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Abnormal synovial membrane morphology

MedGen UID:
1841519
•Concept ID:
C5826346
•
Anatomical Abnormality
Synonym: Abnormality of the synovia
 
HPO: HP:0005262

Definition

Any structural anomaly of the synovium, which is a membrane that lines the cavity of synovial joints and consists of a lining layer of macrophage-like synoviocytes and fibroblast-like synoviocytes, as well as a sublining of connective tissue. Synovial cells are thought to contribute to joint homeostasis by secreting various factors such as hyaluronic acid and lubricin important for joint lubrication and function, as well as disposing of the waste products. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal synovial membrane morphology

Professional guidelines

PubMed

The Investigation of the Application Value of Musculoskeletal Ultrasound in the Diagnosis and Conservative Treatment of Knee Osteoarthritis.
Pan Y, Wang L, Zhou L
Dis Markers 2022;2022:9660067. Epub 2022 Aug 16 doi: 10.1155/2022/9660067. PMID: 36016850Free PMC Article
Potential role of arthroscopy in the management of inflammatory arthritis.
Goëb V, Walsh CA, Reece RJ, Emery P, Ponchel F
Clin Exp Rheumatol 2012 May-Jun;30(3):429-35. Epub 2012 Jun 26 PMID: 22734971
Effusion criteria and clinical importance of glenohumeral joint fluid: MR imaging evaluation.
Schweitzer ME, Magbalon MJ, Fenlin JM, Frieman BG, Ehrlich S, Epstein RE
Radiology 1995 Mar;194(3):821-4. doi: 10.1148/radiology.194.3.7862986. PMID: 7862986

Recent clinical studies

Etiology

The cardiometabolic conditions of psoriatic disease.
Toussirot E, Gallais-Sérézal I, Aubin F
Front Immunol 2022;13:970371. Epub 2022 Sep 8 doi: 10.3389/fimmu.2022.970371. PMID: 36159785Free PMC Article
TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models.
Wu J, Feng Z, Chen L, Li Y, Bian H, Geng J, Zheng ZH, Fu X, Pei Z, Qin Y, Yang L, Zhao Y, Wang K, Chen R, He Q, Nan G, Jiang X, Chen ZN, Zhu P
Nat Commun 2022 Feb 3;13(1):676. doi: 10.1038/s41467-021-27948-4. PMID: 35115492Free PMC Article
Single-cell sequencing of immune cells from anticitrullinated peptide antibody positive and negative rheumatoid arthritis.
Wu X, Liu Y, Jin S, Wang M, Jiao Y, Yang B, Lu X, Ji X, Fei Y, Yang H, Zhao L, Chen H, Zhang Y, Li H, Lipsky PE, Tsokos GC, Bai F, Zhang X
Nat Commun 2021 Aug 17;12(1):4977. doi: 10.1038/s41467-021-25246-7. PMID: 34404786Free PMC Article
Sonographic synovial vascularity of synovitis in rheumatoid arthritis.
Fukae J, Tanimura K, Atsumi T, Koike T
Rheumatology (Oxford) 2014 Apr;53(4):586-91. Epub 2013 Sep 18 doi: 10.1093/rheumatology/ket311. PMID: 24049097
Etiology of osteoarthritis: genetics and synovial joint development.
Sandell LJ
Nat Rev Rheumatol 2012 Jan 10;8(2):77-89. doi: 10.1038/nrrheum.2011.199. PMID: 22231237

Diagnosis

Sonographic synovial vascularity of synovitis in rheumatoid arthritis.
Fukae J, Tanimura K, Atsumi T, Koike T
Rheumatology (Oxford) 2014 Apr;53(4):586-91. Epub 2013 Sep 18 doi: 10.1093/rheumatology/ket311. PMID: 24049097
Psoriatic arthritis: from a dermatological perspective.
Yamamoto T
Eur J Dermatol 2011 Sep-Oct;21(5):660-6. doi: 10.1684/ejd.2011.1452. PMID: 21715249
MR imaging of synovial disorders of the knee.
Chung CB, Boucher R, Resnick D
Semin Musculoskelet Radiol 2009 Dec;13(4):303-25. Epub 2009 Nov 4 doi: 10.1055/s-0029-1242186. PMID: 19890800
Ultrasound in the study and monitoring of osteoarthritis.
Möller I, Bong D, Naredo E, Filippucci E, Carrasco I, Moragues C, Iagnocco A
Osteoarthritis Cartilage 2008;16 Suppl 3:S4-7. Epub 2008 Aug 29 doi: 10.1016/j.joca.2008.06.005. PMID: 18760636
Synovial sarcoma.
Fisher C
Ann Diagn Pathol 1998 Dec;2(6):401-21. doi: 10.1016/s1092-9134(98)80042-7. PMID: 9930576

Therapy

The cardiometabolic conditions of psoriatic disease.
Toussirot E, Gallais-Sérézal I, Aubin F
Front Immunol 2022;13:970371. Epub 2022 Sep 8 doi: 10.3389/fimmu.2022.970371. PMID: 36159785Free PMC Article
TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models.
Wu J, Feng Z, Chen L, Li Y, Bian H, Geng J, Zheng ZH, Fu X, Pei Z, Qin Y, Yang L, Zhao Y, Wang K, Chen R, He Q, Nan G, Jiang X, Chen ZN, Zhu P
Nat Commun 2022 Feb 3;13(1):676. doi: 10.1038/s41467-021-27948-4. PMID: 35115492Free PMC Article
Interleukin-9 Facilitates Osteoclastogenesis in Rheumatoid Arthritis.
Kar S, Gupta R, Malhotra R, Sharma V, Farooque K, Kumar V, Chakraborty S, Mitra DK
Int J Mol Sci 2021 Sep 27;22(19) doi: 10.3390/ijms221910397. PMID: 34638736Free PMC Article
Functional disorders of the temporomandibular joints: Internal derangement of the temporomandibular joint.
Chang CL, Wang DH, Yang MC, Hsu WE, Hsu ML
Kaohsiung J Med Sci 2018 Apr;34(4):223-230. Epub 2018 Feb 7 doi: 10.1016/j.kjms.2018.01.004. PMID: 29655411
Sonographic synovial vascularity of synovitis in rheumatoid arthritis.
Fukae J, Tanimura K, Atsumi T, Koike T
Rheumatology (Oxford) 2014 Apr;53(4):586-91. Epub 2013 Sep 18 doi: 10.1093/rheumatology/ket311. PMID: 24049097

Prognosis

The cardiometabolic conditions of psoriatic disease.
Toussirot E, Gallais-Sérézal I, Aubin F
Front Immunol 2022;13:970371. Epub 2022 Sep 8 doi: 10.3389/fimmu.2022.970371. PMID: 36159785Free PMC Article
The role of synovitis in osteoarthritis pathogenesis.
Scanzello CR, Goldring SR
Bone 2012 Aug;51(2):249-57. Epub 2012 Feb 22 doi: 10.1016/j.bone.2012.02.012. PMID: 22387238Free PMC Article
Epithelioid sarcoma of Enzinger.
Fisher C
Adv Anat Pathol 2006 May;13(3):114-21. doi: 10.1097/00125480-200605000-00002. PMID: 16778474
Synovial sarcoma.
Fisher C
Ann Diagn Pathol 1998 Dec;2(6):401-21. doi: 10.1016/s1092-9134(98)80042-7. PMID: 9930576
Rheumatoid arthritis: sequences.
Scutellari PN, Orzincolo C
Eur J Radiol 1998 May;27 Suppl 1:S31-8. doi: 10.1016/s0720-048x(98)00040-0. PMID: 9652499

Clinical prediction guides

Interleukin-9 Facilitates Osteoclastogenesis in Rheumatoid Arthritis.
Kar S, Gupta R, Malhotra R, Sharma V, Farooque K, Kumar V, Chakraborty S, Mitra DK
Int J Mol Sci 2021 Sep 27;22(19) doi: 10.3390/ijms221910397. PMID: 34638736Free PMC Article
Sonographic synovial vascularity of synovitis in rheumatoid arthritis.
Fukae J, Tanimura K, Atsumi T, Koike T
Rheumatology (Oxford) 2014 Apr;53(4):586-91. Epub 2013 Sep 18 doi: 10.1093/rheumatology/ket311. PMID: 24049097
Pathogenetic overview of psoriatic disease.
Haroon M, Fitzgerald O
J Rheumatol Suppl 2012 Jul;89:7-10. doi: 10.3899/jrheum.120232. PMID: 22751581
The role of synovitis in osteoarthritis pathogenesis.
Scanzello CR, Goldring SR
Bone 2012 Aug;51(2):249-57. Epub 2012 Feb 22 doi: 10.1016/j.bone.2012.02.012. PMID: 22387238Free PMC Article
Epithelioid sarcoma of Enzinger.
Fisher C
Adv Anat Pathol 2006 May;13(3):114-21. doi: 10.1097/00125480-200605000-00002. PMID: 16778474

Recent systematic reviews

The Relationship Between Synovial Pathobiology and Magnetic Resonance Imaging Abnormalities in Rheumatoid Arthritis: A Systematic Review.
Humby F, Mahto A, Ahmed M, Barr A, Kelly S, Buch M, Pitzalis C, Conaghan PG
J Rheumatol 2017 Sep;44(9):1311-1324. Epub 2017 Jul 15 doi: 10.3899/jrheum.161314. PMID: 28711880
Systematic review of the concurrent and predictive validity of MRI biomarkers in OA.
Hunter DJ, Zhang W, Conaghan PG, Hirko K, Menashe L, Li L, Reichmann WM, Losina E
Osteoarthritis Cartilage 2011 May;19(5):557-88. Epub 2011 Mar 23 doi: 10.1016/j.joca.2010.10.029. PMID: 21396463Free PMC Article

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