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Chondrosarcoma, Grade 1

MedGen UID:
1790653
•Concept ID:
C5552785
•
Neoplastic Process

Definition

A locally aggressive, low grade chondrosarcoma arising in the medulla of bone or within the cartilaginous cap of a pre-existing osteochondroma in the axial skeleton. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChondrosarcoma, Grade 1

Professional guidelines

PubMed

Differential Diagnosis of Cartilaginous Lesions of Bone.
Suster D, Hung YP, Nielsen GP
Arch Pathol Lab Med 2020 Jan;144(1):71-82. doi: 10.5858/arpa.2019-0441-RA. PMID: 31877083
Chondroid Tumors as Incidental Findings and Differential Diagnosis between Enchondromas and Low-grade Chondrosarcomas.
Afonso PD, Isaac A, Villagrán JM
Semin Musculoskelet Radiol 2019 Feb;23(1):3-18. Epub 2019 Jan 30 doi: 10.1055/s-0038-1675550. PMID: 30699449
Grade 1 chondrosarcoma of bone: a diagnostic and treatment dilemma.
Randall RL, Gowski W
J Natl Compr Canc Netw 2005 Mar;3(2):149-56. doi: 10.6004/jnccn.2005.0011. PMID: 19817027

Recent clinical studies

Etiology

Long-term follow up of patients with low-grade chondrosarcoma in the appendicular skeleton treated by extended curettage and liquid nitrogen.
El Masry AM, Azmy SI, Mustafa MAR, Abdel Aal MM
Orthop Traumatol Surg Res 2023 May;109(3):103410. Epub 2022 Sep 16 doi: 10.1016/j.otsr.2022.103410. PMID: 36116704
Distinguishing Falcine Chondrosarcomas from Their Mimics and Management.
Omezine S, Bouali S, Taallah M, Zehani A, Kallel J, Jemel H
World Neurosurg 2018 Oct;118:279-283. Epub 2018 Jul 3 doi: 10.1016/j.wneu.2018.06.164. PMID: 30257291
Prevalence of cartilaginous tumours as an incidental finding on MRI of the knee.
Stomp W, Reijnierse M, Kloppenburg M, de Mutsert R, Bovée JV, den Heijer M, Bloem JL; NEO study group
Eur Radiol 2015 Dec;25(12):3480-7. Epub 2015 May 21 doi: 10.1007/s00330-015-3764-6. PMID: 25994192Free PMC Article
Intraosseous atypical chondroid tumor or chondrosarcoma grade 1 in patients with multiple osteochondromas.
Goud AL, Wuyts W, Bessems J, Bramer J, van der Woude HJ, Ham J
J Bone Joint Surg Am 2015 Jan 7;97(1):24-31. doi: 10.2106/JBJS.N.00121. PMID: 25568391
Oncological and functional results of cryosurgical therapy of enchondromas and chondrosarcomas grade 1.
van der Geest IC, de Valk MH, de Rooy JW, Pruszczynski M, Veth RP, Schreuder HW
J Surg Oncol 2008 Nov 1;98(6):421-6. doi: 10.1002/jso.21122. PMID: 18668642

Diagnosis

Differential Diagnosis of Cartilaginous Lesions of Bone.
Suster D, Hung YP, Nielsen GP
Arch Pathol Lab Med 2020 Jan;144(1):71-82. doi: 10.5858/arpa.2019-0441-RA. PMID: 31877083
Non-squamous cell carcinoma diseases of the larynx: clinical and imaging findings.
Doğan S, Vural A, Kahriman G, İmamoğlu H, Abdülrezzak Ü, Öztürk M
Braz J Otorhinolaryngol 2020 Jul-Aug;86(4):468-482. Epub 2019 Mar 16 doi: 10.1016/j.bjorl.2019.02.003. PMID: 30956151Free PMC Article
Distinguishing Falcine Chondrosarcomas from Their Mimics and Management.
Omezine S, Bouali S, Taallah M, Zehani A, Kallel J, Jemel H
World Neurosurg 2018 Oct;118:279-283. Epub 2018 Jul 3 doi: 10.1016/j.wneu.2018.06.164. PMID: 30257291
Identification of novel biomarker candidates for immunohistochemical diagnosis to distinguish low-grade chondrosarcoma from enchondroma.
Lai X, Chen S
Proteomics 2015 Jul;15(13):2358-68. Epub 2015 Apr 24 doi: 10.1002/pmic.201400528. PMID: 25755173
Intraosseous atypical chondroid tumor or chondrosarcoma grade 1 in patients with multiple osteochondromas.
Goud AL, Wuyts W, Bessems J, Bramer J, van der Woude HJ, Ham J
J Bone Joint Surg Am 2015 Jan 7;97(1):24-31. doi: 10.2106/JBJS.N.00121. PMID: 25568391

Therapy

Long-term follow up of patients with low-grade chondrosarcoma in the appendicular skeleton treated by extended curettage and liquid nitrogen.
El Masry AM, Azmy SI, Mustafa MAR, Abdel Aal MM
Orthop Traumatol Surg Res 2023 May;109(3):103410. Epub 2022 Sep 16 doi: 10.1016/j.otsr.2022.103410. PMID: 36116704
Computer-assisted surgery compared to fluoroscopy in curettage of atypical cartilaginous tumors / chondrosarcoma grade 1 in the long bones.
Gerbers JG, Dierselhuis EF, Stevens M, Ploegmakers JJW, Bulstra SK, Jutte PC
PLoS One 2018;13(5):e0197033. Epub 2018 May 17 doi: 10.1371/journal.pone.0197033. PMID: 29771927Free PMC Article
Local Treatment with Adjuvant Therapy for Central Atypical Cartilaginous Tumors in the Long Bones: Analysis of Outcome and Complications in One Hundred and Eight Patients with a Minimum Follow-up of Two Years.
Dierselhuis EF, Gerbers JG, Ploegmakers JJ, Stevens M, Suurmeijer AJ, Jutte PC
J Bone Joint Surg Am 2016 Feb 17;98(4):303-13. doi: 10.2106/JBJS.O.00472. PMID: 26888678
Oncological and functional results of cryosurgical therapy of enchondromas and chondrosarcomas grade 1.
van der Geest IC, de Valk MH, de Rooy JW, Pruszczynski M, Veth RP, Schreuder HW
J Surg Oncol 2008 Nov 1;98(6):421-6. doi: 10.1002/jso.21122. PMID: 18668642

Prognosis

Long-term follow up of patients with low-grade chondrosarcoma in the appendicular skeleton treated by extended curettage and liquid nitrogen.
El Masry AM, Azmy SI, Mustafa MAR, Abdel Aal MM
Orthop Traumatol Surg Res 2023 May;109(3):103410. Epub 2022 Sep 16 doi: 10.1016/j.otsr.2022.103410. PMID: 36116704
Distinguishing Falcine Chondrosarcomas from Their Mimics and Management.
Omezine S, Bouali S, Taallah M, Zehani A, Kallel J, Jemel H
World Neurosurg 2018 Oct;118:279-283. Epub 2018 Jul 3 doi: 10.1016/j.wneu.2018.06.164. PMID: 30257291
Local Treatment with Adjuvant Therapy for Central Atypical Cartilaginous Tumors in the Long Bones: Analysis of Outcome and Complications in One Hundred and Eight Patients with a Minimum Follow-up of Two Years.
Dierselhuis EF, Gerbers JG, Ploegmakers JJ, Stevens M, Suurmeijer AJ, Jutte PC
J Bone Joint Surg Am 2016 Feb 17;98(4):303-13. doi: 10.2106/JBJS.O.00472. PMID: 26888678
Analysis of limb function after various reconstruction methods according to tumor location following resection of pediatric malignant bone tumors.
Yoshida Y, Osaka S, Tokuhashi Y
World J Surg Oncol 2010 May 19;8:39. doi: 10.1186/1477-7819-8-39. PMID: 20482815Free PMC Article
Oncological and functional results of cryosurgical therapy of enchondromas and chondrosarcomas grade 1.
van der Geest IC, de Valk MH, de Rooy JW, Pruszczynski M, Veth RP, Schreuder HW
J Surg Oncol 2008 Nov 1;98(6):421-6. doi: 10.1002/jso.21122. PMID: 18668642

Clinical prediction guides

Long-term follow up of patients with low-grade chondrosarcoma in the appendicular skeleton treated by extended curettage and liquid nitrogen.
El Masry AM, Azmy SI, Mustafa MAR, Abdel Aal MM
Orthop Traumatol Surg Res 2023 May;109(3):103410. Epub 2022 Sep 16 doi: 10.1016/j.otsr.2022.103410. PMID: 36116704
Differential Diagnosis of Cartilaginous Lesions of Bone.
Suster D, Hung YP, Nielsen GP
Arch Pathol Lab Med 2020 Jan;144(1):71-82. doi: 10.5858/arpa.2019-0441-RA. PMID: 31877083
Prevalence of cartilaginous tumours as an incidental finding on MRI of the knee.
Stomp W, Reijnierse M, Kloppenburg M, de Mutsert R, Bovée JV, den Heijer M, Bloem JL; NEO study group
Eur Radiol 2015 Dec;25(12):3480-7. Epub 2015 May 21 doi: 10.1007/s00330-015-3764-6. PMID: 25994192Free PMC Article
Oncological and functional results of cryosurgical therapy of enchondromas and chondrosarcomas grade 1.
van der Geest IC, de Valk MH, de Rooy JW, Pruszczynski M, Veth RP, Schreuder HW
J Surg Oncol 2008 Nov 1;98(6):421-6. doi: 10.1002/jso.21122. PMID: 18668642
PAS inclusions, immunoreactive tenascin and proliferative activity in low-grade chondrosarcomas.
Ranty ML, Michot C, Le Pessot F, Hellot MF, Biga N, Dujardin FH, Simonet J, Billerey C, Metayer J
Pathol Res Pract 2003;199(1):29-34. doi: 10.1078/0344-0338-00349. PMID: 12650515

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