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FOXO1 Gene Rearrangement

MedGen UID:
1784359
•Concept ID:
C5212360
•
Cell or Molecular Dysfunction
Synonyms: FKH1 Gene Rearrangement; FKHR Gene Rearrangement; Forkhead Box O1 Gene Rearrangement; FOXO1 Rearrangement; FOXO1A Gene Rearrangement

Definition

A molecular abnormality indicating rearrangement of the FOXO1 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFOXO1 Gene Rearrangement

Professional guidelines

PubMed

Combined Treatment of MCF-7 Cells with AICAR and Methotrexate, Arrests Cell Cycle and Reverses Warburg Metabolism through AMP-Activated Protein Kinase (AMPK) and FOXO1.
Fodor T, Szántó M, Abdul-Rahman O, Nagy L, Dér Á, Kiss B, Bai P
PLoS One 2016;11(2):e0150232. Epub 2016 Feb 26 doi: 10.1371/journal.pone.0150232. PMID: 26919657Free PMC Article

Recent clinical studies

Diagnosis

Adult Primary Pineal Alveolar Rhabdomyosarcoma with FOXO1 Gene Rearrangement and OLIG2 Expression: A Rare Case Report and Literature Review.
Xie L, Wang W, Zhou H, Han Z, Xu J, Xu Z, Xiang J
Int J Surg Pathol 2022 Oct;30(7):769-775. Epub 2022 Feb 21 doi: 10.1177/10668969221080076. PMID: 35188829
Metastatic alveolar rhabdomyosarcoma on the fine-needle aspiration cytology of cervical lymph node in an elderly patient, with FISH confirmation: A case report.
Zhao Z, Takano A, Lim AST, Lim TH, Selvarajan S
Malays J Pathol 2020 Apr;42(1):115-119. PMID: 32342940
The comparative utility of fluorescence in situ hybridization and reverse transcription-polymerase chain reaction in the diagnosis of alveolar rhabdomyosarcoma.
Thway K, Wang J, Wren D, Dainton M, Gonzalez D, Swansbury J, Fisher C
Virchows Arch 2015 Aug;467(2):217-24. Epub 2015 Apr 26 doi: 10.1007/s00428-015-1777-9. PMID: 25912319

Prognosis

The comparative utility of fluorescence in situ hybridization and reverse transcription-polymerase chain reaction in the diagnosis of alveolar rhabdomyosarcoma.
Thway K, Wang J, Wren D, Dainton M, Gonzalez D, Swansbury J, Fisher C
Virchows Arch 2015 Aug;467(2):217-24. Epub 2015 Apr 26 doi: 10.1007/s00428-015-1777-9. PMID: 25912319

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