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Functioning Lung Carcinoid Tumor

MedGen UID:
1779281
•Concept ID:
C5447389
•
Neoplastic Process

Definition

A lung carcinoid tumor that is associated with carcinoid syndrome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFunctioning Lung Carcinoid Tumor

Professional guidelines

PubMed

Characterization, Prognosis, and Treatment of Patients With Metastatic Lung Carcinoid Tumors.
Robelin P, Hadoux J, Forestier J, Planchard D, Hervieu V, Berdelou A, Scoazec JY, Valette PJ, Leboulleux S, Ducreux M, Lombard-Bohas C, Baudin E, Walter T
J Thorac Oncol 2019 Jun;14(6):993-1002. Epub 2019 Feb 13 doi: 10.1016/j.jtho.2019.02.002. PMID: 30771520
Management of pulmonary neuroendocrine tumors.
Ramirez RA, Chauhan A, Gimenez J, Thomas KEH, Kokodis I, Voros BA
Rev Endocr Metab Disord 2017 Dec;18(4):433-442. doi: 10.1007/s11154-017-9429-9. PMID: 28868578
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366

Recent clinical studies

Etiology

Small-Cell Carcinoma of the Lung: What We Learned about It?
Righi L, Volante M, Papotti M
Acta Cytol 2022;66(4):257-268. Epub 2021 Nov 16 doi: 10.1159/000519688. PMID: 34784591
Recent advances and current controversies in lung neuroendocrine neoplasms(✰).
Metovic J, Bianchi F, Rossi G, Barella M, Sonzogni A, Harari S, Papotti M, Pelosi G
Semin Diagn Pathol 2021 Sep;38(5):90-97. Epub 2021 Mar 19 doi: 10.1053/j.semdp.2021.03.002. PMID: 33810912
Morphologic and molecular classification of lung neuroendocrine neoplasms.
Metovic J, Barella M, Bianchi F, Hofman P, Hofman V, Remmelink M, Kern I, Carvalho L, Pattini L, Sonzogni A, Veronesi G, Harari S, Forest F, Papotti M, Pelosi G
Virchows Arch 2021 Jan;478(1):5-19. Epub 2021 Jan 21 doi: 10.1007/s00428-020-03015-z. PMID: 33474631Free PMC Article
T-Cell-Inflamed Gene-Expression Profile, Programmed Death Ligand 1 Expression, and Tumor Mutational Burden Predict Efficacy in Patients Treated With Pembrolizumab Across 20 Cancers: KEYNOTE-028.
Ott PA, Bang YJ, Piha-Paul SA, Razak ARA, Bennouna J, Soria JC, Rugo HS, Cohen RB, O'Neil BH, Mehnert JM, Lopez J, Doi T, van Brummelen EMJ, Cristescu R, Yang P, Emancipator K, Stein K, Ayers M, Joe AK, Lunceford JK
J Clin Oncol 2019 Feb 1;37(4):318-327. Epub 2018 Dec 13 doi: 10.1200/JCO.2018.78.2276. PMID: 30557521
Causes of death and prognostic factors in multiple endocrine neoplasia type 1: a prospective study: comparison of 106 MEN1/Zollinger-Ellison syndrome patients with 1613 literature MEN1 patients with or without pancreatic endocrine tumors.
Ito T, Igarashi H, Uehara H, Berna MJ, Jensen RT
Medicine (Baltimore) 2013 May;92(3):135-181. doi: 10.1097/MD.0b013e3182954af1. PMID: 23645327Free PMC Article

Diagnosis

Small-Cell Carcinoma of the Lung: What We Learned about It?
Righi L, Volante M, Papotti M
Acta Cytol 2022;66(4):257-268. Epub 2021 Nov 16 doi: 10.1159/000519688. PMID: 34784591
Somatostatin Analogs in Clinical Practice: a Review.
Gomes-Porras M, Cárdenas-Salas J, Álvarez-Escolá C
Int J Mol Sci 2020 Feb 29;21(5) doi: 10.3390/ijms21051682. PMID: 32121432Free PMC Article
Management of pulmonary neuroendocrine tumors.
Ramirez RA, Chauhan A, Gimenez J, Thomas KEH, Kokodis I, Voros BA
Rev Endocr Metab Disord 2017 Dec;18(4):433-442. doi: 10.1007/s11154-017-9429-9. PMID: 28868578
Neuron-Specific Enolase as a Biomarker: Biochemical and Clinical Aspects.
Isgrò MA, Bottoni P, Scatena R
Adv Exp Med Biol 2015;867:125-43. doi: 10.1007/978-94-017-7215-0_9. PMID: 26530364
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366

Therapy

Serotonin Pathway in Cancer.
Balakrishna P, George S, Hatoum H, Mukherjee S
Int J Mol Sci 2021 Jan 28;22(3) doi: 10.3390/ijms22031268. PMID: 33525332Free PMC Article
Somatostatin Analogs in Clinical Practice: a Review.
Gomes-Porras M, Cárdenas-Salas J, Álvarez-Escolá C
Int J Mol Sci 2020 Feb 29;21(5) doi: 10.3390/ijms21051682. PMID: 32121432Free PMC Article
T-Cell-Inflamed Gene-Expression Profile, Programmed Death Ligand 1 Expression, and Tumor Mutational Burden Predict Efficacy in Patients Treated With Pembrolizumab Across 20 Cancers: KEYNOTE-028.
Ott PA, Bang YJ, Piha-Paul SA, Razak ARA, Bennouna J, Soria JC, Rugo HS, Cohen RB, O'Neil BH, Mehnert JM, Lopez J, Doi T, van Brummelen EMJ, Cristescu R, Yang P, Emancipator K, Stein K, Ayers M, Joe AK, Lunceford JK
J Clin Oncol 2019 Feb 1;37(4):318-327. Epub 2018 Dec 13 doi: 10.1200/JCO.2018.78.2276. PMID: 30557521
Advances in anti-IgE therapy.
Yalcin AD
Biomed Res Int 2015;2015:317465. Epub 2015 May 5 doi: 10.1155/2015/317465. PMID: 26075226Free PMC Article
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366

Prognosis

The single-cell transcriptional landscape of lung carcinoid tumors.
Bischoff P, Trinks A, Wiederspahn J, Obermayer B, Pett JP, Jurmeister P, Elsner A, Dziodzio T, Rückert JC, Neudecker J, Falk C, Beule D, Sers C, Morkel M, Horst D, Klauschen F, Blüthgen N
Int J Cancer 2022 Jun 15;150(12):2058-2071. Epub 2022 Mar 16 doi: 10.1002/ijc.33995. PMID: 35262195
Characterization, Prognosis, and Treatment of Patients With Metastatic Lung Carcinoid Tumors.
Robelin P, Hadoux J, Forestier J, Planchard D, Hervieu V, Berdelou A, Scoazec JY, Valette PJ, Leboulleux S, Ducreux M, Lombard-Bohas C, Baudin E, Walter T
J Thorac Oncol 2019 Jun;14(6):993-1002. Epub 2019 Feb 13 doi: 10.1016/j.jtho.2019.02.002. PMID: 30771520
T-Cell-Inflamed Gene-Expression Profile, Programmed Death Ligand 1 Expression, and Tumor Mutational Burden Predict Efficacy in Patients Treated With Pembrolizumab Across 20 Cancers: KEYNOTE-028.
Ott PA, Bang YJ, Piha-Paul SA, Razak ARA, Bennouna J, Soria JC, Rugo HS, Cohen RB, O'Neil BH, Mehnert JM, Lopez J, Doi T, van Brummelen EMJ, Cristescu R, Yang P, Emancipator K, Stein K, Ayers M, Joe AK, Lunceford JK
J Clin Oncol 2019 Feb 1;37(4):318-327. Epub 2018 Dec 13 doi: 10.1200/JCO.2018.78.2276. PMID: 30557521
Neuron-Specific Enolase as a Biomarker: Biochemical and Clinical Aspects.
Isgrò MA, Bottoni P, Scatena R
Adv Exp Med Biol 2015;867:125-43. doi: 10.1007/978-94-017-7215-0_9. PMID: 26530364
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366

Clinical prediction guides

Lung Neuroendocrine Tumors: How Does Molecular Profiling Help?
Sun TY, Hendifar A, Padda SK
Curr Oncol Rep 2022 Jul;24(7):819-824. Epub 2022 Mar 19 doi: 10.1007/s11912-022-01253-9. PMID: 35305210
Small-Cell Carcinoma of the Lung: What We Learned about It?
Righi L, Volante M, Papotti M
Acta Cytol 2022;66(4):257-268. Epub 2021 Nov 16 doi: 10.1159/000519688. PMID: 34784591
Characterization, Prognosis, and Treatment of Patients With Metastatic Lung Carcinoid Tumors.
Robelin P, Hadoux J, Forestier J, Planchard D, Hervieu V, Berdelou A, Scoazec JY, Valette PJ, Leboulleux S, Ducreux M, Lombard-Bohas C, Baudin E, Walter T
J Thorac Oncol 2019 Jun;14(6):993-1002. Epub 2019 Feb 13 doi: 10.1016/j.jtho.2019.02.002. PMID: 30771520
T-Cell-Inflamed Gene-Expression Profile, Programmed Death Ligand 1 Expression, and Tumor Mutational Burden Predict Efficacy in Patients Treated With Pembrolizumab Across 20 Cancers: KEYNOTE-028.
Ott PA, Bang YJ, Piha-Paul SA, Razak ARA, Bennouna J, Soria JC, Rugo HS, Cohen RB, O'Neil BH, Mehnert JM, Lopez J, Doi T, van Brummelen EMJ, Cristescu R, Yang P, Emancipator K, Stein K, Ayers M, Joe AK, Lunceford JK
J Clin Oncol 2019 Feb 1;37(4):318-327. Epub 2018 Dec 13 doi: 10.1200/JCO.2018.78.2276. PMID: 30557521
Molecular alterations of neuroendocrine tumours of the lung.
Rossi G, Bertero L, Marchiò C, Papotti M
Histopathology 2018 Jan;72(1):142-152. doi: 10.1111/his.13394. PMID: 29239031

Recent systematic reviews

An Assessment of Circulating Chromogranin A as a Biomarker of Bronchopulmonary Neuroendocrine Neoplasia: A Systematic Review and Meta-Analysis.
Malczewska A, Kidd M, Matar S, Kos-Kudła B, Bodei L, Oberg K, Modlin IM
Neuroendocrinology 2020;110(3-4):198-216. Epub 2019 Jul 5 doi: 10.1159/000500525. PMID: 31266019
The utility of 18F-FDG and 68Ga-DOTA-Peptide PET/CT in the evaluation of primary pulmonary carcinoid: A systematic review and meta-analysis.
Jiang Y, Hou G, Cheng W
Medicine (Baltimore) 2019 Mar;98(10):e14769. doi: 10.1097/MD.0000000000014769. PMID: 30855482Free PMC Article
Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia of the Lung (DIPNECH): Current Best Evidence.
Wirtschafter E, Walts AE, Liu ST, Marchevsky AM
Lung 2015 Oct;193(5):659-67. Epub 2015 Jun 24 doi: 10.1007/s00408-015-9755-1. PMID: 26104490
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366
Ectopic ACTH syndrome.
Isidori AM, Lenzi A
Arq Bras Endocrinol Metabol 2007 Nov;51(8):1217-25. doi: 10.1590/s0004-27302007000800007. PMID: 18209859

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