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Peripheral primitive neuroectodermal tumor of soft tissues

MedGen UID:
205115
•Concept ID:
C1112437
•
Neoplastic Process
Synonyms: Peripheral Neuroectodermal Tumor of Soft Tissues; peripheral neuroectodermal tumor of soft tissues; Peripheral Neuroectodermal Tumor of the Soft Tissues; peripheral neuroectodermal tumor of the soft tissues; peripheral neuroectodermal tumour of soft tissues; peripheral neuroectodermal tumour of the soft tissues; Peripheral Neuroepithelioma of Soft Tissues; peripheral neuroepithelioma of soft tissues; Peripheral Neuroepithelioma of the Soft Tissues; peripheral neuroepithelioma of the soft tissues; Peripheral Primitive Neuroectodermal Tumor of Soft Tissues; peripheral primitive neuroectodermal tumor of soft tissues; soft tissue peripheral neuroepithelioma
 
Monarch Initiative: MONDO:0002982

Definition

A small round cell tumor with neural differentiation arising from the soft tissues. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPeripheral primitive neuroectodermal tumor of soft tissues

Professional guidelines

PubMed

The new international neuroblastoma response criteria.
Orr KE, McHugh K
Pediatr Radiol 2019 Oct;49(11):1433-1440. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04397-2. PMID: 31620844
Revisions to the International Neuroblastoma Response Criteria: A Consensus Statement From the National Cancer Institute Clinical Trials Planning Meeting.
Park JR, Bagatell R, Cohn SL, Pearson AD, Villablanca JG, Berthold F, Burchill S, Boubaker A, McHugh K, Nuchtern JG, London WB, Seibel NL, Lindwasser OW, Maris JM, Brock P, Schleiermacher G, Ladenstein R, Matthay KK, Valteau-Couanet D
J Clin Oncol 2017 Aug 1;35(22):2580-2587. Epub 2017 May 4 doi: 10.1200/JCO.2016.72.0177. PMID: 28471719Free PMC Article
Current Management of Fetal and Neonatal Tumors.
Fernandez-Pineda I
Curr Pediatr Rev 2015;11(3):142. doi: 10.2174/157339631103150716104012. PMID: 26421332

Recent clinical studies

Etiology

Role and toxicity of radiation therapy in neuroblastoma patients: A literature review.
Zhao Q, Liu Y, Zhang Y, Meng L, Wei J, Wang B, Wang H, Xin Y, Dong L, Jiang X
Crit Rev Oncol Hematol 2020 May;149:102924. Epub 2020 Mar 3 doi: 10.1016/j.critrevonc.2020.102924. PMID: 32172225
Revisions to the International Neuroblastoma Response Criteria: A Consensus Statement From the National Cancer Institute Clinical Trials Planning Meeting.
Park JR, Bagatell R, Cohn SL, Pearson AD, Villablanca JG, Berthold F, Burchill S, Boubaker A, McHugh K, Nuchtern JG, London WB, Seibel NL, Lindwasser OW, Maris JM, Brock P, Schleiermacher G, Ladenstein R, Matthay KK, Valteau-Couanet D
J Clin Oncol 2017 Aug 1;35(22):2580-2587. Epub 2017 May 4 doi: 10.1200/JCO.2016.72.0177. PMID: 28471719Free PMC Article
¹³¹I-Metaiodobenzylguanidine Theranostics in Neuroblastoma: Historical Perspectives; Practical Applications.
Parisi MT, Eslamy H, Park JR, Shulkin BL, Yanik GA
Semin Nucl Med 2016 May;46(3):184-202. doi: 10.1053/j.semnuclmed.2016.02.002. PMID: 27067500
Phenotype and immunophenotype of the most common pediatric tumors.
Picarsic J, Reyes-Múgica M
Appl Immunohistochem Mol Morphol 2015 May-Jun;23(5):313-26. doi: 10.1097/PAI.0000000000000068. PMID: 25390357
Neonatal cancer.
Orbach D, Sarnacki S, Brisse HJ, Gauthier-Villars M, Jarreau PH, Tsatsaris V, Baruchel A, Zerah M, Seigneur E, Peuchmaur M, Doz F
Lancet Oncol 2013 Dec;14(13):e609-20. doi: 10.1016/S1470-2045(13)70236-5. PMID: 24275134

Diagnosis

The new international neuroblastoma response criteria.
Orr KE, McHugh K
Pediatr Radiol 2019 Oct;49(11):1433-1440. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04397-2. PMID: 31620844
Revisions to the International Neuroblastoma Response Criteria: A Consensus Statement From the National Cancer Institute Clinical Trials Planning Meeting.
Park JR, Bagatell R, Cohn SL, Pearson AD, Villablanca JG, Berthold F, Burchill S, Boubaker A, McHugh K, Nuchtern JG, London WB, Seibel NL, Lindwasser OW, Maris JM, Brock P, Schleiermacher G, Ladenstein R, Matthay KK, Valteau-Couanet D
J Clin Oncol 2017 Aug 1;35(22):2580-2587. Epub 2017 May 4 doi: 10.1200/JCO.2016.72.0177. PMID: 28471719Free PMC Article
Neonatal cancer.
Orbach D, Sarnacki S, Brisse HJ, Gauthier-Villars M, Jarreau PH, Tsatsaris V, Baruchel A, Zerah M, Seigneur E, Peuchmaur M, Doz F
Lancet Oncol 2013 Dec;14(13):e609-20. doi: 10.1016/S1470-2045(13)70236-5. PMID: 24275134
Ewing sarcoma/peripheral primitive neuroectodermal tumor and related tumors.
Tsokos M, Alaggio RD, Dehner LP, Dickman PS
Pediatr Dev Pathol 2012;15(1 Suppl):108-26. doi: 10.2350/11-08-1078-PB.1. PMID: 22420726Free PMC Article
Neuroblastoma-like neurilemoma.
Goldblum JR, Beals TF, Weiss SW
Am J Surg Pathol 1994 Mar;18(3):266-73. doi: 10.1097/00000478-199403000-00006. PMID: 8116794

Therapy

Antiangiogenic therapy for primitive neuroectodermal tumor with thalidomide: A case report and review of literature.
Li Q, Liu Y, Yu Y
Medicine (Baltimore) 2017 Dec;96(51):e9272. doi: 10.1097/MD.0000000000009272. PMID: 29390485Free PMC Article
Revisions to the International Neuroblastoma Response Criteria: A Consensus Statement From the National Cancer Institute Clinical Trials Planning Meeting.
Park JR, Bagatell R, Cohn SL, Pearson AD, Villablanca JG, Berthold F, Burchill S, Boubaker A, McHugh K, Nuchtern JG, London WB, Seibel NL, Lindwasser OW, Maris JM, Brock P, Schleiermacher G, Ladenstein R, Matthay KK, Valteau-Couanet D
J Clin Oncol 2017 Aug 1;35(22):2580-2587. Epub 2017 May 4 doi: 10.1200/JCO.2016.72.0177. PMID: 28471719Free PMC Article
¹³¹I-Metaiodobenzylguanidine Theranostics in Neuroblastoma: Historical Perspectives; Practical Applications.
Parisi MT, Eslamy H, Park JR, Shulkin BL, Yanik GA
Semin Nucl Med 2016 May;46(3):184-202. doi: 10.1053/j.semnuclmed.2016.02.002. PMID: 27067500
Ifosfamide in pediatric solid tumors.
Carli M, Passone E, Perilongo G, Bisogno G
Oncology 2003;65 Suppl 2:99-104. doi: 10.1159/000073369. PMID: 14586158
Pesticides and childhood cancer.
Zahm SH, Ward MH
Environ Health Perspect 1998 Jun;106 Suppl 3(Suppl 3):893-908. doi: 10.1289/ehp.98106893. PMID: 9646054Free PMC Article

Prognosis

Stage 4N neuroblastoma before and during the era of anti-G(D2) immunotherapy.
Kushner BH, LaQuaglia MP, Cardenas FI, Basu EM, Gerstle JT, Kramer K, Roberts SS, Wolden SL, Cheung NV, Modak S
Int J Cancer 2023 Dec 15;153(12):2019-2031. Epub 2023 Aug 21 doi: 10.1002/ijc.34693. PMID: 37602920
¹³¹I-Metaiodobenzylguanidine Theranostics in Neuroblastoma: Historical Perspectives; Practical Applications.
Parisi MT, Eslamy H, Park JR, Shulkin BL, Yanik GA
Semin Nucl Med 2016 May;46(3):184-202. doi: 10.1053/j.semnuclmed.2016.02.002. PMID: 27067500
Diagnostic Imaging of Fetal and Neonatal Abdominal and Soft Tissue Tumors.
Nagaraj UD, Kline-Fath BM
Curr Pediatr Rev 2015;11(3):143-50. doi: 10.2174/1573396311666150714110605. PMID: 26168940
Phenotype and immunophenotype of the most common pediatric tumors.
Picarsic J, Reyes-Múgica M
Appl Immunohistochem Mol Morphol 2015 May-Jun;23(5):313-26. doi: 10.1097/PAI.0000000000000068. PMID: 25390357
Ewing sarcoma/peripheral primitive neuroectodermal tumor and related tumors.
Tsokos M, Alaggio RD, Dehner LP, Dickman PS
Pediatr Dev Pathol 2012;15(1 Suppl):108-26. doi: 10.2350/11-08-1078-PB.1. PMID: 22420726Free PMC Article

Clinical prediction guides

Postchemotherapy gross residual tumor in non-high-risk neuroblastoma: Clinical significance and the role of adjuvant therapy.
Seo ES, Lim H, Cho HW, Ju HY, Lee JW, Yoo KH, Lee S, Lim DH, Sung KW, Koo HH
Pediatr Blood Cancer 2022 Nov;69(11):e29840. Epub 2022 Jun 23 doi: 10.1002/pbc.29840. PMID: 35735763
¹³¹I-Metaiodobenzylguanidine Theranostics in Neuroblastoma: Historical Perspectives; Practical Applications.
Parisi MT, Eslamy H, Park JR, Shulkin BL, Yanik GA
Semin Nucl Med 2016 May;46(3):184-202. doi: 10.1053/j.semnuclmed.2016.02.002. PMID: 27067500
Radiologic and clinicopathologic findings of peripheral primitive neuroectodermal tumors.
Ba L, Tan H, Xiao H, Guan Y, Gao J, Gao X
Acta Radiol 2015 Jul;56(7):820-8. Epub 2014 Jul 29 doi: 10.1177/0284185114539321. PMID: 25073463
Ifosfamide in pediatric solid tumors.
Carli M, Passone E, Perilongo G, Bisogno G
Oncology 2003;65 Suppl 2:99-104. doi: 10.1159/000073369. PMID: 14586158
Pesticides and childhood cancer.
Zahm SH, Ward MH
Environ Health Perspect 1998 Jun;106 Suppl 3(Suppl 3):893-908. doi: 10.1289/ehp.98106893. PMID: 9646054Free PMC Article

Recent systematic reviews

Malignant spinal cord compression in the paediatric population-a systematic review, meta-analysis.
Quraishi NA, Palliyil N, Hassanin MA, D'Aquino D, Shetaiwi A, Walker D
Eur Spine J 2023 Dec;32(12):4306-4313. Epub 2023 Jun 20 doi: 10.1007/s00586-023-07820-3. PMID: 37338630

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