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Complete hydatidiform mole(CHM)

MedGen UID:
195706
•Concept ID:
C0678213
•
Neoplastic Process
Synonyms: Complete Hydatidiform Mole; Complete Hydatidiform Moles; Hydatidiform Mole, Complete; Hydatidiform Moles, Complete; Mole, Complete Hydatidiform; Moles, Complete Hydatidiform
SNOMED CT: CHM - Complete hydatidiform mole (237249000); Vesicular mole (237249000); Complete hydatidiform mole (237249000)
Modes of inheritance:
Autosomal recessive inheritance
MedGen UID:
141025
•Concept ID:
C0441748
•
Intellectual Product
Source: Orphanet
A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in individuals with two pathogenic alleles, either homozygotes (two copies of the same mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele).
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Autosomal recessive inheritance (Orphanet)
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0016785
OMIM®: 231090
Orphanet: ORPHA254688

Definition

A form of hydatiform mole characterized by abnormal hyperplastic trophoblasts and hydropic villi due to fertilization of an enucleated ovocyte by one or two haploid spermatozoa that can manifest with vaginal bleeding accompanied by nausea and frequent vomiting, hyperemesis gravidarum, risk of spontaneous miscarriage, hyperthyroidism, and has the potential of developing into choriocarcinoma. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVComplete hydatidiform mole
Follow this link to review classifications for Complete hydatidiform mole in Orphanet.

Professional guidelines

PubMed

Individualistic approach to the management of complete hydatidiform mole with coexisting live fetus.
Rohilla M, Singh P, Kaur J, Jain V, Gupta N, Prasad GR
Eur J Obstet Gynecol Reprod Biol 2015 Aug;191:39-42. Epub 2015 May 30 doi: 10.1016/j.ejogrb.2015.05.017. PMID: 26070126
Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole.
Lurain JR
Am J Obstet Gynecol 2010 Dec;203(6):531-9. Epub 2010 Aug 21 doi: 10.1016/j.ajog.2010.06.073. PMID: 20728069
Prenatal diagnosis and management of twin pregnancies complicated by a co-existing molar pregnancy.
Wee L, Jauniaux E
Prenat Diagn 2005 Sep;25(9):772-6. doi: 10.1002/pd.1272. PMID: 16170836

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Gestational Trophoblastic Neoplasia, 2023

Recent clinical studies

Therapy

Spermatogonium-Derived Complete Hydatidiform Mole.
Usui H, Shozu M
N Engl J Med 2021 Mar 11;384(10):936-943. doi: 10.1056/NEJMoa2005756. PMID: 33704938
Is a Complete Hydatidiform Mole and a Co-existing Normal Fetus an Iatrogenic Effect?
Zilberman Sharon N, Melcer Y, Maymon R
Isr Med Assoc J 2019 Oct;21(10):653-657. PMID: 31599505
Accuracy of p57(KIP)(2) compared with genotyping to diagnose complete hydatidiform mole: a systematic review and meta-analysis.
Madi JM, Braga A, Paganella MP, Litvin IE, Wendland EM
BJOG 2018 Sep;125(10):1226-1233. Epub 2018 Jun 15 doi: 10.1111/1471-0528.15289. PMID: 29782064Free PMC Article
Reproductive outcomes after hydatiform mole and gestational trophoblastic neoplasia.
Gadducci A, Lanfredini N, Cosio S
Gynecol Endocrinol 2015;31(9):673-8. Epub 2015 Aug 18 doi: 10.3109/09513590.2015.1054803. PMID: 26288335
Gestational trophoblastic tumours: an update for 2014.
Froeling FE, Seckl MJ
Curr Oncol Rep 2014 Nov;16(11):408. doi: 10.1007/s11912-014-0408-y. PMID: 25318458

Prognosis

Multiple pregnancy with complete hydatidiform mole and coexisting normal fetus in a retrospective cohort of 141 patients.
Hajri T, Massoud M, Vergne M, Descargues P, Allias F, You B, Lotz JP, Haesebaert J, Bolze PA, Golfier F, Massardier J
Am J Obstet Gynecol 2024 Mar;230(3):362.e1-362.e8. Epub 2023 Sep 16 doi: 10.1016/j.ajog.2023.09.006. PMID: 37722570
Clinical characteristics and thyroid function in complete hydatidiform mole complicated by hyperthyroidism.
Ramos MM, Maesta I, de Araújo Costa RA, Mazeto GMFS, Horowitz NS, Elias KM, Braga A, Berkowitz RS
Gynecol Oncol 2022 Apr;165(1):137-142. Epub 2022 Feb 10 doi: 10.1016/j.ygyno.2022.01.037. PMID: 35153074
Recurrent complete hydatidiform mole: where we are, is there a safe gestational horizon? Opinion and mini-review.
Kalogiannidis I, Kalinderi K, Kalinderis M, Miliaras D, Tarlatzis B, Athanasiadis A
J Assist Reprod Genet 2018 Jun;35(6):967-973. Epub 2018 May 8 doi: 10.1007/s10815-018-1202-9. PMID: 29737470Free PMC Article
Reproductive outcomes after hydatiform mole and gestational trophoblastic neoplasia.
Gadducci A, Lanfredini N, Cosio S
Gynecol Endocrinol 2015;31(9):673-8. Epub 2015 Aug 18 doi: 10.3109/09513590.2015.1054803. PMID: 26288335
Gestational trophoblastic tumours: an update for 2014.
Froeling FE, Seckl MJ
Curr Oncol Rep 2014 Nov;16(11):408. doi: 10.1007/s11912-014-0408-y. PMID: 25318458

Clinical prediction guides

Multiple pregnancy with complete hydatidiform mole and coexisting normal fetus in a retrospective cohort of 141 patients.
Hajri T, Massoud M, Vergne M, Descargues P, Allias F, You B, Lotz JP, Haesebaert J, Bolze PA, Golfier F, Massardier J
Am J Obstet Gynecol 2024 Mar;230(3):362.e1-362.e8. Epub 2023 Sep 16 doi: 10.1016/j.ajog.2023.09.006. PMID: 37722570
Clinical characteristics and thyroid function in complete hydatidiform mole complicated by hyperthyroidism.
Ramos MM, Maesta I, de Araújo Costa RA, Mazeto GMFS, Horowitz NS, Elias KM, Braga A, Berkowitz RS
Gynecol Oncol 2022 Apr;165(1):137-142. Epub 2022 Feb 10 doi: 10.1016/j.ygyno.2022.01.037. PMID: 35153074
The immune microenvironment of the hydatidiform mole.
Dridi M, Papoudou-Bai A, Kanavaros P, Perard M, Clemenson A, Chauleur C, Peoc'h M, Karpathiou G
Hum Pathol 2022 Feb;120:35-45. Epub 2021 Dec 17 doi: 10.1016/j.humpath.2021.12.002. PMID: 34929228
Hydatidiform Moles: Ancillary Techniques to Refine Diagnosis.
Ronnett BM
Arch Pathol Lab Med 2018 Dec;142(12):1485-1502. doi: 10.5858/arpa.2018-0226-RA. PMID: 30500280
Complete hydatidiform mole with co-existing fetus: Predictors of live birth.
Suksai M, Suwanrath C, Kor-Anantakul O, Geater A, Hanprasertpong T, Atjimakul T, Pichatechaiyoot A
Eur J Obstet Gynecol Reprod Biol 2017 May;212:1-8. Epub 2017 Mar 7 doi: 10.1016/j.ejogrb.2017.03.013. PMID: 28301807

Recent systematic reviews

Delivery management of a complete hydatidiform mole and co-existing viable fetus: A meta-analysis and systematic review.
Wang G, Cao J, Xu X, Han X, Cui H
J Gynecol Obstet Hum Reprod 2022 Jan;51(1):102269. Epub 2021 Nov 9 doi: 10.1016/j.jogoh.2021.102269. PMID: 34767996
Obstetric outcomes of twin pregnancies presenting with a complete hydatidiform mole and coexistent normal fetus: a systematic review and meta-analysis.
Zilberman Sharon N, Maymon R, Melcer Y, Jauniaux E
BJOG 2020 Nov;127(12):1450-1457. Epub 2020 May 17 doi: 10.1111/1471-0528.16283. PMID: 32339446
Accuracy of p57(KIP)(2) compared with genotyping to diagnose complete hydatidiform mole: a systematic review and meta-analysis.
Madi JM, Braga A, Paganella MP, Litvin IE, Wendland EM
BJOG 2018 Sep;125(10):1226-1233. Epub 2018 Jun 15 doi: 10.1111/1471-0528.15289. PMID: 29782064Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Gestational Trophoblastic Neoplasia, 2023

    Reviews

    Related information

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      Related records in OMIM
    • PMC Articles
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