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46,XX disorder of sex development induced by fetal androgens excess

MedGen UID:
1843153
•Concept ID:
C5680189
•
Disease or Syndrome
Synonym: 46,XX DSD induced by fetal androgens excess
 
Orphanet: ORPHA90776

Recent clinical studies

Etiology

Hyperandrogenic origins of polycystic ovary syndrome - implications for pathophysiology and therapy.
Abbott DH, Dumesic DA, Levine JE
Expert Rev Endocrinol Metab 2019 Mar;14(2):131-143. Epub 2019 Feb 15 doi: 10.1080/17446651.2019.1576522. PMID: 30767580Free PMC Article
Androgen excess and metabolic disorders in women with PCOS: beyond the body mass index.
Condorelli RA, Calogero AE, Di Mauro M, Mongioi' LM, Cannarella R, Rosta G, La Vignera S
J Endocrinol Invest 2018 Apr;41(4):383-388. Epub 2017 Sep 23 doi: 10.1007/s40618-017-0762-3. PMID: 28942551
Prevalence of Prediabetes Risk in Offspring Born to Mothers with Hyperandrogenism.
Tian S, Lin XH, Xiong YM, Liu ME, Yu TT, Lv M, Zhao W, Xu GF, Ding GL, Xu CM, Jin M, Feng C, Wu YT, Tan YJ, Gao Q, Zhang J, Li C, Ren J, Jin LY, Chen B, Zhu H, Zhang XY, Chen SC, Liu XM, Liu Y, Zhang JY, Wang L, Zhang P, Chen XJ, Jin L, Chen X, Meng YC, Wu DD, Lin H, Yang Q, Zhou CL, Li XZ, Wang YY, Xiang YQ, Liu ZW, Gao L, Chen LT, Pan HJ, Li R, Zhang FH, Xing LF, Zhu YM, Klausen C, Leung PCK, Li JX, Sun F, Sheng JZ, Huang HF
EBioMedicine 2017 Feb;16:275-283. Epub 2017 Jan 11 doi: 10.1016/j.ebiom.2017.01.011. PMID: 28111236Free PMC Article
Maternal serum androgens in pregnant women with polycystic ovarian syndrome: possible implications in prenatal androgenization.
Sir-Petermann T, Maliqueo M, Angel B, Lara HE, Pérez-Bravo F, Recabarren SE
Hum Reprod 2002 Oct;17(10):2573-9. doi: 10.1093/humrep/17.10.2573. PMID: 12351531

Diagnosis

Hyperandrogenic origins of polycystic ovary syndrome - implications for pathophysiology and therapy.
Abbott DH, Dumesic DA, Levine JE
Expert Rev Endocrinol Metab 2019 Mar;14(2):131-143. Epub 2019 Feb 15 doi: 10.1080/17446651.2019.1576522. PMID: 30767580Free PMC Article

Therapy

Prevalence of Prediabetes Risk in Offspring Born to Mothers with Hyperandrogenism.
Tian S, Lin XH, Xiong YM, Liu ME, Yu TT, Lv M, Zhao W, Xu GF, Ding GL, Xu CM, Jin M, Feng C, Wu YT, Tan YJ, Gao Q, Zhang J, Li C, Ren J, Jin LY, Chen B, Zhu H, Zhang XY, Chen SC, Liu XM, Liu Y, Zhang JY, Wang L, Zhang P, Chen XJ, Jin L, Chen X, Meng YC, Wu DD, Lin H, Yang Q, Zhou CL, Li XZ, Wang YY, Xiang YQ, Liu ZW, Gao L, Chen LT, Pan HJ, Li R, Zhang FH, Xing LF, Zhu YM, Klausen C, Leung PCK, Li JX, Sun F, Sheng JZ, Huang HF
EBioMedicine 2017 Feb;16:275-283. Epub 2017 Jan 11 doi: 10.1016/j.ebiom.2017.01.011. PMID: 28111236Free PMC Article

Clinical prediction guides

Undernutrition and hyperandrogenism during pregnancy: Role in programming of cardiovascular disease and infertility.
Mossa F, Latham KE, Ireland JJ, Veiga-Lopez A
Mol Reprod Dev 2019 Sep;86(9):1255-1264. Epub 2019 Jul 25 doi: 10.1002/mrd.23239. PMID: 31347224
Review: fetal programming of polycystic ovary syndrome by androgen excess: evidence from experimental, clinical, and genetic association studies.
Xita N, Tsatsoulis A
J Clin Endocrinol Metab 2006 May;91(5):1660-6. Epub 2006 Mar 7 doi: 10.1210/jc.2005-2757. PMID: 16522691

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