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Cartilaginous tracheobronchomalacia

MedGen UID:
1814106
•Concept ID:
C5558369
•
Disease or Syndrome
Synonym: Cartilaginous malacia
 
HPO: HP:0033990

Definition

Softening of the tracheal and/or bronchial cartilage resulting in segmental tracheal and/or bronchial weakness. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCartilaginous tracheobronchomalacia

Professional guidelines

PubMed

Tracheobronchomalacia, Tracheobronchial Compression, and Tracheobronchial Malformations: Diagnostic and Treatment Strategies.
Kamran A, Baird CW, Jennings RW
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2020;23:53-61. doi: 10.1053/j.pcsu.2020.02.006. PMID: 32354548
The dreaded desaturating baby: a difficult problem in clinical management.
Spitzer AR
Clin Perinatol 2007 Mar;34(1):55-71, vi. doi: 10.1016/j.clp.2006.12.013. PMID: 17394930
Treatment of adult tracheobronchomalacia and excessive dynamic airway collapse : an update.
Murgu SD, Colt HG
Treat Respir Med 2006;5(2):103-15. doi: 10.2165/00151829-200605020-00004. PMID: 16512691

Recent clinical studies

Etiology

Management of bronchomalacia in infants post-cardiac surgery using synchronized nasal DuoPAP: A novel technology.
Kumar A, Praveen M, Tiwari N, Ramamoorthy HR, Joshi A, Parikh B
Ann Card Anaesth 2022 Oct-Dec;25(4):531-535. doi: 10.4103/aca.aca_112_21. PMID: 36254924Free PMC Article
Reoperation to correct unsuccessful vascular ring and vascular decompression surgery.
Labuz DF, Kamran A, Jennings RW, Baird CW
J Thorac Cardiovasc Surg 2022 Jul;164(1):199-207. Epub 2021 Nov 11 doi: 10.1016/j.jtcvs.2021.08.089. PMID: 34922756
Pediatric airway surgery.
Maeda K
Pediatr Surg Int 2017 Apr;33(4):435-443. Epub 2017 Jan 28 doi: 10.1007/s00383-016-4050-7. PMID: 28132084
Tracheobronchomalacia: current concepts and controversies.
Ridge CA, O'donnell CR, Lee EY, Majid A, Boiselle PM
J Thorac Imaging 2011 Nov;26(4):278-89. doi: 10.1097/RTI.0b013e3182203342. PMID: 22009081
Pediatric and adult tracheobronchomalacia.
Masaoka A, Yamakawa Y, Niwa H, Hara F, Kondo S, Fukai I, Kiriyama M
Eur J Cardiothorac Surg 1996;10(2):87-92. doi: 10.1016/s1010-7940(96)80129-1. PMID: 8664011

Diagnosis

Tracheobronchomalacia, Tracheobronchial Compression, and Tracheobronchial Malformations: Diagnostic and Treatment Strategies.
Kamran A, Baird CW, Jennings RW
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2020;23:53-61. doi: 10.1053/j.pcsu.2020.02.006. PMID: 32354548
Pediatric airway surgery.
Maeda K
Pediatr Surg Int 2017 Apr;33(4):435-443. Epub 2017 Jan 28 doi: 10.1007/s00383-016-4050-7. PMID: 28132084
Pediatric tracheomalacia.
Fraga JC, Jennings RW, Kim PC
Semin Pediatr Surg 2016 Jun;25(3):156-64. Epub 2016 Feb 22 doi: 10.1053/j.sempedsurg.2016.02.008. PMID: 27301602
Paediatric Tracheomalacia.
Hysinger EB, Panitch HB
Paediatr Respir Rev 2016 Jan;17:9-15. Epub 2015 Mar 17 doi: 10.1016/j.prrv.2015.03.002. PMID: 25962857
Tracheobronchomalacia: current concepts and controversies.
Ridge CA, O'donnell CR, Lee EY, Majid A, Boiselle PM
J Thorac Imaging 2011 Nov;26(4):278-89. doi: 10.1097/RTI.0b013e3182203342. PMID: 22009081

Therapy

Acquired tracheobronchomalacia developed following voice prosthesis implantation.
Omori H, Wakasaki T, Hongo T, Rikimaru F, Toh S, Higaki Y, Masuda M
Auris Nasus Larynx 2024 Jun;51(3):433-436. Epub 2024 Mar 22 doi: 10.1016/j.anl.2023.12.007. PMID: 38520973
Expiratory central airway collapse - an overlooked entity?: Two case reports.
Janowiak P, Rogoza K, Siemińska A, Jassem E
Medicine (Baltimore) 2020 Oct 16;99(42):e22449. doi: 10.1097/MD.0000000000022449. PMID: 33080680Free PMC Article
Paediatric Tracheomalacia.
Hysinger EB, Panitch HB
Paediatr Respir Rev 2016 Jan;17:9-15. Epub 2015 Mar 17 doi: 10.1016/j.prrv.2015.03.002. PMID: 25962857
Endobronchial ultrasound morphology of expiratory central airway collapse.
Murgu S, Kurimoto N, Colt H
Respirology 2008 Mar;13(2):315-9. doi: 10.1111/j.1440-1843.2007.01216.x. PMID: 18339038
Tracheobronchomalacia and air trapping after mustard gas exposure.
Ghanei M, Akbari Moqadam F, Mohammad MM, Aslani J
Am J Respir Crit Care Med 2006 Feb 1;173(3):304-9. Epub 2005 Oct 27 doi: 10.1164/rccm.200502-247OC. PMID: 16254272

Prognosis

Expiratory central airway collapse - an overlooked entity?: Two case reports.
Janowiak P, Rogoza K, Siemińska A, Jassem E
Medicine (Baltimore) 2020 Oct 16;99(42):e22449. doi: 10.1097/MD.0000000000022449. PMID: 33080680Free PMC Article
Pediatric airway surgery.
Maeda K
Pediatr Surg Int 2017 Apr;33(4):435-443. Epub 2017 Jan 28 doi: 10.1007/s00383-016-4050-7. PMID: 28132084
What's in a name? Expiratory tracheal narrowing in adults explained.
Leong P, Bardin PG, Lau KK
Clin Radiol 2013 Dec;68(12):1268-75. Epub 2013 Aug 13 doi: 10.1016/j.crad.2013.06.017. PMID: 23953005
Central airway mechanics and flow limitation in acquired tracheobronchomalacia.
Loring SH, O'donnell CR, Feller-Kopman DJ, Ernst A
Chest 2007 Apr;131(4):1118-24. doi: 10.1378/chest.06-2556. PMID: 17426218
Pediatric and adult tracheobronchomalacia.
Masaoka A, Yamakawa Y, Niwa H, Hara F, Kondo S, Fukai I, Kiriyama M
Eur J Cardiothorac Surg 1996;10(2):87-92. doi: 10.1016/s1010-7940(96)80129-1. PMID: 8664011

Clinical prediction guides

Management of bronchomalacia in infants post-cardiac surgery using synchronized nasal DuoPAP: A novel technology.
Kumar A, Praveen M, Tiwari N, Ramamoorthy HR, Joshi A, Parikh B
Ann Card Anaesth 2022 Oct-Dec;25(4):531-535. doi: 10.4103/aca.aca_112_21. PMID: 36254924Free PMC Article
BMP4 and Wnt signaling interact to promote mouse tracheal mesenchyme morphogenesis.
Bottasso-Arias N, Leesman L, Burra K, Snowball J, Shah R, Mohanakrishnan M, Xu Y, Sinner D
Am J Physiol Lung Cell Mol Physiol 2022 Feb 1;322(2):L224-L242. Epub 2021 Dec 1 doi: 10.1152/ajplung.00255.2021. PMID: 34851738Free PMC Article
Lung disease associated with periventricular nodular heterotopia and an FLNA mutation.
Masurel-Paulet A, Haan E, Thompson EM, Goizet C, Thauvin-Robinet C, Tai A, Kennedy D, Smith G, Khong TY, Solé G, Guerineau E, Coupry I, Huet F, Robertson S, Faivre L
Eur J Med Genet 2011 Jan-Feb;54(1):25-8. Epub 2010 Oct 1 doi: 10.1016/j.ejmg.2010.09.010. PMID: 20888935
Longitudinal quantification of growth and changes in primary tracheobronchomalacia sites in children.
Masters IB, Zimmerman PV, Chang AB
Pediatr Pulmonol 2007 Oct;42(10):906-13. doi: 10.1002/ppul.20681. PMID: 17708575
Tracheobronchomalacia and air trapping after mustard gas exposure.
Ghanei M, Akbari Moqadam F, Mohammad MM, Aslani J
Am J Respir Crit Care Med 2006 Feb 1;173(3):304-9. Epub 2005 Oct 27 doi: 10.1164/rccm.200502-247OC. PMID: 16254272

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