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Pustular pyoderma gangrenosum

MedGen UID:
1814476
Concept ID:
C5681317
Disease or Syndrome
Synonym: pustular pyoderma gangrenosum
SNOMED CT: Pustular pyoderma gangrenosum (1256081007)
 
Monarch Initiative: MONDO:0035236
Orphanet: ORPHA538866

Definition

A rare subtype of pyoderma gangrenosum characterized by multiple painful, sterile pustules with a surrounding erythematous halo, predominantly occurring on the trunk and extensor surfaces of the limbs, and potentially persisting for months. Histopathology shows a dermal neutrophilic infiltrate and subcorneal neutrophilic micropustules. The condition is commonly associated with inflammatory bowel disease. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPustular pyoderma gangrenosum

Professional guidelines

PubMed

George C, Deroide F, Rustin M
Clin Med (Lond) 2019 May;19(3):224-228. doi: 10.7861/clinmedicine.19-3-224. PMID: 31092515Free PMC Article
Garcovich S, De Simone C, Berti E, Marzano AV
Expert Rev Clin Pharmacol 2017 Oct;10(10):1119-1128. Epub 2017 Jul 27 doi: 10.1080/17512433.2017.1356719. PMID: 28715916
Ahronowitz I, Harp J, Shinkai K
Am J Clin Dermatol 2012 Jun 1;13(3):191-211. doi: 10.2165/11595240-000000000-00000. PMID: 22356259

Recent clinical studies

Etiology

Brouard MC, Chavaz P, Borradori L
J Eur Acad Dermatol Venereol 2004 Jan;18(1):89-92. doi: 10.1111/j.1468-3083.2004.00712.x. PMID: 14678541

Diagnosis

Tomasini C, Michelerio A
J Am Acad Dermatol 2019 Aug;81(2):527-533. Epub 2018 Oct 25 doi: 10.1016/j.jaad.2018.10.029. PMID: 30617027
Chia MW, Teo L, Tay YK, Poh WT
Dermatol Online J 2008 Feb 28;14(2):21. PMID: 18700124
Brouard MC, Chavaz P, Borradori L
J Eur Acad Dermatol Venereol 2004 Jan;18(1):89-92. doi: 10.1111/j.1468-3083.2004.00712.x. PMID: 14678541
Barnes L, Lucky AW, Bucuvalas JC, Suchy FJ
J Am Acad Dermatol 1986 Oct;15(4 Pt 1):608-14. doi: 10.1016/s0190-9622(86)70212-0. PMID: 3771839

Therapy

Leger M, Newlove T, Chu J, Meehan S, Stein J
Dermatol Online J 2011 Oct 15;17(10):17. PMID: 22031643
Shankar S, Sterling JC, Rytina E
Clin Exp Dermatol 2003 Nov;28(6):600-3. doi: 10.1046/j.1365-2230.2003.01418.x. PMID: 14616824

Prognosis

Brouard MC, Chavaz P, Borradori L
J Eur Acad Dermatol Venereol 2004 Jan;18(1):89-92. doi: 10.1111/j.1468-3083.2004.00712.x. PMID: 14678541

Clinical prediction guides

Tomasini C, Michelerio A
J Am Acad Dermatol 2019 Aug;81(2):527-533. Epub 2018 Oct 25 doi: 10.1016/j.jaad.2018.10.029. PMID: 30617027
Brouard MC, Chavaz P, Borradori L
J Eur Acad Dermatol Venereol 2004 Jan;18(1):89-92. doi: 10.1111/j.1468-3083.2004.00712.x. PMID: 14678541

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