Sazawal S, Kanga U, Seth T, Mitra DK
Clin Exp Immunol 2022 May 12;207(3):272-278. doi: 10.1093/cei/uxab006. PMID: 35553631Free PMC Article
Clinical course of non-severe aplastic anemia in adults.
Kwon JH, Kim I, Lee YG, Koh Y, Park HC, Song EY, Kim HK, Yoon SS, Lee DS, Park SS, Shin HY, Park S, Park MH, Ahn HS, Kim BK
Int J Hematol 2010 Jun;91(5):770-5. Epub 2010 Jun 5 doi: 10.1007/s12185-010-0601-1. PMID: 20524094

Clinical prediction guides

Comparison of anti-thymocyte globulin-based immunosuppressive therapy and allogeneic hematopoietic stem cell transplantation in patients with transfusion-dependent non-severe aplastic anaemia: a retrospective study from a single centre.
Shen Y, Li Y, Liu Q, Liu W, Yu Q, Hu H, Liu S, Dong J, Xu M, Hong Y, Chen Y, Deng S, Zhuang H, Hu Z, Lin S, Shen Y, Shen J, Zhou Y, Ye B, Wu D
Ann Med 2023;55(2):2271475. Epub 2023 Oct 23 doi: 10.1080/07853890.2023.2271475. PMID: 37871262Free PMC Article
Deciphering treatment patterns in non-severe/moderate aplastic anemia: an international observational study.
Fattizzo B, Gurnari C, Cassanello G, Bortolotti M, Awada H, Giammarco S, Consonni D, Sica S, Gandhi S, Trikha R, Large J, Salter S, Maciejewski JP, Barcellini W, Kulasekararaj AG
Leukemia 2023 Dec;37(12):2479-2485. Epub 2023 Oct 4 doi: 10.1038/s41375-023-02047-z. PMID: 37794100Free PMC Article
Interferon-gamma and perforin-positive T cells in acquired aplastic anemia: implication in therapeutic response.
Sharma V, Kumar P, Kumar R, Chakraborty S, Namdeo M, Sazawal S, Kanga U, Seth T, Mitra DK
Clin Exp Immunol 2022 May 12;207(3):272-278. doi: 10.1093/cei/uxab006. PMID: 35553631Free PMC Article
Interleukin-6 and Interleukin-8 Levels Correlate With the Severity of Aplastic Anemia in Children.
Gupta V, Kumar S, Sonowal R, Singh SK
J Pediatr Hematol Oncol 2017 Apr;39(3):214-216. doi: 10.1097/MPH.0000000000000724. PMID: 28060106
Natural history of transfusion-independent non-severe aplastic anemia in children.
Nishio N, Yagasaki H, Takahashi Y, Muramatsu H, Hama A, Yoshida N, Kudo K, Kojima S
Int J Hematol 2009 May;89(4):409-413. Epub 2009 Apr 3 doi: 10.1007/s12185-009-0302-9. PMID: 19343478

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