U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Streptococcus pneumoniae-associated hemolytic uremic syndrome

MedGen UID:
1842720
•Concept ID:
C5680164
•
Disease or Syndrome
Synonyms: S. pneumoniae-associated HUS; SP-HUS; streptococcus pneumoniae-associated hemolytic uremic syndrome
 
Monarch Initiative: MONDO:0035293
Orphanet: ORPHA544493

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStreptococcus pneumoniae-associated hemolytic uremic syndrome

Professional guidelines

PubMed

Treatment strategy for Streptococcus pneumoniae-associated hemolytic uremic syndrome.
Madden I, Harambat J
Pediatr Nephrol 2021 Jun;36(6):1655-1656. Epub 2021 Mar 26 doi: 10.1007/s00467-021-05053-4. PMID: 33772368

Recent clinical studies

Etiology

Eculizumab use in patients with pneumococcal-associated hemolytic uremic syndrome and kidney outcomes.
Konopásek P, Zieg J
Pediatr Nephrol 2023 Dec;38(12):4209-4215. Epub 2023 Jun 12 doi: 10.1007/s00467-023-06037-2. PMID: 37306721Free PMC Article
Complement activation in children with Streptococcus pneumoniae associated hemolytic uremic syndrome.
Holle J, Habbig S, Gratopp A, Mauritsch A, Müller D, Thumfart J
Pediatr Nephrol 2021 May;36(5):1311-1315. Epub 2021 Feb 4 doi: 10.1007/s00467-021-04952-w. PMID: 33538911Free PMC Article
Diagnosis of Streptococcus pneumoniae-associated hemolytic uremic syndrome.
Loupiac A, Elayan A, Cailliez M, Adra AL, Decramer S, Thouret MC, Harambat J, Guigonis V
Pediatr Infect Dis J 2013 Oct;32(10):1045-9. doi: 10.1097/INF.0b013e31829ee872. PMID: 24067551
Streptococcus pneumoniae-associated hemolytic uremic syndrome among children in North America.
Banerjee R, Hersh AL, Newland J, Beekmann SE, Polgreen PM, Bender J, Shaw J, Copelovitch L, Kaplan BS, Shah SS; Emerging Infections Network Hemolytic-Uremic Syndrome Study Group
Pediatr Infect Dis J 2011 Sep;30(9):736-9. doi: 10.1097/INF.0b013e3182191c58. PMID: 21772230
Streptococcus pneumoniae--associated hemolytic uremic syndrome: classification and the emergence of serotype 19A.
Copelovitch L, Kaplan BS
Pediatrics 2010 Jan;125(1):e174-82. Epub 2009 Dec 21 doi: 10.1542/peds.2007-2017. PMID: 20026500

Diagnosis

Complement activation in children with Streptococcus pneumoniae associated hemolytic uremic syndrome.
Holle J, Habbig S, Gratopp A, Mauritsch A, Müller D, Thumfart J
Pediatr Nephrol 2021 May;36(5):1311-1315. Epub 2021 Feb 4 doi: 10.1007/s00467-021-04952-w. PMID: 33538911Free PMC Article
Diagnosis of Streptococcus pneumoniae-associated hemolytic uremic syndrome.
Loupiac A, Elayan A, Cailliez M, Adra AL, Decramer S, Thouret MC, Harambat J, Guigonis V
Pediatr Infect Dis J 2013 Oct;32(10):1045-9. doi: 10.1097/INF.0b013e31829ee872. PMID: 24067551
Update on Streptococcus pneumoniae associated hemolytic uremic syndrome.
Spinale JM, Ruebner RL, Kaplan BS, Copelovitch L
Curr Opin Pediatr 2013 Apr;25(2):203-8. doi: 10.1097/MOP.0b013e32835d7f2c. PMID: 23481474
Streptococcus pneumoniae--associated hemolytic uremic syndrome: classification and the emergence of serotype 19A.
Copelovitch L, Kaplan BS
Pediatrics 2010 Jan;125(1):e174-82. Epub 2009 Dec 21 doi: 10.1542/peds.2007-2017. PMID: 20026500
Streptococcus pneumoniae-associated hemolytic uremic syndrome.
Copelovitch L, Kaplan BS
Pediatr Nephrol 2008 Nov;23(11):1951-6. Epub 2007 Jun 13 doi: 10.1007/s00467-007-0518-y. PMID: 17564729Free PMC Article

Therapy

Complement activation in children with Streptococcus pneumoniae associated hemolytic uremic syndrome.
Holle J, Habbig S, Gratopp A, Mauritsch A, Müller D, Thumfart J
Pediatr Nephrol 2021 May;36(5):1311-1315. Epub 2021 Feb 4 doi: 10.1007/s00467-021-04952-w. PMID: 33538911Free PMC Article
Streptococcus pneumoniae-associated hemolytic uremic syndrome in a splenectomized adult patient.
Maki N, Komatsuda A, Ohtani H, Kuroki J, Nishinari T, Asakura K, Sawada K, Wakui H
Intern Med 2012;51(15):2001-5. Epub 2012 Aug 1 doi: 10.2169/internalmedicine.51.7916. PMID: 22864126
Streptococcus pneumoniae--associated hemolytic uremic syndrome: classification and the emergence of serotype 19A.
Copelovitch L, Kaplan BS
Pediatrics 2010 Jan;125(1):e174-82. Epub 2009 Dec 21 doi: 10.1542/peds.2007-2017. PMID: 20026500

Prognosis

Eculizumab use in patients with pneumococcal-associated hemolytic uremic syndrome and kidney outcomes.
Konopásek P, Zieg J
Pediatr Nephrol 2023 Dec;38(12):4209-4215. Epub 2023 Jun 12 doi: 10.1007/s00467-023-06037-2. PMID: 37306721Free PMC Article
Complement activation in children with Streptococcus pneumoniae associated hemolytic uremic syndrome.
Holle J, Habbig S, Gratopp A, Mauritsch A, Müller D, Thumfart J
Pediatr Nephrol 2021 May;36(5):1311-1315. Epub 2021 Feb 4 doi: 10.1007/s00467-021-04952-w. PMID: 33538911Free PMC Article
Update on Streptococcus pneumoniae associated hemolytic uremic syndrome.
Spinale JM, Ruebner RL, Kaplan BS, Copelovitch L
Curr Opin Pediatr 2013 Apr;25(2):203-8. doi: 10.1097/MOP.0b013e32835d7f2c. PMID: 23481474
Streptococcus pneumoniae--associated hemolytic uremic syndrome: classification and the emergence of serotype 19A.
Copelovitch L, Kaplan BS
Pediatrics 2010 Jan;125(1):e174-82. Epub 2009 Dec 21 doi: 10.1542/peds.2007-2017. PMID: 20026500
Renal transplantation after Streptococcus pneumoniae-associated hemolytic uremic syndrome.
Krysan DJ, Flynn JT
Am J Kidney Dis 2001 Feb;37(2):E15. doi: 10.1053/ajkd.2001.21359. PMID: 11157401

Clinical prediction guides

Eculizumab use in patients with pneumococcal-associated hemolytic uremic syndrome and kidney outcomes.
Konopásek P, Zieg J
Pediatr Nephrol 2023 Dec;38(12):4209-4215. Epub 2023 Jun 12 doi: 10.1007/s00467-023-06037-2. PMID: 37306721Free PMC Article
Thomsen-Friedenreich antigen activation as a predictor for clinical outcome of pediatric patients with invasive pneumococcal disease.
Chen YC, Chen HH, Janapatla RP, Dudek A, Hsu MH, Chen CL, Chiu CH
Pediatr Neonatol 2020 Jun;61(3):338-342. Epub 2020 Feb 22 doi: 10.1016/j.pedneo.2020.02.005. PMID: 32156480
New insights into the pathogenesis of Streptococcus pneumoniae-associated hemolytic uremic syndrome.
Scobell RR, Kaplan BS, Copelovitch L
Pediatr Nephrol 2020 Sep;35(9):1585-1591. Epub 2019 Sep 13 doi: 10.1007/s00467-019-04342-3. PMID: 31515631
Streptococcus pneumoniae-associated hemolytic uremic syndrome.
Copelovitch L, Kaplan BS
Pediatr Nephrol 2008 Nov;23(11):1951-6. Epub 2007 Jun 13 doi: 10.1007/s00467-007-0518-y. PMID: 17564729Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...