Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Diffuse pulmonary lymphoid hyperplasia

MedGen UID:: 1841705
•Concept ID:: C5826685
•: Finding

HPO:	HP:0034824

Definition

Diffuse lymphoid hyperplasia (DLH) describes the pathological entity that lies between follicular bronchiolitis and lymphocytic interstitial pneumonia (LIP). It is pathologically characterized by a diffuse peribronchiolar proliferation of hyperplastic lymphoid follicles (BALT), extended along the lymphatics to involve the interlobular septa and pleura. Unlike LIP, DHL does not show uniform involvement of the alveolar septa. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVDiffuse pulmonary lymphoid hyperplasia

Abnormality of the respiratory system
- Abnormal respiratory system physiology
  - Abnormal respiratory system morphology
    - Abnormality of the lung
      - Abnormal pulmonary interstitial morphology
        Pulmonary interstitial lymphocyte infiltration
        Diffuse pulmonary lymphoid hyperplasia

Recent clinical studies

Etiology

Imaging findings of COPA Syndrome.

Nguyen HN, Salman R, Vogel TP, Silva-Carmona M, DeGuzman M, Guillerman RP
Pediatr Radiol 2023 May;53(5):844-853. Epub 2023 Feb 7 doi: 10.1007/s00247-023-05600-1. PMID: 36746811

Pulmonary Hypertension in Patients with Common Variable Immunodeficiency.

Thoré P, Jaïs X, Savale L, Dorfmuller P, Boucly A, Devilder M, Meyrignac O, Pichon J, Mankikian J, Riou M, Boiffard E, Boissin C, De Groote P, Chabanne C, Gagnadoux F, Bergeron A, Noel N, Sitbon O, Humbert M, Montani D
J Clin Immunol 2021 Oct;41(7):1549-1562. Epub 2021 Jun 10 doi: 10.1007/s10875-021-01064-w. PMID: 34110542

Pulmonary involvement in ANCA-associated vasculitis from the view of the pulmonologist.

Homma S, Suzuki A, Sato K
Clin Exp Nephrol 2013 Oct;17(5):667-671. Epub 2012 Nov 28 doi: 10.1007/s10157-012-0710-7. PMID: 23188194

Bronchoalveolar lavage in malignancy.

Poletti V, Poletti G, Murer B, Saragoni L, Chilosi M
Semin Respir Crit Care Med 2007 Oct;28(5):534-45. doi: 10.1055/s-2007-991526. PMID: 17975781

Immunosurveillance, immunodeficiency and lymphoproliferations.

Oertel SH, Riess H
Recent Results Cancer Res 2002;159:1-8. doi: 10.1007/978-3-642-56352-2_1. PMID: 11785833

See all (22)

Diagnosis

Pulmonary involvement in ANCA-associated vasculitis from the view of the pulmonologist.

Homma S, Suzuki A, Sato K
Clin Exp Nephrol 2013 Oct;17(5):667-671. Epub 2012 Nov 28 doi: 10.1007/s10157-012-0710-7. PMID: 23188194

The radiological spectrum of pulmonary lymphoproliferative disease.

Hare SS, Souza CA, Bain G, Seely JM, Frcpc, Gomes MM, Quigley M
Br J Radiol 2012 Jul;85(1015):848-64. doi: 10.1259/bjr/16420165. PMID: 22745203 Free PMC Article

Bronchoalveolar lavage in malignancy.

Poletti V, Poletti G, Murer B, Saragoni L, Chilosi M
Semin Respir Crit Care Med 2007 Oct;28(5):534-45. doi: 10.1055/s-2007-991526. PMID: 17975781

Bronchiolitis: the pathologist's perspective.

Visscher DW, Myers JL
Proc Am Thorac Soc 2006;3(1):41-7. doi: 10.1513/pats.200512-124JH. PMID: 16493150

Pulmonary lymphoid disorders.

Koss MN
Semin Diagn Pathol 1995 May;12(2):158-71. PMID: 7638448

See all (39)

Therapy

Tertiary lymphoid neogenesis is a component of pulmonary lymphoid hyperplasia in patients with common variable immunodeficiency.

Maglione PJ, Ko HM, Beasley MB, Strauchen JA, Cunningham-Rundles C
J Allergy Clin Immunol 2014 Feb;133(2):535-42. Epub 2013 Oct 13 doi: 10.1016/j.jaci.2013.08.022. PMID: 24131823 Free PMC Article

Pulmonary involvement in ANCA-associated vasculitis from the view of the pulmonologist.

Homma S, Suzuki A, Sato K
Clin Exp Nephrol 2013 Oct;17(5):667-671. Epub 2012 Nov 28 doi: 10.1007/s10157-012-0710-7. PMID: 23188194

Lymphoid hyperplasia and eosinophilic pneumonia as histologic manifestations of amiodarone-induced lung toxicity.

Larsen BT, Vaszar LT, Colby TV, Tazelaar HD
Am J Surg Pathol 2012 Apr;36(4):509-16. doi: 10.1097/PAS.0b013e318243fd9a. PMID: 22314187

Idiopathic pulmonary lymphoid diffuse hyperplasia.

Canessa PA, Pratticò L, Fiasella F, Cavazza A, Bacigalupo B, Fedeli F
Monaldi Arch Chest Dis 2009 Jun;71(2):69-70. doi: 10.4081/monaldi.2009.364. PMID: 19719038

Nylon flock-associated interstitial lung disease.

Eschenbacher WL, Kreiss K, Lougheed MD, Pransky GS, Day B, Castellan RM
Am J Respir Crit Care Med 1999 Jun;159(6):2003-8. doi: 10.1164/ajrccm.159.6.9808002. PMID: 10351952

See all (16)

Prognosis

Pulmonary involvement in ANCA-associated vasculitis from the view of the pulmonologist.

Homma S, Suzuki A, Sato K
Clin Exp Nephrol 2013 Oct;17(5):667-671. Epub 2012 Nov 28 doi: 10.1007/s10157-012-0710-7. PMID: 23188194

Bronchoalveolar lavage in malignancy.

Poletti V, Poletti G, Murer B, Saragoni L, Chilosi M
Semin Respir Crit Care Med 2007 Oct;28(5):534-45. doi: 10.1055/s-2007-991526. PMID: 17975781

Granulomatous-lymphocytic lung disease shortens survival in common variable immunodeficiency.

Bates CA, Ellison MC, Lynch DA, Cool CD, Brown KK, Routes JM
J Allergy Clin Immunol 2004 Aug;114(2):415-21. doi: 10.1016/j.jaci.2004.05.057. PMID: 15316526

Lymphoid interstitial pneumonia: a narrative review.

Swigris JJ, Berry GJ, Raffin TA, Kuschner WG
Chest 2002 Dec;122(6):2150-64. doi: 10.1378/chest.122.6.2150. PMID: 12475860

Histopathological approach to patterns of interstitial pneumonia in patient with connective tissue disorders.

Nicholson AG, Colby TV, Wells AU
Sarcoidosis Vasc Diffuse Lung Dis 2002 Mar;19(1):10-7. PMID: 12002379

See all (11)

Clinical prediction guides

Slowly Expanding 18 F-FDG PET-Positive Irregular Opacities in the Lung Due to Diffuse Lymphoid Hyperplasia Preceding Rheumatoid Arthritis.

Sumitomo K, Okamoto T, Arii K, Matumoto M, Shinohara T
Clin Nucl Med 2023 Jun 1;48(6):542-544. Epub 2023 Apr 24 doi: 10.1097/RLU.0000000000004651. PMID: 37083578

Incidental Pelvic and Para-aortic Lymph Node Lymphangioleiomyomatosis Detected During Surgical Staging of Pelvic Cancer in Women Without Symptomatic Pulmonary Lymphangioleiomyomatosis or Tuberous Sclerosis Complex.

Rabban JT, Firetag B, Sangoi AR, Post MD, Zaloudek CJ
Am J Surg Pathol 2015 Aug;39(8):1015-25. doi: 10.1097/PAS.0000000000000416. PMID: 25786086

Pulmonary involvement in ANCA-associated vasculitis from the view of the pulmonologist.

Homma S, Suzuki A, Sato K
Clin Exp Nephrol 2013 Oct;17(5):667-671. Epub 2012 Nov 28 doi: 10.1007/s10157-012-0710-7. PMID: 23188194

Bronchoalveolar lavage in malignancy.

Poletti V, Poletti G, Murer B, Saragoni L, Chilosi M
Semin Respir Crit Care Med 2007 Oct;28(5):534-45. doi: 10.1055/s-2007-991526. PMID: 17975781

Study of bronchus-associated lymphoid tissue in patients with diffuse panbronchiolitis.

Sato A, Chida K, Iwata M, Hayakawa H
Am Rev Respir Dis 1992 Aug;146(2):473-8. doi: 10.1164/ajrccm/146.2.473. PMID: 1489143

See all (13)