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Cranial Nerve II Palsy

MedGen UID:
1793216
•Concept ID:
C5556775
•
Disease or Syndrome
Synonyms: Optic Nerve Palsy; Second Cranial Nerve Palsy

Definition

Partial or complete paralysis of the optic nerve. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCranial Nerve II Palsy

Professional guidelines

PubMed

Neurofibromatosis Type II and Facial Paralysis: Clinical Evaluation and Management.
Mohanty AJ, DeVahl J, Kutz WJ, Rozen SM
Plast Reconstr Surg 2024 Feb 1;153(2):415e-423e. Epub 2023 Apr 20 doi: 10.1097/PRS.0000000000010561. PMID: 37075282
Diagnosis of idiopathic intracranial hypertension: A proposal for evidence-based diagnostic criteria.
Korsbæk JJ, Jensen RH, Høgedal L, Molander LD, Hagen SM, Beier D
Cephalalgia 2023 Mar;43(3):3331024231152795. doi: 10.1177/03331024231152795. PMID: 36786317
Clinical Features, Treatment and Outcome of Childhood Glial Tumors.
Kara B, Ertan K, Karabagli P, Karabagli H, Yavas G, Caglayan AO, Koksal Y
Turk Neurosurg 2022;32(1):135-142. doi: 10.5137/1019-5149.JTN.34801-21.2. PMID: 34751424

Recent clinical studies

Etiology

Cilta-cel or Standard Care in Lenalidomide-Refractory Multiple Myeloma.
San-Miguel J, Dhakal B, Yong K, Spencer A, Anguille S, Mateos MV, Fernández de Larrea C, Martínez-López J, Moreau P, Touzeau C, Leleu X, Avivi I, Cavo M, Ishida T, Kim SJ, Roeloffzen W, van de Donk NWCJ, Dytfeld D, Sidana S, Costa LJ, Oriol A, Popat R, Khan AM, Cohen YC, Ho PJ, Griffin J, Lendvai N, Lonardi C, Slaughter A, Schecter JM, Jackson CC, Connors K, Li K, Zudaire E, Chen D, Gilbert J, Yeh TM, Nagle S, Florendo E, Pacaud L, Patel N, Harrison SJ, Einsele H
N Engl J Med 2023 Jul 27;389(4):335-347. Epub 2023 Jun 5 doi: 10.1056/NEJMoa2303379. PMID: 37272512
Retinal Manifestations of Idiopathic Intracranial Hypertension.
Nichani P, Micieli JA
Ophthalmol Retina 2021 May;5(5):429-437. Epub 2020 Aug 26 doi: 10.1016/j.oret.2020.08.016. PMID: 32860958
Neurocutaneous melanocytosis (melanosis).
Ruggieri M, Polizzi A, Catanzaro S, Bianco ML, Praticò AD, Di Rocco C
Childs Nerv Syst 2020 Oct;36(10):2571-2596. Epub 2020 Oct 13 doi: 10.1007/s00381-020-04770-9. PMID: 33048248
Parasellar Meningiomas.
Graillon T, Regis J, Barlier A, Brue T, Dufour H, Buchfelder M
Neuroendocrinology 2020;110(9-10):780-796. Epub 2020 Jun 3 doi: 10.1159/000509090. PMID: 32492684
Oculomotor palsy in diabetics.
Lajmi H, Hmaied W, Ben Jalel W, Chelly Z, Ben Yakhlef A, Ben Zineb F, El Fekih L
J Fr Ophtalmol 2018 Jan;41(1):45-49. Epub 2017 Dec 28 doi: 10.1016/j.jfo.2017.06.010. PMID: 29290461

Diagnosis

Carbonic anhydrase II deficiency.
Whyte MP
Bone 2023 Apr;169:116684. Epub 2023 Jan 27 doi: 10.1016/j.bone.2023.116684. PMID: 36709914
Parasellar Meningiomas.
Graillon T, Regis J, Barlier A, Brue T, Dufour H, Buchfelder M
Neuroendocrinology 2020;110(9-10):780-796. Epub 2020 Jun 3 doi: 10.1159/000509090. PMID: 32492684
Neuro-Ophthalmic Manifestations of HIV Infection.
Gordon LK, Danesh-Meyer H
Ocul Immunol Inflamm 2020 Oct 2;28(7):1085-1093. Epub 2020 Jan 21 doi: 10.1080/09273948.2019.1704024. PMID: 31961200
MOG antibody-associated encephalomyelitis/encephalitis.
Salama S, Khan M, Pardo S, Izbudak I, Levy M
Mult Scler 2019 Oct;25(11):1427-1433. Epub 2019 Mar 25 doi: 10.1177/1352458519837705. PMID: 30907249Free PMC Article
Orbital apex syndrome.
Yeh S, Foroozan R
Curr Opin Ophthalmol 2004 Dec;15(6):490-8. doi: 10.1097/01.icu.0000144387.12739.9c. PMID: 15523194

Therapy

Benefit of high-dose oral riboflavin therapy in riboflavin transporter deficiency.
Fennessy JR, Cornett KMD, Burns J, Menezes MP
J Peripher Nerv Syst 2023 Sep;28(3):308-316. Epub 2023 Aug 24 doi: 10.1111/jns.12587. PMID: 37537696
Cilta-cel or Standard Care in Lenalidomide-Refractory Multiple Myeloma.
San-Miguel J, Dhakal B, Yong K, Spencer A, Anguille S, Mateos MV, Fernández de Larrea C, Martínez-López J, Moreau P, Touzeau C, Leleu X, Avivi I, Cavo M, Ishida T, Kim SJ, Roeloffzen W, van de Donk NWCJ, Dytfeld D, Sidana S, Costa LJ, Oriol A, Popat R, Khan AM, Cohen YC, Ho PJ, Griffin J, Lendvai N, Lonardi C, Slaughter A, Schecter JM, Jackson CC, Connors K, Li K, Zudaire E, Chen D, Gilbert J, Yeh TM, Nagle S, Florendo E, Pacaud L, Patel N, Harrison SJ, Einsele H
N Engl J Med 2023 Jul 27;389(4):335-347. Epub 2023 Jun 5 doi: 10.1056/NEJMoa2303379. PMID: 37272512
MOG antibody-associated encephalomyelitis/encephalitis.
Salama S, Khan M, Pardo S, Izbudak I, Levy M
Mult Scler 2019 Oct;25(11):1427-1433. Epub 2019 Mar 25 doi: 10.1177/1352458519837705. PMID: 30907249Free PMC Article
Neurological and Ophthalmological Manifestations of Varicella Zoster Virus.
Kedar S, Jayagopal LN, Berger JR
J Neuroophthalmol 2019 Jun;39(2):220-231. doi: 10.1097/WNO.0000000000000721. PMID: 30188405
Sarcoidosis and its neurological manifestations.
Stern BJ, Krumholz A, Johns C, Scott P, Nissim J
Arch Neurol 1985 Sep;42(9):909-17. doi: 10.1001/archneur.1985.04060080095022. PMID: 3896208

Prognosis

Neuro-ophthalmologic complications of coronavirus disease 2019 (COVID-19).
Gold DM, Galetta SL
Neurosci Lett 2021 Jan 18;742:135531. Epub 2020 Nov 25 doi: 10.1016/j.neulet.2020.135531. PMID: 33248158Free PMC Article
Neuro-Ophthalmic Manifestations of Sarcoidosis.
Henderson AD, Tian J, Carey AR
J Neuroophthalmol 2021 Dec 1;41(4):e591-e597. doi: 10.1097/WNO.0000000000001108. PMID: 33110001
Neuro-Ophthalmic Manifestations of Acute Leukemia.
Alrobaian MA, Henderson AD
J Neuroophthalmol 2021 Dec 1;41(4):e584-e590. doi: 10.1097/WNO.0000000000001071. PMID: 32868572
Retinal Manifestations of Idiopathic Intracranial Hypertension.
Nichani P, Micieli JA
Ophthalmol Retina 2021 May;5(5):429-437. Epub 2020 Aug 26 doi: 10.1016/j.oret.2020.08.016. PMID: 32860958
Oculomotor palsy in diabetics.
Lajmi H, Hmaied W, Ben Jalel W, Chelly Z, Ben Yakhlef A, Ben Zineb F, El Fekih L
J Fr Ophtalmol 2018 Jan;41(1):45-49. Epub 2017 Dec 28 doi: 10.1016/j.jfo.2017.06.010. PMID: 29290461

Clinical prediction guides

Osteopetrosis: Gene-based nosology and significance Dysosteosclerosis.
Turan S
Bone 2023 Feb;167:116615. Epub 2022 Nov 17 doi: 10.1016/j.bone.2022.116615. PMID: 36402365
COVID-19 and Eye: A Review of Ophthalmic Manifestations of COVID-19.
Sen M, Honavar SG, Sharma N, Sachdev MS
Indian J Ophthalmol 2021 Mar;69(3):488-509. doi: 10.4103/ijo.IJO_297_21. PMID: 33595463Free PMC Article
Retinal Manifestations of Idiopathic Intracranial Hypertension.
Nichani P, Micieli JA
Ophthalmol Retina 2021 May;5(5):429-437. Epub 2020 Aug 26 doi: 10.1016/j.oret.2020.08.016. PMID: 32860958
Parasellar Meningiomas.
Graillon T, Regis J, Barlier A, Brue T, Dufour H, Buchfelder M
Neuroendocrinology 2020;110(9-10):780-796. Epub 2020 Jun 3 doi: 10.1159/000509090. PMID: 32492684
Neuro-ophthalmologic exploration in non-functioning pituitary adenoma.
Abouaf L, Vighetto A, Lebas M
Ann Endocrinol (Paris) 2015 Jul;76(3):210-9. Epub 2015 Jun 10 doi: 10.1016/j.ando.2015.04.006. PMID: 26070465

Recent systematic reviews

Neuro-Ophthalmological Complications of the COVID-19 Vaccines: A Systematic Review.
Lotan I, Lydston M, Levy M
J Neuroophthalmol 2022 Jun 1;42(2):154-162. Epub 2022 Mar 25 doi: 10.1097/WNO.0000000000001537. PMID: 35427282
Efficacy of mycophenolate mofetil in the treatment of neuromyelitis optica spectrum disorders: An update systematic review and meta -analysis.
Wang Y, Ma J, Chang H, Zhang X, Yin L
Mult Scler Relat Disord 2021 Oct;55:103181. Epub 2021 Jul 31 doi: 10.1016/j.msard.2021.103181. PMID: 34365314
Efficacy of rituximab in the treatment of neuromyelitis optica spectrum disorders: An update systematic review and meta -analysis.
Wang Y, Chang H, Zhang X, Yin L
Mult Scler Relat Disord 2021 May;50:102843. Epub 2021 Feb 13 doi: 10.1016/j.msard.2021.102843. PMID: 33609924
Cranial Nerve Disorders Associated With Immune Checkpoint Inhibitors.
Vogrig A, Muñiz-Castrillo S, Joubert B, Picard G, Rogemond V, Skowron F, Egri M, Desestret V, Tilikete C, Psimaras D, Ducray F, Honnorat J
Neurology 2021 Feb 9;96(6):e866-e875. Epub 2020 Dec 14 doi: 10.1212/WNL.0000000000011340. PMID: 33318162
Central nervous system involvement in eosinophilic granulomatosis with polyangiitis (Churg-Strauss): Report of 26 patients and review of the literature.
André R, Cottin V, Saraux JL, Blaison G, Bienvenu B, Cathebras P, Dhote R, Foucher A, Gil H, Lapoirie J, Launay D, Loustau V, Maurier F, Pertuiset E, Zénone T, Seebach J, Costedoat-Chalumeau N, Puéchal X, Mouthon L, Guillevin L, Terrier B; French Vasculitis Study Group (FVSG)
Autoimmun Rev 2017 Sep;16(9):963-969. Epub 2017 Jul 12 doi: 10.1016/j.autrev.2017.07.007. PMID: 28709761

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