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Central Nervous System Cavernous Hemangioma

MedGen UID:
199825
•Concept ID:
C0752160
•
Congenital Abnormality
Synonyms: Cavernous Hemangioma, Central Nervous System; Hemangioma, Cavernous, Central Nervous System

Definition

A cavernous hemangioma arising from the central nervous system. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral Nervous System Cavernous Hemangioma

Professional guidelines

PubMed

Neuroradiology: Differential Diagnosis, Follow-Up, and Reporting.
Splendiani A, Bruno F, Cerase A
Methods Mol Biol 2020;2152:97-107. doi: 10.1007/978-1-0716-0640-7_8. PMID: 32524547
Clinical Management of Cavernous Malformations.
Flemming KD
Curr Cardiol Rep 2017 Oct 18;19(12):122. doi: 10.1007/s11886-017-0931-1. PMID: 29046973
Synopsis of Guidelines for the Clinical Management of Cerebral Cavernous Malformations: Consensus Recommendations Based on Systematic Literature Review by the Angioma Alliance Scientific Advisory Board Clinical Experts Panel.
Akers A, Al-Shahi Salman R, A Awad I, Dahlem K, Flemming K, Hart B, Kim H, Jusue-Torres I, Kondziolka D, Lee C, Morrison L, Rigamonti D, Rebeiz T, Tournier-Lasserve E, Waggoner D, Whitehead K
Neurosurgery 2017 May 1;80(5):665-680. doi: 10.1093/neuros/nyx091. PMID: 28387823Free PMC Article

Recent clinical studies

Etiology

Cavernous malformations.
Ganz JC
Prog Brain Res 2022;268(1):115-132. Epub 2022 Jan 6 doi: 10.1016/bs.pbr.2021.10.029. PMID: 35074077
Pediatric Cerebral Cavernous Malformations.
Paddock M, Lanham S, Gill K, Sinha S, Connolly DJA
Pediatr Neurol 2021 Mar;116:74-83. Epub 2020 Nov 27 doi: 10.1016/j.pediatrneurol.2020.11.004. PMID: 33494000
Cerebral Cavernous Malformations, Developmental Venous Anomaly, and Its Coexistence: A Review.
Idiculla PS, Gurala D, Philipose J, Rajdev K, Patibandla P
Eur Neurol 2020;83(4):360-368. Epub 2020 Jul 30 doi: 10.1159/000508748. PMID: 32731220
CCM3 and cerebral cavernous malformation disease.
Wang K, Zhou HJ, Wang M
Stroke Vasc Neurol 2019 Jul;4(2):67-70. Epub 2019 Mar 2 doi: 10.1136/svn-2018-000195. PMID: 31338212Free PMC Article
Synopsis of Guidelines for the Clinical Management of Cerebral Cavernous Malformations: Consensus Recommendations Based on Systematic Literature Review by the Angioma Alliance Scientific Advisory Board Clinical Experts Panel.
Akers A, Al-Shahi Salman R, A Awad I, Dahlem K, Flemming K, Hart B, Kim H, Jusue-Torres I, Kondziolka D, Lee C, Morrison L, Rigamonti D, Rebeiz T, Tournier-Lasserve E, Waggoner D, Whitehead K
Neurosurgery 2017 May 1;80(5):665-680. doi: 10.1093/neuros/nyx091. PMID: 28387823Free PMC Article

Diagnosis

Pediatric Cerebral Cavernous Malformations.
Paddock M, Lanham S, Gill K, Sinha S, Connolly DJA
Pediatr Neurol 2021 Mar;116:74-83. Epub 2020 Nov 27 doi: 10.1016/j.pediatrneurol.2020.11.004. PMID: 33494000
Cavernous Sinus Hemangioma: Imaging Diagnosis and Surgical Considerations.
Montoya F, Vidal A, Sepulveda F, Marileo R, Caro J, Castillo M
World Neurosurg 2021 Feb;146:e30-e37. Epub 2020 Oct 5 doi: 10.1016/j.wneu.2020.09.153. PMID: 33031964
Cerebral Cavernous Malformations, Developmental Venous Anomaly, and Its Coexistence: A Review.
Idiculla PS, Gurala D, Philipose J, Rajdev K, Patibandla P
Eur Neurol 2020;83(4):360-368. Epub 2020 Jul 30 doi: 10.1159/000508748. PMID: 32731220
Familial Cavernous Hemangioma.
Torres G, Kini AT, Al Othman B, Lee AG
J Neuroophthalmol 2020 Jun;40(2):262-264. doi: 10.1097/WNO.0000000000000778. PMID: 30893269
Cavernous malformations.
Smith ER, Scott RM
Neurosurg Clin N Am 2010 Jul;21(3):483-90. doi: 10.1016/j.nec.2010.03.003. PMID: 20561497

Therapy

Familial Cerebral Cavernous Malformations.
Zafar A, Quadri SA, Farooqui M, Ikram A, Robinson M, Hart BL, Mabray MC, Vigil C, Tang AT, Kahn ML, Yonas H, Lawton MT, Kim H, Morrison L
Stroke 2019 May;50(5):1294-1301. doi: 10.1161/STROKEAHA.118.022314. PMID: 30909834Free PMC Article
Clinical Management of Cavernous Malformations.
Flemming KD
Curr Cardiol Rep 2017 Oct 18;19(12):122. doi: 10.1007/s11886-017-0931-1. PMID: 29046973
Pharmacotherapy for cavernous malformations.
Rudy RF, Du R
Handb Clin Neurol 2017;143:309-316. doi: 10.1016/B978-0-444-63640-9.00031-X. PMID: 28552155
Endothelial TLR4 and the microbiome drive cerebral cavernous malformations.
Tang AT, Choi JP, Kotzin JJ, Yang Y, Hong CC, Hobson N, Girard R, Zeineddine HA, Lightle R, Moore T, Cao Y, Shenkar R, Chen M, Mericko P, Yang J, Li L, Tanes C, Kobuley D, Võsa U, Whitehead KJ, Li DY, Franke L, Hart B, Schwaninger M, Henao-Mejia J, Morrison L, Kim H, Awad IA, Zheng X, Kahn ML
Nature 2017 May 18;545(7654):305-310. Epub 2017 May 10 doi: 10.1038/nature22075. PMID: 28489816Free PMC Article
Synopsis of Guidelines for the Clinical Management of Cerebral Cavernous Malformations: Consensus Recommendations Based on Systematic Literature Review by the Angioma Alliance Scientific Advisory Board Clinical Experts Panel.
Akers A, Al-Shahi Salman R, A Awad I, Dahlem K, Flemming K, Hart B, Kim H, Jusue-Torres I, Kondziolka D, Lee C, Morrison L, Rigamonti D, Rebeiz T, Tournier-Lasserve E, Waggoner D, Whitehead K
Neurosurgery 2017 May 1;80(5):665-680. doi: 10.1093/neuros/nyx091. PMID: 28387823Free PMC Article

Prognosis

Central nervous system cavernous malformations: cross-sectional study assessing rebleeding risk after a second haemorrhage.
Santos AN, Rauschenbach L, Gull HH, Olbrich A, Lahl K, Darkwah Oppong M, Dinger TF, Rieß C, Chen B, Lenkeit A, Schmidt B, Li Y, Jabbarli R, Wrede KH, Sure U, Dammann P
Eur J Neurol 2023 Jan;30(1):144-149. Epub 2022 Oct 13 doi: 10.1111/ene.15574. PMID: 36181703
Somatic MAP3K3 and PIK3CA mutations in sporadic cerebral and spinal cord cavernous malformations.
Hong T, Xiao X, Ren J, Cui B, Zong Y, Zou J, Kou Z, Jiang N, Meng G, Zeng G, Shan Y, Wu H, Chen Z, Liang J, Xiao X, Tang J, Wei Y, Ye M, Sun L, Li G, Hu P, Hui R, Zhang H, Wang Y
Brain 2021 Oct 22;144(9):2648-2658. doi: 10.1093/brain/awab117. PMID: 33729480
Cerebral Cavernous Malformations, Developmental Venous Anomaly, and Its Coexistence: A Review.
Idiculla PS, Gurala D, Philipose J, Rajdev K, Patibandla P
Eur Neurol 2020;83(4):360-368. Epub 2020 Jul 30 doi: 10.1159/000508748. PMID: 32731220
Epidemiology of cavernous malformations.
Goldstein HE, Solomon RA
Handb Clin Neurol 2017;143:241-247. doi: 10.1016/B978-0-444-63640-9.00023-0. PMID: 28552146
Natural history of spinal cavernous malformations.
Otten M, Mccormick P
Handb Clin Neurol 2017;143:233-239. doi: 10.1016/B978-0-444-63640-9.00022-9. PMID: 28552145

Clinical prediction guides

Central nervous system cavernous malformations: cross-sectional study assessing rebleeding risk after a second haemorrhage.
Santos AN, Rauschenbach L, Gull HH, Olbrich A, Lahl K, Darkwah Oppong M, Dinger TF, Rieß C, Chen B, Lenkeit A, Schmidt B, Li Y, Jabbarli R, Wrede KH, Sure U, Dammann P
Eur J Neurol 2023 Jan;30(1):144-149. Epub 2022 Oct 13 doi: 10.1111/ene.15574. PMID: 36181703
Clinical characteristics and long-term outcome of cerebral cavernous malformations-related epilepsy.
Shih YC, Chou CC, Peng SJ, Yu HY, Hsu SPC, Lin CF, Lee CC, Yang HC, Chen YC, Kwan SY, Chen C, Wang SJ, Lin CJ, Lirng JF, Shih YH, Yen DJ, Liu YT
Epilepsia 2022 Aug;63(8):2056-2067. Epub 2022 Jun 14 doi: 10.1111/epi.17309. PMID: 35593439
Multiple cerebral cavernous malformations: Clinical course of confirmed, assumed and non-familial disease.
Santos AN, Rauschenbach L, Saban D, Chen B, Darkwah Oppong M, Herten A, Gull HH, Rieß C, Deuschl C, Schmidt B, Jabbarli R, Wrede KH, Zhu Y, Frank B, Sure U, Dammann P
Eur J Neurol 2022 May;29(5):1427-1434. Epub 2022 Feb 3 doi: 10.1111/ene.15253. PMID: 35060255
Children with cavernous malformations of the central nervous system.
Arkar U, Vipotnik Vesnaver T, Maver A, Perković Benedik M, Peterlin B, Osredkar D
Eur J Paediatr Neurol 2021 Nov;35:61-66. Epub 2021 Oct 7 doi: 10.1016/j.ejpn.2021.10.001. PMID: 34634677
Somatic MAP3K3 and PIK3CA mutations in sporadic cerebral and spinal cord cavernous malformations.
Hong T, Xiao X, Ren J, Cui B, Zong Y, Zou J, Kou Z, Jiang N, Meng G, Zeng G, Shan Y, Wu H, Chen Z, Liang J, Xiao X, Tang J, Wei Y, Ye M, Sun L, Li G, Hu P, Hui R, Zhang H, Wang Y
Brain 2021 Oct 22;144(9):2648-2658. doi: 10.1093/brain/awab117. PMID: 33729480

Recent systematic reviews

Radiation-Induced Cerebral Cavernous Malformations: A Single-Center Experience and Systematic Literature Review.
Koester SW, Rhodenhiser EG, Dabrowski SJ, Benner D, Rumalla K, Scherschinski L, Catapano JS, Graffeo CS, Srinivasan VM, Lawton MT
World Neurosurg 2023 Nov;179:222-232.e2. Epub 2023 Aug 17 doi: 10.1016/j.wneu.2023.08.036. PMID: 37595838
Gamma Knife® stereotactic radiosurgery for intracranial cavernous malformations.
Shanker MD, Webber R, Pinkham MB, Huo M, Olson S, Hall B, Jayalath R, Watkins T, Foote MC
J Clin Neurosci 2022 Dec;106:96-102. Epub 2022 Oct 20 doi: 10.1016/j.jocn.2022.10.015. PMID: 36274300
Surgery for cerebral cavernous malformations: a systematic review and meta-analysis.
Harris L, Poorthuis MHF, Grover P, Kitchen N, Al-Shahi Salman R
Neurosurg Rev 2022 Feb;45(1):231-241. Epub 2021 Jun 30 doi: 10.1007/s10143-021-01591-5. PMID: 34191202
Cerebral cavernous malformation: Management and outcome during pregnancy and puerperium. A systematic review of literature.
Merlino L, Del Prete F, Titi L, Piccioni MG
J Gynecol Obstet Hum Reprod 2021 Jan;50(1):101927. Epub 2020 Oct 6 doi: 10.1016/j.jogoh.2020.101927. PMID: 33035718
Synopsis of Guidelines for the Clinical Management of Cerebral Cavernous Malformations: Consensus Recommendations Based on Systematic Literature Review by the Angioma Alliance Scientific Advisory Board Clinical Experts Panel.
Akers A, Al-Shahi Salman R, A Awad I, Dahlem K, Flemming K, Hart B, Kim H, Jusue-Torres I, Kondziolka D, Lee C, Morrison L, Rigamonti D, Rebeiz T, Tournier-Lasserve E, Waggoner D, Whitehead K
Neurosurgery 2017 May 1;80(5):665-680. doi: 10.1093/neuros/nyx091. PMID: 28387823Free PMC Article

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