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Osteochondrosis

MedGen UID:
18216
•Concept ID:
C0029429
•
Disease or Syndrome
Synonym: Osteochondroses
SNOMED CT: Osteochondrosis (19579005)
 
HPO: HP:0040188
Monarch Initiative: MONDO:0018381
Orphanet: ORPHA399319

Definition

Abnormal growth ossification centers in children. Initially a degeneration/ necrosis followed by regeneration or recalcification. [from HPO]

Conditions with this feature

Juvenile osteochondrosis of spine
MedGen UID:
19885
•Concept ID:
C0036310
•
Disease or Syndrome
Scheuermann disease is characterized by lumbar or thoracic kyphosis or both, back pain, and a variety of vertebral changes including wedging, endplate irregularity, narrowing of disc spaces, Schmorl nodes, and detached epiphyseal rings. It is reported to occur more frequently in boys than in girls (summary by McKenzie and Sillence, 1992).
See: Condition Record
Juvenile osteochondrosis of spine

Professional guidelines

PubMed

Osteonecrosis of the Upper Extremity: MRI-Based Zonal Patterns and Differential Diagnosis.
Schmitt R, Kalb KH, Christopoulos G, Grunz JP
Semin Musculoskelet Radiol 2019 Oct;23(5):523-533. Epub 2019 Sep 25 doi: 10.1055/s-0039-1695719. PMID: 31556087
Treatment of Freiberg Disease.
Seybold JD, Zide JR
Foot Ankle Clin 2018 Mar;23(1):157-169. doi: 10.1016/j.fcl.2017.09.011. PMID: 29362030
Perthes disease: current principles of diagnosis and treatment.
Nelitz M, Lippacher S, Krauspe R, Reichel H
Dtsch Arztebl Int 2009 Jul;106(31-32):517-23. Epub 2009 Aug 3 doi: 10.3238/arztebl.2009.0517. PMID: 19730720Free PMC Article

Recent clinical studies

Etiology

Conservative treatment of Osgood-Schlatter disease among young professional soccer players.
Bezuglov EN, Tikhonova АА, Chubarovskiy PV, Repetyuk АD, Khaitin VY, Lazarev AM, Usmanova EM
Int Orthop 2020 Sep;44(9):1737-1743. Epub 2020 Apr 28 doi: 10.1007/s00264-020-04572-3. PMID: 32346752
Osgood-Schlatter disease: a 2020 update of a common knee condition in children.
Ladenhauf HN, Seitlinger G, Green DW
Curr Opin Pediatr 2020 Feb;32(1):107-112. doi: 10.1097/MOP.0000000000000842. PMID: 31714260
Apophysitis and Osteochondrosis: Common Causes of Pain in Growing Bones.
Achar S, Yamanaka J
Am Fam Physician 2019 May 15;99(10):610-618. PMID: 31083875
Blount disease.
Janoyer M
Orthop Traumatol Surg Res 2019 Feb;105(1S):S111-S121. Epub 2018 Feb 23 doi: 10.1016/j.otsr.2018.01.009. PMID: 29481866
Osteochondroses.
Danger F, Wasyliw C, Varich L
Semin Musculoskelet Radiol 2018 Feb;22(1):118-124. Epub 2018 Feb 6 doi: 10.1055/s-0038-1627094. PMID: 29409078

Diagnosis

Osgood-Schlatter disease: a 2020 update of a common knee condition in children.
Ladenhauf HN, Seitlinger G, Green DW
Curr Opin Pediatr 2020 Feb;32(1):107-112. doi: 10.1097/MOP.0000000000000842. PMID: 31714260
Apophysitis and Osteochondrosis: Common Causes of Pain in Growing Bones.
Achar S, Yamanaka J
Am Fam Physician 2019 May 15;99(10):610-618. PMID: 31083875
Treatment of Osgood-Schlatter disease: review of the literature.
Circi E, Atalay Y, Beyzadeoglu T
Musculoskelet Surg 2017 Dec;101(3):195-200. Epub 2017 Jun 7 doi: 10.1007/s12306-017-0479-7. PMID: 28593576
Spondylodiscitis.
Márquez Sánchez P
Radiologia 2016 Apr;58 Suppl 1:50-9. Epub 2016 Feb 9 doi: 10.1016/j.rx.2015.12.005. PMID: 26869521
Sports-related overuse injuries in children.
Launay F
Orthop Traumatol Surg Res 2015 Feb;101(1 Suppl):S139-47. Epub 2014 Dec 30 doi: 10.1016/j.otsr.2014.06.030. PMID: 25555804

Therapy

Progress of Signaling Pathways, Stress Pathways and Epigenetics in the Pathogenesis of Skeletal Fluorosis.
Qiao L, Liu X, He Y, Zhang J, Huang H, Bian W, Chilufya MM, Zhao Y, Han J
Int J Mol Sci 2021 Nov 3;22(21) doi: 10.3390/ijms222111932. PMID: 34769367Free PMC Article
A systematic review on conservative treatment options for OSGOOD-Schlatter disease.
Neuhaus C, Appenzeller-Herzog C, Faude O
Phys Ther Sport 2021 May;49:178-187. Epub 2021 Mar 9 doi: 10.1016/j.ptsp.2021.03.002. PMID: 33744766
Pediatric Pain Syndromes and Noninflammatory Musculoskeletal Pain.
Weiss JE, Stinson JN
Pediatr Clin North Am 2018 Aug;65(4):801-826. doi: 10.1016/j.pcl.2018.04.004. PMID: 30031499
Treatment of Freiberg Disease.
Seybold JD, Zide JR
Foot Ankle Clin 2018 Mar;23(1):157-169. doi: 10.1016/j.fcl.2017.09.011. PMID: 29362030
Zinc: the Other Suspected Environmental Factor in Kashin-Beck Disease in Addition to Selenium.
Wang X, Ning Y, Yang L, Yu F, Guo X
Biol Trace Elem Res 2017 Oct;179(2):178-184. Epub 2017 Feb 21 doi: 10.1007/s12011-017-0964-8. PMID: 28224461

Prognosis

Blount disease.
Janoyer M
Orthop Traumatol Surg Res 2019 Feb;105(1S):S111-S121. Epub 2018 Feb 23 doi: 10.1016/j.otsr.2018.01.009. PMID: 29481866
Osteochondroses.
Danger F, Wasyliw C, Varich L
Semin Musculoskelet Radiol 2018 Feb;22(1):118-124. Epub 2018 Feb 6 doi: 10.1055/s-0038-1627094. PMID: 29409078
Treatment of Osgood-Schlatter disease: review of the literature.
Circi E, Atalay Y, Beyzadeoglu T
Musculoskelet Surg 2017 Dec;101(3):195-200. Epub 2017 Jun 7 doi: 10.1007/s12306-017-0479-7. PMID: 28593576
Spondylodiscitis.
Márquez Sánchez P
Radiologia 2016 Apr;58 Suppl 1:50-9. Epub 2016 Feb 9 doi: 10.1016/j.rx.2015.12.005. PMID: 26869521
Osteochondral injuries.
Sanders RK, Crim JR
Semin Ultrasound CT MR 2001 Aug;22(4):352-70. doi: 10.1016/s0887-2171(01)90026-5. PMID: 11513159

Clinical prediction guides

Sesamoidectomy in Athletes: Outcomes From 2-Centers.
Saxena A, Fournier M, Patel P, Maffulli N
J Foot Ankle Surg 2022 Jan-Feb;61(1):139-142. Epub 2021 Jul 21 doi: 10.1053/j.jfas.2021.07.008. PMID: 34353730
Therapeutic interventions in Osgood-Schlatter disease: A case report.
Gaweł E, Zwierzchowska A
Medicine (Baltimore) 2021 Dec 17;100(50):e28257. doi: 10.1097/MD.0000000000028257. PMID: 34918694Free PMC Article
Conservative treatment of Osgood-Schlatter disease among young professional soccer players.
Bezuglov EN, Tikhonova АА, Chubarovskiy PV, Repetyuk АD, Khaitin VY, Lazarev AM, Usmanova EM
Int Orthop 2020 Sep;44(9):1737-1743. Epub 2020 Apr 28 doi: 10.1007/s00264-020-04572-3. PMID: 32346752
Blount disease.
Janoyer M
Orthop Traumatol Surg Res 2019 Feb;105(1S):S111-S121. Epub 2018 Feb 23 doi: 10.1016/j.otsr.2018.01.009. PMID: 29481866
Blount disease.
Birch JG
J Am Acad Orthop Surg 2013 Jul;21(7):408-18. doi: 10.5435/JAAOS-21-07-408. PMID: 23818028

Recent systematic reviews

A systematic review on conservative treatment options for OSGOOD-Schlatter disease.
Neuhaus C, Appenzeller-Herzog C, Faude O
Phys Ther Sport 2021 May;49:178-187. Epub 2021 Mar 9 doi: 10.1016/j.ptsp.2021.03.002. PMID: 33744766
Insight into the possible aetiologies of Blount's disease: a systematic review of the literature.
Banwarie RR, Hollman F, Meijs N, Arts JJ, Vroemen P, Moh P, Staal HM
J Pediatr Orthop B 2020 Jul;29(4):323-336. doi: 10.1097/BPB.0000000000000677. PMID: 31651748
van Neck-Odelberg Disease: A 3.5-Year Follow-Up Case Report and Systematic Review.
Mixa PJ, Segreto FA, Luigi-Martinez H, Diebo BG, Naziri Q, Kolla S, Maheshwari AV
Surg Technol Int 2017 Dec 12;31:365-373. PMID: 29316596
Outcomes and Complications of Tibial Tubercle Fractures in Pediatric Patients: A Systematic Review of the Literature.
Pretell-Mazzini J, Kelly DM, Sawyer JR, Esteban EM, Spence DD, Warner WC Jr, Beaty JH
J Pediatr Orthop 2016 Jul-Aug;36(5):440-6. doi: 10.1097/BPO.0000000000000488. PMID: 25887827
Surgical treatment of osteochondritis dissecans of the talus: a systematic review.
Zwingmann J, Südkamp NP, Schmal H, Niemeyer P
Arch Orthop Trauma Surg 2012 Sep;132(9):1241-50. Epub 2012 May 24 doi: 10.1007/s00402-012-1544-1. PMID: 22622794

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