U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Maximal Oxygen Uptake

MedGen UID:
1791333
•Concept ID:
C5554892
•
Finding
Synonyms: V'O2 Max; VO2 Max; VO2max

Definition

The point at which oxygen uptake no longer increases and beyond which no level of effort can raise it. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMaximal Oxygen Uptake

Professional guidelines

PubMed

Occam's razor at the sharp end: simplified preoperative risk assessment.
Davies SJ, Minto G
Br J Anaesth 2021 Jan;126(1):27-30. Epub 2020 Oct 21 doi: 10.1016/j.bja.2020.09.015. PMID: 33097181
Validity of oxygen uptake cut-off criteria in plateau identification during horizontal treadmill running.
Marsh CE
J Sports Med Phys Fitness 2019 Jan;59(1):10-16. Epub 2018 Jan 4 doi: 10.23736/S0022-4707.18.07952-5. PMID: 29308846
Criteria for maximal oxygen uptake: review and commentary.
Howley ET, Bassett DR Jr, Welch HG
Med Sci Sports Exerc 1995 Sep;27(9):1292-301. PMID: 8531628

Recent clinical studies

Etiology

Exploring shared genetics between maximal oxygen uptake and disease: the HUNT study.
Nordeidet AN, Klevjer M, Wisløff U, Langaas M, Bye A
Physiol Genomics 2023 Oct 1;55(10):440-451. Epub 2023 Aug 14 doi: 10.1152/physiolgenomics.00026.2023. PMID: 37575066
Maximal Oxygen Uptake and Ventilation Improvement Following Sacubitril-Valsartan Therapy.
Gonçalves AV, Pereira-da-Silva T, Galrinho A, Rio P, Soares R, Feliciano J, Moreira RI, Silva S, Alves S, Capilé E, Ferreira RC
Arq Bras Cardiol 2020 Nov;115(5):821-827. doi: 10.36660/abc.20190443. PMID: 33084746Free PMC Article
Contribution of oxygen extraction fraction to maximal oxygen uptake in healthy young men.
Skattebo Ø, Calbet JAL, Rud B, Capelli C, Hallén J
Acta Physiol (Oxf) 2020 Oct;230(2):e13486. Epub 2020 May 30 doi: 10.1111/apha.13486. PMID: 32365270Free PMC Article
Aerobic capacity as an indicator in different kinds of sports.
Rankovic G, Mutavdzic V, Toskic D, Preljevic A, Kocic M, Nedin Rankovic G, Damjanovic N
Bosn J Basic Med Sci 2010 Feb;10(1):44-8. doi: 10.17305/bjbms.2010.2734. PMID: 20192930Free PMC Article
Predictability of VO2 max from submaximal cycle ergometer and bench stepping tests.
Fitchett MA
Br J Sports Med 1985 Jun;19(2):85-8. doi: 10.1136/bjsm.19.2.85. PMID: 4027499Free PMC Article

Diagnosis

Reversing the Cardiac Effects of Sedentary Aging in Middle Age-A Randomized Controlled Trial: Implications For Heart Failure Prevention.
Howden EJ, Sarma S, Lawley JS, Opondo M, Cornwell W, Stoller D, Urey MA, Adams-Huet B, Levine BD
Circulation 2018 Apr 10;137(15):1549-1560. Epub 2018 Jan 8 doi: 10.1161/CIRCULATIONAHA.117.030617. PMID: 29311053Free PMC Article
A new submaximal cycle ergometer test for prediction of VO2max.
Ekblom-Bak E, Björkman F, Hellenius ML, Ekblom B
Scand J Med Sci Sports 2014 Apr;24(2):319-26. Epub 2012 Nov 6 doi: 10.1111/sms.12014. PMID: 23126417
Incremental exercise test design and analysis: implications for performance diagnostics in endurance athletes.
Bentley DJ, Newell J, Bishop D
Sports Med 2007;37(7):575-86. doi: 10.2165/00007256-200737070-00002. PMID: 17595153
Detraining: loss of training-induced physiological and performance adaptations. Part I: short term insufficient training stimulus.
Mujika I, Padilla S
Sports Med 2000 Aug;30(2):79-87. doi: 10.2165/00007256-200030020-00002. PMID: 10966148
Sports haematology.
Shaskey DJ, Green GA
Sports Med 2000 Jan;29(1):27-38. doi: 10.2165/00007256-200029010-00003. PMID: 10688281

Therapy

School-based physical activity programs for promoting physical activity and fitness in children and adolescents aged 6 to 18.
Neil-Sztramko SE, Caldwell H, Dobbins M
Cochrane Database Syst Rev 2021 Sep 23;9(9):CD007651. doi: 10.1002/14651858.CD007651.pub3. PMID: 34555181Free PMC Article
Caffeine Increases Exercise Performance, Maximal Oxygen Uptake, and Oxygen Deficit in Elite Male Endurance Athletes.
Stadheim HK, Stensrud T, Brage S, Jensen J
Med Sci Sports Exerc 2021 Nov 1;53(11):2264-2273. doi: 10.1249/MSS.0000000000002704. PMID: 34033621
Exercise and circulating cortisol levels: the intensity threshold effect.
Hill EE, Zack E, Battaglini C, Viru M, Viru A, Hackney AC
J Endocrinol Invest 2008 Jul;31(7):587-91. doi: 10.1007/BF03345606. PMID: 18787373
Maximal strength training improves running economy in distance runners.
Støren O, Helgerud J, Støa EM, Hoff J
Med Sci Sports Exerc 2008 Jun;40(6):1087-92. doi: 10.1249/MSS.0b013e318168da2f. PMID: 18460997
Aerobic high-intensity intervals improve VO2max more than moderate training.
Helgerud J, Høydal K, Wang E, Karlsen T, Berg P, Bjerkaas M, Simonsen T, Helgesen C, Hjorth N, Bach R, Hoff J
Med Sci Sports Exerc 2007 Apr;39(4):665-71. doi: 10.1249/mss.0b013e3180304570. PMID: 17414804

Prognosis

Performance Determinants in Trail-Running Races of Different Distances.
Pastor FS, Besson T, Varesco G, Parent A, Fanget M, Koral J, Foschia C, Rupp T, Rimaud D, Féasson L, Millet GY
Int J Sports Physiol Perform 2022 Jun 1;17(6):844-851. Epub 2022 Feb 25 doi: 10.1123/ijspp.2021-0362. PMID: 35213820
Survival of the fittest: VO(2)max, a key predictor of longevity?
Strasser B, Burtscher M
Front Biosci (Landmark Ed) 2018 Mar 1;23(8):1505-1516. doi: 10.2741/4657. PMID: 29293447
Biology of VO(2) max: looking under the physiology lamp.
Lundby C, Montero D, Joyner M
Acta Physiol (Oxf) 2017 Jun;220(2):218-228. Epub 2016 Nov 25 doi: 10.1111/apha.12827. PMID: 27888580
Incremental exercise test design and analysis: implications for performance diagnostics in endurance athletes.
Bentley DJ, Newell J, Bishop D
Sports Med 2007;37(7):575-86. doi: 10.2165/00007256-200737070-00002. PMID: 17595153
Predictability of VO2 max from submaximal cycle ergometer and bench stepping tests.
Fitchett MA
Br J Sports Med 1985 Jun;19(2):85-8. doi: 10.1136/bjsm.19.2.85. PMID: 4027499Free PMC Article

Clinical prediction guides

Performance Determinants in Trail-Running Races of Different Distances.
Pastor FS, Besson T, Varesco G, Parent A, Fanget M, Koral J, Foschia C, Rupp T, Rimaud D, Féasson L, Millet GY
Int J Sports Physiol Perform 2022 Jun 1;17(6):844-851. Epub 2022 Feb 25 doi: 10.1123/ijspp.2021-0362. PMID: 35213820
Prediction of Maximal Oxygen Uptake From Submaximal Exercise Testing in Chronic Respiratory Patients. New Perspectives.
Matabuena M, Hayes PR, Puente-Maestu L
Arch Bronconeumol (Engl Ed) 2019 Oct;55(10):507-508. Epub 2019 Feb 4 doi: 10.1016/j.arbres.2018.12.008. PMID: 30733131
Survival of the fittest: VO(2)max, a key predictor of longevity?
Strasser B, Burtscher M
Front Biosci (Landmark Ed) 2018 Mar 1;23(8):1505-1516. doi: 10.2741/4657. PMID: 29293447
A new submaximal cycle ergometer test for prediction of VO2max.
Ekblom-Bak E, Björkman F, Hellenius ML, Ekblom B
Scand J Med Sci Sports 2014 Apr;24(2):319-26. Epub 2012 Nov 6 doi: 10.1111/sms.12014. PMID: 23126417
Predictability of VO2 max from submaximal cycle ergometer and bench stepping tests.
Fitchett MA
Br J Sports Med 1985 Jun;19(2):85-8. doi: 10.1136/bjsm.19.2.85. PMID: 4027499Free PMC Article

Recent systematic reviews

School-based physical activity programs for promoting physical activity and fitness in children and adolescents aged 6 to 18.
Neil-Sztramko SE, Caldwell H, Dobbins M
Cochrane Database Syst Rev 2021 Sep 23;9(9):CD007651. doi: 10.1002/14651858.CD007651.pub3. PMID: 34555181Free PMC Article
Effect of different types of regular exercise on physical fitness in adults with overweight or obesity: Systematic review and meta-analyses.
van Baak MA, Pramono A, Battista F, Beaulieu K, Blundell JE, Busetto L, Carraça EV, Dicker D, Encantado J, Ermolao A, Farpour-Lambert N, Woodward E, Bellicha A, Oppert JM
Obes Rev 2021 Jul;22 Suppl 4(Suppl 4):e13239. Epub 2021 May 3 doi: 10.1111/obr.13239. PMID: 33939229Free PMC Article
Anthropometric and physiological characteristics of male soccer players according to their competitive level, playing position and age group: a systematic review.
Slimani M, Nikolaidis PT
J Sports Med Phys Fitness 2019 Jan;59(1):141-163. Epub 2017 Dec 1 doi: 10.23736/S0022-4707.17.07950-6. PMID: 29199782
Effects of Strength Training on the Physiological Determinants of Middle- and Long-Distance Running Performance: A Systematic Review.
Blagrove RC, Howatson G, Hayes PR
Sports Med 2018 May;48(5):1117-1149. doi: 10.1007/s40279-017-0835-7. PMID: 29249083Free PMC Article
The effect of strength training on performance in endurance athletes.
Beattie K, Kenny IC, Lyons M, Carson BP
Sports Med 2014 Jun;44(6):845-65. doi: 10.1007/s40279-014-0157-y. PMID: 24532151

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...