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Bladder Urothelial Carcinoma, High Grade

MedGen UID:
1792939
Concept ID:
C5556498
Neoplastic Process
Synonyms: Bladder Urothelial Carcinoma, High-Grade; High Grade Bladder Urothelial Carcinoma; High-Grade Bladder Urothelial Carcinoma

Definition

Bladder urothelial carcinoma characterized by the presence of neoplastic epithelial cells with high grade features. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Klaassen Z, Kamat AM, Kassouf W, Gontero P, Villavicencio H, Bellmunt J, van Rhijn BWG, Hartmann A, Catto JWF, Kulkarni GS
Eur Urol 2018 Nov;74(5):597-608. Epub 2018 Jul 13 doi: 10.1016/j.eururo.2018.06.024. PMID: 30017405

Recent clinical studies

Etiology

Paner GP, Kamat A, Netto GJ, Samaratunga H, Varma M, Bubendorf L, van der Kwast TH, Cheng L; Members of the ISUP Bladder Tumor Consensus Panel
Am J Surg Pathol 2024 Jan 1;48(1):e11-e23. Epub 2023 Jun 29 doi: 10.1097/PAS.0000000000002077. PMID: 37382156
Galiya R, Stanislav K, Jawdat J, Benjamin H, Boris C
J Pediatr Urol 2022 Dec;18(6):833.e1-833.e4. Epub 2022 Jun 30 doi: 10.1016/j.jpurol.2022.06.026. PMID: 35871900
Bajorin DF, Witjes JA, Gschwend JE, Schenker M, Valderrama BP, Tomita Y, Bamias A, Lebret T, Shariat SF, Park SH, Ye D, Agerbaek M, Enting D, McDermott R, Gajate P, Peer A, Milowsky MI, Nosov A, Neif Antonio J Jr, Tupikowski K, Toms L, Fischer BS, Qureshi A, Collette S, Unsal-Kacmaz K, Broughton E, Zardavas D, Koon HB, Galsky MD
N Engl J Med 2021 Jun 3;384(22):2102-2114. doi: 10.1056/NEJMoa2034442. PMID: 34077643Free PMC Article
Yip W, Ashrafi A, Daneshmand S
Curr Urol Rep 2019 Nov 28;20(12):79. doi: 10.1007/s11934-019-0945-x. PMID: 31781979
Reisz PA, Laviana AA, Chang SS
Curr Urol Rep 2018 Oct 26;19(12):103. doi: 10.1007/s11934-018-0850-8. PMID: 30367268

Diagnosis

Paner GP, Kamat A, Netto GJ, Samaratunga H, Varma M, Bubendorf L, van der Kwast TH, Cheng L; Members of the ISUP Bladder Tumor Consensus Panel
Am J Surg Pathol 2024 Jan 1;48(1):e11-e23. Epub 2023 Jun 29 doi: 10.1097/PAS.0000000000002077. PMID: 37382156
Galiya R, Stanislav K, Jawdat J, Benjamin H, Boris C
J Pediatr Urol 2022 Dec;18(6):833.e1-833.e4. Epub 2022 Jun 30 doi: 10.1016/j.jpurol.2022.06.026. PMID: 35871900
Dum D, Menz A, Völkel C, De Wispelaere N, Hinsch A, Gorbokon N, Lennartz M, Luebke AM, Hube-Magg C, Kluth M, Fraune C, Möller K, Bernreuther C, Lebok P, Clauditz TS, Jacobsen F, Sauter G, Uhlig R, Wilczak W, Steurer S, Minner S, Marx AH, Simon R, Burandt E, Krech T
Exp Mol Pathol 2022 Jun;126:104762. Epub 2022 Apr 4 doi: 10.1016/j.yexmp.2022.104762. PMID: 35390310
Xu H, Genega EM, Zhuang L, Zhou M
Int J Surg Pathol 2021 Oct;29(7):794-797. Epub 2021 Mar 18 doi: 10.1177/10668969211000428. PMID: 33733892
Cox RM, Magi-Galluzzi C, McKenney JK
Adv Anat Pathol 2018 Nov;25(6):387-399. doi: 10.1097/PAP.0000000000000205. PMID: 30157041

Therapy

Coleman JA, Yip W, Wong NC, Sjoberg DD, Bochner BH, Dalbagni G, Donat SM, Herr HW, Cha EK, Donahue TF, Pietzak EJ, Hakimi AA, Kim K, Al-Ahmadie HA, Vargas HA, Alvim RG, Ghafoor S, Benfante NE, Meraney AM, Shichman SJ, Kamradt JM, Nair SG, Baccala AA Jr, Palyca P, Lash BW, Rizvi MA, Swanson SK, Muina AF, Apolo AB, Iyer G, Rosenberg JE, Teo MY, Bajorin DF
J Clin Oncol 2023 Mar 10;41(8):1618-1625. Epub 2023 Jan 5 doi: 10.1200/JCO.22.00763. PMID: 36603175Free PMC Article
Padua TC, Moschini M, Martini A, Pederzoli F, Nocera L, Marandino L, Raggi D, Briganti A, Montorsi F, Necchi A
Urol Oncol 2022 Oct;40(10):413-423. Epub 2022 Aug 13 doi: 10.1016/j.urolonc.2022.07.006. PMID: 35973928
Bajorin DF, Witjes JA, Gschwend JE, Schenker M, Valderrama BP, Tomita Y, Bamias A, Lebret T, Shariat SF, Park SH, Ye D, Agerbaek M, Enting D, McDermott R, Gajate P, Peer A, Milowsky MI, Nosov A, Neif Antonio J Jr, Tupikowski K, Toms L, Fischer BS, Qureshi A, Collette S, Unsal-Kacmaz K, Broughton E, Zardavas D, Koon HB, Galsky MD
N Engl J Med 2021 Jun 3;384(22):2102-2114. doi: 10.1056/NEJMoa2034442. PMID: 34077643Free PMC Article
Reisz PA, Laviana AA, Chang SS
Curr Urol Rep 2018 Oct 26;19(12):103. doi: 10.1007/s11934-018-0850-8. PMID: 30367268
Sternberg CN, Skoneczna I, Kerst JM, Albers P, Fossa SD, Agerbaek M, Dumez H, de Santis M, Théodore C, Leahy MG, Chester JD, Verbaeys A, Daugaard G, Wood L, Witjes JA, de Wit R, Geoffrois L, Sengelov L, Thalmann G, Charpentier D, Rolland F, Mignot L, Sundar S, Symonds P, Graham J, Joly F, Marreaud S, Collette L, Sylvester R; European Organisation for Research and Treatment of Cancer Genito-Urinary Cancers Group; Groupe d'Etude des Tumeurs Urogénitales; National Cancer Research Institute Bladder Cancer Study Group; National Cancer Institute of Canada Clinical Trials Group; German Association of Urologic Oncology
Lancet Oncol 2015 Jan;16(1):76-86. Epub 2014 Dec 11 doi: 10.1016/S1470-2045(14)71160-X. PMID: 25498218

Prognosis

Paner GP, Kamat A, Netto GJ, Samaratunga H, Varma M, Bubendorf L, van der Kwast TH, Cheng L; Members of the ISUP Bladder Tumor Consensus Panel
Am J Surg Pathol 2024 Jan 1;48(1):e11-e23. Epub 2023 Jun 29 doi: 10.1097/PAS.0000000000002077. PMID: 37382156
Galiya R, Stanislav K, Jawdat J, Benjamin H, Boris C
J Pediatr Urol 2022 Dec;18(6):833.e1-833.e4. Epub 2022 Jun 30 doi: 10.1016/j.jpurol.2022.06.026. PMID: 35871900
Hurst CD, Knowles MA
Urol Oncol 2022 Jul;40(7):295-303. Epub 2018 Nov 13 doi: 10.1016/j.urolonc.2018.10.015. PMID: 30446444
Reisz PA, Laviana AA, Chang SS
Curr Urol Rep 2018 Oct 26;19(12):103. doi: 10.1007/s11934-018-0850-8. PMID: 30367268
Sylvester RJ, van der Meijden A, Witjes JA, Jakse G, Nonomura N, Cheng C, Torres A, Watson R, Kurth KH
Urology 2005 Dec;66(6 Suppl 1):90-107. doi: 10.1016/j.urology.2005.06.135. PMID: 16399418

Clinical prediction guides

Padua TC, Moschini M, Martini A, Pederzoli F, Nocera L, Marandino L, Raggi D, Briganti A, Montorsi F, Necchi A
Urol Oncol 2022 Oct;40(10):413-423. Epub 2022 Aug 13 doi: 10.1016/j.urolonc.2022.07.006. PMID: 35973928
Lopez-Beltran A, Blanca A, Cimadamore A, Montironi R, Luque RJ, Volavšek M, Cheng L
Virchows Arch 2022 May;480(5):989-998. Epub 2022 Feb 4 doi: 10.1007/s00428-021-03264-6. PMID: 35122124Free PMC Article
Mori K, Katayama S, Laukhtina E, Schuettfort VM, Pradere B, Quhal F, Sari Motlagh R, Mostafaei H, Grossmann NC, Rajwa P, Zimmermann K, Karakiewicz PI, Abufaraj M, Fajkovic H, Rouprêt M, Margulis V, Enikeev DV, Egawa S, Shariat SF
Clin Genitourin Cancer 2022 Feb;20(1):95.e1-95.e6. Epub 2021 Oct 10 doi: 10.1016/j.clgc.2021.10.002. PMID: 34764007
Park CK, Cho NH
Urol Oncol 2022 Mar;40(3):109.e1-109.e9. Epub 2021 Oct 16 doi: 10.1016/j.urolonc.2021.08.019. PMID: 34663543
Reisz PA, Laviana AA, Chang SS
Curr Urol Rep 2018 Oct 26;19(12):103. doi: 10.1007/s11934-018-0850-8. PMID: 30367268

Recent systematic reviews

Giulioni C, Brocca C, Tramanzoli P, Stramucci S, Mantovan M, Perpepaj L, Cicconofri A, Gauhar V, Merseburger AS, Galosi AB, Castellani D
World J Urol 2024 May 14;42(1):318. doi: 10.1007/s00345-024-05032-y. PMID: 38743260Free PMC Article
Wu Z, Chen Q, Qu L, Li M, Wang L, Mir MC, Carbonara U, Pandolfo SD, Black PC, Paul AK, Di Lorenzo G, Porpiglia F, Mari A, Necchi A, Rouprêt M, Psutka SP, Autorino R
Eur Urol 2022 Apr;81(4):414-425. Epub 2022 Jan 31 doi: 10.1016/j.eururo.2022.01.028. PMID: 35101302
Laukhtina E, Shim SR, Mori K, D'Andrea D, Soria F, Rajwa P, Mostafaei H, Compérat E, Cimadamore A, Moschini M, Teoh JY, Enikeev D, Xylinas E, Lotan Y, Palou J, Gontero P, Babjuk M, Witjes JA, Kamat AM, Roupret M, Shariat SF, Pradere B; European Association of Urology–Young Academic Urologists (EAU-YAU): Urothelial Carcinoma Working Group
Eur Urol Oncol 2021 Dec;4(6):927-942. Epub 2021 Nov 6 doi: 10.1016/j.euo.2021.10.003. PMID: 34753702
Izquierdo L, Bolton DM, Lawrentschuk N
Minerva Urol Nefrol 2013 Dec;65(4):225-34. PMID: 24091476
Palou J, Wood D, Bochner BH, van der Poel H, Al-Ahmadie HA, Yossepowitch O, Soloway MS, Jenkins LC; International Consultation on Urologic Disease-European Association of Urology Consultation on Bladder Cancer 2012
Eur Urol 2013 Jan;63(1):81-7. Epub 2012 Aug 14 doi: 10.1016/j.eururo.2012.08.011. PMID: 22938869

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