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Increased KCO

MedGen UID:
1787767
•Concept ID:
C5539543
•
Finding
HPO: HP:0033373

Definition

Increased diffusion capacity of the lung for carbon monoxide (CO) rate constant (efficiency index). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased KCO

Professional guidelines

PubMed

Impact of medical treatment on lung diffusion capacity in elderly patients with heart failure. Baseline characteristics and 1-year follow up after medical treatment.
Petersen CL, Kjaer A
Int J Cardiol 2005 Feb 28;98(3):453-7. doi: 10.1016/j.ijcard.2003.12.018. PMID: 15708179
Lung function changes and pulmonary complications in patients with stage III non-small cell lung cancer treated with gemcitabine/cisplatin as part of combined modality treatment.
Maas KW, van der Lee I, Bolt K, Zanen P, Lammers JW, Schramel FM
Lung Cancer 2003 Sep;41(3):345-51. doi: 10.1016/s0169-5002(03)00237-x. PMID: 12928125
Pulmonary complications after long term amiodarone treatment.
Roca J, Heras M, Rodriguez-Roisin R, Magriñà J, Xaubet A, Sanz G
Thorax 1992 May;47(5):372-6. doi: 10.1136/thx.47.5.372. PMID: 1609381Free PMC Article

Recent clinical studies

Etiology

Clinical and functional characteristics of individuals with alpha-1 antitrypsin deficiency: EARCO international registry.
Miravitlles M, Turner AM, Torres-Duran M, Tanash H, Rodríguez-García C, López-Campos JL, Chlumsky J, Guimaraes C, Rodríguez-Hermosa JL, Corsico A, Martinez-González C, Hernández-Pérez JM, Bustamante A, Parr DG, Casas-Maldonado F, Hecimovic A, Janssens W, Lara B, Barrecheguren M, González C, Stolk J, Esquinas C, Clarenbach CF
Respir Res 2022 Dec 16;23(1):352. doi: 10.1186/s12931-022-02275-4. PMID: 36527073Free PMC Article
Long-term care for people treated for cancer during childhood and adolescence.
Tonorezos ES, Cohn RJ, Glaser AW, Lewin J, Poon E, Wakefield CE, Oeffinger KC
Lancet 2022 Apr 16;399(10334):1561-1572. doi: 10.1016/S0140-6736(22)00460-3. PMID: 35430023Free PMC Article
The Short- and Long-Term Impact of Pulmonary Rehabilitation in Subjects with Sarcoidosis: A Prospective Study and Review of the Literature.
Guber E, Wand O, Epstein Shochet G, Romem A, Shitrit D
Respiration 2021;100(5):423-431. Epub 2021 Mar 30 doi: 10.1159/000514917. PMID: 33784708
Acute Effects of a Heat-Not-Burn Tobacco Product on Pulmonary Function.
Pataka A, Kotoulas S, Chatzopoulos E, Grigoriou I, Sapalidis K, Kosmidis C, Vagionas A, Perdikouri ΕI, Drevelegas K, Zarogoulidis P, Argyropoulou P
Medicina (Kaunas) 2020 Jun 12;56(6) doi: 10.3390/medicina56060292. PMID: 32545573Free PMC Article
Impaired lung transfer factor in fibromyalgia syndrome.
Rizzi M, Atzeni F, Airoldi A, Masala IF, Frassanito F, Salaffi F, Macaluso C, Sarzi-Puttini P
Clin Exp Rheumatol 2016 Mar-Apr;34(2 Suppl 96):S114-9. Epub 2016 Apr 22 PMID: 27157396

Diagnosis

Rapid Characterization of the Functional and Pharmacological Consequences of Cantú Syndrome K(ATP) Channel Mutations in Intact Cells.
Gao J, McClenaghan C, Matreyek KA, Grange DK, Nichols CG
J Pharmacol Exp Ther 2023 Sep;386(3):298-309. Epub 2023 Aug 1 doi: 10.1124/jpet.123.001659. PMID: 37527933Free PMC Article
Clinical and functional characteristics of individuals with alpha-1 antitrypsin deficiency: EARCO international registry.
Miravitlles M, Turner AM, Torres-Duran M, Tanash H, Rodríguez-García C, López-Campos JL, Chlumsky J, Guimaraes C, Rodríguez-Hermosa JL, Corsico A, Martinez-González C, Hernández-Pérez JM, Bustamante A, Parr DG, Casas-Maldonado F, Hecimovic A, Janssens W, Lara B, Barrecheguren M, González C, Stolk J, Esquinas C, Clarenbach CF
Respir Res 2022 Dec 16;23(1):352. doi: 10.1186/s12931-022-02275-4. PMID: 36527073Free PMC Article
Early respiratory diagnosis: benefits of enhanced lung function assessment.
Sylvester KP, Youngs L, Rutter MA, Beech R, Mahadeva R
BMJ Open Respir Res 2021 Jul;8(1) doi: 10.1136/bmjresp-2021-001012. PMID: 34312255Free PMC Article
Decreased Serum Sirtuin-1 in COPD.
Yanagisawa S, Papaioannou AI, Papaporfyriou A, Baker JR, Vuppusetty C, Loukides S, Barnes PJ, Ito K
Chest 2017 Aug;152(2):343-352. Epub 2017 May 12 doi: 10.1016/j.chest.2017.05.004. PMID: 28506610Free PMC Article
Impaired lung transfer factor in fibromyalgia syndrome.
Rizzi M, Atzeni F, Airoldi A, Masala IF, Frassanito F, Salaffi F, Macaluso C, Sarzi-Puttini P
Clin Exp Rheumatol 2016 Mar-Apr;34(2 Suppl 96):S114-9. Epub 2016 Apr 22 PMID: 27157396

Therapy

Clinical and functional characteristics of individuals with alpha-1 antitrypsin deficiency: EARCO international registry.
Miravitlles M, Turner AM, Torres-Duran M, Tanash H, Rodríguez-García C, López-Campos JL, Chlumsky J, Guimaraes C, Rodríguez-Hermosa JL, Corsico A, Martinez-González C, Hernández-Pérez JM, Bustamante A, Parr DG, Casas-Maldonado F, Hecimovic A, Janssens W, Lara B, Barrecheguren M, González C, Stolk J, Esquinas C, Clarenbach CF
Respir Res 2022 Dec 16;23(1):352. doi: 10.1186/s12931-022-02275-4. PMID: 36527073Free PMC Article
Opioid Prescribing and Use Among Cancer Survivors: A Mapping Review of Observational and Intervention Studies.
Check DK, Avecilla RAV, Mills C, Dinan MA, Kamal AH, Murphy B, Rezk S, Winn A, Oeffinger KC
J Pain Symptom Manage 2022 Apr;63(4):e397-e417. Epub 2021 Nov 5 doi: 10.1016/j.jpainsymman.2021.10.015. PMID: 34748896
Acute Effects of a Heat-Not-Burn Tobacco Product on Pulmonary Function.
Pataka A, Kotoulas S, Chatzopoulos E, Grigoriou I, Sapalidis K, Kosmidis C, Vagionas A, Perdikouri ΕI, Drevelegas K, Zarogoulidis P, Argyropoulou P
Medicina (Kaunas) 2020 Jun 12;56(6) doi: 10.3390/medicina56060292. PMID: 32545573Free PMC Article
Effect of salbutamol on the measurement of single-breath diffusing capacity.
Yang J, Stanton J, Wang L, Beckert L, Frampton C, Burton D, Swanney MP
Respirology 2013 Nov;18(8):1223-9. doi: 10.1111/resp.12125. PMID: 23701193
Reference values of diffusing capacity of non-smoking Chinese in Hong Kong.
Ip MS, Lam WK, Lai AY, Ko FW, Lau AC, Ling SO, Chan JW, Chan-Yeung MM; Hong Kong Thoracic Society
Respirology 2007 Jul;12(4):599-606. doi: 10.1111/j.1440-1843.2007.01084.x. PMID: 17587430

Prognosis

Obesity-related Changes in Diffusing Capacity and Transfer Coefficient of the Lung for Carbon Monoxide and Resulting Patterns of Abnormality across Reference Equations.
Holley AB, Carbone T, Holtzclaw AW, Huprikar NA, Wagner R, Morris MJ
Ann Am Thorac Soc 2023 Jul;20(7):969-975. doi: 10.1513/AnnalsATS.202207-640OC. PMID: 36763964
The Short- and Long-Term Impact of Pulmonary Rehabilitation in Subjects with Sarcoidosis: A Prospective Study and Review of the Literature.
Guber E, Wand O, Epstein Shochet G, Romem A, Shitrit D
Respiration 2021;100(5):423-431. Epub 2021 Mar 30 doi: 10.1159/000514917. PMID: 33784708
Decreased Serum Sirtuin-1 in COPD.
Yanagisawa S, Papaioannou AI, Papaporfyriou A, Baker JR, Vuppusetty C, Loukides S, Barnes PJ, Ito K
Chest 2017 Aug;152(2):343-352. Epub 2017 May 12 doi: 10.1016/j.chest.2017.05.004. PMID: 28506610Free PMC Article
Examination of the carbon monoxide diffusing capacity (DL(CO)) in relation to its KCO and VA components.
Hughes JM, Pride NB
Am J Respir Crit Care Med 2012 Jul 15;186(2):132-9. Epub 2012 Apr 26 doi: 10.1164/rccm.201112-2160CI. PMID: 22538804
Importance of adjusting carbon monoxide diffusing capacity (DLCO) and carbon monoxide transfer coefficient (KCO) for alveolar volume.
Johnson DC
Respir Med 2000 Jan;94(1):28-37. doi: 10.1053/rmed.1999.0740. PMID: 10714476

Clinical prediction guides

Clinical and functional characteristics of individuals with alpha-1 antitrypsin deficiency: EARCO international registry.
Miravitlles M, Turner AM, Torres-Duran M, Tanash H, Rodríguez-García C, López-Campos JL, Chlumsky J, Guimaraes C, Rodríguez-Hermosa JL, Corsico A, Martinez-González C, Hernández-Pérez JM, Bustamante A, Parr DG, Casas-Maldonado F, Hecimovic A, Janssens W, Lara B, Barrecheguren M, González C, Stolk J, Esquinas C, Clarenbach CF
Respir Res 2022 Dec 16;23(1):352. doi: 10.1186/s12931-022-02275-4. PMID: 36527073Free PMC Article
Older age at Fontan completion is associated with reduced lung volumes and increased lung reactance.
Laohachai K, Badal T, Thamrin C, Robinson PD, Kennedy B, Rice K, Selvadurai H, Weintraub R, Cordina R, d'Udekem Y, Ayer J
Int J Cardiol 2022 Oct 1;364:38-43. Epub 2022 Jun 14 doi: 10.1016/j.ijcard.2022.06.037. PMID: 35714716
Decreased Serum Sirtuin-1 in COPD.
Yanagisawa S, Papaioannou AI, Papaporfyriou A, Baker JR, Vuppusetty C, Loukides S, Barnes PJ, Ito K
Chest 2017 Aug;152(2):343-352. Epub 2017 May 12 doi: 10.1016/j.chest.2017.05.004. PMID: 28506610Free PMC Article
Impaired lung transfer factor in fibromyalgia syndrome.
Rizzi M, Atzeni F, Airoldi A, Masala IF, Frassanito F, Salaffi F, Macaluso C, Sarzi-Puttini P
Clin Exp Rheumatol 2016 Mar-Apr;34(2 Suppl 96):S114-9. Epub 2016 Apr 22 PMID: 27157396
Examination of the carbon monoxide diffusing capacity (DL(CO)) in relation to its KCO and VA components.
Hughes JM, Pride NB
Am J Respir Crit Care Med 2012 Jul 15;186(2):132-9. Epub 2012 Apr 26 doi: 10.1164/rccm.201112-2160CI. PMID: 22538804

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